Towards automated processing and analysis of digital laser scanning micrographs of human skin:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Aachen
Shaker
2008
|
| Series: | Berichte aus der Medizinschen Informatik und Bioinformatik
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 195 S. Ill., graph. Darst. |
| ISBN: | 9783832273736 |
Staff View
MARC
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Record in the Search Index
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|---|---|
| adam_text | IMAGE 1
CONTENTS
CONTENTS
1 INTRODUCTION 1
1.1 MOTIVATION 1
1.2 PROBLEM FORMULATION 3
1.2.1 DESCRIPTION 3
1.2.2 REQUIREMENTS FOR THE SOLUTION 5
1.3 ORGANIZATION OF THE DISSERTATION 6
2 FUNDAMENTALS 7
2.1 HUMAN SKIN 7
2.1.1 FUNCTIONS OF THE SKIN 7
2.1.2 BASIC ANATOMY OF THE SKIN 8
2.2 LASER SCANNING MICROSCOPY 13
2.2.1 IMAGING OF BIOLOGICAL SPECIMEN 13
2.2.2 SCANNING MICROSCOPY 14
2.2.3 FLUORESCENCE IMAGING 15
2.2.4 CONFOCAL MICROSCOPY 17
2.2.5 MULTI PHOTON MICROSCOPY 19
2.2.6 IN VIVO-MICROSCOPY 20
2.3 PROCESSING OF DIGITAL MICROGRAPHS 21
2.3.1 ORGANIZATION OF THE IMAGE DATA 22
2.3.2 IMAGE FORMATION 23
2.3.3 IMAGE DEGRADATIONS 23
2.3.4 ARCHITECTURE OF IMAGE PROCESSING 24
3 IMAGE PROPERTIES 27
3.1 FIAT FIELD IMAGES 27
3.2 NOISE 27
3.2.1 THE SIGNAL-TO-NOISE RATIO 28
3.2.2 COMPONENTSOF NOISE 31
3.2.3 PHOTON NOISE 32
3.2.4 THE INTENSITY DISPERSION DISTRIBUTION 33
3.2.5 DARK CURRENT NOISE 38
3.2.6 STRUCTURED NOISE 40
3.3 THE INTENSITY SPREAD FUNCTION 42
3.4 EFFECTIVE IMAGE RESOLUTION 43
GESCANNT DURCH
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/989550109
DIGITALISIERT DURCH
IMAGE 2
CONTENTS
3.5 INTENSITY SHADING 45
3.5.1 SOURCES OF SHADING 46
3.6 SUMMARY 50
IMAGE PREPROCESSING 51
4.1 DENOISING 52
4.1.1 SELECTION OF A DENOISING FILTER 53
4.1.2 THE SHARPNESS LOSS INDEX 56
4.1.3 RESULTS AND CONCLUSION 58
4.2 IMAGE DECONVOLUTION 61
4.3 SHADING CORRECTION 62
4.3.1 METHODS FOR SHADING CORRECTION 64
4.3.2 VIGNETTING SEEN AS CONVOLUTION 68
4.3.3 THE SHADING INTENSITY INDEX 69
4.3.4 ATTENUATION BY DEPTH 70
4.4 SUMMARY 71
IMAGE ANALYSIS 73
5.1 RELATEDWORK 74
5.2 QUALITATIVE IMAGE APPEARANCE 75
5.2.1 EPIDERMIS 75
5.2.2 DENNIS 76
5.3 SEGMENTATION OF INDIVIDUAL CELLS 77
5.3.1 MODELINGOFCELLGEOMETRY 79
5.3.2 VORONOI TESSELLATION 81
5.3.3 SPLINE CURVES 83
5.3.4 SNAKES ALGORITHMS 87
5.3.5 B-SPLINE SNAKES 91
5.3.6 POTENTIAL MODIFICATIONS OF SEGMENTATION 98
5.4 DETECTIONOFCELLNUCLEI 102
5.5 ANALYSIS OF DERMAL FIBER TISSUE 106
5.5.1 ORIENTEDNESSOFFIBERS 108
5.5.2 TISSUE HOMOGENEITY 109
5.5.3 ELASTIN VS. COLLAGEN-RATIO 111
5.6 SUMMARY 113
VALIDATION 115
6.1 INTRODUCTION 115
6.2 SHADING CORRECTION 115
IMAGE 3
CONTENTS
6.2.1 QUALITATIVE COMPARISON 116
6.2.2 QUANTITATIVE COMPARISON 118
6.2.3 DISCUSSION 120
6.3 DETECTION OF NUCLEI 124
6.3.1 REALIZATION OF NUCLEI DETECTION 125
6.3.2 CLASSIFICATIONOFSHAPES 129
6.4 SEGMENTATION OF CELLS 134
6.4.1 MANUAL SEGMENTATION 134
6.4.2 VORONOI TESSELLATION 141
6.4.3 SNAKES 143
6.4.4 CONCLUSIONS 147
6.5 DERMAL FIBER TISSUE 147
6.6 SUMMARY 148
7 CONCLUSION AND PROSPECTS 149
7.1 SUMMARY 149
7.2 CONCLUSIONS 151
7.3 CONTRIBUTIONS OF THE DISSERTATION 152
7.4 PROSPECTS 153
A ADDITIONAL MATERIAL 155
A.L IMAGES AS RANDOM FIELDS 155
A.2 MOMENTS OF INTENSITY DISTRIBUTIONS 155
A.3 OPTICAL RESOLUTION 157
A.4 VIGNETTING 157
A.5 SIMULATION OFCELL IMAGES 160
A.6 SPLINE SNAKES IMPLEMENTATION 161
B NUMERICAL RESULTS 167
B.L INTENSITY MOMENTS OF THE FIAT FIELD IMAGES 167
B.2 FITTING RESULTS FOR IDD 167
B.3 SNR ESTIMATION OF IN VIVO MICROGRAPHS 169
B.4 EVALUATION OF DENOISING FILTERS 169
C MATHEMATICAL SYMBOLS 173
D ACRONYMS 175
ACKNOWLEDGMENTS 77
BIBLIOGRAPHY 79
IMAGE 4
CONTENTS
INDEX 193
|
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| author | Rahn, Christian-Dennis |
| author_facet | Rahn, Christian-Dennis |
| author_role | aut |
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| dewey-ones | 616 - Diseases |
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| dewey-search | 616.0754 |
| dewey-sort | 3616.0754 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| id | DE-604.BV026658030 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:16:42Z |
| institution | BVB |
| isbn | 9783832273736 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022207365 |
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| physical | XIV, 195 S. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Shaker |
| record_format | marc |
| series2 | Berichte aus der Medizinschen Informatik und Bioinformatik |
| spelling | Rahn, Christian-Dennis Verfasser aut Towards automated processing and analysis of digital laser scanning micrographs of human skin Christian-Dennis Rahn Aachen Shaker 2008 XIV, 195 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Medizinschen Informatik und Bioinformatik Zugl.: Hamburg, Univ., Diss., 2008 Mehrphotonenprozess (DE-588)4131057-3 gnd rswk-swf Laser-Rastermikroskopie (DE-588)4427589-4 gnd rswk-swf Hautzelle (DE-588)4296180-4 gnd rswk-swf Bildgebendes Verfahren (DE-588)4006617-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hautzelle (DE-588)4296180-4 s Laser-Rastermikroskopie (DE-588)4427589-4 s Mehrphotonenprozess (DE-588)4131057-3 s Bildgebendes Verfahren (DE-588)4006617-4 s DE-188 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022207365&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Rahn, Christian-Dennis Towards automated processing and analysis of digital laser scanning micrographs of human skin Mehrphotonenprozess (DE-588)4131057-3 gnd Laser-Rastermikroskopie (DE-588)4427589-4 gnd Hautzelle (DE-588)4296180-4 gnd Bildgebendes Verfahren (DE-588)4006617-4 gnd |
| subject_GND | (DE-588)4131057-3 (DE-588)4427589-4 (DE-588)4296180-4 (DE-588)4006617-4 (DE-588)4113937-9 |
| title | Towards automated processing and analysis of digital laser scanning micrographs of human skin |
| title_auth | Towards automated processing and analysis of digital laser scanning micrographs of human skin |
| title_exact_search | Towards automated processing and analysis of digital laser scanning micrographs of human skin |
| title_full | Towards automated processing and analysis of digital laser scanning micrographs of human skin Christian-Dennis Rahn |
| title_fullStr | Towards automated processing and analysis of digital laser scanning micrographs of human skin Christian-Dennis Rahn |
| title_full_unstemmed | Towards automated processing and analysis of digital laser scanning micrographs of human skin Christian-Dennis Rahn |
| title_short | Towards automated processing and analysis of digital laser scanning micrographs of human skin |
| title_sort | towards automated processing and analysis of digital laser scanning micrographs of human skin |
| topic | Mehrphotonenprozess (DE-588)4131057-3 gnd Laser-Rastermikroskopie (DE-588)4427589-4 gnd Hautzelle (DE-588)4296180-4 gnd Bildgebendes Verfahren (DE-588)4006617-4 gnd |
| topic_facet | Mehrphotonenprozess Laser-Rastermikroskopie Hautzelle Bildgebendes Verfahren Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022207365&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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