Holdings: Genetic dissection of complex traits

Genetic dissection of complex traits: [based on a symposium held in honor of ... Newton E. Morton]

Saved in:

Bibliographic Details
Other Authors:	Rao, Dabeeru C. (Editor)
Format:	Book
Language:	English
Published:	Amsterdam [u.a.] Elsevier 2008
Edition:	2. ed.
Series:	Advances in genetics 60
Subjects:	Gentransfer Gentherapie Gen-Targeting Methode Aufsatzsammlung Konferenzschrift
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Item Description:	Einzelaufnahme eines Zeitschr.-Bd.
Physical Description:	XXVII, 760 S. Ill., graph. Darst.
ISBN:	9780123738837

Staff View

MARC


LEADER	00000nam a2200000 cb4500
001	BV035002681
003	DE-604
005	00000000000000.0
007	t
008	080813s2008 ad\|\| \|\|\|\| 10\|\|\| eng d
020			\|a 9780123738837 \|9 978-0-12-373883-7
035			\|a (OCoLC)634720756
035			\|a (DE-599)HBZHT015523916
040			\|a DE-604 \|b ger \|e rakwb
041	0		\|a eng
049			\|a DE-703
245	1	0	\|a Genetic dissection of complex traits \|b [based on a symposium held in honor of ... Newton E. Morton] \|c ed. by D. C. Rao ...
250			\|a 2. ed.
264		1	\|a Amsterdam [u.a.] \|b Elsevier \|c 2008
300			\|a XXVII, 760 S. \|b Ill., graph. Darst.
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
490	0		\|a Advances in genetics \|v 60
500			\|a Einzelaufnahme eines Zeitschr.-Bd.
650	0	7	\|a Gentransfer \|0 (DE-588)4194102-0 \|2 gnd \|9 rswk-swf
650	0	7	\|a Gentherapie \|0 (DE-588)4296957-8 \|2 gnd \|9 rswk-swf
650	0	7	\|a Gen-Targeting \|0 (DE-588)4294998-1 \|2 gnd \|9 rswk-swf
650	0	7	\|a Methode \|0 (DE-588)4038971-6 \|2 gnd \|9 rswk-swf
655		7	\|0 (DE-588)4143413-4 \|a Aufsatzsammlung \|2 gnd-content
655		7	\|0 (DE-588)1071861417 \|a Konferenzschrift \|2 gnd-content
689	0	0	\|a Gentherapie \|0 (DE-588)4296957-8 \|D s
689	0		\|5 DE-604
689	1	0	\|a Gentransfer \|0 (DE-588)4194102-0 \|D s
689	1	1	\|a Methode \|0 (DE-588)4038971-6 \|D s
689	1		\|5 DE-604
689	2	0	\|a Gen-Targeting \|0 (DE-588)4294998-1 \|D s
689	2	1	\|a Methode \|0 (DE-588)4038971-6 \|D s
689	2		\|5 DE-604
700	1		\|a Rao, Dabeeru C. \|4 edt
856	4		\|u http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2426911&custom_att_2=simple_viewer \|y Genetic dissection of complex traits \|3 Inhaltsverzeichnis
856	4	2	\|m HEBIS Datenaustausch Darmstadt \|q application/pdf \|u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016672055&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA \|3 Inhaltsverzeichnis
999			\|a oai:aleph.bib-bvb.de:BVB01-016672055

Record in the Search Index

_version_	1804137919538003968
adam_text	GENETIC DISSECTION OF COMPLEX TRAITS SECOND EDITION 2008 EDITED BY UNIVERSITIES- I Y: B& IOIHSK D&T BIBSIOTHEK EI II D. C. RAO , WASHINGTON UNIVERSITY SCHOOL OF MEDICINE * DIVISION OF BIOSTATISTICS *. ST. LOUIS, MISSOURI C. CHARLES GU WASHINGTON UNIVERSITY SCHOOL OF MEDICINE DIVISION OF BIOSTATISTICS ST. LOUIS, MISSOURI ELSEVIER AMSTERDAM BOSTON * HEIDELBERG * LONDON NEW YORK * OXFORD * PARIS * SAN DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY * TOKYO ACADEMIC PRESS IS AN IMPRINT OF ELSEVIER CONTENTS CONTRIBUTORS XV PREFACE TO FIRST EDITION XXI PREFACE TO SECOND EDITION XXV ACKNOWLEDGMENTS XXVII PART I: OVERVIEW AND FUNDAMENTALS 1 1 AN OVERVIEW OF THE GENETIC DISSECTION OF COMPLEX TRAITS 3 D. C. RAO I. INTRODUCTION 4 II. CHALLENGES ARISING FROM COMPLEX TRAITS 7 III. STUDY DESIGN 9 IV. ANALYTICAL METHODS 12 V. SPECIAL TOPICS 19 VI. GWA STUDIES 22 VII. EFFICIENT STRATEGIES FOR ENHANCING GENE DISCOVERY 25 VIII. DISCUSSION 28 REFERENCES 30 2 FAMILIAL RESEMBLANCE AND HERITABILITY 35 TREVA K. RICE I. INTRODUCTION 36 II. FAMILIAL RESEMBLANCE AND HERITABILITY 38 III. STUDY DESIGNS AND MULTIFACTORIAL MODELS 41 IV. DISCUSSION 46 REFERENCES 47 3 LINKAGE AND ASSOCIATION: BASIC CONCEPTS 51 INGRID B. BORECKI AND MICHAEL A. PROVINCE I. INTRODUCTION 52 II. HISTORICAL PERSPECTIVE 54 CONTENTS III. FUNDAMENTALS AND METHODS 55 IV. SEVEN STAGES OF RELATIONSHIP WITH GW STUDIES 64 V. CONTEMPORARY APPROACHES 66 VI. CHALLENGES AND ISSUES 69 REFERENCES 70 4 DEFINITION OF PHENOTYPE 75 MARY K. WOJCZYNSKI AND HEMANT K. TIWARI I. INTRODUCTION 76 II. PHENOTYPE CHOICES/OPTIONS 78 III. STUDY DESIGN ISSUES 92 IV. DISCUSSION 99 REFERENCES 100 5 GENOTYPING PLATFORMS FOR MASS-THROUGHPUT GENOTYPING WITH SNPS, INCLUDING HUMAN GENOME-WIDE SCANS 107 KAREN MARESSO AND ULRICH BROECKEL I. INTRODUCTION: EXPLOSIVE NEED FOR MASS-THROUGHPUT GENOTYPING 108 II. MICROSATELLITES VERSUS SNPS 110 III. GENOTYPING PLATFORMS AND GOALS 115 IV. SELECTION OF MARKERS AND SNPS 126 V. NOVEL MARKERS 130 VI. FUTURE PROSPECTS 133 VII. CONCLUSIONS 135 REFERENCES 136 6 GENOTYPING ERRORS AND THEIR IMPACT ON GENETIC ANALYSIS 141 MICHAEL B. MILLER, KAREN SCHWANDER, AND D. C. RAO I. INTRODUCTION 142 II. MISSPECIFICATION OF GENETIC RELATIONSHIPS 143 III. DETECTION AND CORRECTION OF MISSPECIFICATION OF RELATIONSHIPS 144 IV. GENOTYPE MISCLASSIFICATION 147 V. CONCLUSION 151 REFERENCES 151 CONTENTS VII PART II: LINKAGE AND ASSOCIATION ANALYSIS 153 7 MODEL-BASED METHODS FOR LINKAGE ANALYSIS 155 JOHN P. RICE, NANCY L. SACCONE, AND JONATHAN CORBETT I. INTRODUCTION 156 II. THE GENERALIZED SINGLE MAJOR LOCUS MODEL DESCRIPTION 156 III. THE LOD SCORE 157 IV. THE MOD SCORE METHOD 165 V. THE LOD SCORE AND META-ANALYSIS 166 VI. MULTILOCUS MODELS 168 VII. STRENGTHS AND WEAKNESSES OF MODEL-BASED METHODS 170 VIII. DISCUSSION 170 REFERENCES 171 8 CONTEMPORARY MODEL-FREE METHODS FOR LINKAGE ANALYSIS 175 LAURA ALMASY AND JOHN BLANGERO I. INTRODUCTION 176 II. IDENTITY BY DESCENT AND IDENTITY BY STATE 177 III. RELATIVE PAIR LINKAGE METHODS 180 IV. VARIANCE COMPONENTS LINKAGE METHODS 184 V. STRENGTHS AND WEAKNESSES OF MODEL-FREE LINKAGE METHODS 187 VI. CONCLUSION 189 REFERENCES 189 9 DNA SEQUENCE-BASED PHENOTYPIC ASSOCIATION ANALYSIS 195 NICHOLAS J. SCHORK, JENNIFER WESSEL, AND NATHALIE MALO I. INTRODUCTION 196 II. MULTIVARIATE DISTANCE MATRIX REGRESSION 202 III. SIMULATION STUDIES , 206 IV. RESULTS 209 V. DISCUSSION 213 REFERENCES 215 VIII CONTENTS 10 FAMILY-BASED METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS 219 NAN M. LAIRD AND CHRISTOPH LANGE I. INTRODUCTION 220 - II. ANALYSIS METHODS: FBAT AND PBAT 228 III. OTHER APPROACHES TO FAMILY-BASED ANALYSES, INCLUDING THE PDT AND THE QTDT - 240 IV, SOFTWARE 246 V. DISCUSSION 246 REFERENCES 248 11 SEARCHING FOR ADDITIONAL DISEASE LOCI IN A GENOMIC REGION 253 GLENYS THOMSON, LISA F. BARCELLOS, AND ANA M. VALDES I. INTRODUCTION 254 II. PRIMARY DISEASE-PREDISPOSING GENES AND THEIR GENETIC FEATURES 261 III. DETECTING ADDITIONAL GENES IN A GENETIC REGION 271 IV. DISCUSSION 283 REFERENCES 285 12 METHODS FOR HANDLING MULTIPLE TESTING 293 TREVA K. RICE, NICHOLAS J. SCHORK, AND D. C. RAO I. INTRODUCTION 294 II. TYPES OF ERRORS IN HYPOTHESIS TESTING (TYPE I AND TYPE II) 296 III. STRIKING A BALANCE BETWEEN FALSE POSITIVES AND FALSE NEGATIVES 298 IV. ALTERNATIVE ADJUSTMENT METHODS 299 V. CONCLUSION 305 REFERENCES 305 PART III: SPECIAL TOPICS 309 13 META-ANALYSIS METHODS 311 THOMAS A. TRIKALINOS, GEORGIA SALANTI, ELIAS ZINTZARAS, AND JOHN P. A. IOANNIDIS I. INTRODUCTION 312 II. META-ANALYSIS OF POPULATION-BASED ASSOCIATION STUDIES 313 CONTENTS IX III. META-ANALYSIS OF LINKAGE STUDIES 319 IV. SPECIAL ISSUES 324 REFERENCES 329 14 HAPLOTYPE-ASSOCIATION ANALYSIS 335 NIANJUN LIU, KUI ZHANG, AND HONGYU ZHAO I. INTRODUCTION 336 II. HAPLOTYPE INFERENCE FROM UNRELATED INDIVIDUALS 337 III. HAPLOTYPE INFERENCE FROM PEDIGREES 349 IV. * POPULATION-BASED HAPLOTYPE-ASSOCIATION METHODS 362 V. FAMILY-BASED ASSOCIATION METHODS USING HAPLOTYPES 376 VI. DISCUSSION 391 - , REFERENCES 393 15 CHARACTERIZATION OF LD STRUCTURES AND THE UTILITY OF HAPMAP IN GENETIC ASSOCIATION STUDIES 407 C. CHARLES GU, KAI YU, AND D. C. RAO I. INTRODUCTION 408 II. HAPLOTYPE SIMILARITY IN CANDIDATE GENES AND -LD MAPPING 409 III. GLOBAL ORGANIZATION OF LD STRUCTURES 414 IV. VARIATION OF LOCAL LD STRUCTURES 420 V. DISCUSSION 425 REFERENCES 430 16 ASSOCIATIONS AMONG MULTIPLE MARKERS AND COMPLEX DISEASE: MODELS, ALGORITHMS, AND APPLICATIONS 437 THEMISTOCLES L. ASSIMES, ADAM B. OLSHEN, BALASUBRAMANIAN NARASIMHAN, AND RICHARD A. OLSHEN I. INTRODUCTION 438 II. A MODEL FOR DIPLOTYPES 441 III. STRAND-SPECIFIC INFERENCE IN THE ABSENCE OF RANDOMNESS IN P 446 IV. HAPLOVIEW AND OUR VIEW 447 , V. APPROACHES TO TWO-CLASS ASSOCIATION/CLASSIFICATION 454 VI. RESTRICTIONS ON PROBABILITIES ENTAILED BY HARDY-WEINBERG EQUILIBRIUM 459 VII. DISCUSSION AND SUMMARY 460 REFERENCES 462 CONTENTS 17 STUDY DESIGNS FOR GENOME-WIDE ASSOCIATION STUDIES 465 PETER KRAFT AND DAVID G. COX I. INTRODUCTION 466 II. BASIC PRINCIPLES OF ASSOCIATION DESIGN 471 III. THE GENETIC ARCHITECTURE OF COMPLEX TRAITS 480 IV. GENOTYPING TECHNOLOGIES 482 V. POWER CALCULATIONS FOR MULTISTAGE DESIGN 485 VI. DISCUSSION 493 REFERENCES 495 18 ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS OF BIOBANKS FOR GENETICS RESEARCH 505 SUSANNE B. HAGA AND LAURA M. BESKOW I. INTRODUCTION 506 1 - II. GOVERNANCE OF BIOBANKS 507 III. RISKS AND BENEFITS 512 IV. RECRUITMENT OF VULNERABLE AND MINORITY POPULATIONS 516 V. INFORMED CONSENT 518 VI. STORAGE OF GENETIC INFORMATION*OPTIMIZING PRIVACY 522 VII. BIOSPECIMEN/DATA ACCESS 524 VIII. OWNERSHIP AND INTELLECTUAL PROPERTY 525 IX. DISCLOSURE OF RESEARCH RESULTS 527 X. COMMERCIALIZATION OF BIOBANKS 536 . XI. CONCLUSION 538 REFERENCES 539 PART IV: PROMISING TOPICS 545 19 ADMIXTURE MAPPING AND THE ROLE OF POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES 547 XIAOFENG ZHU, HUA TANG, AND NEIL RISCH I. INTRODUCTION 548 II. POPULATION GENETIC STRUCTURE IN HUMANS 549 III. POPULATION ADMIXTURE 550 IV. METHODS OF ADMIXTURE MAPPING 551 V. DESIGN CONSIDERATION 561 CONTENTS VI. PROSPECTS AND CONCERNS OF ADMIXTURE MAPPING 563 VII. CONCLUSIONS 565 REFERENCES 566 20 INTEGRATING GLOBAL GENE EXPRESSION ANALYSIS AND GENETICS 571 CHARLES R. FARBER AND ALDONS J. LUSIS I. INTRODUCTION 572 II. TECHNICAL AND EXPERIMENTAL DESIGN ISSUES FOR MICROARRAYS 575 III. IDENTIFYING DISEASE CANDIDATES USING DNA MICROARRAYS 582 IV. INTEGRATION OF GENETICS AND GENOMICS 586 V. CONCLUSIONS 596 REFERENCES 597 21 A SYSTEMS BIOLOGY APPROACH TO DRUG DISCOVERY 603 JUN ZHU, BIN ZHANG, AND ERIC E. SCHADT I. INTRODUCTION 604 II. CAUSAL INFERENCE: AN INTEGRATED APPROACH TO DRUG DISCOVERY 606 III. COEXPRESSION NETWORKS 612 IV. PROBABILISTIC CAUSAL NETWORKS: BAYESIAN NETWORKS AS A FRAMEWORK FOR DATA INTEGRATION 617 V. AN INSIGHTFUL EXAMPLE: INTEGRATING DATA LEADS TO THE IDENTIFICATION OF GENE AFFECTING PLASMA CHOLESTEROL LEVELS 625 VI. CONCLUSIONS 628 REFERENCES 630 22 THE PROMISE OF COMPOSITE LIKELIHOOD METHODS FOR ADDRESSING COMPUTATIONALLY INTENSIVE CHALLENGES 637 NALI I. INTRODUCTION 638 II. COMPOSITE LIKELIHOOD METHODS 638 III. APPLICATIONS IN POPULATION GENETICS 641 XII CONTENTS IV. APPLICATIONS IN FINE MAPPING OF DISEASE MUTATIONS 643 V. OTHER APPLICATIONS 649 VI. PROSPECTIVES AND DISCUSSION 650 REFERENCES 652 23 COMPARATIVE GENOMICS FOR DETECTING HUMAN DISEASE GENES 655 CAROL MORENO, JOZEF LAZAR, HOWARD J. JACOB, AND ANNE E. KWITEK I. INTRODUCTION 656 II. THE POWER AND PROMISE OF COMPARATIVE GENOMICS 659 III. ANIMAL MODELS FOR HUMAN DISEASE 665 IV. COMPARATIVE GENOMICS AND BUILDING BETTER ANIMAL MODELS 676 V. DISCUSSION 681 REFERENCES 683 PART V: OUTSTANDING CHALLENGES 699 24 FROM GENETICS TO MECHANISM OF DISEASE LIABILITY 701 ANDREAS ROHRWASSER, PAUL LOTT, ROBERT B. WEISS, AND JEAN-MARC LALOUEL I. INTRODUCTION 702 II. IDENTIFICATION OF QTL BY STATISTICAL ANALYSIS 703 III. A STRONG QTL FOR SODIUM SENSITIVITY IN THE C57BL/6J MOUSE INBRED LINE 707 IV. FROM QTL TO GENES: GENE PRIORITIZATION 713 V. FROM QTL TO GENES: HIGH-THROUGHPUT FUNCTIONAL SCREENS 721 VI. PERSPECTIVE 723 REFERENCES 723 25 INTO THE POST-HAPMAP ERA 727 NEWTON E. MORTON I. INTRODUCTION 728 II. LINKAGE MAPPING AND CYTOGENETIC ASSIGNMENT 729 III. ASSOCIATION MAPPING AND FUNCTIONAL ASSIGNMENT 730 IV. FULLY PARAMETRIC ANALYSIS 732 CONTENTS XIII V. META-ANALYSIS 732 VI. ANALYSIS OF MSSNPS 733 VII. THE FALSE DISCOVERY RATE 734 VIII. EARLYHAPMAP PROJECTS 735 IX. GENOME-WIDE ASSOCIATION SCANS 737 X. WHAT NEXT? 738 REFERENCES 740 INDEX 743
adam_txt	GENETIC DISSECTION OF COMPLEX TRAITS SECOND EDITION 2008 EDITED BY UNIVERSITIES- I'Y:' B&'IOIHSK D&T BIBSIOTHEK EI II D. C. RAO , WASHINGTON UNIVERSITY SCHOOL OF MEDICINE * DIVISION OF BIOSTATISTICS *. ST. LOUIS, MISSOURI C. CHARLES GU WASHINGTON UNIVERSITY SCHOOL OF MEDICINE DIVISION OF BIOSTATISTICS ST. LOUIS, MISSOURI ELSEVIER AMSTERDAM BOSTON * HEIDELBERG * LONDON NEW YORK * OXFORD * PARIS * SAN DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY * TOKYO ACADEMIC PRESS IS AN IMPRINT OF ELSEVIER CONTENTS CONTRIBUTORS XV PREFACE TO FIRST EDITION XXI PREFACE TO SECOND EDITION XXV ACKNOWLEDGMENTS XXVII PART I: OVERVIEW AND FUNDAMENTALS 1 1 AN OVERVIEW OF THE GENETIC DISSECTION OF COMPLEX TRAITS 3 D. C. RAO I. INTRODUCTION 4 II. CHALLENGES ARISING FROM COMPLEX TRAITS 7 III. STUDY DESIGN 9 IV. ANALYTICAL METHODS 12 V. SPECIAL TOPICS 19 VI. GWA STUDIES 22 VII. EFFICIENT STRATEGIES FOR ENHANCING GENE DISCOVERY 25 VIII. DISCUSSION 28 REFERENCES 30 2 FAMILIAL RESEMBLANCE AND HERITABILITY 35 TREVA K. RICE I. INTRODUCTION 36 II. FAMILIAL RESEMBLANCE AND HERITABILITY 38 III. STUDY DESIGNS AND MULTIFACTORIAL MODELS 41 IV. DISCUSSION 46 REFERENCES 47 3 LINKAGE AND ASSOCIATION: BASIC CONCEPTS 51 INGRID B. BORECKI AND MICHAEL A. PROVINCE I. INTRODUCTION 52 II. HISTORICAL PERSPECTIVE 54 CONTENTS III. FUNDAMENTALS AND METHODS 55 IV. SEVEN STAGES OF RELATIONSHIP WITH GW STUDIES 64 V. CONTEMPORARY APPROACHES 66 VI. CHALLENGES AND ISSUES 69 REFERENCES 70 4 DEFINITION OF PHENOTYPE 75 MARY K. WOJCZYNSKI AND HEMANT K. TIWARI I. INTRODUCTION 76 II. PHENOTYPE CHOICES/OPTIONS 78 III. STUDY DESIGN ISSUES 92 IV. DISCUSSION 99 REFERENCES 100 5 GENOTYPING PLATFORMS FOR MASS-THROUGHPUT GENOTYPING WITH SNPS, INCLUDING HUMAN GENOME-WIDE SCANS 107 KAREN MARESSO AND ULRICH BROECKEL I. INTRODUCTION: EXPLOSIVE NEED FOR MASS-THROUGHPUT GENOTYPING 108 II. MICROSATELLITES VERSUS SNPS 110 III. GENOTYPING PLATFORMS AND GOALS 115 IV. SELECTION OF MARKERS AND SNPS 126 V. NOVEL MARKERS 130 VI. FUTURE PROSPECTS 133 VII. CONCLUSIONS 135 REFERENCES 136 6 GENOTYPING ERRORS AND THEIR IMPACT ON GENETIC ANALYSIS 141 MICHAEL B. MILLER, KAREN SCHWANDER, AND D. C. RAO I. INTRODUCTION 142 II. MISSPECIFICATION OF GENETIC RELATIONSHIPS 143 III. DETECTION AND CORRECTION OF MISSPECIFICATION OF RELATIONSHIPS 144 IV. GENOTYPE MISCLASSIFICATION 147 V. CONCLUSION 151 REFERENCES 151 CONTENTS VII PART II: LINKAGE AND ASSOCIATION ANALYSIS 153 7 MODEL-BASED METHODS FOR LINKAGE ANALYSIS 155 JOHN P. RICE, NANCY L. SACCONE, AND JONATHAN CORBETT I. INTRODUCTION 156 II. THE GENERALIZED SINGLE MAJOR LOCUS MODEL DESCRIPTION 156 III. THE LOD SCORE 157 IV. THE MOD SCORE METHOD 165 V. THE LOD SCORE AND META-ANALYSIS 166 VI. MULTILOCUS MODELS 168 VII. STRENGTHS AND WEAKNESSES OF MODEL-BASED METHODS 170 VIII. DISCUSSION 170 REFERENCES 171 8 CONTEMPORARY MODEL-FREE METHODS FOR LINKAGE ANALYSIS 175 LAURA ALMASY AND JOHN BLANGERO I. INTRODUCTION 176 II. IDENTITY BY DESCENT AND IDENTITY BY STATE 177 III. RELATIVE PAIR LINKAGE METHODS 180 IV. VARIANCE COMPONENTS LINKAGE METHODS 184 V. STRENGTHS AND WEAKNESSES OF MODEL-FREE LINKAGE METHODS 187 VI. CONCLUSION 189 REFERENCES 189 9 DNA SEQUENCE-BASED PHENOTYPIC ASSOCIATION ANALYSIS 195 NICHOLAS J. SCHORK, JENNIFER WESSEL, AND NATHALIE MALO I. INTRODUCTION 196 II. MULTIVARIATE DISTANCE MATRIX REGRESSION 202 III. SIMULATION STUDIES , 206 IV. RESULTS 209 V. DISCUSSION 213 REFERENCES 215 VIII CONTENTS 10 FAMILY-BASED METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS 219 NAN M. LAIRD AND CHRISTOPH LANGE I. INTRODUCTION 220 - II. ANALYSIS METHODS: FBAT AND PBAT 228 III. OTHER APPROACHES TO FAMILY-BASED ANALYSES, INCLUDING THE PDT AND THE QTDT - 240 IV, SOFTWARE 246 V. DISCUSSION 246 REFERENCES 248 11 SEARCHING FOR ADDITIONAL DISEASE LOCI IN A GENOMIC REGION 253 GLENYS THOMSON, LISA F. BARCELLOS, AND ANA M. VALDES I. INTRODUCTION 254 II. PRIMARY DISEASE-PREDISPOSING GENES AND THEIR ' GENETIC FEATURES 261 III. DETECTING ADDITIONAL GENES IN A GENETIC REGION 271 IV. DISCUSSION 283 REFERENCES 285 12 METHODS FOR HANDLING MULTIPLE TESTING 293 TREVA K. RICE, NICHOLAS J. SCHORK, AND D. C. RAO I. INTRODUCTION ' 294 II. TYPES OF ERRORS IN HYPOTHESIS TESTING (TYPE I AND TYPE II) 296 III. STRIKING A BALANCE BETWEEN FALSE POSITIVES AND FALSE NEGATIVES 298 IV. ALTERNATIVE ADJUSTMENT METHODS 299 V. CONCLUSION 305 REFERENCES 305 PART III: SPECIAL TOPICS 309 13 META-ANALYSIS METHODS 311 THOMAS A. TRIKALINOS, GEORGIA SALANTI, ELIAS ZINTZARAS, AND JOHN P. A. IOANNIDIS I. INTRODUCTION 312 II. META-ANALYSIS OF POPULATION-BASED ASSOCIATION STUDIES 313 CONTENTS IX III. META-ANALYSIS OF LINKAGE STUDIES 319 IV. SPECIAL ISSUES 324 REFERENCES 329 14 HAPLOTYPE-ASSOCIATION ANALYSIS 335 NIANJUN LIU, KUI ZHANG, AND HONGYU ZHAO I. INTRODUCTION 336 II. HAPLOTYPE INFERENCE FROM UNRELATED INDIVIDUALS 337 III. HAPLOTYPE INFERENCE FROM PEDIGREES 349 IV. * POPULATION-BASED HAPLOTYPE-ASSOCIATION METHODS 362 V. FAMILY-BASED ASSOCIATION METHODS USING HAPLOTYPES 376 VI.' DISCUSSION 391 - , REFERENCES 393 15 CHARACTERIZATION OF LD STRUCTURES AND THE UTILITY OF HAPMAP IN GENETIC ASSOCIATION STUDIES 407 C. CHARLES GU, KAI YU, AND D. C. RAO I. INTRODUCTION 408 II. HAPLOTYPE SIMILARITY IN CANDIDATE GENES AND -LD MAPPING 409 III. GLOBAL ORGANIZATION OF LD STRUCTURES 414 IV. VARIATION OF LOCAL LD STRUCTURES 420 V. DISCUSSION 425 REFERENCES 430 16 ASSOCIATIONS AMONG MULTIPLE MARKERS AND COMPLEX DISEASE: MODELS, ALGORITHMS, AND APPLICATIONS 437 THEMISTOCLES L. ASSIMES, ADAM B. OLSHEN, BALASUBRAMANIAN NARASIMHAN, AND RICHARD A. OLSHEN I. INTRODUCTION 438 II. A MODEL FOR "DIPLOTYPES" 441 III. STRAND-SPECIFIC INFERENCE IN THE ABSENCE OF RANDOMNESS IN P 446 IV. HAPLOVIEW AND OUR VIEW 447 , V. APPROACHES TO TWO-CLASS ASSOCIATION/CLASSIFICATION 454 VI. RESTRICTIONS ON PROBABILITIES ENTAILED BY HARDY-WEINBERG EQUILIBRIUM 459 VII. DISCUSSION AND SUMMARY 460 REFERENCES 462 CONTENTS 17 STUDY DESIGNS FOR GENOME-WIDE ASSOCIATION STUDIES 465 PETER KRAFT AND DAVID G. COX I. INTRODUCTION 466 II. BASIC PRINCIPLES OF ASSOCIATION DESIGN 471 III. THE GENETIC ARCHITECTURE OF COMPLEX TRAITS 480 IV. GENOTYPING TECHNOLOGIES 482 V. POWER CALCULATIONS FOR MULTISTAGE DESIGN 485 VI. DISCUSSION 493 REFERENCES 495 18 ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS OF BIOBANKS FOR GENETICS RESEARCH 505 SUSANNE B. HAGA AND LAURA M. BESKOW I. INTRODUCTION 506 1 - II. GOVERNANCE OF BIOBANKS 507 III. RISKS AND BENEFITS 512 IV. RECRUITMENT OF VULNERABLE AND MINORITY POPULATIONS 516 V. INFORMED CONSENT 518 VI. STORAGE OF GENETIC INFORMATION*OPTIMIZING PRIVACY 522 VII. BIOSPECIMEN/DATA ACCESS 524 VIII. OWNERSHIP AND INTELLECTUAL PROPERTY 525 IX. DISCLOSURE OF RESEARCH RESULTS 527 X. COMMERCIALIZATION OF BIOBANKS 536 . XI. CONCLUSION 538 REFERENCES 539 PART IV: PROMISING TOPICS 545 19 ADMIXTURE MAPPING AND THE ROLE OF POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES 547 XIAOFENG ZHU, HUA TANG, AND NEIL RISCH I. INTRODUCTION 548 II. POPULATION GENETIC STRUCTURE IN HUMANS 549 III. POPULATION ADMIXTURE 550 IV. METHODS OF ADMIXTURE MAPPING 551 V. DESIGN CONSIDERATION 561 CONTENTS VI. PROSPECTS AND CONCERNS OF ADMIXTURE MAPPING 563 VII. CONCLUSIONS 565 REFERENCES 566 20 INTEGRATING GLOBAL GENE EXPRESSION ANALYSIS AND GENETICS 571 CHARLES R. FARBER AND ALDONS J. LUSIS I. INTRODUCTION 572 II. TECHNICAL AND EXPERIMENTAL DESIGN ISSUES FOR MICROARRAYS 575 III. IDENTIFYING DISEASE CANDIDATES USING DNA MICROARRAYS 582 IV. INTEGRATION OF GENETICS AND GENOMICS 586 V. CONCLUSIONS 596 REFERENCES 597 21 A SYSTEMS BIOLOGY APPROACH TO DRUG DISCOVERY 603 JUN ZHU, BIN ZHANG, AND ERIC E. SCHADT I. INTRODUCTION 604 II. CAUSAL INFERENCE: AN INTEGRATED APPROACH TO DRUG DISCOVERY 606 III. COEXPRESSION NETWORKS 612 IV. PROBABILISTIC CAUSAL NETWORKS: BAYESIAN NETWORKS AS A FRAMEWORK FOR DATA INTEGRATION 617 V. AN INSIGHTFUL EXAMPLE: INTEGRATING DATA LEADS TO THE IDENTIFICATION OF GENE AFFECTING PLASMA CHOLESTEROL LEVELS 625 VI. CONCLUSIONS 628 REFERENCES 630 22 THE PROMISE OF COMPOSITE LIKELIHOOD METHODS FOR ADDRESSING COMPUTATIONALLY INTENSIVE CHALLENGES 637 NALI I. INTRODUCTION 638 II. COMPOSITE LIKELIHOOD METHODS 638 III. APPLICATIONS IN POPULATION GENETICS 641 XII CONTENTS IV. APPLICATIONS IN FINE MAPPING OF DISEASE MUTATIONS 643 V. OTHER APPLICATIONS 649 VI. PROSPECTIVES AND DISCUSSION 650 REFERENCES 652 23 COMPARATIVE GENOMICS FOR DETECTING HUMAN DISEASE GENES 655 CAROL MORENO, JOZEF LAZAR, HOWARD J. JACOB, AND ANNE E. KWITEK I. INTRODUCTION 656 II. THE POWER AND PROMISE OF COMPARATIVE GENOMICS 659 III. ANIMAL MODELS FOR HUMAN DISEASE 665 IV. COMPARATIVE GENOMICS AND BUILDING BETTER ANIMAL MODELS 676 V. DISCUSSION 681 REFERENCES 683 PART V: OUTSTANDING CHALLENGES 699 24 FROM GENETICS TO MECHANISM OF DISEASE LIABILITY 701 ANDREAS ROHRWASSER, PAUL LOTT, ROBERT B. WEISS, AND JEAN-MARC LALOUEL I. INTRODUCTION 702 II. IDENTIFICATION' OF QTL BY STATISTICAL ANALYSIS 703 III. A STRONG QTL FOR SODIUM SENSITIVITY IN THE C57BL/6J MOUSE INBRED LINE 707 IV. FROM QTL TO GENES: GENE PRIORITIZATION 713 V. FROM QTL TO GENES: HIGH-THROUGHPUT FUNCTIONAL SCREENS 721 VI. PERSPECTIVE 723 REFERENCES 723 25 INTO THE POST-HAPMAP ERA 727 NEWTON E. MORTON I. INTRODUCTION 728 II. LINKAGE MAPPING AND CYTOGENETIC ASSIGNMENT 729 III. ASSOCIATION MAPPING AND FUNCTIONAL ASSIGNMENT 730 IV. FULLY PARAMETRIC ANALYSIS 732 CONTENTS XIII V. META-ANALYSIS 732 VI. ANALYSIS OF MSSNPS 733 VII. THE FALSE DISCOVERY RATE 734 VIII. EARLYHAPMAP PROJECTS 735 IX. GENOME-WIDE ASSOCIATION SCANS 737 X. WHAT NEXT? 738 REFERENCES 740 INDEX 743
any_adam_object	1
any_adam_object_boolean	1
author2	Rao, Dabeeru C.
author2_role	edt
author2_variant	d c r dc dcr
author_facet	Rao, Dabeeru C.
building	Verbundindex
bvnumber	BV035002681
ctrlnum	(OCoLC)634720756 (DE-599)HBZHT015523916
edition	2. ed.
format	Book
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>02014nam a2200481 cb4500</leader><controlfield tag="001">BV035002681</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">080813s2008 ad\|\| \|\|\|\| 10\|\|\| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780123738837</subfield><subfield code="9">978-0-12-373883-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)634720756</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)HBZHT015523916</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-703</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetic dissection of complex traits</subfield><subfield code="b">[based on a symposium held in honor of ... Newton E. Morton]</subfield><subfield code="c">ed. by D. C. Rao ...</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">2. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Amsterdam [u.a.]</subfield><subfield code="b">Elsevier</subfield><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXVII, 760 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Advances in genetics</subfield><subfield code="v">60</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Einzelaufnahme eines Zeitschr.-Bd.</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gentransfer</subfield><subfield code="0">(DE-588)4194102-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gentherapie</subfield><subfield code="0">(DE-588)4296957-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Gen-Targeting</subfield><subfield code="0">(DE-588)4294998-1</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Methode</subfield><subfield code="0">(DE-588)4038971-6</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)1071861417</subfield><subfield code="a">Konferenzschrift</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Gentherapie</subfield><subfield code="0">(DE-588)4296957-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Gentransfer</subfield><subfield code="0">(DE-588)4194102-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Methode</subfield><subfield code="0">(DE-588)4038971-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="689" ind1="2" ind2="0"><subfield code="a">Gen-Targeting</subfield><subfield code="0">(DE-588)4294998-1</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2="1"><subfield code="a">Methode</subfield><subfield code="0">(DE-588)4038971-6</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="2" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rao, Dabeeru C.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2426911&custom_att_2=simple_viewer</subfield><subfield code="y">Genetic dissection of complex traits</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch Darmstadt</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016672055&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016672055</subfield></datafield></record></collection>
genre	(DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content
genre_facet	Aufsatzsammlung Konferenzschrift
id	DE-604.BV035002681
illustrated	Illustrated
index_date	2024-07-02T21:41:00Z
indexdate	2024-07-09T21:19:57Z
institution	BVB
isbn	9780123738837
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-016672055
oclc_num	634720756
open_access_boolean
owner	DE-703
owner_facet	DE-703
physical	XXVII, 760 S. Ill., graph. Darst.
publishDate	2008
publishDateSearch	2008
publishDateSort	2008
publisher	Elsevier
record_format	marc
series2	Advances in genetics
spelling	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ... 2. ed. Amsterdam [u.a.] Elsevier 2008 XXVII, 760 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in genetics 60 Einzelaufnahme eines Zeitschr.-Bd. Gentransfer (DE-588)4194102-0 gnd rswk-swf Gentherapie (DE-588)4296957-8 gnd rswk-swf Gen-Targeting (DE-588)4294998-1 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content Gentherapie (DE-588)4296957-8 s DE-604 Gentransfer (DE-588)4194102-0 s Methode (DE-588)4038971-6 s Gen-Targeting (DE-588)4294998-1 s Rao, Dabeeru C. edt http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2426911&custom_att_2=simple_viewer Genetic dissection of complex traits Inhaltsverzeichnis HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016672055&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] Gentransfer (DE-588)4194102-0 gnd Gentherapie (DE-588)4296957-8 gnd Gen-Targeting (DE-588)4294998-1 gnd Methode (DE-588)4038971-6 gnd
subject_GND	(DE-588)4194102-0 (DE-588)4296957-8 (DE-588)4294998-1 (DE-588)4038971-6 (DE-588)4143413-4 (DE-588)1071861417
title	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton]
title_auth	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton]
title_exact_search	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton]
title_exact_search_txtP	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton]
title_full	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ...
title_fullStr	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ...
title_full_unstemmed	Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ...
title_short	Genetic dissection of complex traits
title_sort	genetic dissection of complex traits based on a symposium held in honor of newton e morton
title_sub	[based on a symposium held in honor of ... Newton E. Morton]
topic	Gentransfer (DE-588)4194102-0 gnd Gentherapie (DE-588)4296957-8 gnd Gen-Targeting (DE-588)4294998-1 gnd Methode (DE-588)4038971-6 gnd
topic_facet	Gentransfer Gentherapie Gen-Targeting Methode Aufsatzsammlung Konferenzschrift
url	http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2426911&custom_att_2=simple_viewer http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016672055&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT raodabeeruc geneticdissectionofcomplextraitsbasedonasymposiumheldinhonorofnewtonemorton

Holdings

There is no print copy available.

Interlibrary loan Place Request Caution: Not in THWS collection! Indexes
Indexes

MARC

Record in the Search Index

There is no print copy available.

Similar Items