Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon: = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a)
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2004
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Nebentitel: Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| Physical Description: | 129 Bl. graph. Darst. |
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MARC
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| 100 | 1 | |a Seif, Hany Ahmed Ibrahim |d 1962- |e Verfasser |0 (DE-588)12976177X |4 aut | |
| 245 | 1 | 0 | |a Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon |b = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |c vorgelegt von Hany Ahmed Ibrahim Seif |
| 246 | 1 | 1 | |a Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| 264 | 1 | |c 2004 | |
| 300 | |a 129 Bl. |b graph. Darst. | ||
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| 500 | |a Nebentitel: Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) | ||
| 502 | |a Berlin, Univ.-Medizin, Diss., 2004 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
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| _version_ | 1804145078980050944 |
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| adam_text | Contents Page
1. Introduction 1
2. Problem presentation and aim of the work 3
2.1 Problem presentation 3
2.2 Aim of the work 4
3. Review of literature 5
3.1. Structure of bone 5
3.1.1. Elementary constituents of bone 5
3.1.2. Classification of bony tissue 7
3.1.3. Physiologic and cellular basis of bone metabolism 9
3.2. Biochemical markers of bone turnover 17
3.2.1. Markers of bone formation 18
3.2.2. Markers of bone resorption 22
3.3. Endometriosis 28
3.3.1. Definition 28
3.3.2. Aetiology and pathogenesis 28
3.3.3. Pathology 28
3.3.4. Classification 30
3.3.5. Diagnosis of endometriosis 30
3.3.6. Treatment 35
3.4 Gonadotrophin releasing hormone (GnRH)
agonist and antagonist 38
3.4.1. Chemistry of GnRH 38
3.4.2. GnRH receptors 39
3.4.3. Mechanism of action of GnRH 39
3.4.4. GnRH pulse generation 40
3.4.5. Pattern of secretion of GnRH 41
3.4.6. GnRH analogues (GnRH-a) 41
Contents Page
3.5 Clinical applications of GnRH analogues 47
3.6. Side effects and add back therapy of GnRH analogues 51
3.6.2. Types and patterns of add back therapy 54
4. Patients and methods 58
4.3. Criteria of patients 59
4.4. Methods of samples taking 60
5. Results 69
5.1 Baseline results at the starting of the study 69
5.2. Clinical, laboratory and biochemical bone markers
results during the treatment protocol 74
6. Discussion 90
7. Conclusion 101
8. Summary 102
8.1. English summary 102
8.2. German summary 104
8.3. Arabic summary 106
9. References 108
10. Acknowledgment 128
11. Curriculum vitae 129
List of figures page
5.1.1.1. Mean of the age in the study group 88
5.1.1.2. Mean body weight in the study group 88
5.1.1.3. Mean height in the study group 89
5.1.1.4. Mean of the body mass index in the study groups 89
6.1. Hormonal level at base line and after two weeks 97
6.2. Hormonal level at base line and after three months 98
6.3. Hormonal level at base line and after six months 98
6.4. Biochemical markers at base line and after two Weeks 99
6.5. Biochemical markers at base line and after three
months 100
6.6. Biochemical markers at base line and after six months 100
List of schemes
4.2.2.1. Design of the study groups 59
4.4.1. Blood and urine sampling 60
List of tables Page
3.1.3.5.1. Systemic and local mediators of bone metabolism 13
3.2.1. Biochemical markers of bone turnover 17
3.3.6.1. Variuos hormonal states and their
effects upon normal endometrium and
ectopic endometrial deposits 36
3.4.6.1.1, Structure of GnRH and GnRH agonists 42
3.4.6.2.1. Names, plasma half-life, relative potency
route of administrative and recommended
dose for the clinically available gonadotrophins 43
5.1.1.1. Descriptive statistics of age, body weight,
height and BMI in group 1 (patients under
program of IVF (frozen embryo transfer);
(GroupiA) used GnRH with add back therapy
and (group 1B) without using add back therapy 69
5.1.1.2. Descriptive statistics of age, weight, body mass
index and height in women prepared for
treatment of endometriosis used GnRH and
calcitonin (group 2A) and without using calcitonin
(group 2B) 70
5.1.1.3. Proportions of parity in groupi 70
5.1.1.4. Proportions of parity in group 2 71
5.1.2.1.1. Baseline Hemoglobin level in group 1 71
5.1.2.1.2. Baseline Hemoglobin level in group 2 71
5.1.2.2.1. Baseline serum createnine (Cr) in groupi 72
5.1.2.2.2: Baseline serum createnine in group2 72
5.1.2.3.1. Baseline estradiol, progesterone and lutenizing
hormone (LH) levels in groupi 72
5.1.2.3.2. Baseline estradiol, progesterone and lutenizing
hormone (LH) levels in group 2 73
5.1.2.4.1. Baseline calcium (Ca), phosphorus (P), alkaline
phosphatase (ALK), urinary deoxypyridinoline (D-pyr)
and ostoecalcin (OC) in group 1 73
List of tables Page
5.1.2.4.2. Baseline Calcium (Ca), phosphorus (P), alkaline
phosphatase(ALK), urinary deoxypyridinoline (D-pyr)
and ostoecalcin (OC) in group 2 74
5.2.1.1. Clinical data during the GnRH agonist treatment 75
5.2.2.1.1. Hemoglobin in Women prepared for IVF after two
weeks of GnRH-a using calcitonin (group1-A) and
without using calcitonin (group 1-B) 75
5.2.2.1.2. Comparison of hemoglobin level after two
weeks (in Women prepared for treatment of
endometriosis by GnRH-a) using calcitonin
(group 2-A) and without using calcitonin (group 2-B) 76
5.2.2.1.3. Comparison of hemoglobin level after three months
in Women prepared for treatment of endometriosis
by GnRH-a using calcitonin (group 2A) and
without using calcitonin (group 2B) 76
5.2.2.1.4. Comparison of hemoglobin after six months
in Women prepared for treatment of endometriosis
by GnRH-a using calcitonin (group 2-A) and
without using calcitonin (group 2-B). 76
5.2.2.1.5 Haemoglobin levels in study groups during the
GnRH treatment 77
5.2.2.1.6. Serum creatinine (Cr) levels in study groups
during the GnRH treatment 77
5.2.2.2.1: Estradiol, progesterone and lutenizing
hormone in women prepared for IVF after
two weeks of GnRH-a using calcitonin(groupi-A)
and without using calcitonin (group 1-B) 78
5.2.2.2.2. Estradiol, progesterone and lutenizing hormone after
two weeks in Women prepared for treatment of
endometriosis by GnRH-a using calcitonin (group 2-A)
and without using calcitonin (group 2-B) 78
List of tables Page
5.2.2.2.3. Estradiol, progesterone and lutenizing
hormone in endometriosis group after three
months of GnRH-a treatment with calcitonin (group 2-A)
and without calcitonin (group 2-B) 79
5.2.2.2.4. Estradiol, progesterone and lutenizing hormone levels
in group 2 with endometriosis group after six months
of GnRH-a treatment with calcitonin (group 2A) and
without calcitonin (group 2B) 79
5.2.2.2.5. Estradiol (Est) Levels in study groups during the
GnRH treatment 80
5.2.2.2.6 Progesterone (Prog.) levels in study groups
during the GnRH treatment 80
5.2.2.2.7 Lutenizing (LH) Levels in study groups during
the GnRH treatment 81
5.2.2.3.1. Biochemical markers in Women prepared for
IVF after two weeks of GnRH-a using calcitonin
(group1-A) and without using calcitonin (group 1-B) 82
5.2.2.3.2. Comparison of biochemical markers after two
weeks in Women prepared for treatment of
endometriosis by GnRH-a using calcitonin 82
(group 2A) and without using calcitonin (group 2B).
5.2.2.3.3. Biochemical markers of bone turnover in
endometriosis group after three months of
GnRH-a treatment with calcitonin (group2-A)
and without calcitonin (group 2-B) 83
5.2.2.3.4. Biochemical markers of bone turnover in
endometriosis group after six months of GnRH-a
treatment with calcitonin (group 2A) and without
calcitonin (group 2B) 83
5.2.2.3.5. Calcium (Ca) Levels in study groups during
GnRH treatment 84
List of tables Page
5.2.2.3.6. Phosphorous (P) levels in study groups during
GnRH treatment 84
5.2.2.3.7. Alkaline Phosphatase (ALP) levels in
study groups during the GnRH treatment 85
5.2.2.3.8. D-pyr levels in study groups during the GnRH
treatment 85
5.2.2.3.9. Osteocalcine (OC) levels in study groups during
the GnRH treatment 86
5.2.3.1 Correlation between biochemical markers after
months GnRH agonist treatment in group 2A 86
5.2.3.2 Correlation between biochemical markers after
6 months GnRH agonist treatment in group 2B 87
|
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| author | Seif, Hany Ahmed Ibrahim 1962- |
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| indexdate | 2024-07-09T23:13:44Z |
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| physical | 129 Bl. graph. Darst. |
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| spelling | Seif, Hany Ahmed Ibrahim 1962- Verfasser (DE-588)12976177X aut Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) vorgelegt von Hany Ahmed Ibrahim Seif Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) 2004 129 Bl. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nebentitel: Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) Berlin, Univ.-Medizin, Diss., 2004 (DE-588)4113937-9 Hochschulschrift gnd-content HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022064827&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Seif, Hany Ahmed Ibrahim 1962- Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| subject_GND | (DE-588)4113937-9 |
| title | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| title_alt | Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| title_auth | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| title_exact_search | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| title_full | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) vorgelegt von Hany Ahmed Ibrahim Seif |
| title_fullStr | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) vorgelegt von Hany Ahmed Ibrahim Seif |
| title_full_unstemmed | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) vorgelegt von Hany Ahmed Ibrahim Seif |
| title_short | Biochemische Marker als Voraussage von Knochenumsatz bei Frauen während der Therapie mit analogem Gonadotropin-Releasing Hormon |
| title_sort | biochemische marker als voraussage von knochenumsatz bei frauen wahrend der therapie mit analogem gonadotropin releasing hormon biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy gnrh a |
| title_sub | = Biochemical markers as predictors of bone turnover changes in women during gonadotrophin releasing hormone analogues therapy (GnRH-a) |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022064827&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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