Histochemistry and cytochemistry of nuclear receptors:
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Jena
Urban & Fischer
2001
|
| Edition: | [Bindeeinh.] |
| Series: | Progress in histochemistry and cytochemistry
36,2 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | S. 94 - 176 Ill |
Staff View
MARC
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Record in the Search Index
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|---|---|
| adam_text | Contents
1 Introduction 99
2 Nuclear receptor (NR) families 100
2.1 Overview 100
2.2 Functional domains of NRs 100
2.3 Transcnptional regulation of target genes by NRs 101
2.4 Crosstalk between NRs and other signaling pathways 103
3 Histochemical techniques to demonstrate NR localization 103
3.1 Autoradiography 104
3.2 Immunohistochemistry 105
3.2.1 Characteristics of antibodies 105
3.2.2 Tissue processing: fixation and embedding 106
3.2.3 Antigen retrieval procedures 107
3.2.4 Immunoelectron microscopy 107
3.3 In situ hybridization histochemistry 109
3.4 Southwestern histochemistry 109
3.5 Green fluorescent protein-tagged NRs 110
4 Steroid hormone receptors (SHRs) and their isoforms 110
4.1 Estrogen receptor (ER) 110
4.1.1 Localization of ERa 110
4.1.2 Localization of ER(3 HI
4.1.3 Function of ER isoforms 113
4.2 Progesterone receptor (PR) 114
4.2.1 Localization of PR isoforms 114
4.2.2 Function of PR isoforms 115
4.3 Androgen receptor (AR) H5
4.3.1 Localization of AR 115
4.3.2 Subcellular localization of unliganded AR 116
4.4 Glucocorticoid receptor (GR) 116
4.4.1 Subcellular localization of unliganded GR 116
4.4.2 Localization of GRP U7
4-5 Mineralocorticoid receptor (MR) 118
4.6 Vitamin D receptor (VDR) H8
4.6.1 Localization of VDR H8
4.6.2 Subcellular localization of VDR 119
5 Nonsteroid NRs 119
5.1 Thyroid hormone receptor (TR) H9
5.1.1 Subcellular localization of TR 120
5.1.2 Localization of TR isoforms 120
5-2 Retinoid receptors 120
94 ¦ Contents
5.2.1 Retinoic acid receptor 121
5.2.2 Retinoid X receptor/9-as retinoic acid receptor (RXR) 121
6 Orphan NRs 122
6.1 Orphan NRs which form heterodimers with RXR 122
6.1.1 Peroxisome proliferator-activated receptor 122
6.1.2 Farnesoid X-activated receptor 123
6.1.3 Liver X receptor 123
6.2 Orphan NRs that form homodimers 124
6.2.1 Chicken ovalbumin upstream promoter transcription factors 124
6.2.2 Hepatocyte nuclear factor-4 124
6.2.3 Germ cell nuclear factor 125
6.3 Orphan NRs bind DNA as a monomer 125
6.3.1 Retinoic acid-related orphan receptor/retinoid Z receptor 125
6.3.2 Steroidogenic factor-l/Adrenal-4 binding-protein 126
7 Subcellular localization of NRs 27
7.1 Technical problems in immunohistochemistry 2
7.1.1 Fixatives and diffusion artifact 2/
7.1.2 Specificity of antibodies 2
7.2 Nucleocytoplasmic shuttling of SHRs 28
7.2.1 Nuclear import of SHRs 12S
7.2.2 Nuclear export of SHRs 129
7.2.3 Regulation of nucleocytoplasmic shuttling ^
7.3 SHRs during mitosis *
8 Subnuclear localization of NRs 8.1 Immunoelectron microscopy of NRs 8.2 Localization of NRs in special nuclear compartments 9 Gonadal SHRs during development 9.1 Ontogeny of gonadal SHRs in target organs 9.1.1 Ontogeny of ER in reproductive tissue 9.1.1.1 Female reproductive tissue 9.1.1.2 Male reproductive tissue 9.1.2 ER in the brain: ontogeny and sex differences 9.1.3 AR in male reproductive tissue 9.2 Effect of gonadal steroids on developing genital tissue: epithelial and
mesenchymal interaction 9.2.1 Histochemical studies 9.2.2 Studies using ERa-knockout mice 9.3. Genital tract abnormlities in estrogen-exposed rodents during development
9.3.1 ER induction by estrogen exposure during perinatal period 9.3.2 Expression of transcription factors and growth factors in perinatally
estrogen-exposed animals
Contents ¦ 95
9.3.2.1 Expression of ER 149
9.3.2.2 Expression of c-fos and c-jun protooncogenes 150
9.3.2.3 Expression of growth factors 151
10 Interaction between NRs and other proteins 152
10.1 Heat shock proteins 152
10.2 Cytoskeletons 154
10.3 Nuclear matrix 155
10.4 Coactivators 158
11 Concluding remarks 159
References 161
|
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| illustrated | Illustrated |
| indexdate | 2024-07-09T21:30:39Z |
| institution | BVB |
| language | English |
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| physical | S. 94 - 176 Ill |
| publishDate | 2001 |
| publishDateSearch | 2001 |
| publishDateSort | 2001 |
| publisher | Urban & Fischer |
| record_format | marc |
| series | Progress in histochemistry and cytochemistry |
| series2 | Progress in histochemistry and cytochemistry |
| spelling | Yamashita, Shūji Verfasser aut Histochemistry and cytochemistry of nuclear receptors Shuji Yamashita [Bindeeinh.] Jena Urban & Fischer 2001 S. 94 - 176 Ill txt rdacontent n rdamedia nc rdacarrier Progress in histochemistry and cytochemistry 36,2 Celkernen gtt Cytochemie gtt Histochemie gtt Receptoren gtt Cytochemistry Histochemistry Histocytochemistry Nuclear receptors (Biochemistry) Histochemie (DE-588)4025087-8 gnd rswk-swf Cytochemie (DE-588)4070172-4 gnd rswk-swf Kernrezeptor (DE-588)4635996-5 gnd rswk-swf Kernrezeptor (DE-588)4635996-5 s Cytochemie (DE-588)4070172-4 s DE-604 Histochemie (DE-588)4025087-8 s Progress in histochemistry and cytochemistry 36,2 (DE-604)BV000005277 36,2 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017100189&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Yamashita, Shūji Histochemistry and cytochemistry of nuclear receptors Progress in histochemistry and cytochemistry Celkernen gtt Cytochemie gtt Histochemie gtt Receptoren gtt Cytochemistry Histochemistry Histocytochemistry Nuclear receptors (Biochemistry) Histochemie (DE-588)4025087-8 gnd Cytochemie (DE-588)4070172-4 gnd Kernrezeptor (DE-588)4635996-5 gnd |
| subject_GND | (DE-588)4025087-8 (DE-588)4070172-4 (DE-588)4635996-5 |
| title | Histochemistry and cytochemistry of nuclear receptors |
| title_auth | Histochemistry and cytochemistry of nuclear receptors |
| title_exact_search | Histochemistry and cytochemistry of nuclear receptors |
| title_full | Histochemistry and cytochemistry of nuclear receptors Shuji Yamashita |
| title_fullStr | Histochemistry and cytochemistry of nuclear receptors Shuji Yamashita |
| title_full_unstemmed | Histochemistry and cytochemistry of nuclear receptors Shuji Yamashita |
| title_short | Histochemistry and cytochemistry of nuclear receptors |
| title_sort | histochemistry and cytochemistry of nuclear receptors |
| topic | Celkernen gtt Cytochemie gtt Histochemie gtt Receptoren gtt Cytochemistry Histochemistry Histocytochemistry Nuclear receptors (Biochemistry) Histochemie (DE-588)4025087-8 gnd Cytochemie (DE-588)4070172-4 gnd Kernrezeptor (DE-588)4635996-5 gnd |
| topic_facet | Celkernen Cytochemie Histochemie Receptoren Cytochemistry Histochemistry Histocytochemistry Nuclear receptors (Biochemistry) Kernrezeptor |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017100189&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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