The treatment of advanced Parkinson's disease:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Bremen [u.a.]
UNI-MED-Verl.
2008
|
| Edition: | 1. Aufl. |
| Series: | UNI-MED science
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | 95 S. Ill., graph. Darst. |
| ISBN: | 9783837410709 9781848151352 |
Staff View
MARC
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| 245 | 1 | 0 | |a The treatment of advanced Parkinson's disease |c [Wolfgang Jost. In collab. with Horst Baas ...] |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |a Bremen [u.a.] |b UNI-MED-Verl. |c 2008 | |
| 300 | |a 95 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 700 | 1 | |a Jost, Wolfgang H. |d 1959- |e Sonstige |0 (DE-588)115190147 |4 oth | |
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Record in the Search Index
| _version_ | 1804138057039872000 |
|---|---|
| adam_text | Contents
Contents
Introduction
12
The Clinical
Picture
16
2.1. Motor
disturbances ¡n advanced stages
...................................................16
2.1.1.
Fluctuations
...................................................................................16
2.1.1.1.
End-of-doseakinesia
................................................................................16
2.1.1.2.
Paroxysmal on/off-phenomena
......................................................................17
2.1.1.3.
Freezing phenomena
................................................................................18
2.1.2.
Dyskinesia/Dystonia
...........................................................................19
2.1.2.1.
Choreiform dyskinesia
...............................................................................19
2.1.2.2.
Dystonia
............................................................................................19
2.1.3.
Axial malpositions
.............................................................................19
2.1.3.1.
Camptocormia
......................................................................................19
2.1.3.2.
Anterocollis/Dropped head syndrome
...............................................................20
2.1.3.3.
Pisa syndrome
.......................................................................................20
2.2.
Psychiatric disturbances
.................................................................22
2.2.1.
Psychoses
.....................................................................................22
2.2.1.1.
Epidemiology
.......................................................................................22
2.2.1.2.
Pathophysiology
....................................................................................23
2.2.1.3.
Clinical Picture
......................................................................................23
2.2.1.4.
Treatment
...........................................................................................24
2.2.2.
Depression
....................................................................................26
2.2.2.1.
Diagnosis of depressive symptoms in Parkinson s disease
.............................................27
2.2.2.2.
Treatment
...........................................................................................29
2.2.3.
Dementia
.....................................................................................32
2.2.3.1.
Clinical picture
......................................................................................35
2.2.3.2.
Diagnosis
...........................................................................................36
2.2.3.3.
Treatment
...........................................................................................37
2.3. Autonomie dysregulation
in advanced Parkinson s disease
................................38
2.3.1.
Cardiovascular symptoms
.....................................................................39
2.3.2.
Gastrointestinal symptoms
....................................................................40
2.3.3. Urogenital
symptoms
.........................................................................42
2.4.
Sleep disorders in Parkinson s disease
....................................................44
2.4.1.
Pathophysiology
..............................................................................45
2.4.2.
Clinical symptoms
.............................................................................45
2.4.3.
Diagnostic workup
............................................................................47
2.4.4.
Treatment of sleep disorders
..................................................................47
Pharmacotherapy
52
3.1.
Avoidance of late motor complications
..................................................52
3.1.1.
Dyskinesias caused by antiparkinsonian treatment
.............................................52
3.1.2.
Preventative strategies
........................................................................53
3.1.3.
Symptomatic treatment of dyskinesias
.........................................................54
3.2.
Standard therapy of advanced Parkinson s disease
.......................................56
3.2.1.
Hypokinetic fluctuations
.......................................................................56
3.2.2.
Hyperkinetic fluctuations (dopaminergic-induced dyskinesias)
.................................58
3.2.3.
Akinetic crisis
.................................................................................58
3.2.4.
Tremor refractory to treatment
................................................................59
10 Contents
3.3.
Continuous
jejunal levodopa/carbidopa
infusion in patients with advanced Parkinson s
disease
..................................................................................60
3.3.1.
Characterization
...............................................................................60
3.3.2.
Indication and methods
.......................................................................61
3.3.3.
Pharmacokinetics and efficacy
.................................................................61
3.3.4.
Side effects and technical problems
............................................................61
3.3.5.
Perspectives
..................................................................................62
3.4.
Apomorphine in Parkinson s disease
......................................................63
3.4.1.
Subcutaneous injection of apomorphine as on-demand therapy
................................63
3.4.2.
Continuous subcutaneous apomorphine infusions
.............................................65
3.5.
Drug interactions in Parkinson s disease
..................................................68
3.5.1.
Mechanisms of drug interactions
..............................................................68
3.5.2.
Contraindications/restricted application in Parkinson s disease
.................................69
3.5.3.
interactions between antiparkinsonian drugs
..................................................69
3.5.4.
Interactions with associated therapies
.........................................................69
3.5.5.
Adjuvant therapy
..............................................................................72
Nondrug Treatment
76
4.1.
Exercise treatment and rehabilitation in Parkinson s disease
...............................76
4.1.1.
The basics of exercise treatment and rehabilitative therapy
.....................................76
4.1.2.
Special therapeutic strategies
..................................................................77
4.2.
Surgical treatment of Parkinson s disease
.................................................80
4.2.1.
Deep brain stimulation
........................................................................80
4.2.1.1.
Mechanisms of action
...............................................................................81
4.2.1.2.
Indications
..........................................................................................82
4.2.1.3.
Clinical results
......................................................................................82
4.2.1.4.
Comparison of therapeutic objectives
................................................................83
4.2.2.
Experimental surgical interventions
............................................................84
4.2.2.1.
Transplantation of dopaminergic neurons
............................................................84
4.2.2.2.
Implantation of non-neuronal dopaminergic cells
....................................................84
4.2.2.3.
Gene therapy
........................................................................................84
4.3.
Future perspectives/developments
.......................................................85
4.3.1.
Rotigotine
....................................................................................86
4.3.2.
Adenosine A^-receptor antagonists
............................................................86
4.3.3.
Additional antidyskinetic approaches
..........................................................86
4.3.4.
The implantation of Spheramine®
..............................................................87
4.3.5.
Neurotrophic factors
..........................................................................88
4.3.6.
Gene therapy
.................................................................................88
4.3.7.
Neuroprotective agents
.......................................................................89
Ц
Index
94
|
| adam_txt |
Contents
Contents
Introduction
12
The Clinical
Picture
16
2.1. Motor
disturbances ¡n advanced stages
.16
2.1.1.
Fluctuations
.16
2.1.1.1.
End-of-doseakinesia
.16
2.1.1.2.
Paroxysmal on/off-phenomena
.17
2.1.1.3.
Freezing phenomena
.18
2.1.2.
Dyskinesia/Dystonia
.19
2.1.2.1.
Choreiform dyskinesia
.19
2.1.2.2.
Dystonia
.19
2.1.3.
Axial malpositions
.19
2.1.3.1.
Camptocormia
.19
2.1.3.2.
Anterocollis/Dropped head syndrome
.20
2.1.3.3.
Pisa syndrome
.20
2.2.
Psychiatric disturbances
.22
2.2.1.
Psychoses
.22
2.2.1.1.
Epidemiology
.22
2.2.1.2.
Pathophysiology
.23
2.2.1.3.
Clinical Picture
.23
2.2.1.4.
Treatment
.24
2.2.2.
Depression
.26
2.2.2.1.
Diagnosis of depressive symptoms in Parkinson's disease
.27
2.2.2.2.
Treatment
.29
2.2.3.
Dementia
.32
2.2.3.1.
Clinical picture
.35
2.2.3.2.
Diagnosis
.36
2.2.3.3.
Treatment
.37
2.3. Autonomie dysregulation
in advanced Parkinson's disease
.38
2.3.1.
Cardiovascular symptoms
.39
2.3.2.
Gastrointestinal symptoms
.40
2.3.3. Urogenital
symptoms
.42
2.4.
Sleep disorders in Parkinson's disease
.44
2.4.1.
Pathophysiology
.45
2.4.2.
Clinical symptoms
.45
2.4.3.
Diagnostic workup
.47
2.4.4.
Treatment of sleep disorders
.47
Pharmacotherapy
52
3.1.
Avoidance of late motor complications
.52
3.1.1.
Dyskinesias caused by antiparkinsonian treatment
.52
3.1.2.
Preventative strategies
.53
3.1.3.
Symptomatic treatment of dyskinesias
.54
3.2.
Standard therapy of advanced Parkinson's disease
.56
3.2.1.
Hypokinetic fluctuations
.56
3.2.2.
Hyperkinetic fluctuations (dopaminergic-induced dyskinesias)
.58
3.2.3.
Akinetic crisis
.58
3.2.4.
Tremor refractory to treatment
.59
10 Contents
3.3.
Continuous
jejunal levodopa/carbidopa
infusion in patients with advanced Parkinson's
disease
.60
3.3.1.
Characterization
.60
3.3.2.
Indication and methods
.61
3.3.3.
Pharmacokinetics and efficacy
.61
3.3.4.
Side effects and technical problems
.61
3.3.5.
Perspectives
.62
3.4.
Apomorphine in Parkinson's disease
.63
3.4.1.
Subcutaneous injection of apomorphine as on-demand therapy
.63
3.4.2.
Continuous subcutaneous apomorphine infusions
.65
3.5.
Drug interactions in Parkinson's disease
.68
3.5.1.
Mechanisms of drug interactions
.68
3.5.2.
Contraindications/restricted application in Parkinson's disease
.69
3.5.3.
interactions between antiparkinsonian drugs
.69
3.5.4.
Interactions with associated therapies
.69
3.5.5.
Adjuvant therapy
.72
Nondrug Treatment
76
4.1.
Exercise treatment and rehabilitation in Parkinson's disease
.76
4.1.1.
The basics of exercise treatment and rehabilitative therapy
.76
4.1.2.
Special therapeutic strategies
.77
4.2.
Surgical treatment of Parkinson's disease
.80
4.2.1.
Deep brain stimulation
.80
4.2.1.1.
Mechanisms of action
.81
4.2.1.2.
Indications
.82
4.2.1.3.
Clinical results
.82
4.2.1.4.
Comparison of therapeutic objectives
.83
4.2.2.
Experimental surgical interventions
.84
4.2.2.1.
Transplantation of dopaminergic neurons
.84
4.2.2.2.
Implantation of non-neuronal dopaminergic cells
.84
4.2.2.3.
Gene therapy
.84
4.3.
Future perspectives/developments
.85
4.3.1.
Rotigotine
.86
4.3.2.
Adenosine A^-receptor antagonists
.86
4.3.3.
Additional antidyskinetic approaches
.86
4.3.4.
The implantation of Spheramine®
.87
4.3.5.
Neurotrophic factors
.88
4.3.6.
Gene therapy
.88
4.3.7.
Neuroprotective agents
.89
Ц
Index
94 |
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| id | DE-604.BV035096991 |
| illustrated | Illustrated |
| index_date | 2024-07-02T22:12:41Z |
| indexdate | 2024-07-09T21:22:08Z |
| institution | BVB |
| isbn | 9783837410709 9781848151352 |
| language | English |
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| physical | 95 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
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| publisher | UNI-MED-Verl. |
| record_format | marc |
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| spelling | The treatment of advanced Parkinson's disease [Wolfgang Jost. In collab. with Horst Baas ...] 1. Aufl. Bremen [u.a.] UNI-MED-Verl. 2008 95 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier UNI-MED science Literaturangaben Parkinson-Krankheit - Therapie Therapie (DE-588)4059798-2 gnd rswk-swf Parkinson-Krankheit (DE-588)4044683-9 gnd rswk-swf Parkinson-Krankheit (DE-588)4044683-9 s Therapie (DE-588)4059798-2 s DE-604 Jost, Wolfgang H. 1959- Sonstige (DE-588)115190147 oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016765027&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The treatment of advanced Parkinson's disease Parkinson-Krankheit - Therapie Therapie (DE-588)4059798-2 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd |
| subject_GND | (DE-588)4059798-2 (DE-588)4044683-9 |
| title | The treatment of advanced Parkinson's disease |
| title_auth | The treatment of advanced Parkinson's disease |
| title_exact_search | The treatment of advanced Parkinson's disease |
| title_exact_search_txtP | The treatment of advanced Parkinson's disease |
| title_full | The treatment of advanced Parkinson's disease [Wolfgang Jost. In collab. with Horst Baas ...] |
| title_fullStr | The treatment of advanced Parkinson's disease [Wolfgang Jost. In collab. with Horst Baas ...] |
| title_full_unstemmed | The treatment of advanced Parkinson's disease [Wolfgang Jost. In collab. with Horst Baas ...] |
| title_short | The treatment of advanced Parkinson's disease |
| title_sort | the treatment of advanced parkinson s disease |
| topic | Parkinson-Krankheit - Therapie Therapie (DE-588)4059798-2 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd |
| topic_facet | Parkinson-Krankheit - Therapie Therapie Parkinson-Krankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016765027&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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