Advances in bioactivation research:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York, NY
Springer [u.a.]
2008
|
| Edition: | 1. Ed. |
| Series: | Biotechnology: pharmaceutical aspects
9 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | VII, 503 S. Ill., graph. Darst. 235 mm x 155 mm |
| ISBN: | 9780387772998 9780387773001 0387772995 |
Staff View
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| 245 | 1 | 0 | |a Advances in bioactivation research |c [ed.] Adnan A. Elfarra |
| 250 | |a 1. Ed. | ||
| 264 | 1 | |a New York, NY |b Springer [u.a.] |c 2008 | |
| 300 | |a VII, 503 S. |b Ill., graph. Darst. |c 235 mm x 155 mm | ||
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| 490 | 1 | |a Biotechnology: pharmaceutical aspects |v 9 | |
| 650 | 4 | |a Biotransformation | |
| 650 | 4 | |a Biotransformation (Metabolism) | |
| 650 | 4 | |a Drug activation | |
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Record in the Search Index
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| adam_text | Contents
Part I General Concepts and Basic Mechanisms
1. Metabolic Concerns in Drug Design 3
Jeffrey P. Jones
2. Role of Bioactivation in Idiosyncratic Drug Toxicity:
Structure-Toxicity Relationships 27
Amit S. Kalgutkar
3. Michael Addition-Elimination Reactions: Roles in
Toxicity and Potential New Therapeutic Applications 57
Adnan A. Elfarra and Renee J. Krause
4. Induction of Drug-Metabolizing Enzymes: Contrasting
Roles in Detoxification and Bioactivation of Drugs
and Xenobiotics 69
Sharon L. Ripp
5. Mechanism-Based Inactivation of Cytochrome P450 2A
and 2B Enzymes 103
Sharon E. Murphy and Linda B. von Weymarn
6. CYP2E1 - Biochemical and Toxicological Aspects and Role in
Alcohol-Induced Liver Injury 133
Arthur I. Cederbaum
7. One- and Two-Electron-Mediated Reduction of Quinones:
Enzymology and Toxicological Implications 169
David Siegel, Phillip Reigan and David Ross
8. Lipoxidation-Derived Electrophiles as Biological Reactive
Intermediates 199
De Lin and Lawrence M. Sayre
9. Bioactivation and Protein Modification Reactions of
Unsaturated Aldehydes 233
J. Cai, B.G. Hill, A. Bhatnagar, W.M. Pierce, Jr. and
R.A. Prough
v
Part II Tissue-Specific Features and Risk Assessment
Applications
10. Adaptive Responses and Signal Transduction Pathways in
Chemically Induced Mitochondrial Dysfunction and
Cell Death 257
Lawrence H. Lash
11. Hepatic Bioactivation and Drug-Induced Liver Injury 291
Raymond A. Kemper and George Lai
12. Role of Cysteine S-Conjugate (3-Lyases in the Bioactivation
of Renal Toxicants 325
Arthur J .L. Cooper and John T. Pinto
13. Bioactivation of Xenobiotics in Lung: Role of CYPs
and FMOs 349
David E. Williams
14. Generation of Reactive Metabolites and Associated DNA
Adducts from Benzene, Butadiene, and PAH in Bone
Marrow: Their Effects on Hematopoiesis and Impact on
Human Health 377
Colin Jefcoate and Michele Larsen
15. Butadiene-Mediated Mutagenesis and Carcinogenesis 411
Jonathan B. Ward, Jeffrey K. Wickliffe, Michael P. Stone,
Thomas M. Harris, Priscilla H. Fernandes, and
R. Stephen Lloyd
16. Pharmacogenetics of Drug Bioactivation Pathways 443
Lauren A. Trepanier
17. Human Phenanthrene Metabolites as Probes for the Metabolic
Activation and Detoxification of Carcinogenic Polycyclic
Aromatic Hydrocarbons 463
Stephen S. Hecht
Index 485
|
| adam_txt |
Contents
Part I General Concepts and Basic Mechanisms
1. Metabolic Concerns in Drug Design 3
Jeffrey P. Jones
2. Role of Bioactivation in Idiosyncratic Drug Toxicity:
Structure-Toxicity Relationships 27
Amit S. Kalgutkar
3. Michael Addition-Elimination Reactions: Roles in
Toxicity and Potential New Therapeutic Applications 57
Adnan A. Elfarra and Renee J. Krause
4. Induction of Drug-Metabolizing Enzymes: Contrasting
Roles in Detoxification and Bioactivation of Drugs
and Xenobiotics 69
Sharon L. Ripp
5. Mechanism-Based Inactivation of Cytochrome P450 2A
and 2B Enzymes 103
Sharon E. Murphy and Linda B. von Weymarn
6. CYP2E1 - Biochemical and Toxicological Aspects and Role in
Alcohol-Induced Liver Injury 133
Arthur I. Cederbaum
7. One- and Two-Electron-Mediated Reduction of Quinones:
Enzymology and Toxicological Implications 169
David Siegel, Phillip Reigan and David Ross
8. Lipoxidation-Derived Electrophiles as Biological Reactive
Intermediates 199
De Lin and Lawrence M. Sayre
9. Bioactivation and Protein Modification Reactions of
Unsaturated Aldehydes 233
J. Cai, B.G. Hill, A. Bhatnagar, W.M. Pierce, Jr. and
R.A. Prough
v
Part II Tissue-Specific Features and Risk Assessment
Applications
10. Adaptive Responses and Signal Transduction Pathways in
Chemically Induced Mitochondrial Dysfunction and
Cell Death 257
Lawrence H. Lash
11. Hepatic Bioactivation and Drug-Induced Liver Injury 291
Raymond A. Kemper and George Lai
12. Role of Cysteine S-Conjugate (3-Lyases in the Bioactivation
of Renal Toxicants 325
Arthur J'.L. Cooper and John T. Pinto
13. Bioactivation of Xenobiotics in Lung: Role of CYPs
and FMOs 349
David E. Williams
14. Generation of Reactive Metabolites and Associated DNA
Adducts from Benzene, Butadiene, and PAH in Bone
Marrow: Their Effects on Hematopoiesis and Impact on
Human Health 377
Colin Jefcoate and Michele Larsen
15. Butadiene-Mediated Mutagenesis and Carcinogenesis 411
Jonathan B. Ward, Jeffrey K. Wickliffe, Michael P. Stone,
Thomas M. Harris, Priscilla H. Fernandes, and
R. Stephen Lloyd
16. Pharmacogenetics of Drug Bioactivation Pathways 443
Lauren A. Trepanier
17. Human Phenanthrene Metabolites as Probes for the Metabolic
Activation and Detoxification of Carcinogenic Polycyclic
Aromatic Hydrocarbons 463
Stephen S. Hecht
Index 485 |
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| discipline_str_mv | Chemie / Pharmazie Medizin |
| edition | 1. Ed. |
| format | Book |
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| illustrated | Illustrated |
| index_date | 2024-07-02T22:54:31Z |
| indexdate | 2024-07-09T21:26:37Z |
| institution | BVB |
| isbn | 9780387772998 9780387773001 0387772995 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016978410 |
| oclc_num | 192027297 |
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| owner_facet | DE-19 DE-BY-UBM |
| physical | VII, 503 S. Ill., graph. Darst. 235 mm x 155 mm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer [u.a.] |
| record_format | marc |
| series | Biotechnology: pharmaceutical aspects |
| series2 | Biotechnology: pharmaceutical aspects |
| spelling | Advances in bioactivation research [ed.] Adnan A. Elfarra 1. Ed. New York, NY Springer [u.a.] 2008 VII, 503 S. Ill., graph. Darst. 235 mm x 155 mm txt rdacontent n rdamedia nc rdacarrier Biotechnology: pharmaceutical aspects 9 Biotransformation Biotransformation (Metabolism) Drug activation Elfarra, Adnan A. edt Biotechnology: pharmaceutical aspects 9 (DE-604)BV021640956 9 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016978410&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Advances in bioactivation research Biotechnology: pharmaceutical aspects Biotransformation Biotransformation (Metabolism) Drug activation |
| title | Advances in bioactivation research |
| title_auth | Advances in bioactivation research |
| title_exact_search | Advances in bioactivation research |
| title_exact_search_txtP | Advances in bioactivation research |
| title_full | Advances in bioactivation research [ed.] Adnan A. Elfarra |
| title_fullStr | Advances in bioactivation research [ed.] Adnan A. Elfarra |
| title_full_unstemmed | Advances in bioactivation research [ed.] Adnan A. Elfarra |
| title_short | Advances in bioactivation research |
| title_sort | advances in bioactivation research |
| topic | Biotransformation Biotransformation (Metabolism) Drug activation |
| topic_facet | Biotransformation Biotransformation (Metabolism) Drug activation |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016978410&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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