Iron therapy: with special emphasis on intravenous administration
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| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Bremen [u.a.]
UNI-MED-Verl.
2008
|
| Edition: | 4. ed. |
| Series: | UNI-MED science
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturverz. S. 116 - 126 |
| Physical Description: | 128 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783837410778 3837410773 9781848151383 |
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MARC
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| 245 | 1 | 0 | |a Iron therapy |b with special emphasis on intravenous administration |c [Robert R. Crichton ; Bo G. Danielson ; Peter Geisser] |
| 250 | |a 4. ed. | ||
| 264 | 1 | |a Bremen [u.a.] |b UNI-MED-Verl. |c 2008 | |
| 300 | |a 128 S. |b Ill., graph. Darst. |c 25 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a UNI-MED science | |
| 500 | |a Literaturverz. S. 116 - 126 | ||
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| 650 | 0 | 7 | |a Parenterales Arzneimittel |0 (DE-588)4305652-0 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Danielson, Bo G. |e Verfasser |4 aut | |
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Record in the Search Index
| _version_ | 1804138620632694784 |
|---|---|
| adam_text | 8 Contents
Contents
H Introduction 12
^J Iron Metabolism: Biologic and Molecular Aspects 14
2.1. Iron Distribution in the Human Body 14
2.2. Transport and Storage of Body Iron 15
2.2.1. Transferrin 15
2.2.2. The Transferrin Receptor 16
2.2.3. Ferritin 16
2.3. Cellular Iron Uptake 17
2.3.1. Transferrin Iron Uptake 17
2.3.2. Body Iron Supply and Intestinal Iron Absorption 18
2.4. Intracellular Iron 22
2.5. Cellular Iron Homeostasis 23
^| Laboratory Evaluation of Iron Status 26
3.1. Bone Marrow Aspiration 26
3.2. Liver Biopsy 26
3.3. Serum Ferritin 27
3.4. Serum Transferrin 27
3.5. Serum Iron and Transferrin Saturation 28
3.6. Total Serum Iron and Transferrin Saturation 28
3.7. Serum Transferrin Receptor 29
3.8. Examination of Peripheral Blood Cells 29
U Iron Deficiency 32
4.1. Epidemiology 32
4.2. Etiology and Diagnosis 32
4.3. Iron Depletion 34
4.4. Functional Iron Deficiency 34
^| Iron Salts, Complexes and Hydroxides as Therapeutic Agents 38
5.1. Hydrated Ferrous and Ferric Ions 38
5.2. Biologically Relevant solubility 39
5.3. Iron Salts 39
5.4. Polynuclear Ferric Hydroxo Complexes and Colloidal Solubility 39
5.5. Highly Stable Iron Complexes 40
jj^l Iron Therapy and Oxidative Stress 42
6.1. The Chemistry of Oxidative Stress 42
6.2. Biochemistry 43
6.3. Biological Observations 44
6.4. DNA damage 47
Contents 9
6.5. Preclinical and Clinical Observations 49
6.5.1. Lipid Peroxidation 49
6.5.2. Pregnancy 49
6.5.2.1. Animal and Human Studies of Oral Iron ingestion During Pregnancy 50
6.5.3. Oxidative Stress in Premature Infants and Children 51
6.6. Toxicity Induced by Iron Supplementation 52
6.7. Reactive Oxygen Species (ROS), Iron Status/Therapy and Immunology 53
6.8. Erythropoietin (EPO) Activity and Reactive Oxygen Species (ROS) 55
6.9. Anaemia of Chronic Disease 55
6.10. Effects of Special Iron Complexes 55
6.11. Conclusion 56
^| Iron Therapy 60
7.1. Oral Iron Supplementation: Ferrous Salts and Iron Polymaltose Complex 60
7.1.1. Pharmacokinetics, Bioavailability and Therapeutic Equivalence 62
7.1.1.1. Iron Salt Preparations 62
7.1.1.2. Iron Polymaltose Complex Preparations 67
7.2. Parenteral Iron Therapy 70
7.2.1. Structure/Histotoxicity Relationship of Parenteral Iron Preparations 70
7.2.2. Classification of Polynuclear Iron(lll)-Hydroxide Carbohydrate Complexes 70
7.2.3. Preparations Available for Parenteral Iron Therapy 73
7.2.3.1. Ferric Carboxymaltose (FCM) (VIT-45, Iron Carboxymaltose) 73
7.2.3.1.1. The Safety of Ferric Carboxymaltose (Ferinject®) 78
7.2.3.1.2. Dosing of Ferric Carboxymaltose (Ferinject®) 78
7.2.3.1.3. Adverse Effects of Ferric Carboxymaltose (Ferinject®) 78
7.2.3.2. Iron Sucrose (Venofer®) 78
7.2.3.2.1. Comparisons of Venofer® with Different Intravenous Iron Preparations 81
7.2.3.2.2. Adverse Effects of Iron Sucrose Complex (Venofer®) 81
7.2.3.2.3. The Safety of Iron Sucrose Complex (Venofer®) 81
7.2.3.2.4. Dosing of Iron Sucrose Complex (Venofer®) 82
7.2.3.3. Iron Dextran 82
7.2.3.4. Ferric Gluconate 83
7.2.3.5. Iron Sorbitol 84
7.2.4. Indications for Intravenous Iron Therapy .84
7.2.5. Dose Calculation of Parenteral Iron 84
m Examples of Use of Intravenous Iron Therapy 90
8.1. Treatment of Renal Anaemia with rh-EPO and Intravenous Ferric Carboxymaltose (FMC)
and Iron Sucrose 90
8.2. Treatment of Anaemia in Inflammatory Bowel Disease (IBD) with Intravenous Iron 93
8.3. Iron Therapy in Conjunction with Autologous Blood Transfusion 95
8.3.1. Anaemia Management in Surgery 96
8.4. Use of Low Dose Intravenous Iron in Patients with Anaemia due to Rheumatoid Arthritis... 96
8.5. Use of Intravenous Iron in Obstetrics and Gynaecology 97
8.5.1. Anaemia due to Heavy Uterine Bleeding (HUB) 101
8.6. Use of Intravenous Iron in Paediatrics 101
8.7. Use of Intravenous Iron in Oncology 102
8.8. Treatment of Anaemia in Congestive Heart Failure (CHF) with rh-EPO and Intravenous
Iron Sucrose 103
10 Contents
8.9. Intravenous Iron Treatment of Restless Legs Syndrome (RLS) 105
8.10. Advantages of Iron Sucrose and Ferric Carboxymaltose Over Other Iron Complexes 106
8.11. Overdosing 106
8.12. Health-Economic Aspects of Iron Treatment 106
8.13. Recommendations 107
^| Conclusions 110
mi Appendix 112
10.1. Normal Haematological and Biochemical Values 112
10.2. Glossary/List of Abbreviations 112
m References 116
H Index 127
|
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| dewey-full | 616.152061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
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| discipline | Medizin |
| edition | 4. ed. |
| format | Book |
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| id | DE-604.BV035314721 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:31:05Z |
| institution | BVB |
| isbn | 9783837410778 3837410773 9781848151383 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017119404 |
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| physical | 128 S. Ill., graph. Darst. 25 cm |
| publishDate | 2008 |
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| publisher | UNI-MED-Verl. |
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| series2 | UNI-MED science |
| spelling | Crichton, Robert R. 1941- Verfasser (DE-588)172027764 aut Iron therapy with special emphasis on intravenous administration [Robert R. Crichton ; Bo G. Danielson ; Peter Geisser] 4. ed. Bremen [u.a.] UNI-MED-Verl. 2008 128 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier UNI-MED science Literaturverz. S. 116 - 126 Gynecology Eisenmangel (DE-588)4151569-9 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Parenterales Arzneimittel (DE-588)4305652-0 gnd rswk-swf Eisenmangel (DE-588)4151569-9 s Therapie (DE-588)4059798-2 s Parenterales Arzneimittel (DE-588)4305652-0 s DE-604 Danielson, Bo G. Verfasser aut Geisser, Peter 1945- Verfasser (DE-588)1075569966 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017119404&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Crichton, Robert R. 1941- Danielson, Bo G. Geisser, Peter 1945- Iron therapy with special emphasis on intravenous administration Gynecology Eisenmangel (DE-588)4151569-9 gnd Therapie (DE-588)4059798-2 gnd Parenterales Arzneimittel (DE-588)4305652-0 gnd |
| subject_GND | (DE-588)4151569-9 (DE-588)4059798-2 (DE-588)4305652-0 |
| title | Iron therapy with special emphasis on intravenous administration |
| title_auth | Iron therapy with special emphasis on intravenous administration |
| title_exact_search | Iron therapy with special emphasis on intravenous administration |
| title_full | Iron therapy with special emphasis on intravenous administration [Robert R. Crichton ; Bo G. Danielson ; Peter Geisser] |
| title_fullStr | Iron therapy with special emphasis on intravenous administration [Robert R. Crichton ; Bo G. Danielson ; Peter Geisser] |
| title_full_unstemmed | Iron therapy with special emphasis on intravenous administration [Robert R. Crichton ; Bo G. Danielson ; Peter Geisser] |
| title_short | Iron therapy |
| title_sort | iron therapy with special emphasis on intravenous administration |
| title_sub | with special emphasis on intravenous administration |
| topic | Gynecology Eisenmangel (DE-588)4151569-9 gnd Therapie (DE-588)4059798-2 gnd Parenterales Arzneimittel (DE-588)4305652-0 gnd |
| topic_facet | Gynecology Eisenmangel Therapie Parenterales Arzneimittel |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017119404&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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