Molecular biology of B cells:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2004
|
| Schlagworte: | |
| Online-Zugang: | Publisher description Table of contents Inhaltsverzeichnis |
| Beschreibung: | XIV, 589 S. Ill., graph. Darst. |
| ISBN: | 0120536412 9780120536412 |
Internformat
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| 245 | 1 | 0 | |a Molecular biology of B cells |c ed. by Tasuku Honjo ... |
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier, Acad. Press |c 2004 | |
| 300 | |a XIV, 589 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a Biologia molecular |2 larpcal | |
| 650 | 4 | |a Gènes de l'immunoglobuline | |
| 650 | 4 | |a Immunoglobulines | |
| 650 | 4 | |a Immunologie moléculaire | |
| 650 | 7 | |a Imunoglobulinas |2 larpcal | |
| 650 | 7 | |a Imunologia celular |2 larpcal | |
| 650 | 7 | |a Linfócitos b |2 larpcal | |
| 650 | 4 | |a Lymphocytes B | |
| 650 | 4 | |a Molecular immunology | |
| 650 | 4 | |a B cells | |
| 650 | 4 | |a Immunoglobulins | |
| 650 | 4 | |a Immunoglobulin genes | |
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Datensatz im Suchindex
| _version_ | 1804138622914396160 |
|---|---|
| adam_text | Contents
Preface
xiii
1.
Human Immunoglobulin Heavy
Chain Locus
FUMIHIKO MATSUDA
Organization of the Human VH Locus
2
Analysis of Human VH Segments
7
Evolution of the Human VH Locus
10
Human CH Locus
12
2.
Immunoglobulin Heavy Chain Genes
of Mouse
ROY RIBLET
Igh-V or VH Genes of the Ighb Haplotype
19
Polymorphism in VH Genes
20
Evolution
24
Genomic Considerations
24
3.
Immunoglobulin
К
Genes of Human
and Mouse
HANS G. ZACHAU
27
General Features of Human and Mouse
К
Genes
Human Immunoglobulin
К
Genes
27
Mouse Immunoglobulin
К
Genes
30
Aspects of Evolution of the
К
Genes
33
4.
Immunoglobulin Lambda (IGL) Genes of
Human and Mouse
МАИЕ
-PAULE
LEFRANC AND
GÉRARD
LEFRANC
IGL Genes and IMGT-ONCOLOGY
The Human IGL Genes
40
The Mouse IGL Genes
50
37
5.
The Mechanisms of V(D)J Recombination
JOANN
SEKIGUCHI, FREDERICK W. ALT, AND
MARJORIE OETTINGER
Antigen Receptor Gene Assembly
62
Mutational Analyses of Recombination Signal
Sequences
64
Beyond
12/23
Restriction of V(D)J
Rearrangements
64
Influence of Coding Flanks
65
The Biochemistry of
V(D)J
Cleavage
65
RAG1/2-RSS Binding
66
RAAG
1/2
Post-Cleavage Complex
67
A Role for HMG1 (or HMG2) in V(D)J
Recombination
67
A Closer Look at RAAG3 and RAG2
68
Colding and Signal Joint Formation Requires the NHEJ
Pathway
71
6.
Transcription of Immunoglobulin Genes
KATHRYN
CÁLAME
AND RANJAN SEN
Transcriptional Regulatory Elements in Immunoglobulin
Heavy and Light Chain Genes
83
Proteins Binding in
Ig
Transcriptional Regulatory
Elements
86
Areas of Current Research
89
Discoveries Resulting from the Study of
Ig Gene
Transcription
93
7.
Early
В
Cell Development to a Mature,
Antigen-Sensitive Cell
FRITZ MELCHERS AND PAUL K1NCADE
Three Waves of Hematopoiesis During Embryonic
Development
101
vu
VIH
Contents
Pluripotent Hematopoietic
Stem Cells
103
Pathways of Hematopoietic Progenitor Cells Toward
В
Lymphocyte Lineage Commitment and
Differentiation
106
Control of Lymphoid Cell Development by Transcription
Factors
107
Plasticity if PAX-o-Deficient Pre-B Cells
109
The Surrogate Light Chain
110
Pre-B Cells and Their Differentiation to More Mature
В
Lineage Cells
112
Rearrangements at the
L
Chain Loci at the Transition from
Large to Small Pre-B-II Cells
114
Immature
В
Cells
116
Selections of Immature
В
Cells
117
8.
Allelic Exclusion,
Isoţypic
Exclusion,
and the Developmental Regulation of
V(D) Recombination
MICHAEL S.
KRÅNGEL
AND MARK S. SCHLISSEL
Rag Expression
127
The
12/23
Rule
128
Accessibility Hypothesis
128
Enhancer and Promoter Control of V(D)J
Recombination
128
Trans-Acting Factors
130
Chromatin Dynamics and V(D)J Recombination
130
Ordered Rearrangement Within
Ig
and TCR Loci
132
Allelic Exclusion at
Ig
and TCR Loci
133
Ig
Light Chain Isotypic Exclusion
136
Future Directions
136
9.
The Development of Human
В
Lymphocytes
PETER D. BURROWS, TUCKER LEBIEN, ZH1X1N ZHANG,
RANDALL S. DAVIS, AND MAX D. COOPER
Stages of Human
В
Cell Differentiation
141
Sites of Human
В
Cell Development
143
Human Immunoglobulin Genes
143
The Role of Surrogate Light Chains in Human
В
Cell
Development
144
Repertoire Diversification via Receptor Editing and VH
Replacement
145
Regulation of Antibody Production by
В
Cell
Receptors
147
Immunodeficiency Diseases
148
В
Lineage Leukemia
149
10.
Development and Function of
В
Cell Subsets
JOHN T. KEARNEY
Selection and Differential Survival Mechanisms
—
В
Cell
Receptor Signaling
156
Compartmentalization of
В
Cell Subsets
157
Other Factors Involved in Formation of
В
Cell
Subsets
157
11.
Structure and Function of
В
Cell Antigen
Receptor Complexes
MICHAEL RETH AND
JÜRGEN WIENANDS
Structure of the
BCR
Complex
161
Coupling Between the
BCR
and
SYK
162
Redox
Regulation of
BCR
Signaling
162
ITAM- and Non-ITAM-Controlled Signaling Pathways to
SLP-65
163
ITAM-Independent Signaling and Fine-Tuning
165
12.
Regulation of Antigen Receptor Signaling
by the Co-Receptors, CD
19
and CD22
LARS NrrSCHKE AND DOUGLAS
T. FEARON
CD19
171
Inhibitory Co-Receptors on
В
Cells
177
13.
The Dynamic Structure of
Antibody Responses
IAN
С
MACLENNAN AND DEBORAH L.
HARDIE
Three Routes to Antibody Production
187
Stages of Adaptive Antibody Responses
187
How and Where
В
Cells Encounter Antigen
188
Primary Cognate Interaction of
В
Cells with Primed
T
Cells
189
Exponential Growth of Activated
В
Cells
190
Proliferation, Hypermutation, and Selection in GC
192
Sustained Survival of Memory
В
Cell Clones and Plasma
Cells
197
14.
Dynamics of
В
Cell Migration to and
within Secondary Lymphoid Organs
JASON G. CYSTER AND
ULRICH H.
VON ANDRIAN
Lymphoid Organ Entry
203
Compartmentalization of Mature
В
Cells
209
В
Cells at Sites of Inflammation
213
Homing of Antibody Secreting Cells (ACSs)
213
Contents
ЇХ
15. Characteristics
of
Mucosal
В
Cells with
Emphasis on the Human Secretory
Immune System
PER BRANDTZAEG, H. CRAIG MORTON, AND
MICHAEL E. LAMM
Immune-Inductive Tissue Compartments
223
Characteristics of
В
Cells in Secretory Effector
Tissues
226
B-Cell Stimulation in MALT Structures
229
Class Switch and
Ig
A Isotype
Promotion
232
Mechanisms Directing Homing and Retention of Mucosal
В
Cells
234
What Is Actually Known About Human Mucosal
В
Cells?
238
19.
Regulation of Class
Switch Recombination
MICHEL COGNÉ
AND BARBARA K. BIRSHTE1N
CSR Requires Specific Stimuli Occurring in a Defined
Germinal Center (GC)
Microenvironment 289
Proximal CIS Regulatory Elements for GT
291
Distant Regulatory Region for GT and CSR: The
3
IGH
Enhancers
293
Mechanisms for
3
IGH Regulatory Region-Mediated
Regulation of GT
295
Coordinated Regulation of Transcription, Recombination,
and Replication
300
16.
The Cellular Basis of
В
Cell Memory
KLAUS RAJEWSKY AND ANDREAS RADBRUCH
Generation of
В
Cell memory and Memory
В
Cells in
Τ
Cell-Dependent Antibody Responses
247
Memory Plasma Cells
252
Adaptive
В
Cell Memory
254
17.
Immunoglobulin Assembly
and Secretion
LINDA
M. HENDERSHOT
AND ROBERTO
SITIA
Mechanisms of
IG
Synthesis and Assembly
261
Multiple Layers of Quality Control Exist to Aid and
Monitor the Assembly of Functional IGs
264
Transport of Assembled
IG
Molecules to the Golgi
267
Degradation of Misfolded and Unassembled
IG
Subunits
267
Differentiation to Plasma Cell
268
18.
Fc and Complement Responses
JEFFREY V. RAVETCH AND MICHAEL C. CARROLL
Consequences of
ГСуКІІВ
Deficiency
275
Consequences of Complement and Complement Receptor
Deficiencies
276
Fc Receptors
2276
Complement Receptors
280
Co-Receptor Signaling Versus Antigen Localization to
FDC
281
Frontiers: Complement Versus Fc Receptors
285
20.
Molecular Mechanisms of Class
Switch Recombination
JANET STAVNEZER, KAZUO KINOSHITA,
MASAM1CHI MURAMATSU, AND TASUKU HONJO
Outline of Mechanisms for CSR
307
Isotype
Specificity of CSR
312
AID, The Sole
В
Cell-Specific Factor Required for
CSR
313
Cleavage of the
S
Region
314
Processing and Joining of
DNA
Ends After
Cleavage
315
Comparison of CSR with SHM
319
21.
Molecular Mechanisms
of Hypermutation
NANCY MAIZELS AND MATTHEW D. SCHARFF
Characteristics of Somatic Hypermutation of
Immunoglobulin Variable Regions
327
Activation and Targeting of Hypermutation by
Transcription and
C/S-Elements
329
Hypermutation Occurs Within a Limited Window of
В
Cell development
330
The AID Gene Is Critical for Hypermutation
331
Phase One of Hypermutation:
С
—>
U Deamination
and
Base Excision Repair
332
Mismatch Repair Factors in Phase Two of
Hypermutation
332
DNA
Breaks in Hypermutation
334
Competing Pathways of Repair: Error-Prone
DNA
Synthesis or Strand Transfer
335
Evolution and Hypermutation
335
Contents
22.
Selection During
Antigen-Driven B
Cell
Immune Responses: The Basis for High
Affinity Antibody
MARK J. SHLOMCHIK
Overview of the B-Cell Immune Response
339
Affinity Maturation in the Early Stages of the B-Cell
Immune Response
341
The
CG
Is a Second Major Site for Affinity
Maturation
342
Affinity-Based Selection Continues After the GC Reaction
Has Ended
344
An Integrated View of the Strategic Design of the B-Cell
Immune Response: Future Directions
344
23.
Chromosomal
Translocations
in
В
Cell
Leukémiás
and Lymphomas
A. THOMAS LOOK AND
ADOLFO FERRANDO
Translocations
Associated with a Block in Lymphoid
Differentiation
349
Translocations
Associated with Suppression of Apoptosis
During Lymphoid Development
352
Translocations
Associated with Increased Proliferation in
Lymphoid Precursors
354
Activation Cell Cycle Regulation in Mantle Cell
Lymphoma and Myeloma
355
24.
Classification and Characteristics of
Mouse
В
Cell-Lineage Lymphomas
HERBERT
С
MORSE III
Comparative Classification of Mouse and Human
В
Cell-Lineage Neoplasms
366
Characteristics of Mouse
В
Cell-Lineage
Lymphomas
368
Pathogenesis
373
25.
В
Cells Producing
Pathogenic Autoantibodies
CONSTANTIN
A. BONA
AND FREDA K. STEVENSON
Subsets of Autoantibodies
382
Criteria to Define Pathogenic Autoantibodies
383
Genetics of Autoantibodies
384
Molecular and Immunochemical Characteristics of Human
Pathogenic Autoantibodies
388
Human Pathogenic Autoantibodies with
Murine
Counterparts
392
26.
Immunodeficiencies Caused by
В
Cell Defects
FRANCISCO A. BONILLA
AND RAIF
S. GEHA
Clinical Features of the Agammaglobulinemias
403
Autosomal Recessive Hyper-IGM Syndrome
410
Murine
Models of Human B-Cell Deficiency
411
27.
Diverse Forms of Immunoglobulin Genes
in Lower Vertebrates
GARY W. LITMAN, MARTIN F. FLAJNIK, AND
GREGORY W. WARR
Cartilaginous Fish: An Unusual Example of Gene
Multiplicity
417
Bony Fish:
IG
Heavy Chain Genes Resemble IgM and
IgD
419
Lobe-Finned Fish: A Transitional Arrangement of
Recombining Elements
422
Fleshy-Finned Fish: An Ancient Origin for
Isotype
Diversity
422
Amphibians and Reptiles: The Possible Origins of Class
Switching
422
Light Chain Genes: Diverse Structures and Organization
in Lower Vertebrates
423
Transcriptional Control of
IG
Genes in Lower
Vertebrates
425
A Unifying Hypothesis to Explain the Origins of the
Adaptive Immune Receptor
427
Immune Molecules in lawless Vertebrates
427
Protochordates: Different Contexts for Diversified
В
Regions
428
28.
Immunoglobulin Genes and Generation
of Antibody Repertoires in Higher
Vertebrates: A Key Role for
GALT
DENNIS LANNING, BARBARA A. OSBORNE, AND
KATHERINE L.
KNIGHT
Avians
433
Lagomorphs
436
Artiodactyls
440
Other Mammals
444
29.
The Zebrafish Immune System
LISA A.
STEINER,
CATHERINE
E.
WILLETT, AND
NADIA DANILOVA
Hematopoiesis
450
Adaptive Immunity in Zebrafish: Organs and Molecules
452
Contents
Xl
Genetic Approaches
457
Major Histocompatibility Complex (MHC)
460
Innate Immunity
460
Infection
464
30.
The Origin of
V(D)j
Diversification
SUSANNA M. LEWIS, GILLIAN
E. WU,
AND ELLEN HSU
The Alien Seed
473
The Evolution of
BCR
and TCR Loci
481
Considerations on the UR-V Gene
483
31.
Antibody Structure and Recognition
of Antigen
ERIC J.
SUNDBERG
AND ROY A. MARIUZZA
A Structural Framework for Molecular Recognition
491
Antibody Phage Display
516
Use of Phage Display to Bypass Hybridoma
Technology
519
Use of Phage Display to Bypass Immunization
520
A Comparison of Different Phage Antibody Library Types
and Applications
521
Strategies for Selection of Phage Antibodies
522
Increasing Antibody Affinity Using Phage Display
522
Alternative Antibody Display Technologies
524
33.
Humanization of Monoclonal Antibodies
NAOYA TSURUSHITA AND
MAXIMILIANO
VASQUEZ
Murine, Chimeric,
and Humanized Antibodies
533
Computer-Guided Design of Humanized V Regions
534
Other Humanization Methods
537
Immunogenicity of Humanized Antibodies
540
Humanized Antibodies Approved for Clinical Use
540
32.
Monoclonal Antibodies from
Display Libraries
JIM MARKS
Overview of Antibody Phage Display
513
Prokaryotic Expression of Antibody Fragments
514
Generation of Antibody Gene Repertoires Using the
Polymerase Chain Reaction
515
34.
Human Monoclonal Antibodies from
Translocus Mice
MARIANNE BRÜGGEMANN
Human
IG Transloci 547
The Mouse Strains
552
Index
563
|
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV035316362 |
| callnumber-first | Q - Science |
| callnumber-label | QR185 |
| callnumber-raw | QR185.6 |
| callnumber-search | QR185.6 |
| callnumber-sort | QR 3185.6 |
| callnumber-subject | QR - Microbiology |
| classification_rvk | WF 9880 |
| ctrlnum | (OCoLC)53970703 (DE-599)BVBBV035316362 |
| dewey-full | 616.07/98 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.07/98 |
| dewey-search | 616.07/98 |
| dewey-sort | 3616.07 298 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Book |
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| id | DE-604.BV035316362 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:31:07Z |
| institution | BVB |
| isbn | 0120536412 9780120536412 |
| language | English |
| lccn | 2003064380 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017121014 |
| oclc_num | 53970703 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XIV, 589 S. Ill., graph. Darst. |
| publishDate | 2004 |
| publishDateSearch | 2004 |
| publishDateSort | 2004 |
| publisher | Elsevier, Acad. Press |
| record_format | marc |
| spelling | Molecular biology of B cells ed. by Tasuku Honjo ... Amsterdam [u.a.] Elsevier, Acad. Press 2004 XIV, 589 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologia molecular larpcal Gènes de l'immunoglobuline Immunoglobulines Immunologie moléculaire Imunoglobulinas larpcal Imunologia celular larpcal Linfócitos b larpcal Lymphocytes B Molecular immunology B cells Immunoglobulins Immunoglobulin genes Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Molekularbiologe (DE-588)1023071983 gnd rswk-swf B-Lymphozyt (DE-588)4137121-5 gnd rswk-swf B-Zelle (DE-588)4147096-5 gnd rswk-swf B-Lymphozyt (DE-588)4137121-5 s Molekularbiologie (DE-588)4039983-7 s DE-604 Molekularbiologe (DE-588)1023071983 s 1\p DE-604 B-Zelle (DE-588)4147096-5 s 2\p DE-604 Honjo, Tasuku Sonstige oth http://www.loc.gov/catdir/description/els041/2003064380.html Publisher description http://www.loc.gov/catdir/toc/els041/2003064380.html Table of contents Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017121014&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Molecular biology of B cells Biologia molecular larpcal Gènes de l'immunoglobuline Immunoglobulines Immunologie moléculaire Imunoglobulinas larpcal Imunologia celular larpcal Linfócitos b larpcal Lymphocytes B Molecular immunology B cells Immunoglobulins Immunoglobulin genes Molekularbiologie (DE-588)4039983-7 gnd Molekularbiologe (DE-588)1023071983 gnd B-Lymphozyt (DE-588)4137121-5 gnd B-Zelle (DE-588)4147096-5 gnd |
| subject_GND | (DE-588)4039983-7 (DE-588)1023071983 (DE-588)4137121-5 (DE-588)4147096-5 |
| title | Molecular biology of B cells |
| title_auth | Molecular biology of B cells |
| title_exact_search | Molecular biology of B cells |
| title_full | Molecular biology of B cells ed. by Tasuku Honjo ... |
| title_fullStr | Molecular biology of B cells ed. by Tasuku Honjo ... |
| title_full_unstemmed | Molecular biology of B cells ed. by Tasuku Honjo ... |
| title_short | Molecular biology of B cells |
| title_sort | molecular biology of b cells |
| topic | Biologia molecular larpcal Gènes de l'immunoglobuline Immunoglobulines Immunologie moléculaire Imunoglobulinas larpcal Imunologia celular larpcal Linfócitos b larpcal Lymphocytes B Molecular immunology B cells Immunoglobulins Immunoglobulin genes Molekularbiologie (DE-588)4039983-7 gnd Molekularbiologe (DE-588)1023071983 gnd B-Lymphozyt (DE-588)4137121-5 gnd B-Zelle (DE-588)4147096-5 gnd |
| topic_facet | Biologia molecular Gènes de l'immunoglobuline Immunoglobulines Immunologie moléculaire Imunoglobulinas Imunologia celular Linfócitos b Lymphocytes B Molecular immunology B cells Immunoglobulins Immunoglobulin genes Molekularbiologie Molekularbiologe B-Lymphozyt B-Zelle |
| url | http://www.loc.gov/catdir/description/els041/2003064380.html http://www.loc.gov/catdir/toc/els041/2003064380.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017121014&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT honjotasuku molecularbiologyofbcells |