Posttranscriptional gene regulation: RNA processing in eukaryotes
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| Format: | Book |
| Language: | English |
| Published: |
Weinheim
Wiley-Blackwell
2013
|
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis Klappentext |
| Physical Description: | XVI, 260 S. Ill., graph. Darst. |
| ISBN: | 3527322027 9783527322022 9783527665433 |
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| 245 | 1 | 0 | |a Posttranscriptional gene regulation |b RNA processing in eukaryotes |c ed. by Jane Wu |
| 264 | 1 | |a Weinheim |b Wiley-Blackwell |c 2013 | |
| 300 | |a XVI, 260 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Posttranskriptionelle Regulation |0 (DE-588)4356177-9 |2 gnd |9 rswk-swf |
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| 689 | 0 | 1 | |a Posttranskriptionelle Regulation |0 (DE-588)4356177-9 |D s |
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| 700 | 1 | |a Wu, Jane |0 (DE-588)1036617858 |4 edt | |
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| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, MOBI |z 978-3-527-66540-2 |
| 776 | 0 | 8 | |i Erscheint auch als |n Online-Ausgabe, PDF |z 978-3-527-66542-6 |
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Contents
Fonwortl
Xl
UftofCofltribwtert
Xlii
\
Th«
RoJ·
of
Cotrtiwcriptìontl
Recruitment of RNA-BJftding Proteins in
the
Malmenine·
of Genomk: Stability
1
Jennifer A. Aoki
ond
Jomes
L.
Manley
1.1
Introduction I
1.2
THO/TRHX
2
1.2.1
THO/TREX in
Sau/uiromyvrs
ierrvisiac
2
1.2.2
THO/TREX
m
Higher Eukaryotcs
j
1.2.3
THO/TREX and R-loop Formation
Ì
1.3
Linking Transcription to Export of mRNP
4
1.3.1
The TliplSacSSusl-Cdcil (THSC) Complex
4
1.3.2
SR Proteins
5
1.3.3
The Exon Junction Complex
6
1.3.4
The Exosome
6
1.4
Cotranscriptiorul R-loop Formation
7
1.4.1
R-loops in Escherichia
cdi
8
1.4.2
Naturally Occurring R-loops
8
1.4.3
TREX Protects against R-loop Formation
8
1.4.4
SR Proteins Protect against R-loop Formation
9
1.5
R-loop-induced Double-Stranded (ds)
DNA
Breaks
10
1.5.1
Class Switch Recombination
10
1.5.2
Formation of Double-Strand Breaks
10
1.5.3
Rrm3 and Pifl
DNA Helkases 11
1.6
Concluding Remarks
12
References
12
2
Transcription Termination by
RNA
Połymeratse
II
19
Minkyu
Kim ond
Stephen Burotowiki
2.1
Messenger
RNA
Gene Termination
í
9
2.1.1
The
Allosteric
Model
20
2.1.2
The Torpedo Model
21
(
onícnls
I.'} Small Nucleolar
RNA
Gene Termination Pathway
2.3
2.3
Choice between the Two Termination Pathways
75
2.4
Regulation of "I
réinscription
by Termination
27
7.4.1
Transcription Attenuation, Promoter Upstream/Associated
Transcription, and Pausing of RNApII
27
2.4.2
Alternative Polyadenylation and Termination
29
2.5
Mechanisms of Termination by Other
RNA
Polymerases
30
2.6
Future Perspectives
31
Acknowledgments
.32
References
32
3
Posttranscriptional Gene Regulation by an Editor: ADAR and its Role in
RNA
Editing
41
Louis Valente,
Yukio KawaharQ,
Hons
Zinshteyn, Htsoshi li'/asa,
and Kazuko Nishikura
3.1
Introduction
41
37
The
RNA
Ľchling
Kinship
44
3.5
The .ADAR Gene J-armly
45
3.4
The Role of
RNA
in the A-to-I Editing Mechanism
5І
3.3
Splice Site Alterations
5/
3.6
A-to-I
RNA
Receding Modifies Proteins Such As
N
euro rran
s m
liters
і
5
.3.6.1
Glutamate
Receptor Ldiring-GluR-
В
57
3.6.2
Serotonin Receptor editing-.
S-HT^R
58
3.7
Cellular Hffects and in Vivo Phenotypes of ADAR Gene
Inactiva
lion
5 9
3.8
Noncoding
RNA
and Repetitive Sequences
61
3.9
Ľffccts
on the
RNA
Interference Silencing Pathway
64
3.1.0
Hffects on MicroRN.A Processing and Target Selection
66
3.11
RNA
Editing Role as an Antiviral Mechanism
67
3.12
Conclusions
68
Acknowledgments
69
References
69
4
Posttranslational Modification of Sm Proteins: Diverse Roles in snRNP
Assembly and Germ Line Specification
85
Craydon B. Consaluez and A. Gregory
Matera
4.1
Introduction
83
4.2
Protein Methylahon
-
idavors and Functions
84
4.3
Sm Proteins
Contam
sDMA- and aDMA-Modified Argmmes
86
4.4-
SnRNP Assembly, the Survival Motor Neuron (SMN) Complex, and
Spinal Muscular Atrophy (SMA)
87
4.3
PRMT5 and PRMT7 -The Sm Protein Methyltransferases
89
4.6
Sm Protein Methyiation is Required for sn/RNP Assembly in
Mammals
92
Contents
4.7
Sm
Protein Meth.yiat.ion in
Drosophila
94
4.8
Unresolved Questions:
Srn Protein
Methylationand snRNP Assembly
95
4.9
Conclusion-The Fvolution of snRNP Assembly
96
4.10
Sm Pro'.ems Are Recpiired for Germ Cell Specification
97
4.11
P)art5,
Valois,
Sm Proteins,
and Tudot Anchoring
100
4.12
Unresolved Questions:
Sni
Proteins and Germ
Ce]]
Specification
101
4.13
The Transcriptional Functions
oí PRMT5
102
4.14
Arginine
Methyiation No bonger in. the Shadow of
Phosphorylation
10.Ì
4.15
Sm Proteins-Doughnut-Shaped Relics of Our
RNA
Past
104
References
106
5
Structure, Function, and Biogenesis of Small Nucleolar
Ribonucleoprotein Particles
117
Katherine S.
Godin
and
Gabriele Varani
5.1
Introduction
ì
17
5.2
The Guide
RNA
119
5.3
The Core srio/sRNP Proteins
120
5.4
Assembly and Structural Organization of sno/sRKPs
122
5.5
Asymmetric. Assembly, Structure, and Activity of the Box C/D
122
5.5.1
in vitro
Reconstitution
of C/D sno/sRNPs
122
5.5.2
The Initial Bipartite C/D sRivP Mode!
123
5.5.3
The di-C/D sRNP Model and Asymmetric Activity
./24
5.6
The Box H/ACA RNP Structure and Assembly of the Eukaryotic
RNP
125
5.6.1
The Complete Substrate-Bound Box
І-Ї/ЛСА Г25
5.6.2
Structure of
Ľukaryohc
H/ACA snoRNPs
127
5.6.3
Assembly of
Ľukaryotic
H/ACA snoRNPs
127
5.7
Summary
128
References
128
6
Mechanistic Insights into Mammalian Pre-mRNA Splicing I'M
Sebastian M.
Fica,
Πίζα
С.
Small,
Melissa Meßord,
and
Jonathan
P. Staley
6.1
Introduction
133
6.2
Chemistry of Splicing
133
6.3
Composition and Assembly of the Spliceosome
135
6.4
Control of Spliceosome Assembly and Activation
139
6.J Spliceosome Structure and Dynamics
141
6.6
The Structure of the Spliceosomal Active Site and the Mechanism of
Catalysis
í
45
6.7
Fidelity in Splicing
149
6.8
Concluding Remarks
151
Acknowledgments 1'j2
References
152
Vili Con
7
Splicing Decisions Shape
Neuronal
Protein Function across the
Transcriptome
163
Jill
A Dembowski
and Paula J. Crabowski
7.1
Introduction
163
7.2
A Diversity of RNA-Binding
Protein
Regulators
2 65
7.3
Gene-Specific and
Globa]
Experimental
Approaches
lo
Splicing
Mechanisms
167
7.4
Alternative Splicing of Dicam Pre-mRNA.: Mechanism and Significance
for the Development of Memorial Circuits
1.69
7.5
The NMDA Rl Receptor: Btain-Region-Speafic and Activity-Dependent
Splicing
171
7.6
Alternative Splicing Response to
Neuronal
Excitation
172
7.7
Splicing Silencing by
PTB:
Versatility of Mechanism and
Cross-Regulation of nPTR
17}
7.8
Upstream Regulation oi Splicing
Vårtors
by MicroRNAs 17b
7.9
Conclusions and Prospects
176
Acknowledgments
í
77
References
177
8
Noncoding
RNA:
The Major Output of Gene Expression
I8Î
Matthias Harten,
arid
Piero Cammei
8 1
Introduction IS
í
8.2
What is ncRNA5
182
8.3
Discovery of ncRNAs
182
8.3 1
Discovery
oí
ncRNAs by function
182
8 3.7
Large-Scale
с
DNA
Cloning Projects
.183
8.3.3
Tag-Based Sequencing Methods
184
8.3 4
Short
RNA
libraries
185
8 3.5
New Microarray Approaches
186
8.3.6
Other Experimental Approaches
187
8.3.7
Computational Methods
188
8.4
ncRNA
Farmlies
190
8.4.1
tRNA
19.1
8.4.2
rRNA
191
8.4.3
snRNA
191
8.4.4
snoRNA
191
8.4.5
Guide
RNA
192
8.4.6
miRNA
.1.92
8.4.7
siRNA
193
8.4.8
piRNA
193
8.4.9
tasiRNA
.1.94
8.4.10
rmRNA
194
8.4.11
Ribozymes
194
8.4.17
Untranslated Regions
m mRNA
195
8.4.13
Long ncRNAs
196
8.
з
Examples
fot ricRN.A Purictions
196
8.6
Perspectives
200
8.7
Note
Added in Proof'
20/
Acknowledgments
202
References
203
9
Noncoding RNAs, Neurodevelopment,
and Neurodegeneration
21b
Mengmeng
Chen, Jianwtn Deng, Mengxue
Yang, Kun
¿hu,
Jiiinghong
Iju,
і і
¿hu,
and Jane Y. Wu
9.1
Introduction
2
j S
9.2
Expression of
ne R K
As in the Nervous System
235
9.2.1
Long ncRNAs
215
9.
λ
2
Smal!
ricRNAs
216
9.2.2.1
Small Nucleolar RNAs (snoRNAs)
216
9.2.2.2
Small Cytoplasrmc
RNA
216
9.2.2.3
MicroRNAs
217
9.3
ncRNA.s
m
Ncurodeveloprnent
218
9.3.1
ncRNA Regulation of
Neuronal
Dilíerentiation
218
9.3.2
nc.RNAs
Regúlale
Synapüc
Development
anei
Function
238
9.3.2.1
n c R
N
A s
ι π Ν
c u r 11 e O u t g r o
win
218
9.3.2.2
ncRNAs
in Synapfc Formation and Maturation
219
9.3.2.3
nc.RNAs
m Synaptic
Function and Plasticity
219
9.4
ncRNAs
m
Neurodevelopmental and
Neuropsychiatrie
Diseases
219
9.4.1
MicroRNAs and Neurodcveloprncntal Disorders
220
9.4.1.1
Aurism Spectrum Disorders
220
9.4.1.2
Rett
Syndrome
220
9.4.1.3
F r
a g
ι
le
X
S
утн.1
1
о
me
221
9.4.1.4
DiGeorce Syndrome
221
5.4.1.
S
Down Syndrome
222
9.4.1.6
Neuropsychiatrie
.Diseases: Schizophrenia and Bipolar Disorder
222
9.4.2
Long ncRNAs
m Neurodevelopmental
arid Psychiatric Disorders
223
9.5
ncRNAs ¡n Neurodegeneration 222A
9.5.1
Alzheimer's Disease
224
9.5.2
Parkinson's Disease
225
9.5.3
Hunting-ton's Disease
226
9.5.4
Frontotemporal Lobar Degeneration
226
9.6
Conciliili
rig Remarks and Perspectives
22.7
Acknowledgments
228
References
228
Further Reading
236
10
The Evolution of the Modern
RNA
World
239
Ying Chen, I longzheng Dai, and Manyuan Long
10.1
Evolution
oř'
Noncoding
RNA
Gene
239
10 1.1
Conserved and Nonconservcd Nature of ncRNA Genes
240
Cot
tents
10
1
2
1.0
'J
10
3
10
3
1
10
і
2
10
3
3
10
4
10
4
1
10
4.
Lineage-Specific ncRNA Genes 240
Evolution
of Transcriptional Regulation
242
Evolution
of Posttranscriptional
Gene Regulation 243
Evolution
of Alternative Splicing
243
Compensatory
Evolution
of RNA
Secondary and
Tertiär)1
Structure
245
Evolution of Posttranscriptional Gene Silencing
246
Phenolypic Evolution by the Origination of New ncRNA Genes and
Perspectives between Protein-Codmg and ncRNA Genes
247
Evolution of Phenotypes Contributed by New ncRNA
(ienes
247
Perspectives between Proiein-Coding and nc.RNA Genes
248
References
24 9
Index
753
Reflecting the rapid progress in the field, the book presents the current understanding
of molecular mechanisms underlying posttranscriptional gene regulation. It focuses
on
RNA
processing mechanisms in eukaryotic cells. With chapters on
RNA
splicing,
RNA
interference, MicroRNA regulation,
RNA
editing and other biological processes
involving RNAs, the book also discusses critical roles of
RNA
processing in the patho-
genesis of a wide range of human diseases. The interdisciplinary importance of the
topic makes the title a useful resource for a wide reader group in science, in clinics as
well as in the pharmaceutical industry.
Jane Y. Wu is the Charles Louis Mix Professor in the Depart¬
ment of Neurology, the Lurie Cancer Center and the Center
for Genetic Medicine at Northwestern University in Chicago,
USA as well as a senior consulting investigator at the Chi¬
nese Academy of Science, Beijing, China. After obtaining
her doctorate from Stanford University and her postdoctoral
training at Harvard University, Dr. Wu has been focusing on
studying molecular mechanisms controlling gene regulation,
in particular, those critical for neural development and neu-
rodegeneration. Her research has significantly advanced our
understanding of the fundamental role of
RNA
processing
in biology and in human pathogenesis. |
| any_adam_object | 1 |
| author2 | Wu, Jane |
| author2_role | edt |
| author2_variant | j w jw |
| author_GND | (DE-588)1036617858 |
| author_facet | Wu, Jane |
| building | Verbundindex |
| bvnumber | BV025554511 |
| classification_rvk | WG 1900 |
| ctrlnum | (OCoLC)551898105 (DE-599)BVBBV025554511 |
| discipline | Biologie |
| format | Book |
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| id | DE-604.BV025554511 |
| illustrated | Illustrated |
| indexdate | 2024-09-06T00:16:48Z |
| institution | BVB |
| isbn | 3527322027 9783527322022 9783527665433 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020154487 |
| oclc_num | 551898105 |
| open_access_boolean | |
| owner | DE-11 DE-355 DE-BY-UBR DE-703 |
| owner_facet | DE-11 DE-355 DE-BY-UBR DE-703 |
| physical | XVI, 260 S. Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Wiley-Blackwell |
| record_format | marc |
| spelling | Posttranscriptional gene regulation RNA processing in eukaryotes ed. by Jane Wu Weinheim Wiley-Blackwell 2013 XVI, 260 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Posttranskriptionelle Regulation (DE-588)4356177-9 gnd rswk-swf Eukaryoten (DE-588)4070991-7 gnd rswk-swf Eukaryoten (DE-588)4070991-7 s Posttranskriptionelle Regulation (DE-588)4356177-9 s b DE-604 Wu, Jane (DE-588)1036617858 edt Erscheint auch als Online-Ausgabe, EPUB 978-3-527-66541-9 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-66540-2 Erscheint auch als Online-Ausgabe, PDF 978-3-527-66542-6 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3294457&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020154487&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020154487&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Posttranscriptional gene regulation RNA processing in eukaryotes Posttranskriptionelle Regulation (DE-588)4356177-9 gnd Eukaryoten (DE-588)4070991-7 gnd |
| subject_GND | (DE-588)4356177-9 (DE-588)4070991-7 |
| title | Posttranscriptional gene regulation RNA processing in eukaryotes |
| title_auth | Posttranscriptional gene regulation RNA processing in eukaryotes |
| title_exact_search | Posttranscriptional gene regulation RNA processing in eukaryotes |
| title_full | Posttranscriptional gene regulation RNA processing in eukaryotes ed. by Jane Wu |
| title_fullStr | Posttranscriptional gene regulation RNA processing in eukaryotes ed. by Jane Wu |
| title_full_unstemmed | Posttranscriptional gene regulation RNA processing in eukaryotes ed. by Jane Wu |
| title_short | Posttranscriptional gene regulation |
| title_sort | posttranscriptional gene regulation rna processing in eukaryotes |
| title_sub | RNA processing in eukaryotes |
| topic | Posttranskriptionelle Regulation (DE-588)4356177-9 gnd Eukaryoten (DE-588)4070991-7 gnd |
| topic_facet | Posttranskriptionelle Regulation Eukaryoten |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3294457&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020154487&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020154487&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT wujane posttranscriptionalgeneregulationrnaprocessingineukaryotes |