Genetic dissection of complex traits: [based on a symposium held in honor of ... Newton E. Morton]
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2008
|
| Ausgabe: | 2. ed. |
| Schriftenreihe: | Advances in genetics
60 |
| Schlagworte: | |
| Online-Zugang: | Genetic dissection of complex traits Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | XXVII, 760 S. Ill., graph. Darst. |
| ISBN: | 9780123738837 |
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Datensatz im Suchindex
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| adam_text | GENETIC DISSECTION OF COMPLEX TRAITS SECOND EDITION 2008 EDITED BY
UNIVERSITIES- I Y: B& IOIHSK D&T BIBSIOTHEK EI II D. C. RAO ,
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE * DIVISION OF BIOSTATISTICS **.
ST. LOUIS, MISSOURI C. CHARLES GU WASHINGTON UNIVERSITY SCHOOL OF
MEDICINE DIVISION OF BIOSTATISTICS ST. LOUIS, MISSOURI ELSEVIER
AMSTERDAM * BOSTON * HEIDELBERG * LONDON NEW YORK * OXFORD * PARIS * SAN
DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY * TOKYO ACADEMIC PRESS IS AN
IMPRINT OF ELSEVIER CONTENTS CONTRIBUTORS XV PREFACE TO FIRST EDITION
XXI PREFACE TO SECOND EDITION XXV ACKNOWLEDGMENTS XXVII PART I: OVERVIEW
AND FUNDAMENTALS 1 1 AN OVERVIEW OF THE GENETIC DISSECTION OF COMPLEX
TRAITS 3 D. C. RAO I. INTRODUCTION 4 II. CHALLENGES ARISING FROM COMPLEX
TRAITS 7 III. STUDY DESIGN 9 IV. ANALYTICAL METHODS 12 V. SPECIAL TOPICS
19 VI. GWA STUDIES 22 VII. EFFICIENT STRATEGIES FOR ENHANCING GENE
DISCOVERY 25 VIII. DISCUSSION 28 REFERENCES 30 2 FAMILIAL RESEMBLANCE
AND HERITABILITY 35 TREVA K. RICE I. INTRODUCTION 36 II. FAMILIAL
RESEMBLANCE AND HERITABILITY 38 III. STUDY DESIGNS AND MULTIFACTORIAL
MODELS 41 IV. DISCUSSION 46 REFERENCES 47 3 LINKAGE AND ASSOCIATION:
BASIC CONCEPTS 51 INGRID B. BORECKI AND MICHAEL A. PROVINCE I.
INTRODUCTION 52 II. HISTORICAL PERSPECTIVE 54 CONTENTS III. FUNDAMENTALS
AND METHODS 55 IV. SEVEN STAGES OF RELATIONSHIP WITH GW STUDIES 64 V.
CONTEMPORARY APPROACHES 66 VI. CHALLENGES AND ISSUES 69 REFERENCES 70 4
DEFINITION OF PHENOTYPE 75 MARY K. WOJCZYNSKI AND HEMANT K. TIWARI I.
INTRODUCTION 76 II. PHENOTYPE CHOICES/OPTIONS 78 III. STUDY DESIGN
ISSUES 92 IV. DISCUSSION 99 REFERENCES 100 5 GENOTYPING PLATFORMS FOR
MASS-THROUGHPUT GENOTYPING WITH SNPS, INCLUDING HUMAN GENOME-WIDE SCANS
107 KAREN MARESSO AND ULRICH BROECKEL I. INTRODUCTION: EXPLOSIVE NEED
FOR MASS-THROUGHPUT GENOTYPING 108 II. MICROSATELLITES VERSUS SNPS 110
III. GENOTYPING PLATFORMS AND GOALS 115 IV. SELECTION OF MARKERS AND
SNPS 126 V. NOVEL MARKERS 130 VI. FUTURE PROSPECTS 133 VII. CONCLUSIONS
135 REFERENCES 136 6 GENOTYPING ERRORS AND THEIR IMPACT ON GENETIC
ANALYSIS 141 MICHAEL B. MILLER, KAREN SCHWANDER, AND D. C. RAO I.
INTRODUCTION 142 II. MISSPECIFICATION OF GENETIC RELATIONSHIPS 143 III.
DETECTION AND CORRECTION OF MISSPECIFICATION OF RELATIONSHIPS 144 IV.
GENOTYPE MISCLASSIFICATION 147 V. CONCLUSION 151 REFERENCES 151 CONTENTS
VII PART II: LINKAGE AND ASSOCIATION ANALYSIS 153 7 MODEL-BASED METHODS
FOR LINKAGE ANALYSIS 155 JOHN P. RICE, NANCY L. SACCONE, AND JONATHAN
CORBETT I. INTRODUCTION 156 II. THE GENERALIZED SINGLE MAJOR LOCUS MODEL
DESCRIPTION 156 III. THE LOD SCORE 157 IV. THE MOD SCORE METHOD 165 V.
THE LOD SCORE AND META-ANALYSIS 166 VI. MULTILOCUS MODELS 168 VII.
STRENGTHS AND WEAKNESSES OF MODEL-BASED METHODS 170 VIII. DISCUSSION 170
REFERENCES 171 8 CONTEMPORARY MODEL-FREE METHODS FOR LINKAGE ANALYSIS
175 LAURA ALMASY AND JOHN BLANGERO I. INTRODUCTION 176 II. IDENTITY BY
DESCENT AND IDENTITY BY STATE 177 III. RELATIVE PAIR LINKAGE METHODS 180
IV. VARIANCE COMPONENTS LINKAGE METHODS 184 V. STRENGTHS AND WEAKNESSES
OF MODEL-FREE LINKAGE METHODS 187 VI. CONCLUSION 189 REFERENCES 189 9
DNA SEQUENCE-BASED PHENOTYPIC ASSOCIATION ANALYSIS 195 NICHOLAS J.
SCHORK, JENNIFER WESSEL, AND NATHALIE MALO I. INTRODUCTION 196 II.
MULTIVARIATE DISTANCE MATRIX REGRESSION 202 III. SIMULATION STUDIES ,
206 IV. RESULTS 209 V. DISCUSSION 213 REFERENCES 215 VIII CONTENTS 10
FAMILY-BASED METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS 219 NAN M.
LAIRD AND CHRISTOPH LANGE I. INTRODUCTION 220 - II. ANALYSIS METHODS:
FBAT AND PBAT 228 III. OTHER APPROACHES TO FAMILY-BASED ANALYSES,
INCLUDING THE PDT AND THE QTDT - 240 IV, SOFTWARE 246 V. DISCUSSION 246
REFERENCES 248 11 SEARCHING FOR ADDITIONAL DISEASE LOCI IN A GENOMIC
REGION 253 GLENYS THOMSON, LISA F. BARCELLOS, AND ANA M. VALDES I.
INTRODUCTION 254 II. PRIMARY DISEASE-PREDISPOSING GENES AND THEIR
GENETIC FEATURES 261 III. DETECTING ADDITIONAL GENES IN A GENETIC REGION
271 IV. DISCUSSION 283 REFERENCES 285 12 METHODS FOR HANDLING MULTIPLE
TESTING 293 TREVA K. RICE, NICHOLAS J. SCHORK, AND D. C. RAO I.
INTRODUCTION 294 II. TYPES OF ERRORS IN HYPOTHESIS TESTING (TYPE I AND
TYPE II) 296 III. STRIKING A BALANCE BETWEEN FALSE POSITIVES AND FALSE
NEGATIVES 298 IV. ALTERNATIVE ADJUSTMENT METHODS 299 V. CONCLUSION 305
REFERENCES 305 PART III: SPECIAL TOPICS 309 13 META-ANALYSIS METHODS 311
THOMAS A. TRIKALINOS, GEORGIA SALANTI, ELIAS ZINTZARAS, AND JOHN P. A.
IOANNIDIS I. INTRODUCTION 312 II. META-ANALYSIS OF POPULATION-BASED
ASSOCIATION STUDIES 313 CONTENTS IX III. META-ANALYSIS OF LINKAGE
STUDIES 319 IV. SPECIAL ISSUES 324 REFERENCES 329 14
HAPLOTYPE-ASSOCIATION ANALYSIS 335 NIANJUN LIU, KUI ZHANG, AND HONGYU
ZHAO I. INTRODUCTION 336 II. HAPLOTYPE INFERENCE FROM UNRELATED
INDIVIDUALS 337 III. HAPLOTYPE INFERENCE FROM PEDIGREES 349 IV. *
POPULATION-BASED HAPLOTYPE-ASSOCIATION METHODS 362 V. FAMILY-BASED
ASSOCIATION METHODS USING HAPLOTYPES 376 VI. DISCUSSION 391 - ,
REFERENCES 393 15 CHARACTERIZATION OF LD STRUCTURES AND THE UTILITY OF
HAPMAP IN GENETIC ASSOCIATION STUDIES 407 C. CHARLES GU, KAI YU, AND D.
C. RAO I. INTRODUCTION 408 II. HAPLOTYPE SIMILARITY IN CANDIDATE GENES
AND -LD MAPPING 409 III. GLOBAL ORGANIZATION OF LD STRUCTURES 414 IV.
VARIATION OF LOCAL LD STRUCTURES 420 V. DISCUSSION 425 REFERENCES 430 16
ASSOCIATIONS AMONG MULTIPLE MARKERS AND COMPLEX DISEASE: MODELS,
ALGORITHMS, AND APPLICATIONS 437 THEMISTOCLES L. ASSIMES, ADAM B.
OLSHEN, BALASUBRAMANIAN NARASIMHAN, AND RICHARD A. OLSHEN I.
INTRODUCTION 438 II. A MODEL FOR DIPLOTYPES 441 III. STRAND-SPECIFIC
INFERENCE IN THE ABSENCE OF RANDOMNESS IN P 446 IV. HAPLOVIEW AND OUR
VIEW 447 , V. APPROACHES TO TWO-CLASS ASSOCIATION/CLASSIFICATION 454 VI.
RESTRICTIONS ON PROBABILITIES ENTAILED BY HARDY-WEINBERG EQUILIBRIUM 459
VII. DISCUSSION AND SUMMARY 460 REFERENCES 462 CONTENTS 17 STUDY DESIGNS
FOR GENOME-WIDE ASSOCIATION STUDIES 465 PETER KRAFT AND DAVID G. COX I.
INTRODUCTION 466 II. BASIC PRINCIPLES OF ASSOCIATION DESIGN 471 III. THE
GENETIC ARCHITECTURE OF COMPLEX TRAITS 480 IV. GENOTYPING TECHNOLOGIES
482 V. POWER CALCULATIONS FOR MULTISTAGE DESIGN 485 VI. DISCUSSION 493
REFERENCES 495 18 ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS OF BIOBANKS
FOR GENETICS RESEARCH 505 SUSANNE B. HAGA AND LAURA M. BESKOW I.
INTRODUCTION 506 1 - II. GOVERNANCE OF BIOBANKS 507 III. RISKS AND
BENEFITS 512 IV. RECRUITMENT OF VULNERABLE AND MINORITY POPULATIONS 516
V. INFORMED CONSENT 518 VI. STORAGE OF GENETIC INFORMATION*OPTIMIZING
PRIVACY 522 VII. BIOSPECIMEN/DATA ACCESS 524 VIII. OWNERSHIP AND
INTELLECTUAL PROPERTY 525 IX. DISCLOSURE OF RESEARCH RESULTS 527 X.
COMMERCIALIZATION OF BIOBANKS 536 . XI. CONCLUSION 538 REFERENCES 539
PART IV: PROMISING TOPICS 545 19 ADMIXTURE MAPPING AND THE ROLE OF
POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES 547 XIAOFENG ZHU, HUA
TANG, AND NEIL RISCH I. INTRODUCTION 548 II. POPULATION GENETIC
STRUCTURE IN HUMANS 549 III. POPULATION ADMIXTURE 550 IV. METHODS OF
ADMIXTURE MAPPING 551 V. DESIGN CONSIDERATION 561 CONTENTS VI. PROSPECTS
AND CONCERNS OF ADMIXTURE MAPPING 563 VII. CONCLUSIONS 565 REFERENCES
566 20 INTEGRATING GLOBAL GENE EXPRESSION ANALYSIS AND GENETICS 571
CHARLES R. FARBER AND ALDONS J. LUSIS I. INTRODUCTION 572 II. TECHNICAL
AND EXPERIMENTAL DESIGN ISSUES FOR MICROARRAYS 575 III. IDENTIFYING
DISEASE CANDIDATES USING DNA MICROARRAYS 582 IV. INTEGRATION OF GENETICS
AND GENOMICS 586 V. CONCLUSIONS 596 REFERENCES 597 21 A SYSTEMS BIOLOGY
APPROACH TO DRUG DISCOVERY 603 JUN ZHU, BIN ZHANG, AND ERIC E. SCHADT I.
INTRODUCTION 604 II. CAUSAL INFERENCE: AN INTEGRATED APPROACH TO DRUG
DISCOVERY 606 III. COEXPRESSION NETWORKS 612 IV. PROBABILISTIC CAUSAL
NETWORKS: BAYESIAN NETWORKS AS A FRAMEWORK FOR DATA INTEGRATION 617 V.
AN INSIGHTFUL EXAMPLE: INTEGRATING DATA LEADS TO THE IDENTIFICATION OF
GENE AFFECTING PLASMA CHOLESTEROL LEVELS 625 VI. CONCLUSIONS 628
REFERENCES 630 22 THE PROMISE OF COMPOSITE LIKELIHOOD METHODS FOR
ADDRESSING COMPUTATIONALLY INTENSIVE CHALLENGES 637 NALI I. INTRODUCTION
638 II. COMPOSITE LIKELIHOOD METHODS 638 III. APPLICATIONS IN POPULATION
GENETICS 641 XII CONTENTS IV. APPLICATIONS IN FINE MAPPING OF DISEASE
MUTATIONS 643 V. OTHER APPLICATIONS 649 VI. PROSPECTIVES AND DISCUSSION
650 REFERENCES 652 23 COMPARATIVE GENOMICS FOR DETECTING HUMAN DISEASE
GENES 655 CAROL MORENO, JOZEF LAZAR, HOWARD J. JACOB, AND ANNE E. KWITEK
I. INTRODUCTION 656 II. THE POWER AND PROMISE OF COMPARATIVE GENOMICS
659 III. ANIMAL MODELS FOR HUMAN DISEASE 665 IV. COMPARATIVE GENOMICS
AND BUILDING BETTER ANIMAL MODELS 676 V. DISCUSSION 681 REFERENCES 683
PART V: OUTSTANDING CHALLENGES 699 24 FROM GENETICS TO MECHANISM OF
DISEASE LIABILITY 701 ANDREAS ROHRWASSER, PAUL LOTT, ROBERT B. WEISS,
AND JEAN-MARC LALOUEL I. INTRODUCTION 702 II. IDENTIFICATION OF QTL BY
STATISTICAL ANALYSIS 703 III. A STRONG QTL FOR SODIUM SENSITIVITY IN THE
C57BL/6J MOUSE INBRED LINE 707 IV. FROM QTL TO GENES: GENE
PRIORITIZATION 713 V. FROM QTL TO GENES: HIGH-THROUGHPUT FUNCTIONAL
SCREENS 721 VI. PERSPECTIVE 723 REFERENCES 723 25 INTO THE POST-HAPMAP
ERA 727 NEWTON E. MORTON I. INTRODUCTION 728 II. LINKAGE MAPPING AND
CYTOGENETIC ASSIGNMENT 729 III. ASSOCIATION MAPPING AND FUNCTIONAL
ASSIGNMENT 730 IV. FULLY PARAMETRIC ANALYSIS 732 CONTENTS XIII V.
META-ANALYSIS 732 VI. ANALYSIS OF MSSNPS 733 VII. THE FALSE DISCOVERY
RATE 734 VIII. EARLYHAPMAP PROJECTS 735 IX. GENOME-WIDE ASSOCIATION
SCANS 737 X. WHAT NEXT? 738 REFERENCES 740 INDEX 743
|
| adam_txt |
GENETIC DISSECTION OF COMPLEX TRAITS SECOND EDITION 2008 EDITED BY
UNIVERSITIES- I'Y:' B&'IOIHSK D&T BIBSIOTHEK EI II D. C. RAO ,
WASHINGTON UNIVERSITY SCHOOL OF MEDICINE * DIVISION OF BIOSTATISTICS **.
ST. LOUIS, MISSOURI C. CHARLES GU WASHINGTON UNIVERSITY SCHOOL OF
MEDICINE DIVISION OF BIOSTATISTICS ST. LOUIS, MISSOURI ELSEVIER
AMSTERDAM * BOSTON * HEIDELBERG * LONDON NEW YORK * OXFORD * PARIS * SAN
DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY * TOKYO ACADEMIC PRESS IS AN
IMPRINT OF ELSEVIER CONTENTS CONTRIBUTORS XV PREFACE TO FIRST EDITION
XXI PREFACE TO SECOND EDITION XXV ACKNOWLEDGMENTS XXVII PART I: OVERVIEW
AND FUNDAMENTALS 1 1 AN OVERVIEW OF THE GENETIC DISSECTION OF COMPLEX
TRAITS 3 D. C. RAO I. INTRODUCTION 4 II. CHALLENGES ARISING FROM COMPLEX
TRAITS 7 III. STUDY DESIGN 9 IV. ANALYTICAL METHODS 12 V. SPECIAL TOPICS
19 VI. GWA STUDIES 22 VII. EFFICIENT STRATEGIES FOR ENHANCING GENE
DISCOVERY 25 VIII. DISCUSSION 28 REFERENCES 30 2 FAMILIAL RESEMBLANCE
AND HERITABILITY 35 TREVA K. RICE I. INTRODUCTION 36 II. FAMILIAL
RESEMBLANCE AND HERITABILITY 38 III. STUDY DESIGNS AND MULTIFACTORIAL
MODELS 41 IV. DISCUSSION 46 REFERENCES 47 3 LINKAGE AND ASSOCIATION:
BASIC CONCEPTS 51 INGRID B. BORECKI AND MICHAEL A. PROVINCE I.
INTRODUCTION 52 II. HISTORICAL PERSPECTIVE 54 CONTENTS III. FUNDAMENTALS
AND METHODS 55 IV. SEVEN STAGES OF RELATIONSHIP WITH GW STUDIES 64 V.
CONTEMPORARY APPROACHES 66 VI. CHALLENGES AND ISSUES 69 REFERENCES 70 4
DEFINITION OF PHENOTYPE 75 MARY K. WOJCZYNSKI AND HEMANT K. TIWARI I.
INTRODUCTION 76 II. PHENOTYPE CHOICES/OPTIONS 78 III. STUDY DESIGN
ISSUES 92 IV. DISCUSSION 99 REFERENCES 100 5 GENOTYPING PLATFORMS FOR
MASS-THROUGHPUT GENOTYPING WITH SNPS, INCLUDING HUMAN GENOME-WIDE SCANS
107 KAREN MARESSO AND ULRICH BROECKEL I. INTRODUCTION: EXPLOSIVE NEED
FOR MASS-THROUGHPUT GENOTYPING 108 II. MICROSATELLITES VERSUS SNPS 110
III. GENOTYPING PLATFORMS AND GOALS 115 IV. SELECTION OF MARKERS AND
SNPS 126 V. NOVEL MARKERS 130 VI. FUTURE PROSPECTS 133 VII. CONCLUSIONS
135 REFERENCES 136 6 GENOTYPING ERRORS AND THEIR IMPACT ON GENETIC
ANALYSIS 141 MICHAEL B. MILLER, KAREN SCHWANDER, AND D. C. RAO I.
INTRODUCTION 142 II. MISSPECIFICATION OF GENETIC RELATIONSHIPS 143 III.
DETECTION AND CORRECTION OF MISSPECIFICATION OF RELATIONSHIPS 144 IV.
GENOTYPE MISCLASSIFICATION 147 V. CONCLUSION 151 REFERENCES 151 CONTENTS
VII PART II: LINKAGE AND ASSOCIATION ANALYSIS 153 7 MODEL-BASED METHODS
FOR LINKAGE ANALYSIS 155 JOHN P. RICE, NANCY L. SACCONE, AND JONATHAN
CORBETT I. INTRODUCTION 156 II. THE GENERALIZED SINGLE MAJOR LOCUS MODEL
DESCRIPTION 156 III. THE LOD SCORE 157 IV. THE MOD SCORE METHOD 165 V.
THE LOD SCORE AND META-ANALYSIS 166 VI. MULTILOCUS MODELS 168 VII.
STRENGTHS AND WEAKNESSES OF MODEL-BASED METHODS 170 VIII. DISCUSSION 170
REFERENCES 171 8 CONTEMPORARY MODEL-FREE METHODS FOR LINKAGE ANALYSIS
175 LAURA ALMASY AND JOHN BLANGERO I. INTRODUCTION 176 II. IDENTITY BY
DESCENT AND IDENTITY BY STATE 177 III. RELATIVE PAIR LINKAGE METHODS 180
IV. VARIANCE COMPONENTS LINKAGE METHODS 184 V. STRENGTHS AND WEAKNESSES
OF MODEL-FREE LINKAGE METHODS 187 VI. CONCLUSION 189 REFERENCES 189 9
DNA SEQUENCE-BASED PHENOTYPIC ASSOCIATION ANALYSIS 195 NICHOLAS J.
SCHORK, JENNIFER WESSEL, AND NATHALIE MALO I. INTRODUCTION 196 II.
MULTIVARIATE DISTANCE MATRIX REGRESSION 202 III. SIMULATION STUDIES ,
206 IV. RESULTS 209 V. DISCUSSION 213 REFERENCES 215 VIII CONTENTS 10
FAMILY-BASED METHODS FOR LINKAGE AND ASSOCIATION ANALYSIS 219 NAN M.
LAIRD AND CHRISTOPH LANGE I. INTRODUCTION 220 - II. ANALYSIS METHODS:
FBAT AND PBAT 228 III. OTHER APPROACHES TO FAMILY-BASED ANALYSES,
INCLUDING THE PDT AND THE QTDT - 240 IV, SOFTWARE 246 V. DISCUSSION 246
REFERENCES 248 11 SEARCHING FOR ADDITIONAL DISEASE LOCI IN A GENOMIC
REGION 253 GLENYS THOMSON, LISA F. BARCELLOS, AND ANA M. VALDES I.
INTRODUCTION 254 II. PRIMARY DISEASE-PREDISPOSING GENES AND THEIR '
GENETIC FEATURES 261 III. DETECTING ADDITIONAL GENES IN A GENETIC REGION
271 IV. DISCUSSION 283 REFERENCES 285 12 METHODS FOR HANDLING MULTIPLE
TESTING 293 TREVA K. RICE, NICHOLAS J. SCHORK, AND D. C. RAO I.
INTRODUCTION ' 294 II. TYPES OF ERRORS IN HYPOTHESIS TESTING (TYPE I AND
TYPE II) 296 III. STRIKING A BALANCE BETWEEN FALSE POSITIVES AND FALSE
NEGATIVES 298 IV. ALTERNATIVE ADJUSTMENT METHODS 299 V. CONCLUSION 305
REFERENCES 305 PART III: SPECIAL TOPICS 309 13 META-ANALYSIS METHODS 311
THOMAS A. TRIKALINOS, GEORGIA SALANTI, ELIAS ZINTZARAS, AND JOHN P. A.
IOANNIDIS I. INTRODUCTION 312 II. META-ANALYSIS OF POPULATION-BASED
ASSOCIATION STUDIES 313 CONTENTS IX III. META-ANALYSIS OF LINKAGE
STUDIES 319 IV. SPECIAL ISSUES 324 REFERENCES 329 14
HAPLOTYPE-ASSOCIATION ANALYSIS 335 NIANJUN LIU, KUI ZHANG, AND HONGYU
ZHAO I. INTRODUCTION 336 II. HAPLOTYPE INFERENCE FROM UNRELATED
INDIVIDUALS 337 III. HAPLOTYPE INFERENCE FROM PEDIGREES 349 IV. *
POPULATION-BASED HAPLOTYPE-ASSOCIATION METHODS 362 V. FAMILY-BASED
ASSOCIATION METHODS USING HAPLOTYPES 376 VI.' DISCUSSION 391 - ,
REFERENCES 393 15 CHARACTERIZATION OF LD STRUCTURES AND THE UTILITY OF
HAPMAP IN GENETIC ASSOCIATION STUDIES 407 C. CHARLES GU, KAI YU, AND D.
C. RAO I. INTRODUCTION 408 II. HAPLOTYPE SIMILARITY IN CANDIDATE GENES
AND -LD MAPPING 409 III. GLOBAL ORGANIZATION OF LD STRUCTURES 414 IV.
VARIATION OF LOCAL LD STRUCTURES 420 V. DISCUSSION 425 REFERENCES 430 16
ASSOCIATIONS AMONG MULTIPLE MARKERS AND COMPLEX DISEASE: MODELS,
ALGORITHMS, AND APPLICATIONS 437 THEMISTOCLES L. ASSIMES, ADAM B.
OLSHEN, BALASUBRAMANIAN NARASIMHAN, AND RICHARD A. OLSHEN I.
INTRODUCTION 438 II. A MODEL FOR "DIPLOTYPES" 441 III. STRAND-SPECIFIC
INFERENCE IN THE ABSENCE OF RANDOMNESS IN P 446 IV. HAPLOVIEW AND OUR
VIEW 447 , V. APPROACHES TO TWO-CLASS ASSOCIATION/CLASSIFICATION 454 VI.
RESTRICTIONS ON PROBABILITIES ENTAILED BY HARDY-WEINBERG EQUILIBRIUM 459
VII. DISCUSSION AND SUMMARY 460 REFERENCES 462 CONTENTS 17 STUDY DESIGNS
FOR GENOME-WIDE ASSOCIATION STUDIES 465 PETER KRAFT AND DAVID G. COX I.
INTRODUCTION 466 II. BASIC PRINCIPLES OF ASSOCIATION DESIGN 471 III. THE
GENETIC ARCHITECTURE OF COMPLEX TRAITS 480 IV. GENOTYPING TECHNOLOGIES
482 V. POWER CALCULATIONS FOR MULTISTAGE DESIGN 485 VI. DISCUSSION 493
REFERENCES 495 18 ETHICAL, LEGAL, AND SOCIAL IMPLICATIONS OF BIOBANKS
FOR GENETICS RESEARCH 505 SUSANNE B. HAGA AND LAURA M. BESKOW I.
INTRODUCTION 506 1 - II. GOVERNANCE OF BIOBANKS 507 III. RISKS AND
BENEFITS 512 IV. RECRUITMENT OF VULNERABLE AND MINORITY POPULATIONS 516
V. INFORMED CONSENT 518 VI. STORAGE OF GENETIC INFORMATION*OPTIMIZING
PRIVACY 522 VII. BIOSPECIMEN/DATA ACCESS 524 VIII. OWNERSHIP AND
INTELLECTUAL PROPERTY 525 IX. DISCLOSURE OF RESEARCH RESULTS 527 X.
COMMERCIALIZATION OF BIOBANKS 536 . XI. CONCLUSION 538 REFERENCES 539
PART IV: PROMISING TOPICS 545 19 ADMIXTURE MAPPING AND THE ROLE OF
POPULATION STRUCTURE FOR LOCALIZING DISEASE GENES 547 XIAOFENG ZHU, HUA
TANG, AND NEIL RISCH I. INTRODUCTION 548 II. POPULATION GENETIC
STRUCTURE IN HUMANS 549 III. POPULATION ADMIXTURE 550 IV. METHODS OF
ADMIXTURE MAPPING 551 V. DESIGN CONSIDERATION 561 CONTENTS VI. PROSPECTS
AND CONCERNS OF ADMIXTURE MAPPING 563 VII. CONCLUSIONS 565 REFERENCES
566 20 INTEGRATING GLOBAL GENE EXPRESSION ANALYSIS AND GENETICS 571
CHARLES R. FARBER AND ALDONS J. LUSIS I. INTRODUCTION 572 II. TECHNICAL
AND EXPERIMENTAL DESIGN ISSUES FOR MICROARRAYS 575 III. IDENTIFYING
DISEASE CANDIDATES USING DNA MICROARRAYS 582 IV. INTEGRATION OF GENETICS
AND GENOMICS 586 V. CONCLUSIONS 596 REFERENCES 597 21 A SYSTEMS BIOLOGY
APPROACH TO DRUG DISCOVERY 603 JUN ZHU, BIN ZHANG, AND ERIC E. SCHADT I.
INTRODUCTION 604 II. CAUSAL INFERENCE: AN INTEGRATED APPROACH TO DRUG
DISCOVERY 606 III. COEXPRESSION NETWORKS 612 IV. PROBABILISTIC CAUSAL
NETWORKS: BAYESIAN NETWORKS AS A FRAMEWORK FOR DATA INTEGRATION 617 V.
AN INSIGHTFUL EXAMPLE: INTEGRATING DATA LEADS TO THE IDENTIFICATION OF
GENE AFFECTING PLASMA CHOLESTEROL LEVELS 625 VI. CONCLUSIONS 628
REFERENCES 630 22 THE PROMISE OF COMPOSITE LIKELIHOOD METHODS FOR
ADDRESSING COMPUTATIONALLY INTENSIVE CHALLENGES 637 NALI I. INTRODUCTION
638 II. COMPOSITE LIKELIHOOD METHODS 638 III. APPLICATIONS IN POPULATION
GENETICS 641 XII CONTENTS IV. APPLICATIONS IN FINE MAPPING OF DISEASE
MUTATIONS 643 V. OTHER APPLICATIONS 649 VI. PROSPECTIVES AND DISCUSSION
650 REFERENCES 652 23 COMPARATIVE GENOMICS FOR DETECTING HUMAN DISEASE
GENES 655 CAROL MORENO, JOZEF LAZAR, HOWARD J. JACOB, AND ANNE E. KWITEK
I. INTRODUCTION 656 II. THE POWER AND PROMISE OF COMPARATIVE GENOMICS
659 III. ANIMAL MODELS FOR HUMAN DISEASE 665 IV. COMPARATIVE GENOMICS
AND BUILDING BETTER ANIMAL MODELS 676 V. DISCUSSION 681 REFERENCES 683
PART V: OUTSTANDING CHALLENGES 699 24 FROM GENETICS TO MECHANISM OF
DISEASE LIABILITY 701 ANDREAS ROHRWASSER, PAUL LOTT, ROBERT B. WEISS,
AND JEAN-MARC LALOUEL I. INTRODUCTION 702 II. IDENTIFICATION' OF QTL BY
STATISTICAL ANALYSIS 703 III. A STRONG QTL FOR SODIUM SENSITIVITY IN THE
C57BL/6J MOUSE INBRED LINE 707 IV. FROM QTL TO GENES: GENE
PRIORITIZATION 713 V. FROM QTL TO GENES: HIGH-THROUGHPUT FUNCTIONAL
SCREENS 721 VI. PERSPECTIVE 723 REFERENCES 723 25 INTO THE POST-HAPMAP
ERA 727 NEWTON E. MORTON I. INTRODUCTION 728 II. LINKAGE MAPPING AND
CYTOGENETIC ASSIGNMENT 729 III. ASSOCIATION MAPPING AND FUNCTIONAL
ASSIGNMENT 730 IV. FULLY PARAMETRIC ANALYSIS 732 CONTENTS XIII V.
META-ANALYSIS 732 VI. ANALYSIS OF MSSNPS 733 VII. THE FALSE DISCOVERY
RATE 734 VIII. EARLYHAPMAP PROJECTS 735 IX. GENOME-WIDE ASSOCIATION
SCANS 737 X. WHAT NEXT? 738 REFERENCES 740 INDEX 743 |
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| edition | 2. ed. |
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| id | DE-604.BV035002681 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:41:00Z |
| indexdate | 2024-07-09T21:19:57Z |
| institution | BVB |
| isbn | 9780123738837 |
| language | English |
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| physical | XXVII, 760 S. Ill., graph. Darst. |
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| series2 | Advances in genetics |
| spelling | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ... 2. ed. Amsterdam [u.a.] Elsevier 2008 XXVII, 760 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in genetics 60 Einzelaufnahme eines Zeitschr.-Bd. Gentransfer (DE-588)4194102-0 gnd rswk-swf Gentherapie (DE-588)4296957-8 gnd rswk-swf Gen-Targeting (DE-588)4294998-1 gnd rswk-swf Methode (DE-588)4038971-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content (DE-588)1071861417 Konferenzschrift gnd-content Gentherapie (DE-588)4296957-8 s DE-604 Gentransfer (DE-588)4194102-0 s Methode (DE-588)4038971-6 s Gen-Targeting (DE-588)4294998-1 s Rao, Dabeeru C. edt http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2426911&custom_att_2=simple_viewer Genetic dissection of complex traits Inhaltsverzeichnis HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016672055&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] Gentransfer (DE-588)4194102-0 gnd Gentherapie (DE-588)4296957-8 gnd Gen-Targeting (DE-588)4294998-1 gnd Methode (DE-588)4038971-6 gnd |
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| title | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] |
| title_auth | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] |
| title_exact_search | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] |
| title_exact_search_txtP | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] |
| title_full | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ... |
| title_fullStr | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ... |
| title_full_unstemmed | Genetic dissection of complex traits [based on a symposium held in honor of ... Newton E. Morton] ed. by D. C. Rao ... |
| title_short | Genetic dissection of complex traits |
| title_sort | genetic dissection of complex traits based on a symposium held in honor of newton e morton |
| title_sub | [based on a symposium held in honor of ... Newton E. Morton] |
| topic | Gentransfer (DE-588)4194102-0 gnd Gentherapie (DE-588)4296957-8 gnd Gen-Targeting (DE-588)4294998-1 gnd Methode (DE-588)4038971-6 gnd |
| topic_facet | Gentransfer Gentherapie Gen-Targeting Methode Aufsatzsammlung Konferenzschrift |
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