Mild cognitive impairment and early Alzheimer's disease: detections and diagnosis
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Chichester
John Wiley & Sons
2008
|
| Subjects: | |
| Online Access: | Publisher description Table of contents only Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references (p. [123]-141) and index |
| Physical Description: | VII, 148 S. Ill., graph. Darst. 22 cm |
| ISBN: | 9780470319369 |
Staff View
MARC
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| 245 | 1 | 0 | |a Mild cognitive impairment and early Alzheimer's disease |b detections and diagnosis |c Jeffrey M. Burns, John C. Morris |
| 264 | 1 | |a Chichester |b John Wiley & Sons |c 2008 | |
| 300 | |a VII, 148 S. |b Ill., graph. Darst. |c 22 cm | ||
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| 500 | |a Includes bibliographical references (p. [123]-141) and index | ||
| 650 | 4 | |a Cognition disorders in old age |x Diagnosis | |
| 650 | 4 | |a Cognition disorders in old age |x Treatment | |
| 650 | 4 | |a Presenile dementia |x Diagnosis | |
| 650 | 4 | |a Presenile dementia |x Treatment | |
| 650 | 4 | |a Cognition Disorders | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Alzheimer Disease | |
| 650 | 4 | |a Dementia | |
| 650 | 0 | 7 | |a Alzheimerkrankheit |0 (DE-588)4112510-1 |2 gnd |9 rswk-swf |
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| 700 | 1 | |a Morris, John C. |d 1948- |e Sonstige |0 (DE-588)135540356 |4 oth | |
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Record in the Search Index
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|---|---|
| adam_text | Contents
Introduction 1
What is mild cognitive impairment? 3
Epidemiological studies of MCI 5
The border zone between aging and dementia: cognitive and
neuropathological changes 10
Aging and cognitive performance 11
Neuropathology of Alzheimer s disease, non-demented
aging and MCI 17
Histopathological features 17
Plaques 18
Neurofibrillary pathology 18
Neuronal loss 19
Topography of neuropathological changes 22
Neuropathological AD diagnosis 24
Neuropathology of aging 27
Neuropathology of MCI 31
Does a subset of MCI patients actually have early Alzheimer s
* disease? 32
Clinical studies 32
Neuroimaging 32
detecting and diagnosing MCI and early AD 35
Early detection 35
Recognition of MCI and early AD 36
Informant-based history 39
Neurological examination 41
Laboratory and radiological evaluation 42
Psychometric / mental status testing 44
Dementia-screening instruments 45
Mini-mental state examination 45
Clock-drawing test 46
Seven-minute screen 48
Contents
Dementia staging instruments 49
CDR 49
Global deterioration scale 50
Etiology of MCI: differential diagnosis 53
Worried-well 53
Depression 54
Other etiologies 55
Neurodegenerative dementias 55
Overlap disorders 58
Dementia with Lewy bodies 58
Vascular dementia 59
Frontotemporal lobar dementias 60
Identifying the subset of MCI that is AD 65
Treatment of MCI and dementia 69
MCI 69
The case for early treatment 69
Non-pharmacological treatment 71
Dementia therapy 73
Approved therapies 73
Cholinergic hypothesis 73
Cholinesterase inhibitors 75
Donepezil 77
Rivastigmine 78
Galantamine 79
Memantine 79
Agents under investigation for AD treatment and
prevention 81
Vitamin E and selegiline 81
Estrogen 82
Anti-inflammatory agents 83
Cholesterol-reducing agents 84
Chelation therapy 84
Contents
Future therapeutic and diagnostic strategies 85
Amyloid hypothesis 85
Secretase inhibitors 87
Amyloid vaccine 88
Potential biomarkers 89
CSF biomarkers 90
CSF amyloid beta (A(3) 91
CSF tau 91
CSFsulfatide 92
CSF markers of inflammation 93
CSF markers of oxidative stress 93
Serum biomarkers 94
Structural imaging 95
Functional neuroimaging 96
PET and SPECT 97
Functional MRI (fMRI) 98
Imaging amyloid 100
Genetic testing 101
Early-onset familial AD 102
Amyloid precursor protein 102
Presenilin genes 103
Late-onset AD 103
Apolipoprotein E 104
Case studies 105
Case report 1: MCI as early-stage Alzheimer s disease 105
Comment 108
Case report 2: Diagnosis of dementia prior to impairment
sufficient for MCI 110
Comment 113
Case report 3: Memory complaints associated with
non-demented aging 118
Comment 121
References 123
Index 143
|
| adam_txt |
Contents
Introduction 1
What is mild cognitive impairment? 3
Epidemiological studies of MCI 5
The border zone between aging and dementia: cognitive and
neuropathological changes 10
Aging and cognitive performance 11
Neuropathology of Alzheimer's disease, non-demented
aging and MCI 17
Histopathological features 17
Plaques 18
Neurofibrillary pathology 18
Neuronal loss 19
Topography of neuropathological changes 22
Neuropathological AD diagnosis 24
Neuropathology of aging 27
Neuropathology of MCI 31
Does a subset of MCI patients actually have early Alzheimer's
* disease? 32
Clinical studies 32
Neuroimaging 32
detecting and diagnosing MCI and early AD 35
Early detection 35
Recognition of MCI and early AD 36
Informant-based history 39
Neurological examination 41
Laboratory and radiological evaluation 42
Psychometric / mental status testing 44
Dementia-screening instruments 45
Mini-mental state examination 45
Clock-drawing test 46
Seven-minute screen 48
Contents
Dementia staging instruments 49
CDR 49
Global deterioration scale 50
Etiology of MCI: differential diagnosis 53
"Worried-well" 53
Depression 54
Other etiologies 55
Neurodegenerative dementias 55
Overlap disorders 58
Dementia with Lewy bodies 58
Vascular dementia 59
Frontotemporal lobar dementias 60
Identifying the subset of MCI that is AD 65
Treatment of MCI and dementia 69
MCI 69
The case for early treatment 69
Non-pharmacological treatment 71
Dementia therapy 73
Approved therapies 73
Cholinergic hypothesis 73
Cholinesterase inhibitors 75
Donepezil 77
Rivastigmine 78
Galantamine 79
Memantine 79
Agents under investigation for AD treatment and
prevention 81
Vitamin E and selegiline 81
Estrogen 82
Anti-inflammatory agents 83
Cholesterol-reducing agents 84
Chelation therapy 84
Contents
Future therapeutic and diagnostic strategies 85
Amyloid hypothesis 85
Secretase inhibitors 87
Amyloid vaccine 88
Potential biomarkers 89
CSF biomarkers 90
CSF amyloid beta (A(3) 91
CSF tau 91
CSFsulfatide 92
CSF markers of inflammation 93
CSF markers of oxidative stress 93
Serum biomarkers 94
Structural imaging 95
Functional neuroimaging 96
PET and SPECT 97
Functional MRI (fMRI) 98
Imaging amyloid 100
Genetic testing 101
Early-onset familial AD 102
Amyloid precursor protein 102
Presenilin genes 103
Late-onset AD 103
Apolipoprotein E 104
Case studies 105
Case report 1: MCI as early-stage Alzheimer's disease 105
Comment 108
Case report 2: Diagnosis of dementia prior to impairment
sufficient for MCI 110
Comment 113
Case report 3: Memory complaints associated with
non-demented aging 118
Comment 121
References 123
Index 143 |
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| index_date | 2024-07-02T22:18:46Z |
| indexdate | 2024-07-09T21:22:37Z |
| institution | BVB |
| isbn | 9780470319369 |
| language | English |
| lccn | 2008007182 |
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| physical | VII, 148 S. Ill., graph. Darst. 22 cm |
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| spelling | Burns, Jeffrey M. Verfasser aut Mild cognitive impairment and early Alzheimer's disease detections and diagnosis Jeffrey M. Burns, John C. Morris Chichester John Wiley & Sons 2008 VII, 148 S. Ill., graph. Darst. 22 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references (p. [123]-141) and index Cognition disorders in old age Diagnosis Cognition disorders in old age Treatment Presenile dementia Diagnosis Presenile dementia Treatment Cognition Disorders Aged Alzheimer Disease Dementia Alzheimerkrankheit (DE-588)4112510-1 gnd rswk-swf Alzheimerkrankheit (DE-588)4112510-1 s DE-604 Morris, John C. 1948- Sonstige (DE-588)135540356 oth http://www.loc.gov/catdir/enhancements/fy0810/2008007182-d.html Publisher description http://www.loc.gov/catdir/enhancements/fy0810/2008007182-t.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016781712&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Burns, Jeffrey M. Mild cognitive impairment and early Alzheimer's disease detections and diagnosis Cognition disorders in old age Diagnosis Cognition disorders in old age Treatment Presenile dementia Diagnosis Presenile dementia Treatment Cognition Disorders Aged Alzheimer Disease Dementia Alzheimerkrankheit (DE-588)4112510-1 gnd |
| subject_GND | (DE-588)4112510-1 |
| title | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis |
| title_auth | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis |
| title_exact_search | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis |
| title_exact_search_txtP | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis |
| title_full | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis Jeffrey M. Burns, John C. Morris |
| title_fullStr | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis Jeffrey M. Burns, John C. Morris |
| title_full_unstemmed | Mild cognitive impairment and early Alzheimer's disease detections and diagnosis Jeffrey M. Burns, John C. Morris |
| title_short | Mild cognitive impairment and early Alzheimer's disease |
| title_sort | mild cognitive impairment and early alzheimer s disease detections and diagnosis |
| title_sub | detections and diagnosis |
| topic | Cognition disorders in old age Diagnosis Cognition disorders in old age Treatment Presenile dementia Diagnosis Presenile dementia Treatment Cognition Disorders Aged Alzheimer Disease Dementia Alzheimerkrankheit (DE-588)4112510-1 gnd |
| topic_facet | Cognition disorders in old age Diagnosis Cognition disorders in old age Treatment Presenile dementia Diagnosis Presenile dementia Treatment Cognition Disorders Aged Alzheimer Disease Dementia Alzheimerkrankheit |
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