Neurotoxicology in Vitro:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
London
Taylor and Francis
1999
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XI, 291 S. |
| ISBN: | 0748403892 |
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| adam_text | Neurotoxicology In Vitro
PREFACE ix
ACKNOWLEDGEMENTS xi
PART I NEUROTOXICOLOGY AND IN VIVO-IN VITRO RELATIONSHIPS 1
CHAPTER 1
An Introduction to the Practical Applications of New In Vitro Tests 3
OP Flint
1.1 The objective of toxicity testing 5
1.2 The nature of preclinical in vivo toxicity tests 5
1.3 The nature of in vitro tests 6
1.4 Predicting in vivo toxicity 7
1.5 Retrospective studies of toxic mechanism 8
1.6 Use of human tissue 9
1.7 In vitro tests for neurotoxic agents 10
1.8 Conclusions 11
1.9 References 11
CHAPTER 2
Structure, Function and Toxicity in Nervous Tissue 17
VWPentreath
2.1 Introduction 19
2.2 Barrier systems between blood and nervous tissue 19
2.3 Aspects of the responses of neurons to toxic substances 24
2.4 Myelin-forming cells 27
2.5 Astroglial cell lineage 29
2.6 Microglia and neurotoxicity 34
2.7 Mast cells 36
2.8 Conclusions 36
2.9 References 37
CHAPTER 3
Assessment of Toxicant-induced Damage 43
TL Parker and R H Clothier
3.1 Introduction 45
3.2 In vivo and in vitro morphological studies 46
3.3 In vivo and in vitro biochemical studies 52
¦ V
NEUROTOXICOLOGY IN VITRO
3.4 In vivo and in vitro physiological studies 56
3.5 In vivo and in vitro developmental studies 58
3.6 In vivo and in vitro degenerative and regenerative studies 60
3.7 In vivo and in vitro behavioural studies 62
3.8 Conclusions 63
3.9 References 64
CHAPTER 4
Toxic Cell Damage 77
David E Ray
4.1 Introduction 79
4.2 Reversible and irreversible injury 80
4.3 Injury responses in different cell types 82
4.4 Cell death and apoptosis 83
4.5 Cytotoxicity and cell-specific toxicities 85
4.6 Threshold, dose-response, time- and dose-dependent changes 91
4.7 Direct and indirect toxic effects 94
4.8 The nature of toxic chemicals 95
4.9 Practical implications 97
4.10 Conclusions 99
4.11 References 99
CHAPTER 5
Endpoints and Mechanisms 105
MLeist, E Ferrando-May, A Castoldi and P Nicotera
5.1 Introduction 107
5.2 Endpoints for cell death 107
5.3 Emerging mechanistic principles of cellular neurotoxicity 116
5.4 Conclusions 129
5.5 References 129
PART II The Developing In Vitro Neurotoxicology 147
CHAPTER 6
Functional Biochemical Indicators 149
Mark R Cookson
6.1 Introduction 151
6.2 Energy and metabolism 152
6.3 Protein changes 153
vi ¦
NEUROTOXICOLOGY IN VITRO
6.4 Enzymes 159
6.5 Calcium and other ions 160
6.6 Protective systems and lipid damage 166
6.7 Conclusions 170
6.8 References 170
CHAPTER 7
Nuclear and Cell Control 177
Mark R Cookson
7.1 Introduction 179
7.2 DNA and RNA 179
7.3 Cell division 181
7.4 Altered gene expression and products 186
7.5 Conclusions 191
7.6 References 191
CHAPTER 8
Cell Contact and Cell Communication 197
/ Jiang and f E Klaunig
8.1 Introduction 199
8.2 Use of cell culture and tissue slice preparations for the assessment
of gap junctional intercellular communication 202
8.3 Dye coupling vs electrophysiological coupling 203
8.4 Methodological considerations 205
8.5 Conclusions 208
8.6 References 209
CHAPTER 9
Brain Spheroid and Other Organotypic Culture Systems in In Vitro
Neurotoxicology 213
CKA tterwill andWM Purcell
9.1 Introduction 215
9.2 Brain spheroid culture 215
9.3 Other organotypic models 218
9.4 Methodological considerations 220
9.5 Neurotoxicological investigations 224
9.6 Recent progress and future directions 227
9.7 Conclusions 230
9.8 Acknowledgements 231
9.9 References 231
¦ vii
NEUROTOXICOLOGY IN VITRO
CHAPTER 10
Cell Culture Models of Environmental Chemical Neurotoxicity 239
B Veronesi and M Ehrich
10.1 Introduction 241
10.2 Technical considerations in the design of neurotoxicity experiments .. 241
10.3 Cytotoxic and neurotoxic endpoints 243
10.4 Cell culture models: screening versus mechanistic 244
10.5 Useful cell culture models for chemical neurotoxicity 244
10.6 Cell culture models of insecticide neurotoxicity 253
10.7 Conclusions 256
10.8 References 256
CHAPTER 11
Toward the Acceptance of In Vitro Neurotoxicity Tests 269
M Balls andE Walum
11.1 Introduction 271
11.2 Special aspects of the validation of neurotoxicity tests 273
11.3 Generalized mechanisms of neurotoxicity 273
11.4 Some examples of efforts made to develop and evaluate cellular
neurotoxicity tests 275
11.5 Proposals for further action 279
11.6 References 281
INDEX 285
viii ¦
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| spelling | Neurotoxicology in Vitro ed. by V. W. Pentreath London Taylor and Francis 1999 XI, 291 S. txt rdacontent n rdamedia nc rdacarrier Neurotoxikologie (DE-588)4457830-1 gnd rswk-swf Neurotoxikologie (DE-588)4457830-1 s DE-604 Pentreath, V. W. edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=019806574&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neurotoxicology in Vitro Neurotoxikologie (DE-588)4457830-1 gnd |
| subject_GND | (DE-588)4457830-1 |
| title | Neurotoxicology in Vitro |
| title_auth | Neurotoxicology in Vitro |
| title_exact_search | Neurotoxicology in Vitro |
| title_full | Neurotoxicology in Vitro ed. by V. W. Pentreath |
| title_fullStr | Neurotoxicology in Vitro ed. by V. W. Pentreath |
| title_full_unstemmed | Neurotoxicology in Vitro ed. by V. W. Pentreath |
| title_short | Neurotoxicology in Vitro |
| title_sort | neurotoxicology in vitro |
| topic | Neurotoxikologie (DE-588)4457830-1 gnd |
| topic_facet | Neurotoxikologie |
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