Hot Topics in Neural Membrane Lipidology:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York, NY
Springer
2009
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXIII, 406 S. graph. Darst. 235 mm x 155 mm |
| ISBN: | 9780387096933 9780387096926 |
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| 245 | 1 | 0 | |a Hot Topics in Neural Membrane Lipidology |c Akhlaq A. Farooqui |
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| 650 | 4 | |a Cell membranes | |
| 650 | 4 | |a Membrane lipids | |
| 650 | 4 | |a Neurons | |
| 650 | 4 | |a Phospholipases | |
| 650 | 4 | |a Phospholipids | |
| 650 | 4 | |a Sphingolipids | |
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| adam_text | Titel: Hot topics in neural membrane lipidology
Autor: Farooqui, Akhlaq A.
Jahr: 2009
Contents
1 Neural Membranes: A Pandora s Box of Lipid Mediators 1
1.1 Lipid Composition of Neural Membranes 1
1.2 Glycerophospholipids and Their Metabolism in Brain 3
1.3 Arachidonic Acid and Its Enzymically Derived Oxidation
Products 4
1.3.1 Arachidonic Acid and Lyso-glycerophospholipids ... 5
1.3.2 Lysophosphatidylcholine (lyso-PtdCho) 5
1.3.3 Eicosanoids 8
1.3.4 Lipoxins 10
1.4 Non-enzymic Oxidation of Arachidonic Acid 10
1.4.1 4-Hydroxynonenal (4-HNE) 11
1.4.2 Isoprostanes 13
1.4.3 Isoketals 14
1.4.4 Isofurans 14
1.5 Enzymic and Non-enzymic Oxidation of DHA 15
1.5.1 Enzymically Derived Lipid Mediators of DHA 15
1.5.2 Resolvins 15
1.5.3 Protectins and Neuroprotectins 16
1.6 Non-enzymic Oxidation of Docosahexaenoic Acid 17
1.6.1 4-Hydroxyhexenal 18
1.6.2 Neuroprostanes 18
1.6.3 Neuroketals (NK) 19
1.7 Sphingolipid Metabolism in Brain 19
1.7.1 Ceramide and Ceramide 1-Phosphate 20
1.7.2 Sphingosine and Sphingosine 1-Phosphate 22
1.8 Cholesterol Metabolism in Brain 23
1.9 Association of Lipid Mediators with Neurological
Disorders 25
1.10 Conclusion 25
References 26
xiii
xiv Contents
2 Interplay Among Glycerophospholipid, Sphingolipid,
and Cholesterol-Derived Lipid Mediators in Brain: A Matter
of Life and Death 37
2.1 Introduction 37
2.2 Generation of Glycerophospholipid-Derived Lipid
Mediators 38
2.3 Enzymically-Derived AA Metabolites
and Neuroinflammation 38
2.4 Platelet-Activating Factor in Brain 45
2.5 Metabolism of Sphingolipid-Derived Lipid Mediators
in Brain 46
2.6 Neurochemical Effects and Roles of Ceramides 50
2.7 Generation of Cholesterol-Derived Metabolites in Brain .... 51
2.8 Interactions Among Phospholipid, Sphingolipid,
and Cholesterol-Derived Lipid Mediators 53
2.8.1 Interactions Between Glycerophospholipid
and Sphingolipid Metabolism 53
2.8.2 Interactions Between Glycerophospholipid
and Sphingolipid-Derived Lipid Mediators 54
2.8.3 Interactions Between Glycerophospholipid
and Cholesterol-Derived Lipid Mediators 57
2.8.4 Interactions Between Sphingolipid
and Cholesterol-Derived Lipid Mediators 58
2.9 Conclusion 60
References 61
3 Janus Face of Phospholipase A2: Role of Phospholipase A2
in Neural Cell Survival and Death 71
3.1 Introduction 71
3.2 Multiplicity of PLA2 in Brain Tissue 72
3.2.1 Cytosolic Phospholipase A2 (cPLA2) 72
3.2.2 Calcium Independent Phospholipase A2(iPLA2) 76
3.2.3 Secretory Phospholipase A2 (sPLA2) 79
3.2.4 Plasmalogen Selective Phospholipase A2
(PlsEtn-PLA2) 80
3.3 Role of Multiple Forms of PLA2 in Brain 81
3.3.1 Multiple Forms of PL A2 and Neurotransmitter
Release 81
3.3.2 Multiple Forms of PLA2 in Long-Term
Potentiation and Long-Term Depression 83
3.3.3 Multiple Forms of PLA2 in Membrane Repair 85
3.3.4 Multiple Forms of PLA2 in Modulation
of Neurite Outgrowth and Regeneration 86
3.3.5 Multiple Forms of PLA2 in Tubule Formation
and Membrane Trafficking 87
Contents xv
3.3.6 Multiple Forms of PLA2 in the Cell Cycle 88
3.3.7 Multiple Forms of PLA2 in Neuroinflammation .... 89
3.3.8 Multiple Forms of PLA2 in Nociception
and Vacuous Chewing Movements 91
3.3.9 Multiple Forms of PLA2 in Oxidative Stress 92
3.3.10 Multiple Forms of PLA2 in Apoptotic
and Necrotic Cell Death 93
3.3.11 Multiple Forms of PLA2 in Chemotaxis 95
3.4 Regulation of Multiple Forms of PLA2 Activity in Brain .... 96
3.4.1 Regulation of cPLA2 96
3.4.2 Regulation of iPLA2 97
3.4.3 Regulation of sPLA2 98
3.5 Conclusion 98
References 99
4 Glycerophospholipid Metabolism in the Nucleus: Cross Talk
Among Phospholipase A2, Phospholipase C and Phospholipase D . . . Ill
4.1 Introduction Ill
4.2 Phospholipid Metabolism in the Nucleus 113
4.3 Importance of Phospholipases and Glycerophospholipid
Metabolism in the Nucleus 114
4.4 Occurrence of Isoforms of Phospholipase A2,
Phospholipase C, and Phospholipase D in Nucleus 116
4.4.1 PLA2 Activities in the Nucleus 118
4.4.2 Nuclear PLC Activities 125
4.4.3 Nuclear PLD Activities 129
4.5 Interplay Among Nuclear and Non-Nuclear PLA2,
PLC, and PLD Activities 130
4.6 Nuclear PLA2, PLC, and PLD and Nuclear Inclusions
in Neurological Disorders 131
4.7 Conclusion 132
References 133
5 Ether Glycerophospholipids: The Workhorse Lipids of Neural
Membranes 141
5.1 Introduction 141
5.2 Plasmalogens in Brain 143
5.3 Biosynthesis of Plasmalogens 143
5.4 Degradation of Plasmalogens 145
5.4.1 Plasmalogen-Selective Phospholipase A2
(PlsEtn-PLA2) 145
5.4.2 Receptor-Mediated Degradation of Plasmalogens . . . 147
5.5 Roles of Plasmalogens in Brain 149
5.6 Platelet-Activating Factor (PAF) 151
5.7 Biosynthesis of PAF 151
xvi Contents
5.7.1 Remodeling Pathway 152
5.7.2 De Novo Synthesis of PAF 153
5.7.3 Oxidative Fragmentation Pathway for PAF
Synthesis 153
5.8 Catabolism of PAF 153
5.8.1 Mammalian Brain Type I PAF-Acetyl Hydrolases. . . 154
5.8.2 Type II PAF-Acetyl Hydrolases in Mammalian
Tissues 155
5.8.3 PAF-Acetyl Hydrolases in Mammalian Plasma 155
5.9 Roles of PAF in Brain 156
5.10 Involvement of Plasmalogens in Neurological Disorders ... 158
5.10.1 Plasmalogens in Ischemic Injury 159
5.10.2 Plasmalogens in Alzheimer Disease 159
5.10.3 Plasmalogens in Spinal Cord Injury 159
5.10.4 Plasmalogens in Peroxisomal Disorders 160
5.11 Involvement of Platelet-Activating Factor in
Neurological Disorders 160
5.12 Conclusion 161
References 162
6 Excitotoxicity-Mediated Neurochemical Changes in Neurological
Disorders 173
6.1 Introduction 173
6.2 Glutamate-Mediated Neurochemical Changes in Brain 174
6.2.1 Glutamate-Mediated Changes in Arachidonic
Acid and Lysophosphatidylcholine Metabolism 174
6.2.2 Glutamate-Mediated Changes in Platelet-Activating
Factor Metabolism 178
6.2.3 Glutamate-Mediated Alterations in Eicosanoid
Metabolism 179
6.2.4 Glutamate-Mediated Generation of Reactive
Oxygen Species 180
6.2.5 Glutamate-Mediated Depletion of Reduced
Glutathione 180
6.2.6 Glutamate-Mediated Alterations in Nuclear
Transcription Factor kB (NF-kB) 181
6.2.7 Glutamate-Mediated Changes in Enzymic
Activities 182
6.2.8 Glutamate-Mediated Expression of Cytokines 185
6.2.9 Glutamate-Mediated Changes in Growth Factors ... 186
6.2.10 Glutamate-Mediated Changes in Heat Shock
Protein Expression 187
6.2.11 Glutamate-Mediated Upregulation of Genes 188
6.2.12 Glutamate and Apoptotic Neural Cell Death 189
Contents xvii
6.3 Mechanism of Glutamate-Mediated Neural Cell Injury in
Neurological Disorders 189
6.4 Involvement of Excitotoxicity in Neurological Disorders .... 191
6.4.1 Glutamate in Ischemic Injury 192
6.4.2 Glutamate in Spinal Cord Injury 193
6.4.3 Glutamate in Head Injury 193
6.4.4 Glutamate in Epilepsy 194
6.4.5 Glutamate in Alzheimer Disease 194
6.4.6 Glutamate in Amyotrophic Lateral Sclerosis (ALS). . 195
6.4.7 Glutamate in Huntington Disease 196
6.4.8 Glutamate in AIDS Dementia Complex 197
6.4.9 Glutamate in Creutzfeldt-Jakob Disease (CJD) 198
6.4.10 Glutamate in Multiple Sclerosis (MS) 199
6.4.11 Domoic Acid Neurotoxicity 200
6.5 Conclusion 201
References 201
7 Recent Developments on Kainate-Mediated Neurotoxicity
and Their Association with Generation of Lipid Mediators 215
7.1 Introduction 215
7.2 KA Receptor-Mediated Ion Fluxes in Neural Cells 216
7.3 KA-Mediated Alterations in Neural Membrane
Glycerophospholipids 219
7.4 KA-Mediated Alterations in Sphingolipid Metabolism 224
7.5 Cholesterol Metabolism in Brain 227
7.5.1 KA-Mediated Changes in Cholesterol and Its
Metabolites 227
7.5.2 KA-Mediated Alterations in Oxycholesterols 229
7.5.3 KA-Mediated Changes in Steroid Hormones 230
7.6 Consequences of Interactions Among Glycerophospholipid,
Sphingolipid, and Cholesterol-Derived Lipid Mediators
in KA-Mediated Neurotoxicity 232
7.7 Interactions Between Ceramide and Cholesterol
Metabolism in KA-Mediated Toxicity 234
7.8 Interactions Between Glycerophospholipid and Cholesterol
Metabolism in KA-Mediated Neurotoxicity 235
7.9 Conclusion 236
References 236
8 Beneficial Effects of Docosahexaenoic Acid on Health of the
Human Brain 243
8.1 Introduction 243
8.2 Synthesis of DHA in Brain 245
8.3 Transport and Incorporation of Docosahexaenoic
Acid in Brain 246
xviii Contents
8.4 Release and Catabolism of DHA in Brain 247
8.5 Role of DHA in Brain Tissue 251
8.5.1 Modulation of Gene Expression by DHA 253
8.5.2 Modulation of Enzymic Activities by DHA 254
8.5.3 Modulation of Inflammation and Immunity
by DHA 254
8.5.4 Modulation of Learning and Memory by DHA 255
8.5.5 Modulation of Apoptotic Cell Death by DHA 256
8.5.6 DHA and Generation of Docosanoids 257
8.5.7 DHA and Neurite Outgrowth 257
8.5.8 DHA in Visual Function 258
8.5.9 DHA in Nociception (Pain) 259
8.6 Alterations in DHA Levels in Aging and Neurological
Disorders 260
8.6.1 DHA Levels in Normal Aging Brain 260
8.6.2 DHA Levels in Neurological Disorders 261
8.6.3 Dietary DHA and Cancer 263
8.7 The Adverse Effects of DHA 265
8.8 Conclusion 266
References 267
9 Effects of Statins and n-3 Fatty Acids on Heart and Brain Tissues:
The Clash of the Titans 277
9.1 Introduction 277
9.2 Properties, Metabolic Sites and Mechanism of Action
of Statins 278
9.3 Composition of Fish Oil and Its Importance in Human
Nutrition 283
9.4 Biochemical Effects of Statins on Cardiovascular System. .. 285
9.5 Biochemical Effects of Statins on Brain 289
9.5.1 Cholesterol-Independent Effects of Statins 290
9.5.2 Cholesterol-Dependent Effects of Statins 292
9.6 Biochemical Effects of Fish Oil on Heart 294
9.7 Biochemical Effects of Fish Oil on Brain 296
9.8 Therapeutic Value of Statins and DHA in Cardiovascular
and Cerebrovascular Systems Disorders 297
9.8.1 Statins in Cardiovascular System 297
9.8.2 Stains in Cerebrovascular System 298
9.8.3 n-3 Fatty Acids in Cardiovascular System 302
9.8.4 m-3 Fatty Acids in Cerebrovascular System 302
9.9 Effects of Combination of Statin and Fish Oil in
Cardiovascular and Neurological Disorders 304
9.10 Adverse Effects of Statins and n-3 Fatty Acids 305
9.11 Conclusions 306
References 307
Contents xix
10 Apoptosis and Necrosis in Brain: Contribution of Glycerophospholipid,
Sphingolipid, and Cholesterol-Derived Lipid Mediators 319
10.1 Introduction 319
10.2 Apoptosis and Necrosis Death in Brain 321
10.2.1 Mechanisms Associated with the Activation
of Caspases 322
10.2.2 Biochemical Changes Associated with Apoptosis... 326
10.2.3 Biochemical Changes Associated with Necrosis .... 327
10.3 Apoptosis and Necrosis-Mediated Alterations in
Glycerophospholipid, Sphingolipid, and Cholesterol
Metabolism 328
10.3.1 Apoptosis and Necrosis-Mediated Changes
in Glycerophospholipid Metabolism 330
10.3.2 Apoptosis and Necrosis-Mediated Changes
in Sphingolipid Metabolism 334
10.3.3 Apoptosis and Necrosis-Mediated Changes in Cho¬
lesterol Metabolism 336
10.4 Interactions Among Glycerophospholipid, Sphingolipid,
and Cholesterol Metabolism in Apoptosis and Necrosis .... 337
10.5 Apoptotic and Necrotic Cell Death in Neurological
Disorders 339
10.6 Association of Mitochondrial Dysfunction with Apoptotic
and Necrotic Cell Death in Neurological Disorders 341
10.7 Prevention of Apoptotic Cell Death by Inhibitors of
Enzymes Associated with Exicitoxicity, Inflammation,
and Oxidative Stress 343
10.7.1 Glutamate Receptor Antagonists 344
10.7.2 Antioxidants and Anti-inflammatory Agents 346
10.7.3 Prevention of Apoptosis by Inhibitors of Caspases,
Calpains, PLA2, Nitric Oxide Synthase,
and SMase 347
10.8 Conclusion 351
References 352
11 Perspective and Directions for Future Developments on
Glycerophospholipid-, Sphingolipid-, and Cholesterol-Derived Lipid
Mediators 365
11.1 Introduction 365
11.2 Association of Lipid Mediators with Neural Cell Death.... 367
11.3 Detection and Levels of Lipid Mediators in Neurological
Disorders by Lipidomics 370
11.4 Detection of Lipid Mediators by Positron Emission
Tomography 371
11.5 Proteomics, Enzymes of Lipid Metabolism, and
Neurodegenerative Diseases 373
i .6 Antisense and RNAi as Neuroprotective Agents 374
1.7 Significance of Developing Early Detection Procedures
and Treatment for Neurodegenerative Diseases 375
11.8 Conclusion 376
References 377
ex 383
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| genre_facet | Konferenzschrift 1979 Königstein Konferenzschrift Konferenzschrift 1979 Königstein Taunus |
| id | DE-604.BV035428142 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:35:01Z |
| institution | BVB |
| isbn | 9780387096933 9780387096926 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017348578 |
| oclc_num | 302346758 |
| open_access_boolean | |
| owner | DE-384 |
| owner_facet | DE-384 |
| physical | XXIII, 406 S. graph. Darst. 235 mm x 155 mm |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| spelling | Farooqui, Akhlaq A. Verfasser aut Hot Topics in Neural Membrane Lipidology Akhlaq A. Farooqui New York, NY Springer 2009 XXIII, 406 S. graph. Darst. 235 mm x 155 mm txt rdacontent n rdamedia nc rdacarrier Cell membranes Membrane lipids Neurons Phospholipases Phospholipids Sphingolipids Physik (DE-588)4045956-1 gnd rswk-swf Selen (DE-588)4180872-1 gnd rswk-swf Tellur (DE-588)4184665-5 gnd rswk-swf Physikalische Eigenschaft (DE-588)4134738-9 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 1979 Königstein gnd-content (DE-588)1071861417 Konferenzschrift gnd-content (DE-588)1071861417 Konferenzschrift 1979 Königstein Taunus gnd-content Tellur (DE-588)4184665-5 s Physikalische Eigenschaft (DE-588)4134738-9 s DE-604 Selen (DE-588)4180872-1 s Physik (DE-588)4045956-1 s HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017348578&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Farooqui, Akhlaq A. Hot Topics in Neural Membrane Lipidology Cell membranes Membrane lipids Neurons Phospholipases Phospholipids Sphingolipids Physik (DE-588)4045956-1 gnd Selen (DE-588)4180872-1 gnd Tellur (DE-588)4184665-5 gnd Physikalische Eigenschaft (DE-588)4134738-9 gnd |
| subject_GND | (DE-588)4045956-1 (DE-588)4180872-1 (DE-588)4184665-5 (DE-588)4134738-9 (DE-588)1071861417 |
| title | Hot Topics in Neural Membrane Lipidology |
| title_auth | Hot Topics in Neural Membrane Lipidology |
| title_exact_search | Hot Topics in Neural Membrane Lipidology |
| title_full | Hot Topics in Neural Membrane Lipidology Akhlaq A. Farooqui |
| title_fullStr | Hot Topics in Neural Membrane Lipidology Akhlaq A. Farooqui |
| title_full_unstemmed | Hot Topics in Neural Membrane Lipidology Akhlaq A. Farooqui |
| title_short | Hot Topics in Neural Membrane Lipidology |
| title_sort | hot topics in neural membrane lipidology |
| topic | Cell membranes Membrane lipids Neurons Phospholipases Phospholipids Sphingolipids Physik (DE-588)4045956-1 gnd Selen (DE-588)4180872-1 gnd Tellur (DE-588)4184665-5 gnd Physikalische Eigenschaft (DE-588)4134738-9 gnd |
| topic_facet | Cell membranes Membrane lipids Neurons Phospholipases Phospholipids Sphingolipids Physik Selen Tellur Physikalische Eigenschaft Konferenzschrift 1979 Königstein Konferenzschrift Konferenzschrift 1979 Königstein Taunus |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017348578&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT farooquiakhlaqa hottopicsinneuralmembranelipidology |