BioMEMS:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Dordrecht
Springer
2007
|
| Schriftenreihe: | Microsystems
16 |
| Schlagworte: | |
| Online-Zugang: | Cover Inhaltsverzeichnis Klappentext |
| Beschreibung: | XIX, 373 S. Ill., graph. Darst. |
| ISBN: | 0387287310 9780387287317 |
Internformat
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| 490 | 1 | |a Microsystems |v 16 | |
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| 650 | 4 | |a Biotechnology | |
| 650 | 4 | |a Biotechnology |x methods | |
| 650 | 4 | |a Microelectromechanical systems | |
| 650 | 4 | |a Nanotechnology | |
| 650 | 4 | |a Nanotechnology |x methods | |
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Datensatz im Suchindex
| _version_ | 1804138565276270592 |
|---|---|
| adam_text | Contents
Contributing Authors
xv
Preface
xvii
EARLY BIOMEMS MULTI-SENSOR
NEUROPROBES
1
1
.
Introduction
1
2.
Evolution of micro-sensor array designs
for medical research
3
2.1
Electrical signal monitoring
3
2.2
Sensor Design Evolution: from 2D to
3D 6
2.3
Chamber Type of Electrochemical Oxygen Sensors
7
3.
Other Applications
—
the first micro-fluidic device
11
4.
Conclusion
1
1
5.
References
11
MULTI-PARAMETER BIOMEMS FOR CLINICAL MONITORING
15
1.
Introduction
15
2.
Biosensors
16
2.1
Principle of Biosensors
16
2.2
Amperometric Biosensors
17
3.
Clinical Monitoring
18
3.1
Multi-analyte measurement
20
3.2
Micro-dialysis
21
3.3
BioMEMS for clinical monotoring
24
viii Contents
3.4
Multi-parameter
monitoring
26
3.5
Applications
32
3.5.1
Monitoring of glucose and
lactate
with a micro-dialysis probe
3 2
3.5.2
Ammonia monitoring
34
4.
Conclusions and outlook
36
5.
References
36
NEURAL IMPLANTS IN CLINICAL PRACTICE
Interfacing neurons for neuro-modulation, limb control,
and to restore vision-Part I
41
1.
Introduction to Neural Implants
41
2.
Anatomical and Biophysical Fundamentals
45
2.1
Peripheral Nerve Anatomy
45
2.2
Mechanisms of Peripheral Nerve Damage
47
2.3
Excitability of Nerves
48
2.4
Electrical Modelling of the Nerve Membrane
49
2.5
Propagation of Action Potentials
50
2.6
Extra-cellular Stimulation of Nerve Fibres
52
2.7
Selective Activation of Nerve Fibres
54
3.
Clinical Implants
55
3.1
Electrodes
—
The Key Component in Neural
Prostheses
56
3.2
Cardiac Pacemakers
57
3.3
Implantable Defibrillators
59
3.4
Cochlea Implants
60
3.5
Phrenic Pacemakers
61
3.6
Grasp Neuroprostheses
61
3.7
Neuroprostheses for gait and posture
63
3.8
Spinal Root Stimulator
65
3.9
Drop Foot Stimulator
66
3.10
Neuro-modulation
67
3.11
Deep Brain Stimulation
68
3.12
Vagai
Nerve Stimulation
69
4.
References
70
BIOMEDICAL
MICRODEVICES
FOR NEURAL IMPLANTS
Interfacing neurons for
neuromodulation,
limb control,
and to restore vision-Part II
71
1.
The Challenge of Micro-implants
71
2.
Vision
Prostheses
75
2.1
Cortical Vision
Prostheses
77
Contents ix
80
81
81
85
90
90
91
94
96
96
97
99
102
105
105
108
109
ПО
111
113
139
139
141
3.
Examples of micro-fluidic platforms
142
3.1
PDMS based Micro-fluidics for Large Scale
Integration ( Fluidigm platform )
142
3.2
Micro-fluidics on a Rotating Disk ( Lab on a Disk )
146
3.3
Droplet based micro-fluidics (DBM)
149
3.3.1
DBM based on electro-wetting
149
3.3.2
DBM based on surface acoustic waves
151
3.3.3
DBM based on two phase liquid flow
153
3.4
Non-contact liquid dispensing
155
3.4.1
Dispensing Well Plate for High Throughput Screening
158
3.4.2
TopSpot print heads for High Throughput
Fabrication of Microarrays
160
4.
Conclusion
161
5.
References
162
2.2
Optic Nerve Vision Prosthesis
2.3
Retinal Implants
2.3.1
Subretinal Vision
Prostheses
2.3.2
Epiretinal Vision
Prostheses
2.4
Conclusions on Vision
Prostheses
3.
Periphereral Nerve interfaces
3.1
Non-Invasive Nerve Interfaces
3.2
Semi -Invasive Interfaces
3.3
Invasive Interfaces
3.3.1
Intrafascicular Electrodes
3.3.2
Needle-Like Electrodes
3.3.3
Regenerative type of electrode
3.4
Biohybrid
Approaches
4.
Future Applications
4.1
Interfacing the Brain
4.2
Spinal Cord Implants
4.3
Multi-modal Neural Implants
5.
Concluding Remarks
6.
Neural Implants: Boon or Bane?
7.
References
MICRO-FLUIDIC PLATFORMS
1.
Introduction
2.
What is a micro-fluidic platform
x
Contents
DNA
BASED BIO-MICRO-ELECTRONIC
MECHANICAL SYSTEMS
167
1.
Introduction
167
1.1
The unique features of nucleic acids
168
1.2
Lab on the Chip
168
1.2.1
Electrophoresis
169
1.2.2
Polymerase Chain Reaction (PCR)
169
1.3
Biochemical reaction chains for integration:
biosensors and the lab
biochip
171
2.
MlCROARRAYS AND BlOCHIPS BASED ON
DNA 172
2.1
The typical microarray experiment
173
2.2
Manufacturing of Microarrays
173
2.2.1
Synthesis on the chip
174
2.2.2
Spotting techniques
175
2.3
Transcription Analysis
175
2.4
Oligonucleotide Arrays for sequencing
176
2.5
Active arrays
176
2.5.1
Enzymes acting on immobilised
DNA 177
2.5.2
PCR on the Chip
178
2.6
Integrated PCR
182
2.6.1
Micro-chamber Chips
182
2.6.2
Micro-fluidics Chips
183
3.
Nano-
biotechnology:
DNA
as material
184
3.1 DNA
directed immobilisation and nucleic acid tags
185
3.2 DNA
for regular structures
187
3.3 DNA
to structure surfaces
189
3.3.1
Stretching of
DNA
by fluidics
189
3.3.2
Stretching
DNA
by AC electric fields
190
3.4
Metallisation of
DNA
for electronic circuits
191
4.
References
192
SEPARATION AND DETECTION ON A CHIP
199
1.
Introduction
199
2.
Theory of capillary electrophoresis on
a CE
chip
201
2.1
Mobility of ions
201
2.2
Electro-osmotic flow
203
3.
Joule heating in microfabricated devices
206
3.1
Separation efficiency of
a CE
chip
208
3.2
Separation of biomacromolecules and particles
209
Contents xi
4. Building
blocks of
CE
chip devices
209
4.1
Wafer materials, micromachining and wafer bonding
209
4.2
Power supplies, pumping, injection and channel geometries
214
4.3
Detection strategies
218
5.
Selected examples for
CE on a
chip
225
6.
dlelectrophoresis
227
7.
Outlook
230
8.
References
230
PROTEIN MICROARRAYS: TECHNOLOGIES
AND APPLICATIONS
245
1.
Introduction
245
2.
Forward Phase Protein Microarrays
249
2.1
Protein Expression Analysis Using Protein Microarrays
249
2.2
Protein Interaction Microarrays
255
3.
Reverse Microarrays
257
4.
Outlook
260
5.
References
261
LAB-ON-A-CHIP SYSTEMS FOR CELLULAR ASSAYS
269
1.
Introduction
269
2.
Design and Fabrication of Chips for
Cell based Assays
274
3.
Cell Culture on Chips and Micro-fluidic systems
278
4.
Detectable Cellular Output Signals
280
4.1
Cell Metabolism
282
4.1.1
Extra-cellular Acidification
282
4.1.2
Cellular Oxygen Exchange
283
4.1.3
Miscellaneous Metabolic Parameters
285
4.2
Cell Morphology
286
4.3
Electrical Patterns
288
5.
Cell Manipulation on Chips
292
6.
Conclusions and Future Prospects
295
7.
References
298
xii
Contents
NETWORK ON CHIPS
Spatial and temporal activity dynamics of functional networks
in brain slices and cardiac tissue
309
1.
Introduction
309
2.
Technical Aspects and Underlying Assumptions
312
2.1
System requirements
314
3.
Origin of the signal recorded
317
4.
Spatial resolution
319
5.
lfp and plasticity
320
6.
Network dynamics and epileptiform activity
323
7.
Drug Testing with MEAs
326
7.1
Using Network Properties as
Endpoints
in Drug Assays
327
7.2
Assessing Distributions of
Neuronal
Responses to Dopamine
327
7.3
Cardiopharmacology
331
8.
Data Analysis
333
9.
Outlook
335
10.
Acknowledgements
337
11.
References
338
BIO-NANO-SYSTEMS
Overview and Outlook
351
1.
Introduction
351
2.
Basic concepts and experimental methods
352
2.1
Self-assembly
353
2.2
Optical properties of semiconducting nanocrystals
354
2.3
Optical properties of metal nanocrystals
356
2.4
Magnetic nanoparticles
357
2.5
Conjugation of nanomaterials and biomolecules
358
2.6
Bioanalysis
with bio-nano-systems
360
2.6.1
DNA
detection
360
2.6.2
Immuno assays
363
2.6.3
Fluorescence resonance energy transfer (FRET)
363
2.7
Imaging
364
3.
Applications
364
3.1
DNA
detection
364
3.1.1
DNA
detection by spectral shift
365
3.1.2
DNA
detection bv
Mie
scatterine
366
Contents xiii
366
367
367
369
370
371
372
372
3.2
Immuno
assays
3.2.1
Immuno
assay on a microtiter plate
3.2.2
Immuno assays on polymer beads
3.2.3
FRET with nanocrystals
3.3
Imaging
4.
Conclusion and Outlook
5.
Acknowledgements
6.
References
BioMEMS
Gerald A. Urban
(Ed.)
Explosive
growth in the field of microsystem technology (MST) has introduced a
variety of promising products in major disciplines from microelectronics to life
sciences. Especially the life sciences and health care business was, and is
expected to be a major market for MST products. Undoubtedly the merging of
biological sciences with micro- and nanoscience will create a scientific and
technological revolution in future. Microminiaturization of devices, down to the
nanoscale, approaching the size of biological structures, will be a prerequisite for
the future success of life sciences. Bioanalytical and therapeutic micro- and
nanosystems will be mandatory for system biologists in the long run, to obtain
insight into morphology, the function and the interactive processes of the living
system. With such a deeper understanding new and personalized drugs could be
developed leading to a revolution in life sciences. Today, microanalytical devices
are used in clinical analytics or molecular biology as gene chips. In parallel,
standard microbiomedical products are employed in the intensive care and
surgical theatre, mainly for monitoring and implantation purposes. The gap
between these two different scientific fields will be closed, however, as soon as
functional micro devices can be produced, allowing a deeper view into the
function of cells and whole organisms.
Here, a new discipline evolved which focuses on microsystems for living systems
called BIOMEMS . In this review at a glance the exciting field of bio-
microsystems, from their beginnings to indicators of future successes are
presented. It will also show that a broad penetration of micro and
nano
technologies into biology and medicine will be mandatory for future scientific and
new product development progress in life science.
It wasn t too long ago that BioMEMS and its impact could be treated in one or
two modest chapters of a general book on MEMS. No longer. From
DNA
analysis
to retinal implants to artificially created networks of neurons, this field has simply
exploded. Prof. Urban and his contributors have created a welcome and urgently
needed digest of this diverse and exciting field, supported by extensive citations
to the relevant original work. Every researcher in BioMEMS, and every student
hoping to work in this field, will need this on his or her desk.
Stephen D. Senturia, Professor of Electrical Engineering, Emeritus
Massachusetts Institute of Technology
|
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| id | DE-604.BV035275285 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:30:12Z |
| institution | BVB |
| isbn | 0387287310 9780387287317 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017080914 |
| oclc_num | 69105211 |
| open_access_boolean | |
| owner | DE-703 |
| owner_facet | DE-703 |
| physical | XIX, 373 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Springer |
| record_format | marc |
| series | Microsystems |
| series2 | Microsystems |
| spelling | BioMEMS ed. by Gerald A. Urban Dordrecht Springer 2007 XIX, 373 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Microsystems 16 Bioelectronics Biotechnology Biotechnology methods Microelectromechanical systems Nanotechnology Nanotechnology methods MEMS (DE-588)4824724-8 gnd rswk-swf MEMS (DE-588)4824724-8 s DE-604 Urban, Gerald A. edt Erscheint auch als Online-Ausgabe 0-387-28732-9 Erscheint auch als Online-Ausgabe 978-0-387-28732-4 Microsystems 16 (DE-604)BV013437684 16 text/html http://swbplus.bsz-bw.de/bsz252918827cov.htm Cover Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017080914&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017080914&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | BioMEMS Microsystems Bioelectronics Biotechnology Biotechnology methods Microelectromechanical systems Nanotechnology Nanotechnology methods MEMS (DE-588)4824724-8 gnd |
| subject_GND | (DE-588)4824724-8 |
| title | BioMEMS |
| title_auth | BioMEMS |
| title_exact_search | BioMEMS |
| title_full | BioMEMS ed. by Gerald A. Urban |
| title_fullStr | BioMEMS ed. by Gerald A. Urban |
| title_full_unstemmed | BioMEMS ed. by Gerald A. Urban |
| title_short | BioMEMS |
| title_sort | biomems |
| topic | Bioelectronics Biotechnology Biotechnology methods Microelectromechanical systems Nanotechnology Nanotechnology methods MEMS (DE-588)4824724-8 gnd |
| topic_facet | Bioelectronics Biotechnology Biotechnology methods Microelectromechanical systems Nanotechnology Nanotechnology methods MEMS |
| url | http://swbplus.bsz-bw.de/bsz252918827cov.htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017080914&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017080914&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV013437684 |
| work_keys_str_mv | AT urbangeralda biomems |