History of research on tumor angiogenesis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Springer Netherland
2009
|
| Ausgabe: | 1. ed. |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 112 S. |
| Beschreibung: | 120 S. graph. Darst. 235 mm x 155 mm |
| ISBN: | 9781402095597 |
Internformat
MARC
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: History of research on tumor angiogenesis
Autor: Ribatti, Domenico
Jahr: 2009
Contents
Chapter 1 I
1.1 Early Evidence of the Vascular Phase and Its Importance
in Tumor Growth I
1.2 Early Evidence of Tumor Cells Releasing Specific Growth Factor
for Blood Vessels 2
1.3 Tumors in Isolated Perfused Organs: Absence of Angiogenesis ... 5
1.3.1 Hypothesis: Tumor Growth Is Angiogenesis-Dependent.. 6
1.3.2 Evidence that Tumors Are Angiogenesis-Dependent 6
1.4 The Avascular and Vascular Phases of Solid Tumor Growth 9
1.4.1 First Evidence of the Existence of the Avascular and
Vascular Phases of Solid Tumor Growth 9
1.4.2 The Significance of Angiogenesis in Hematological
Malignancies 10
1.4.3 Non-Angiogenesis-Dependent Pathways for Tumor
Growth: Vascular Cooption and Vasculogenic Mimicry .. 15
Chapter 2 19
2.1 Isolation of the First Angiogenic Tumor Factor 19
2.2 The Discovery of Basic Fibroblast Growth Factor/Fibroblast
Growth Factor-2 20
2.2.1 FGF-2 Receptors and FGF-2 Interactions 21
2.2.2 The Role of FGF-2 in Tumor Growth and Vascularization 22
2.3 The Discovery of Vascular Permeability Factor/Vascular
Endothelial Growth Factor 23
2.3.1 The Contribution of Harold F. Dvorak. Tumor Blood
Vessels Are Hyperpermeable to Plasma Proteins
and to Other Circulating Macromolecules 23
2.3.2 The Contribution of Napoleone Ferrara 26
2.3.3 The Discovery of Angiopoietins 29
Chapter 3 31
3.1 How Do Tumor Cells Switch to the Angiogenic Phenotype? 31
3.2 The Concept of Angiogenic Switch 32
vii
viii „
Contents
3.3 Factors Involved in the Angiogenic Switch 33
3.4 What Is the Evidence that Genetic Instability Promotes
the Angiogenic Switch? 34
3.4.1 The RIP1-TAG2 Model 35
3.4.2 The K14-HPV16 Model 37
3.4.3 The Papilloma Virus Type 1 Model 38
Chapter 4 4 ]
4.1 Tumor Endothelial Cell s Features 41
4.2 Tumor Basement Membrane 43
4.3 Tumor Pericytes 43
Chapter 5 47
5.1 Tumor Lymphangiogenesis 47
Chapter 6 53
6.1 The Contribution of Inflammatory Cells to Tumor Angiogenesis .. 53
6.1.1 Neutrophils 54
6.1.2 Monocytes and Macrophages 56
6.1.3 Lymphocytes 59
6.1.4 Eosinophils 59
6. J .5 Mast Cells 60
Chapter 7 63
7.1 The Role of Endothelial Progenitor Cells in Tumor Angiogenesis.
The First Isolation of Putative Endothelial Progenitor Cells 63
7.2 Characterization of Endothelial Progenitor Cells 63
7.3 Triggers and Inhibitors of Endothelial Progenitor Cells to Sites
of Active Neovascularization 64
7.4 The Transplantation Models to Study Endothelial Progenitor Cells 65
7.5 The Identification of Bone Marrow-Derived Multipotent
Progenitor Cells 66
7.6 Monocyte/Macrophage as a Source of Endothelial Progenitor Cells 67
7.7 Contribution of Endothelial Progenitor Cells to Tumor
Angiogenesis 67
Chapter 8 71
8.1 Tumor Microvascular Density as a Prognostic Indicator 71
8.2 Use of Panendothelial Cell Markers 72
8.3 Topography 74
8.4 Certain Human Tumor Types Can Exhibit Lower Microvascular
Density than the Corresponding Normal Tissues 74
8.5 Prognostic Value of Microvascular Density 75
8.6 The Relationship Between Microvascular Density
and Intercapillary Distance 75
Contents jx
Chapter 9 77
9.1 Inhibitors of Angiogenesis 77
9.1.1 Interferons 79
9.1.2 Cartilage 80
9.1.3 Protamine and Platelet Factor 4 81
9.1.4 Vascular Disrupting Agents 81
9.1.5 Angiostatic Steroids 82
9.1.6 Fumagillin 83
9.1.7 Thrombospondin-1 83
9.1.8 Angiostatin and Endostatin 84
9.1.9 Thalidomide 86
9.2 Metronomic Chemotherapy 87
9.3 Receptor Tyrosine Kinase (RTK) Inhibitors 89
9.4 Inhibitors of VEGF 90
9.5 Antiangiogenic Monoclonal Antibodies: Toward the Discovery of
Avastin 91
9.6 Microvascular Density Has Not Been Shown to Be a Valid
Measurement to Guide or Evaluate Antiangiogenic Treatment .... 94
9.7 Perspectives 95
References 99
|
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| discipline | Medizin |
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| id | DE-604.BV035435621 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:35:12Z |
| institution | BVB |
| isbn | 9781402095597 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017355954 |
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| physical | 120 S. graph. Darst. 235 mm x 155 mm |
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| spelling | Ribatti, Domenico 1956- Verfasser (DE-588)138309019 aut History of research on tumor angiogenesis Domenico Ribatti 1. ed. Berlin Springer Netherland 2009 120 S. graph. Darst. 235 mm x 155 mm txt rdacontent n rdamedia nc rdacarrier XIV, 112 S. HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017355954&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ribatti, Domenico 1956- History of research on tumor angiogenesis |
| title | History of research on tumor angiogenesis |
| title_auth | History of research on tumor angiogenesis |
| title_exact_search | History of research on tumor angiogenesis |
| title_full | History of research on tumor angiogenesis Domenico Ribatti |
| title_fullStr | History of research on tumor angiogenesis Domenico Ribatti |
| title_full_unstemmed | History of research on tumor angiogenesis Domenico Ribatti |
| title_short | History of research on tumor angiogenesis |
| title_sort | history of research on tumor angiogenesis |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017355954&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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