Notch signaling:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier [u.a.]
2010
|
| Edition: | 1. ed. |
| Series: | Current topics in developmental biology
92 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVI, 530 S., [8] Bl. Ill., graph. Darst. |
| ISBN: | 9780123809124 |
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MARC
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Record in the Search Index
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| adam_text |
Titel: Notch signaling
Autor: Kopan, Raphael
Jahr: 2010
Contents
Contributors xi
Prologue xv
1. Notch: The Past, the Present, and the Future 1
Spyros Artavanis-Tsakonas and Marc A. T. Muskavitch
1. The Beginnings: Embryology and Genetics 2
2. The Developmental Logic of Notch: A Constant Frame of Reference 7
3. The Notch Receptor: Key Features 9
4. Cloning the Ligands: Engaging Notch 11
5. Ligand-Receptor Interactions: Not a One-Way Street 14
6. Targets, Signal Integration, and the Genetic Circuitry of Notch:
On Being Old 15
7. Disease and Notch: The Pathobiology of Gain and Loss of Function 18
8. Notch and Cancer: Affecting Proliferation Where it Matters? 20
9. Notch: What's Next 22
Acknowledgments 23
References 23
2. Mechanistic Insights into Notch Receptor Signaling from
Structural and Biochemical Studies 31
Rhett A. Kovall and Stephen C. Blacklow
1. Introduction 32
2. Notch-Ligand Interactions 35
3. The Activation Event 40
4. Effector Function 45
5. Therapeutic Implications of Structural Insights 59
6. Summary 61
References 62
3. Canonical and Non-Canonical Notch Ligands 73
Brendan D'Souza, Laurence Meloty-Kapella, and Gerry Weinmaster
1. Introduction 74
2. Canonical Notch Ligand Structure 76
3. Canonical Ligands as Inhibitors of Notch Signaling 79
vi Contents
4. Regulation of Ligand-Induced Notch Signaling by Posttranslational
Modification 83
5. Ligand Endocytosis in Activation of Notch Signaling 87
6. Regulation of DSL Ligand Activity by Proteolysis 93
7. DSL Ligand Interactions with PDZ-Domain Containing Proteins 99
8. Regulation of DSL Ligand Expression Patterns 100
9. Noncanonical Ligands 105
10. Conclusions and Future Directions 113
Acknowledgments 114
References 114
4. Roles of Glycosylation in Notch Signaling 131
Pamela Stanley and Tetsuya Okajima
1. Introduction 132
2. Glycans of Notch Receptors and DSL Notch Ligands 135
3. Consequences of Glycan Removal for Notch Signaling 143
4. Mechanisms of Glycan Regulation of Notch Signaling 151
Acknowledgments 156
References 156
5. Endocytosis and Intracellular Trafficking of Notch
and Its Ligands 165
Shinya Yamamoto, Wu-Lin Charng, and Hugo J. Bellen
1. Notch Signaling and its Regulation by Endocytosis
and Vesicle Trafficking 166
2. Ligand Endocytosis and Trafficking 171
3. Notch Receptor Endocytosis and Endosomal Trafficking 177
4. Regulation of Notch Signaling by Endocytosis and Vesicle Trafficking
During Mechanosensory Organ Development in Drosophila 185
5. Conclusion and Future Directions 190
Acknowledgments 191
References 191
6. y-Secretase and the Intramembrane Proteolysis of Notch 201
Ellen Jorissen and Bart De Strooper
1. Introduction 202
2. Regulated Intramembrane Proteolysis of Notch 202
3. Discovery of y-Secretase 203
4. y-Secretase Cleaves Many Substrates 204
5. Unraveling the y-Secretase Complex 205
Contents vii
6. y-Secretases Are Tetrameric Complexes 209
7. Structure and Assembly of the Complex 211
8. Consecutive Cleavage Model for y-Secretase 212
9. Regulation of y-Secretase Activity 213
10. y-Secretase as a Drug Target: AD and Cancer 214
11. Conclusion 217
Acknowledgments 218
References 218
7. Two Opposing Roles of RBP-J in Notch Signaling 231
Kenji Tanigaki and Tasuku Honjo
1. The Identification of RBP-J and its Connection to
Notch Signaling 232
2. RBP-J as a Transcription Factor 233
3. Biological Functions of RBP-J in Drosophila 235
4. Regulation of Mammalian Neuronal Development
by RBP-J 237
5. Regulation of Mammalian Hematopoietic Cell Development
by RBP-J 240
6. Notch-Independent RBP-J Functions 242
Acknowledgments 244
References 244
8. Notch Targets and Their Regulation 253
Sarah Bray and Fred Bernard
1. Introduction 253
2. Number and Diversity of Notch Targets 254
3. How Does the Notch Switch Work? 258
4. Different Enhancer Logics 262
5. Context Dependence of Notch Responses 263
6. Concluding Comments 266
References 266
9. Notch Signaling in the Vasculature 277
Thomas Gridley
1. Introduction 278
2. Arteriovenous Differentiation 280
3. Endothelial Tip Cell Differentiation 286
4. Tumor Angiogenesis 290
5. Notch Signaling and Vascular Smooth Muscle Cells 292
viii Contents
6. Medical Consequences of Aberrant NOCH3 Signaling in
Vascular Smooth Muscle Cells: CADASIL 295
7. Perspectives and Conclusions 301
Acknowledgments 301
References 301
10. Ultradian Oscillations in Notch Signaling Regulate Dynamic
Biological Events 311
Ryoichiro Kageyama, Yasutaka Niwa, Hiromi Shimojo,
Taeko Kobayashi, and Toshiyuki Ohtsuka
1. Introduction 312
2. Hes7 Oscillations Regulate Somite Segmentation 314
3. Hesi Oscillations Regulate Neural Stern Cells 320
4. Hesi Oscillations Regulate ES Cell Differentiation 325
5. Conclusions 327
References 328
11. Notch Signaling in Cardiac Development and Disease 333
Donal MacGrogan, Meritxell Nus, and Jose Luis de la Pompa
1. Outline of Cardiac Development 334
2. Cardiomyocyte Specification and Differentiation 335
3. Atrioventricular Canal Development 336
4. Cardiac Valve Development 339
5. Ventricular Chamber Development: Trabeculation 341
6. Outflow Tract Development 344
7. Left Ventricular Outflow Tract Obstruction (Lvoto) 348
8. Right Ventricular Outflow Tract Obstruction 351
9. Acquired Disease 355
10. Conclusions 357
Acknowledgments 358
References 358
12. Notch Signaling in the Regulation of Stern Cell Self-Renewal
and Differentiation 367
Jianing Liu, Chihiro Sato, Massimiliano Cerletti, and Amy Wagers
1. Introduction to stem cells and stem cell biology 368
2. The Notch Pathway in Stem Cell Regulation and Function 378
3. Conclusions and Perspective 395
References 397
Contents ix
13. Notch Signaling in Solid Tumors 411
Ute Koch and Freddy Radtke
1. Introduction 412
2. Notch and Breast Cancer 415
3. Notch signaling in Cutaneous Melanoma 422
4. Notch and Colon Cancer 425
5. Notch Signaling in Pancreatic Cancer 43a
6. Notch Signaling in Medulloblastoma 435
7. Notch and Its Tumor-suppressive Properties in the Skin 437
8. Therapeutically Targeting Notch in Cancer 442
9. Concluding Remarks 445
Acknowledgments 445
References 446
14. Biodiversity and Noncanonical Notch Signaling 457
Pascal Heitzler
1. A Wide Range of Notch-dependent Activities 458
2. Noncanonical Notch Signaling and Bristle Patterning 460
3. Noncanonical N Signals in Vertebrates 463
4. Misappropriation by Viruses 469
5. New Insights on MAML 469
6. Rheostat and Fine-tuning 469
7. Nonnuclear Mechanisms 470
8. Discussion 472
Acknowledgments 475
References 475
Index 483
Contents ofPrevious Volumes 497 |
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| spelling | Notch signaling ed. by Peter Koopman 1. ed. Amsterdam [u.a.] Elsevier [u.a.] 2010 XVI, 530 S., [8] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in developmental biology 92 Gen notch (DE-588)4762370-6 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 s Gen notch (DE-588)4762370-6 s DE-188 Koopman, Peter edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022452353&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Notch signaling Gen notch (DE-588)4762370-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4762370-6 (DE-588)4318717-1 |
| title | Notch signaling |
| title_auth | Notch signaling |
| title_exact_search | Notch signaling |
| title_full | Notch signaling ed. by Peter Koopman |
| title_fullStr | Notch signaling ed. by Peter Koopman |
| title_full_unstemmed | Notch signaling ed. by Peter Koopman |
| title_short | Notch signaling |
| title_sort | notch signaling |
| topic | Gen notch (DE-588)4762370-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Gen notch Signaltransduktion |
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