Integrated molecular and cellular biophysics:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
[Dordrecht]
Springer
2008
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 250 S. Ill., graph. Darst. |
| ISBN: | 9781402082672 1402082673 |
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MARC
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Record in the Search Index
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| adam_text | Titel: Integrated Molecular and Cellular Biophysics
Autor: Raicu, Valerica
Jahr: 2008
Contents
Preface.................................................. ix
Introduction..................................................... j
1 The Molecular Basis of Life..................................... 7
1 -1 Molecular Interactions...................................... 7
1.1.1 Interactions Between Polar Entities..................... 8
1.1.2 van der Waals Interactions............................. 10
1 -2 Water and Polar Interactions ................................. IX
1.2.1 Physical Properties of Water........................... 19
1.2.2 Overview of the Importance of Water for the Living Mutter
State............................................... 28
1.2.3 The pH............................................. 29
1.3 Hydrophobic Interactions and Molecular Self-Association ...... 30
1.3.1 The Hydrophobic Effect .............................. 30
1.3.2 Amphiphilic Molecules............................... 31
References..................................................... 37
2 The Composition and Architecture of the Cell..................... 39
2.1 The Cell: An Overview...................................... 39
2.1.1 Eukaryotic Cells..................................... 40
2.1.2 Cellular Self-Reproduction............................ 43
2.1.3 Cellular Metabolism.................................. 46
2.2 Proteins................................................... 47
2.2.1 Protein Structure..................................... 47
2.2.2 Protein Folding...................................... ^
2.3 Deoxyribonucleic Acid (DNA): The Cell s Legislative Power...... 60
2.3.1 DNA Structure...................................... 6°
2.3.2 DNA Replication (Gene Autoreproduction).............. 66
2.4 Determination of Molecular Structure ......................... 6S
References..................................................... 70
Contents
Cell Membrane: Structure and Physical Properties................ 73
3.1 Membrane Structure........................................ 73
3.1.1 Chemical Composition of the Plasma Membrane.......... 74
3.1.2 Spatial Architecture of the Plasma Membrane............ 75
3.2 Surface Charges............................................ 78
3.2.1 Origin of the Surface Charges.......................... 78
3.2.2 Electrical Double Layer............................... 79
3.2.3 Gouy-Chapman-Stern Theory of the Electrical Double Layer 79
3.3 Static Electrical Properties of Planar Membranes................ 88
3.3.1 Electrical Parameters as Complex Quantities............. 88
3.3.2 Dielectric Relaxation of a Dielectric Multi-Layet ......... 90
3.3.3 Dielectric Properties of Random Suspensions of Particles
with Particular Relevance to Biological Cells............. 95
References..................................................... 98
Substance Transport Across Membranes .........................101
4.1 Brief Overview ............................................101
4.2 Diffusion in Biological Systems..............................103
4.2.1 Fick s Laws of Diffusion..............................103
4.2.2 Simple Diffusion Through Membranes..................105
4.2.3 Determination of Membrane Permeability from Membrane
Potential Energy Profile...............................107
4.3 Osmosis and Osmotic Pressure...............................110
4.3.1 van t Hoff s Laws....................................Ill
4.3.2 Deviations from van t Hoff Laws.......................113
4.3.3 Osmotic Pressure of Biological Liquids..................114
4.3.4 The Cellular Osmotic Pressure Menace ................115
4.4 Facilitated Transport........................................116
4.4.1 Channel-Mediated Transport...........................116
4.4.2 Carrier-Mediated Transport............................116
4.4.3 Main Characteristics of Facilitated Transport.............120
4.5 Active Ion Transport........................................120
References.....................................................122
Reaction, Diffusion and Dimensionality...........................123
5.1 Equilibrium and the Law of Mass Action.......................123
5.1.1 Molecular Association................................123
5.1.2 Determination of Affinity Constant by Equilibrium Dialysis 125
5.1.3 Competitive Binding .................................127
5.1.4 Allosteric Activation and Inhibition of Binding...........128
5.2 Introduction to Fractals......................................131
5.2.1 .. .The Measure of Everything ........................132
5.2.2 Examples of Fractals of Biological Interest...............136
5.2.3 Practical Considerations and Limitations
of the Above Theory .................................138
Contents vjj
5.3 Fractal Diffusion and the Law of Mass Action ..................140
5.3.1 Diffusion on Fractal Lattices...........................141
5.3.2 The Carrier-Mediated Transport of Glucose Revisited......143
References.....................................................145
6 Electrophysiology and Excitability...............................147
6.1 Electric Charges and the Transmembrane Potential...............147
6.1.1 Models for Calculating the Transmembrane Potential......149
6.2 Excitable Membranes.......................................155
6.2.1 Electrotonic Versus Action Potentials ...................155
6.2.2 The Voltage-Clamp Technique and Transmembrane
Ionic Currents.......................................160
6.2.3 The Hodgkin-Huxley Model of Action Potential..........164
References.....................................................171
7 Structure and Function of Molecular Machines....................173
7.1 Channels and Pores.........................................173
7.1.1 Electrical Behavior of Individual Ion Channels ...........174
7.1.2 Structural Characterization by X-Ray Crystallography.....177
7.2 X-Ray Investigations of Channels and Pores....................181
7.3 Ion Pumps ................................................185
7.3.1 The Na-K-ATPase ...................................185
7.3.2 Other Ionic Pumps................................... 88
7.4 Light Absorption in Photosynthesis ...........................189
7.4.1 Brief Overview of the Mechanism of Photosynthesis.......189
7.4.2 Thermodynamics of Light Absorption...................190
References..................................................... 9-
8 Protein-Protein Interactions..................................... ?
8.1 Probing Protein Association In Vivo...........................
8.1.1 Elementary Theory of Fluorescence and FRET...........197
8.1.2 FRET-Based Determinations of Interaction Stoichiometry .201
8.2 Structural Studies of Protein-Protein Interactions................209
8.2.1 Principles of Nuclear Magnetic Resonance (NMR)........209
8.2.2 Chemical Shift and the NMR Spectroscopy..............211
8.2.3 NMR Studies of Protein-Protein Interactions.............214
References.....................................................
Answers to Selected Quizzes
Appendix.................
Index___
219
227
231
|
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| dewey-ones | 571 - Physiology & related subjects |
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| dewey-sort | 3571.4 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| institution | BVB |
| isbn | 9781402082672 1402082673 |
| language | English |
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| spelling | Raicu, Valerica Verfasser aut Integrated molecular and cellular biophysics Valerica Raicu ; Aurel Popescu [Dordrecht] Springer 2008 XI, 250 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molekulare Biophysik (DE-588)4170391-1 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Molekulare Biophysik (DE-588)4170391-1 s DE-604 Popescu, Aurel Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020160778&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Raicu, Valerica Popescu, Aurel Integrated molecular and cellular biophysics Molekulare Biophysik (DE-588)4170391-1 gnd |
| subject_GND | (DE-588)4170391-1 (DE-588)4123623-3 |
| title | Integrated molecular and cellular biophysics |
| title_auth | Integrated molecular and cellular biophysics |
| title_exact_search | Integrated molecular and cellular biophysics |
| title_full | Integrated molecular and cellular biophysics Valerica Raicu ; Aurel Popescu |
| title_fullStr | Integrated molecular and cellular biophysics Valerica Raicu ; Aurel Popescu |
| title_full_unstemmed | Integrated molecular and cellular biophysics Valerica Raicu ; Aurel Popescu |
| title_short | Integrated molecular and cellular biophysics |
| title_sort | integrated molecular and cellular biophysics |
| topic | Molekulare Biophysik (DE-588)4170391-1 gnd |
| topic_facet | Molekulare Biophysik Lehrbuch |
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