The Chlamydomonas sourcebook: 3 Cell motility and behavior
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2009
|
| Ausgabe: | 2. ed. |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXXIX, 501 S. Ill., graph. Darst. |
| ISBN: | 9780123708762 |
Internformat
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| 245 | 1 | 0 | |a The Chlamydomonas sourcebook |n 3 |p Cell motility and behavior |c Elizabeth H. Harris, ed. in chief |
| 250 | |a 2. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier |c 2009 | |
| 300 | |a XXXIX, 501 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 700 | 1 | |a Harris, Elizabeth H. |e Sonstige |4 oth | |
| 700 | 1 | |a Stern, David B. |e Sonstige |4 oth | |
| 700 | 1 | |a Witman, George B. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804138074849935360 |
|---|---|
| adam_text | Contents of Volume 3
Preface xi
Acknowledgments xiii
List of Contributors xv
Conventions Used xvii
Abbreviations xix
List of Tables xxi
List of Figures xxiii
Contents of Volume 1 xxix
Contents of Volume 2 xxxi
CHAPTER 1 A Stroll through Time with Chlamydomonas 1
Joel Rosenbaum
CHAPTER 2 Basal Bodies and Associated Structures 15
Susan K. Dutcher
I. Introduction 16
II. Fibers attached to the basal bodies 19
III. Global approaches to the identification of basal
body proteins 22
IV. Mutations that alter basal bodies 23
V. Mutations in basal body segregation 28
VI. DNA in the basal body 29
VII. Function of basal bodies 29
VIII. Duplication of basal bodies 34
IX. Genes with connections to human disease 36
X. Conclusion 37
References 37
CHAPTER 3 Deflagellation 43
Lynne M. Quarmby
I. Introduction 43
II. Deflagellation: key tool of flagellar research 44
III. Why do cells deflagellate? 46
IV. Signaling pathways to deflagellation 48
V. The mechanism of flagellar severing 54
VI. Deflagellation and the cell cycle 61
VII. Summary and thoughts for future directions 63
References 64
CHAPTER 4 Intraflagellar Transport 71
Douglas G. Cole
I. The identification of intraflagellar transport 71
II. IFT machinery 75
III. Visualization of IFT 89
IV. Functional analysis of Chlamydomonas IFT 95
V. Summary 104
References 104
CHAPTER 5 Flagellar Length Control 115
Paul A. Lefebvre
I. Introduction 115
II. Genetic evidence for a flagellar length
control mechanism 117
III. LF4: an unusual MAP kinase 119
IV. LF1, LF2, LF3: partners in the Length
Regulatory Complex 119
V. What other genes are involved in flagellar
length control? 121
VI. Models for flagellar length control 123
VII. Questions about flagellar length control 125
VIII. Conclusion and future directions 126
References 127
CHAPTER 6 Axonemal Dyneins: Assembly, Structure, and
Force Generation 131
Stephen M. King and Ritsu Kamiya
I. Introduction 132
II. Arrangement of dyneins in the axoneme 132
III. Dynein genetics 136
IV. Composition and physical properties of
purified dyneins 142
V. Other components that affect dynein assembly
and/or function 183
VI. Preassembly of dyneins in the cytoplasm 186
VII. Molecular mechanism of force generation 187
VIII. Conclusions and prospects 191
Acknowledgments 191
References 191
CHAPTER 7 The Flagellar Radial Spokes 209
Pinfen Yang and Elizabeth F. Smith
I. Introduction 209
II. Genetic dissection of the radial spokes 210
III. Biochemical characterization of radial spokes
and spoke proteins 214
IV. Assembly of the radial spoke complex 221
V. Radial spoke function: part of the control system
for regulating flagellar beating 223
VI. Future directions 228
References 229
CHAPTER 8 The Flagellar Central Pair Apparatus 235
David R. Mitchell
I. Introduction 235
II. Central pair structure 236
III. Genetic dissection of central pair structure
and function 239
IV. Biochemical identification of central pair proteins 242
V. Central pair regulation of flagellar motility 244
VI. Future directions 247
References 248
CHAPTER 9 The Regulation of Axonemal Bending 253
Maureen Wirschell, Daniela Nicastro,
Mary E. Porter and Winfield S. Sale
I. Introduction 253
II. Suppressor mutants and the DRC 256
III. The 96-nm axoneme repeat 262
IV. Regulation of flagellar motility by phosphorylation 267
V. Future directions 274
References 275
CHAPTER 10 Microtubule-Membrane Interactions in
Chlamydomonas Flagella , 283
William Dentler
I. Introduction 284
II. Ciliary bases and transition regions 284
III. Lateral interactions in the axoneme 289
IV. Capping structures link the microtubule ends
to the membrane 294
V. Summary 301
Acknowledgment 301
References 301
CHAPTER 11 The Chlamydomonas Flagellar Membrane and Its
Dynamic Properties 309
Robert A. Bloodgood
I. The flagellum as a membrane-bounded organelle 310
II. The Chlamydomonas plasma membrane 311
III. Structure of the flagellar membrane 316
IV. Composition of the flagellar membrane 324
V. Assembly and turnover of the flagellar membrane 335
VI. Dynamic properties of the flagellar membrane 340
VII. Summary 358
References 359
CHAPTER 12 Flagellar Adhesion, Flagellar-Generated Signaling, and
Gamete Fusion during Mating 369
William J. Snell and Ursula W. Goodenough
I. Introduction 370
II. Flagellar agglutination 374
III. Flagellar-generated signaling 380
IV. Gamete fusion 385
V. Evolutionary perspectives 389
References 390
CHAPTER 13 Sensory Photoreceptors and Light Control of
Flagellar Activity 395
Peter Hegemann and Peter Berthold
I. Behavioral light responses 396
II. The Chlamydomonas eye 401
III. Photocurrents as rapid light signaling elements 404
IV. Rhodopsins as photoreceptors for behavioral
responses 410
V. Blue-light sensitive flavin-based photoreceptors 418
VI. Summary and future prospects 421
Acknowledgments 422
References 422
CHAPTER 14 Mitosis and Cytokinesis 431
Wallace F. Marshall
I. Introduction 431
II. Mitosis 433
III. Cytokinesis 438
IV. Perspectives 440
References 441
CHAPTER 15 The Chlamydomonas Flagellum as a Model for
Human Ciliary Disease 445
Gregory J. Pazour and George B. Witman
I. Introduction 445
II. Primary ciliary dyskinesia 447
III. Hydrocephalus 451
IV. Juvenile myoclonic epilepsy 453
V. Situs inversus 455
VI. Polycystic kidney disease 457
VII. Syndromes involving primary cilia 461
VIII. Retinal degeneration and blindness 465
IX. Cancer 466
X. Conclusion 467
Acknowledgments 468
References 468
Index 479
|
| adam_txt |
Contents of Volume 3
Preface xi
Acknowledgments xiii
List of Contributors xv
Conventions Used xvii
Abbreviations xix
List of Tables xxi
List of Figures xxiii
Contents of Volume 1 xxix
Contents of Volume 2 xxxi
CHAPTER 1 A Stroll through Time with Chlamydomonas 1
Joel Rosenbaum
CHAPTER 2 Basal Bodies and Associated Structures 15
Susan K. Dutcher
I. Introduction 16
II. Fibers attached to the basal bodies 19
III. Global approaches to the identification of basal
body proteins 22
IV. Mutations that alter basal bodies 23
V. Mutations in basal body segregation 28
VI. DNA in the basal body 29
VII. Function of basal bodies 29
VIII. Duplication of basal bodies 34
IX. Genes with connections to human disease 36
X. Conclusion 37
References 37
CHAPTER 3 Deflagellation 43
Lynne M. Quarmby
I. Introduction 43
II. Deflagellation: key tool of flagellar research 44
III. Why do cells deflagellate? 46
IV. Signaling pathways to deflagellation 48
V. The mechanism of flagellar severing 54
VI. Deflagellation and the cell cycle 61
VII. Summary and thoughts for future directions 63
References 64
CHAPTER 4 Intraflagellar Transport 71
Douglas G. Cole
I. The identification of intraflagellar transport 71
II. IFT machinery 75
III. Visualization of IFT 89
IV. Functional analysis of Chlamydomonas IFT 95
V. Summary 104
References 104
CHAPTER 5 Flagellar Length Control 115
Paul A. Lefebvre
I. Introduction 115
II. Genetic evidence for a flagellar length
control mechanism 117
III. LF4: an unusual MAP kinase 119
IV. LF1, LF2, LF3: partners in the Length
Regulatory Complex 119
V. What other genes are involved in flagellar
length control? 121
VI. Models for flagellar length control 123
VII. Questions about flagellar length control 125
VIII. Conclusion and future directions 126
References 127
CHAPTER 6 Axonemal Dyneins: Assembly, Structure, and
Force Generation 131
Stephen M. King and Ritsu Kamiya
I. Introduction 132
II. Arrangement of dyneins in the axoneme 132
III. Dynein genetics 136
IV. Composition and physical properties of
purified dyneins 142
V. Other components that affect dynein assembly
and/or function 183
VI. Preassembly of dyneins in the cytoplasm 186
VII. Molecular mechanism of force generation 187
VIII. Conclusions and prospects 191
Acknowledgments 191
References 191
CHAPTER 7 The Flagellar Radial Spokes 209
Pinfen Yang and Elizabeth F. Smith
I. Introduction 209
II. Genetic dissection of the radial spokes 210
III. Biochemical characterization of radial spokes
and spoke proteins 214
IV. Assembly of the radial spoke complex 221
V. Radial spoke function: part of the control system
for regulating flagellar beating 223
VI. Future directions 228
References 229
CHAPTER 8 The Flagellar Central Pair Apparatus 235
David R. Mitchell
I. Introduction 235
II. Central pair structure 236
III. Genetic dissection of central pair structure
and function 239
IV. Biochemical identification of central pair proteins 242
V. Central pair regulation of flagellar motility 244
VI. Future directions 247
References 248
CHAPTER 9 The Regulation of Axonemal Bending 253
Maureen Wirschell, Daniela Nicastro,
Mary E. Porter and Winfield S. Sale
I. Introduction 253
II. Suppressor mutants and the DRC 256
III. The 96-nm axoneme repeat 262
IV. Regulation of flagellar motility by phosphorylation 267
V. Future directions 274
References 275
CHAPTER 10 Microtubule-Membrane Interactions in
Chlamydomonas Flagella , 283
William Dentler
I. Introduction 284
II. Ciliary bases and transition regions 284
III. Lateral interactions in the axoneme 289
IV. Capping structures link the microtubule ends
to the membrane 294
V. Summary 301
Acknowledgment 301
References 301
CHAPTER 11 The Chlamydomonas Flagellar Membrane and Its
Dynamic Properties 309
Robert A. Bloodgood
I. The flagellum as a membrane-bounded organelle 310
II. The Chlamydomonas plasma membrane 311
III. Structure of the flagellar membrane 316
IV. Composition of the flagellar membrane 324
V. Assembly and turnover of the flagellar membrane 335
VI. Dynamic properties of the flagellar membrane 340
VII. Summary 358
References 359
CHAPTER 12 Flagellar Adhesion, Flagellar-Generated Signaling, and
Gamete Fusion during Mating 369
William J. Snell and Ursula W. Goodenough
I. Introduction 370
II. Flagellar agglutination 374
III. Flagellar-generated signaling 380
IV. Gamete fusion 385
V. Evolutionary perspectives 389
References 390
CHAPTER 13 Sensory Photoreceptors and Light Control of
Flagellar Activity 395
Peter Hegemann and Peter Berthold
I. Behavioral light responses 396
II. The Chlamydomonas eye 401
III. Photocurrents as rapid light signaling elements 404
IV. Rhodopsins as photoreceptors for behavioral
responses 410
V. Blue-light sensitive flavin-based photoreceptors 418
VI. Summary and future prospects 421
Acknowledgments 422
References 422
CHAPTER 14 Mitosis and Cytokinesis 431
Wallace F. Marshall
I. Introduction 431
II. Mitosis 433
III. Cytokinesis 438
IV. Perspectives 440
References 441
CHAPTER 15 The Chlamydomonas Flagellum as a Model for
Human Ciliary Disease 445
Gregory J. Pazour and George B. Witman
I. Introduction 445
II. Primary ciliary dyskinesia 447
III. Hydrocephalus 451
IV. Juvenile myoclonic epilepsy 453
V. Situs inversus 455
VI. Polycystic kidney disease 457
VII. Syndromes involving primary cilia 461
VIII. Retinal degeneration and blindness 465
IX. Cancer 466
X. Conclusion 467
Acknowledgments 468
References 468
Index 479 |
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| isbn | 9780123708762 |
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| spelling | The Chlamydomonas sourcebook 3 Cell motility and behavior Elizabeth H. Harris, ed. in chief 2. ed. Amsterdam [u.a.] Elsevier 2009 XXXIX, 501 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Harris, Elizabeth H. Sonstige oth Stern, David B. Sonstige oth Witman, George B. Sonstige oth (DE-604)BV035102784 3 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016770766&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The Chlamydomonas sourcebook |
| title | The Chlamydomonas sourcebook |
| title_auth | The Chlamydomonas sourcebook |
| title_exact_search | The Chlamydomonas sourcebook |
| title_exact_search_txtP | The Chlamydomonas sourcebook |
| title_full | The Chlamydomonas sourcebook 3 Cell motility and behavior Elizabeth H. Harris, ed. in chief |
| title_fullStr | The Chlamydomonas sourcebook 3 Cell motility and behavior Elizabeth H. Harris, ed. in chief |
| title_full_unstemmed | The Chlamydomonas sourcebook 3 Cell motility and behavior Elizabeth H. Harris, ed. in chief |
| title_short | The Chlamydomonas sourcebook |
| title_sort | the chlamydomonas sourcebook cell motility and behavior |
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