Innovative endocrinology of cancer:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
New York, NY
Springer [u.a.]
2008
|
| Series: | Advances in experimental medicine and biology
630 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | XIX, 242 S. Ill., graph. Darst. |
| ISBN: | 9780387788173 0387788174 |
Staff View
MARC
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| 650 | 4 | |a Estrogen Receptor Modulators |x pharmacology | |
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Record in the Search Index
| _version_ | 1804138649407717376 |
|---|---|
| adam_text | CONTENTS
1.
MECHANISMS OF HORMONE CARCINOGENESIS:
EVOLUTION OF VIEWS, ROLE OF MITOCHONDRIA.
.................1
Jin-Qiang Chen, Terry R. Brown and James D. Yager
Abstract
................................................................................„..„„........„...............................1
Introduction..
........................................................................................................................1
A Novel Paradigm: Estrogen/Estrogen Receptor-Mediated
Mitochondria! Pathway
...............................................................................................2
Potential Role of E^R-Mediated Mitocbondrial Pathway in Estrogen
Carcinogenesis
».■.........»......·■■...»...■■»■«..—..»■..»·..■«■■.»■■.»■■■■..»..·■«...........»..■»..■»..■» 6
Deregulation of Mitochondrial Bioenergetics in Cancer Cells and Involvement
of Estrogens and ERs
................................................................................................10
Concluding Remarks, Evolutionary View and Future Directions
.................................11
2.
ADAPTATION TO ESTRADIOL DEPRIVATION CAUSES
UP-REGULATION OF GROWTH FACTOR PATHWAYS
AND HYPERSENSITIVITY TO ESTRADIOL IN BREAST
CANCERCELLS
______________________________________._____19
Richard J.
Santen,
Robert X. Song, Shigera
Masamura,
Wei Yue, Ping Fan,
Tetsuya Sogon, Shin-ichi Hayashi,
Kei
Nakachi and Hidtek Eguchi
Abstract
__._____.___________________________________________.__________19
Introduction........................................................................................................................
20
Phenomenon of Hypersensitivity: Mechanisms and Pathways
__________________20
Significance of Our Findings to Development of Further Therapies
_____________31
Synthesis of Our Current Thinking
_______________________________________31
3.
ROLE OF ENDOCRINE-GENOTOXIC SWITCHINGS
IN CANCER AND OTHER HUMAN DISEASES:
BASIC TRIAD
_______________________________________________35
Lev M. Berstein
Abstract................
__..............................................................___.....................................35
Introduction.»».........·..»..»..»..«......»·.»..«.·....».«·.·»..»....*..·......··.—
»».»....«..«·»«««.«..« 35
General Principle: Types of Effects
___________________________.-----------------36
Phenomenon of Switching of Estrogen Effects (PSEE)
------------------------------------36
Janus (Dual) Function of Glucose
____..-------------.—-------.—.------------»---------40
Adipogenotoiicosis
_____________________.----------------.-----------»----------.-----43
Basic Triad: Interactions and Implications
.................................................................... 46
xiii
ών
Contents
4.
BREAST DEVELOPMENT, HORMONES AND CANCER
-----------------52
Jose
Russo
and
Irma H.
Russo
Abstract....····.»...
.........................·...........···.......··.··.......·.··..........··...·..........··..·.··-·..............52
Introduction
--------------------------------------------------------------------------------------52
Defining the Cell of Origin of Breast Cancer
..................................................................52
Breast Architecture and Cancer
___________________................................................54
5.
EPIDEMIOLOGY OF HORMONE-ASSOCIATED CANCERS
AS A REFLECTION OF AGE
..............................................................57
Svetlana
V. Ukraintseva,
Konstantin
G. Aŕbeev
and Anatoli I. Yashin
Abstract..........................................................................................
.....................................57
Introduction
.■.■.···.■.■■■■■.·■»·.·■·.·■*■■.■··■······■.·■■.·■■■■····«··■·■■■■■■■■■.·.·.··■■■■■■■*.···.■·*.■....■···.·.·*....·...··· 57
Data Sources and Basic Definitions
.....__.............................___..................................... 59
Typical Age Patterns of Cancer Incidence and Mortality Rates
-------------------------59
Patterns and Trends of Incidence Rates for Hormone Associated Cancers
------------61
Conclusions
·.·.····.··„···.···.·.·············....·.··.·····...··„·.·.....······„«···»······„········...·...«»..».„··««„.««.„ 69
6.
OBESITY AND DIABETES EPIDEMICS:
CANCER REPERCUSSIONS
...............................................................72
Anette
Hjartåker,
Hilde Langseth
and
Elisabete
Weiderpass
Abstract...........
...................................................................................................................72
Introduction..».....·...........··...«............................................................................·.........·.....
73
Current Research on the Associations between Obesity and Diabetes
and the Risk of Cancer
.............____............................____.................................... 76
Cancer of the Digestive Organs
...................................................................................... 76
Respiratory Organs
...............·....................................·»·,.................................................. 81
Skin Melanoma
___..................___________________________________________81
Breast Cancer
____.______.______________________.______________________82
Female Genital Organs
________________________.________________________83
Male Genital Organs
_____________________.___________________.______.___85
Urinary Organs
..............................................................................__..............................86
Thyroid Cancer
_____________„_______„_________________________________87
Lymphoid and Haematopoietic Cancers....
___................___.___................__............. 87
Summary of Findings
.................................................. „...„ . 88
Concluding Remarks and Recommendations for Further Research
_____________88
7.
PROGESTERONE RECEPTOR ACTION: TRANSLATING
STUDIES IN BREAST CANCER MODELS TO CLINICAL
INSIGHTS
___________________________________________________94
Carol A.
Lange,
Carol A. Sartorius,
Hany
Abdel-Hafiz,
Monique
A. Spillman,
Kathryn B. Horwitz and
Britta
M. Jacobsen
Abstr«ct.....„.™..„..„......„„„..............„......„......„....„„„„..„.„„.„......„..„..„„.„„,„„„„„„„„94
..„,.H..„..„..........„..........„..H..H„„„„..„HH...........,..H(...,.HaM,(.H..H
мш
„., „ 94
Contents
xv
Classical Actions of PRs
________________________________________________95
Direct PR Phosphorylation in Breast Cancer Models
______________.......................96
PR Ser294 Pbosphorylation in Breast Cancer Models
...................................................97
Extranuclear Actions of PR.............
.........................„.......................................................98
Integration of Rapid Signaling and Nuclear SR Actions
______________________100
PR Action and Breast Cancer Cell Growth, Apoptosis and Aggressiveness
in Vitro
________________________________________________________101
Expression Profiling in Vitro
__......................................................................................102
ProgestJns and Antiprogestins in Breast Tumor Models
________............................102
Progesterone Regulation of BRCA1
...............................................................................103
General Steroid Receptors and Breast Cancer
.............................................................104
Progesterone Receptors and Tamoxifeu Responsiveness
.............................................104
Clinical Significance of PR-Avs. PR-B: Two Subsets of ER+, PR+ Tumors?
______104
Concluding Remarks
.......................................................................................................105
8.
AROMATASE EXPRESSION IN WOMEN S CANCERS
......................112
Serdar
E.
Bulim
and Evan
R.
Simpson
Abstract
___.______........______________________.________________________112
Introduction
......................................................................................................................112
Pathological Expression of Aromatase in Women s Cancers
.......................................116
Conclusion
........................................................................................................................127
9.
PROTEOMICS OF CANCER OF HORMONE-DEPENDENT
TISSUES
................................................................................................133
Darren R. Tyson and David K. Ornstein
Abstract
.............................................................................................................................133
Introduction and Overview
...».. ..»....».»...»■»··.·.»■··«■..»» ··«»· .».«··».■.«·· «·..·.··«.». 133
Biomarkers
versus Biology..........................................
....................................................135
Cancer Proteomics: Sample Sources and Methodological Approaches
...................... 135
Recent Innovations and Technological Advances..........................................................
142
Tbe Future of Clinical Proteomics
................................................................................142
10.
ENDOGENOUS HORMONE
LEVELSAND
RISK OF BREAST,
ENDOMETRIAL AND OVARIAN CANCERS:
PROSPECTIVE STUDIES
..................................................................148
A. Heather Eliassen and Susan E. Hankinson
Abstract................................................................................
............................................. 148
Introduction·»»·«·»··»«»·«.«»·.»·»».»»»»»»» »»»..· ·» »»» »·· » »»»·» .»»·»»
148
Méthodologie
Considerations.......................................
__.».,«»........»..»..»..»..„,.»...... 149
Breast Cancer
__...........__.„...........„...».»..»..»..„» .....«...»..__.....__»»..».........».....,.150
Endometrial Cancer.....................................................
.................................................... 156
Ovarian Cancer»..·..»..·».·»»»..».»··.»»·
...............».·»»».«. . ·.· ««..»»««·.»»» ».«.·..«. 157
Conclusions
.......................................................................................................................159
Summarv·»
· »· »··· · ·».·
..«•»••»»•»••»••»»»»m«»»»«·««··«» »··»»·»«·»»·«» . «· ·
ló !
Tfì
Contents
11. HORMONAL
HETEROGENEITY OF ENDOMETRIAL
CANCER
...............................................................................................166
Carsten Gründker,
Andreas
R.
Günthert
and
Günter Emons
Abstract...
..........................................................................................................................166
Introduction
.. ..»........................................................................................ 166
Etiology
.............................................■...·■...■·■....................................................................167
Estrogen-Associated Endometria) Cancer (Type I)
-------------------.--------------.—168
Non-Estrogen-Associated Endometrial Cancer (Type
Π)------------------------------
168
Uterine Carcinosarcomas (Malignant Mixed Mttllerian Tumors)
.............................. 170
Molecular Pathogenesis of Endometrial Cancer
-----------------------------------------170
Hormone Receptors and Aromatase
____________________________________176
Future Perspective
___________________..................................................................178
12.
CELL CYCLE MACHINERY: LINKS WITH GENESIS
AND TREATMENT OF BREAST CANCER
....................................189
Alison J. Butt, C. Elizabeth Caldon, Catriona M. McNeil, Alexander Swarbrick,
Elizabeth A. Musgrove and Robert L. Sutherland
Abstract
_______________________________________________________.....189
Introduction.....................................................................................................................
189
Cell Cycle Control Mechanisms and Their Regulation in Breast Cancer Cells.........
190
Cell Cycle Control Genes as Putative Breast Cancer Oncogenes/Tunior
Suppressor Genes
.....................................................................................................194
Relationship of Cell Cycle Deregulation to Patient Outcome and Response
to Endocrine Therapy.«
......................................................................................198
Conclusion
........................................................................................................................ 201
13.
SELECTIVE ESTROGEN MODULATORS AS AN
ANTICANCER
TOOL: MECHANISMS OF EFFICIENCY
AND RESISTANCE
..............................................................................206
Surojeet Sengupta and V. Craig Jordan
Abstract
_____________________________________.___._________________206
Introduction.............................................................
.............„......„......„..„......_..„.......... 206
Estrogen, Tamoxifen and Cancer
................................................................................... 208
Molecular Mechanism of SERM Action
____„___._____________________.____209
Evolution of SERM Resistant Breast Cancers
________________________.____211
Mechanism of SERM Resistance
_________.____________________________. 211
Therapeutic Options for SERM Resistant Breast Cancers
___________________213
Resistance to Long Term
Antihormone
Therapy
..„..„..„......„..„.._.„„„..„................„ 214
Estrogen Induced Apoptosis
_________„______„„„.___________._____.______214
Conclusion»
____„.„________________„_____._______„.._______________214
Contents
xvii
14.
PHARMACOGENOMICS OF ENDOCRINE THERAPY
IN BREAST CANCER
.........................................................................220
Richard Weinshilboum
Abstract.
............................................................................................................................220
Introduction
.........................................................................____._________________220
Tamoxifeo Pbarmacogenomics
.......................................................................................221
Aromatase Inhibitor Pharmacogenomics
_________________________________228
Conclusions and Future Directions
................................................................................229
15.
PREVENTION OF BREAST CANCER USING SERMS
......................232
Trevor J. Powles
Abstract
_________________________________.______________........................232
Introduction.......................
...............................................................................................232
Tamoxifen Trials......
.........................................................................................................232
Raloxifene Trials
____________________________________________________234
Summary of SERM Breast Cancer Risk Reduction Trials
..........................................235
Conclusion
.......................................................................................................................235
GENERAL CONCLUSION
.............................................................................237
INDEX
................................................................................................................239
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| lccn | 2008006861 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017139842 |
| oclc_num | 192042330 |
| open_access_boolean | 1 |
| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XIX, 242 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Innovative endocrinology of cancer ed. by Lev M. Berstein ... New York, NY Springer [u.a.] 2008 XIX, 242 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 630 Cancer / Endocrine aspects Breast Neoplasms drug therapy Breast Neoplasms physiopathology Cancer Endocrine aspects Estrogen Receptor Modulators pharmacology Receptors, Estrogen physiology Receptors, Progesterone physiology Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Endokrinologie (DE-588)4014663-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Endokrinologie (DE-588)4014663-7 s b DE-604 Berstein, Lev M. Sonstige oth Advances in experimental medicine and biology 630 (DE-604)BV000003102 630 http://www.loc.gov/catdir/toc/fy0804/2008006861.html kostenfrei Inhaltsverzeichnis DE-601 pdf/application http://www.gbv.de/dms/bowker/toc/9780387788173.pdf Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017139842&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Innovative endocrinology of cancer Advances in experimental medicine and biology Cancer / Endocrine aspects Breast Neoplasms drug therapy Breast Neoplasms physiopathology Cancer Endocrine aspects Estrogen Receptor Modulators pharmacology Receptors, Estrogen physiology Receptors, Progesterone physiology Krebs Medizin (DE-588)4073781-0 gnd Endokrinologie (DE-588)4014663-7 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4014663-7 (DE-588)4143413-4 |
| title | Innovative endocrinology of cancer |
| title_auth | Innovative endocrinology of cancer |
| title_exact_search | Innovative endocrinology of cancer |
| title_full | Innovative endocrinology of cancer ed. by Lev M. Berstein ... |
| title_fullStr | Innovative endocrinology of cancer ed. by Lev M. Berstein ... |
| title_full_unstemmed | Innovative endocrinology of cancer ed. by Lev M. Berstein ... |
| title_short | Innovative endocrinology of cancer |
| title_sort | innovative endocrinology of cancer |
| topic | Cancer / Endocrine aspects Breast Neoplasms drug therapy Breast Neoplasms physiopathology Cancer Endocrine aspects Estrogen Receptor Modulators pharmacology Receptors, Estrogen physiology Receptors, Progesterone physiology Krebs Medizin (DE-588)4073781-0 gnd Endokrinologie (DE-588)4014663-7 gnd |
| topic_facet | Cancer / Endocrine aspects Breast Neoplasms drug therapy Breast Neoplasms physiopathology Cancer Endocrine aspects Estrogen Receptor Modulators pharmacology Receptors, Estrogen physiology Receptors, Progesterone physiology Krebs Medizin Endokrinologie Aufsatzsammlung |
| url | http://www.loc.gov/catdir/toc/fy0804/2008006861.html http://www.gbv.de/dms/bowker/toc/9780387788173.pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017139842&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT bersteinlevm innovativeendocrinologyofcancer |
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