Antioxidant and redox regulation of genes:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
San Diego [u.a.]
Acad. Press
2000
|
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXIV, 562 S. Ill., graph. Darst. |
| ISBN: | 0126366705 |
Internformat
MARC
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| 245 | 1 | 0 | |a Antioxidant and redox regulation of genes |c ed. by Chandan K. Sen ... |
| 264 | 1 | |a San Diego [u.a.] |b Acad. Press |c 2000 | |
| 300 | |a XXIV, 562 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 700 | 1 | |a Sen, Chandan K. |4 edt | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017289684&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-017289684 | ||
Datensatz im Suchindex
| _version_ | 1804138790386663424 |
|---|---|
| adam_text | Contents
Contributors xv
Foreword xxi
Luc Montagnier
Preface xxiii
I Reactive Species as Intracellular
Messengers
1 Signaling by Singlet Oxygen in
Biological Systems
Lars-Oliver Klotz, Karlis Briviba, and Helmut Sies
I. Singlet Oxygen in Biological Systems 3
II. Effects of Singlet Oxygen on Gene Expression 6
III. Comparison of Effects of Singlet Oxygen and Other
Oxidants on the AP-1 Pathway 7
IV. Induction of Transcription Factors by Singlet
Oxygen: Mechanism 9
References 14
V
i Contents
2 Redox Regulation of Gene Expression
Dana R. Crawford, Toshihide Suzuki,
and Kelvin J. A. Davies
I. Introduction 21
II. Methods of Analysis 22
III. Modulation of Nuclear Gene Expression 24
IV. Modulation of Mitochondrial Gene
Expression 28
V. Stable versus Transient Gene Expression 29
VI. Modes of Regulation 31
VII. Oxidant Stress-Related Pathologies 33
VIII. Concluding Remarks 37
References 39
3 Rac, Superoxide, and Signal Transduction
Hamdy H. Hassanain
and Pascal J. Goldschmidt-Clermont
I. Introduction 48
II. Activation of Rac Proteins 50
III. Rac and Respiratory Burst in Phagocytes 52
IV. Rac in Nonphagocytic Cells 54
V. Rac and ROS Production 57
VI. Rac and the Cytoskeleton 63
VII. Rac Gene in Development 66
VIII. Oxidative Burst in Plants 61
References 69
4 Redox Regulation of Ion Channels
Suneil K. Koliwad, Anna K. Brzezinska, and Stephen J. Elliott
I. Ion Channels 81
II. The Patch Clamp 85
III. Redox Regulation of Ion Channels 87
References 101
Contents vii
5 Cell Ca2+ in Signal Transduction: Modulation in
Oxidative Stress
Julio Giron-Calle and Henry Jay Forman
I. Ca2+ in Signal Transduction and Cell Death 106
II. Lethal Alterations of the Intracellular Ca2+
Concentration: Necrosis, Apoptosis, and
Oxidative Stress 111
III. Modulation of Ca2+ Signaling by Oxidative
Stress 114
IV. Concluding Remarks 122
References 122
6 Induction of Protein Tyrosine Phosphorylation by
Oxidative Stress and Its Implications
Gary L Schieven
I. Introduction 129
II. Tyrosine Phosphorylation Signal
Pathways 130
III. Ionizing Radiation 133
IV. Ultraviolet Radiation 135
V. Chemical Oxidants 136
VI. Dimerization Hypothesis 141
References 142
7 Regulation of Signal Transduction and Gene
Expression by Reactive Nitrogen Species
Ami A. Deora and Harry M. Lander
I. Introduction 147
II. Signal Transduction by Reactive Nitrogen
Species 149
III. Gene Expression by Reactive Nitrogen
Species 163
References 170
Hi Contents
II Redox-Sensitive Molecular Processes
and Cellular Responses
8 Reactive Oxygen Species as Costimulatory
Signals of Cytokine-lnduced NF-kB Activation
Pathways
Patrick A. Baeuerle
I. Functions of Transcription Factor NF-kB 181
II. How TNF and IL-1 Activate NF-kB 184
III. NF-kB Activation by Prooxidant Conditions 187
IV. Inhibitory Effect of Antioxidants and
Redox-Regulating Proteins on NF-kB
Activation by Cytokines 190
V. How Can Antioxidants and Enzymes Affect NF-kB
Activation by Cytokines? 191
VI. Why Should ROS Modulate Proinflammatory
Cytokine Signaling? 195
VII. Conclusion: ROS May Act as Costimulatory
Signals 197
References 198
9 Redox Regulation of NF-kB
Takashi Okamoto, Toshifumi Tetsuka, Sinichi Yoshida,
and Takumi Kawabe
I. Introduction: Transcription Factor NF-kB and Its
Biological Functions 203
II. Involvement of NF-kB in Various Pathologies 205
III. Signal Transduction Pathway to Activate NF-kB 207
IV. Conclusion: Redox Regulation of NF-kB 214
References 215
10 Oxidants and Antioxidants in Apoptosis:
Role of Bcl-2
Chandan K. Sen
I. Introduction 221
II. Induction of Apoptosis by Reactive Oxygen
Species 222
Contents ix
III. Antiapoptotic Properties of Antioxidants 225
IV. Proapoptotic Properties of Antioxidants 228
V. Bcl-2 229
VI. Bcl-2 Functions via an Antioxidant
Mechanism? 231
VII. Summary 236
References 237
11 Role of Reactive Oxygen Species in Tumor
Necrosis Factor Toxicity
Vera Goossens, Kurt De Vos, Dominique Vercammen,
Margino Steemans, Katia Vancompernolle, Walter Fiers,
Peter Vandenabeele, and Johan Grooten
I. Introduction 245
II. Reactive Oxygen Species as Mediators of Cell
Death by TNF 248
III. Concluding Remarks 259
References 260
12 Redox Regulation of Cell Adhesion Processes
Sashwati Roy, Chandan K. Sen, Alexia Gozin, Valerie Andrieu,
and Catherine Pasquier
I. Introduction 266
II. Cell Adhesion Molecules 266
III. Multistep Model of Cell Adhesion 270
IV. Direct Activation of Cell Adhesion Processes by
Reactive Oxygen Species 271
V. Ionizing Radiations and Ultraviolet Radiation 276
VI. Cigarette Smoke, Heavy Metals, and Other
Oxidative Environmental Pollutants 278
VII. Nitric Oxide 278
VIII. Antioxidant Regulation of Agonist-Induced Cell
Adhesion Process 278
IX. Cell Adhesion Processes and Pathologies with
Redox Imbalances 283
References 287
Contents
13 Role of Thioredoxin and Redox Regulation in
Oxidative Stress Response and Signaling
Hiroshi Masutani, Masaya Ueno, Shugo Ueda, and Junji Yodoi
I. Introduction 298
II. Thioredoxin and Related Molecules 298
III. Thioredoxin Induction by Oxidative Stress 299
IV. Cytoprotective Action of Thioredoxin 300
V. Oxidative Stress and Apoptosis 301
VI. Redox Regulation of p53 302
VII. Nuclear Translocation of Thioredoxin and Gene
Regulation 303
VIII. Conclusion 305
References 305
14 Redox Regulation of p21, Role of Reactive
Oxygen and Nitrogen Species in Cell Cycle
Progression
Axel H. Schonthal, Sebastian Mueller, and Enrique Cadenas
I. Introduction 312
II. p21 Expression and Cell Cycle Control 313
III. Induction of p21: p53-Dependent and -Independent
Pathways 316
IV. Role of Free Radicals in the Redox Regulation
ofp21 318
V. Concluding Remarks 330
References 331
III Clinical Implications of Redox
Signaling and Antioxidant Therapy
15 Effects of Lipoxygenases on Gene Expression in
Mammalian Cells
Helena Viita and Seppo Yla-Herttuala
I. Introduction 339
II. Effects of Lipoxygenases on Gene Expression 343
III. Conclusions 352
References 352
Contents Xi
16 a-Tocopherol in the Pathogenesis of
Atherosclerosis: One Molecule, Several Functions
Angelo Azzi
I. Vitamin E as an Antioxidant 360
II. Vitamin E Function at the Level of Protein Kinase C:
Smooth Muscle Cell Proliferation, Monocyte
Adhesion, Thrombocyte Aggregation and Adhesion,
and Neutrophil Activation 363
III. Consumption of Vitamin E and the Development
of Atherosclerotic Modifications of the
Arterial Wall 365
IV. Other Nonantioxidant Properties or Effects of
Vitamin E 374
References 374
17 Peroxiredoxins in Cell Signaling and HIV Infection
Dong-Yan Jin and Kaun-Teh Jeang
I. Peroxiredoxins: A Large Family of Antioxidant
Enzymes 382
II. Peroxiredoxins: Structure and Function 391
III. Peroxiredoxins in Cell Signaling 394
IV. Peroxiredoxins in HIV Infection 399
V. Future Directions 400
References 401
18 Enhanced Activity of an Oxidation Product of
Lycopene Found in Tomato Products and Human
Serum Relevant to Cancer Prevention
John S. Bertram, Timothy King, Laurie Fukishima,
and Frederick Khachik
I. Introduction 410
II. Materials and Methods 411
III. Results 413
IV. Discussion 419
References 421
i Contents
19 Antioxidant Genes and Reactive Oxygen Species
in Down s Syndrome
Cecile Bladier, Judy B. de Haan, and Ismail Kola
I. Introduction 425
II. Premature Aging 427
III. Alzheimer s Disease 432
IV. Other Neuropathologies 435
V. Immunological Deficiency 436
VI. Inflammation 437
VII. Other Antioxidant Genes or Genes Regulated by an
Altered Redox State on Chromosome 21 440
VIII. Conclusion 441
References 443
20 Oxidant-Mediated Repression of Mitochondrial
DNA Transcription
Bruce S. Kristal and Byung P. Yu
I. Introduction 452
II. Mitochondrial Genome 453
III. mtDNA Expression and Replication 454
IV. Mitochondria-Oxidant Interactions 457
V. Oxidant-Mediated Repression of mtDNA
Transcription 458
VI. Summary 471
References 472
21 Suppression of Insulin Gene Promoter Activity by
Oxidative Stress
Yoshitaka Kajimoto, Yoshimitsu Yamasaki, Taka-aki Matsuoka,
Hideaki Kaneto, and Masatsugu Hori
I. Introduction 479
II. Chronic Hyperglycemia Induces Glycation Reaction
in Pancreatic /3 Cells 482
III. Cis- and Trans-Acting Factors Regulating Insulin
Gene Transcription 482
Contents xiii
IV. Sensitivity of Insulin Gene Promoter to Glycation
and Oxidative Stress 484
V. Glycation Reduces Insulin mRNA Amount and
Insulin Content 485
VI. Glycation-Dependent Reduction of DNA-Binding
Activity of PDX-1 486
VII. Conclusions 488
References 488
22 Redox Regulation of Ischemic Adaptation
Nilanjana Maulik and Dipak K. Das
I. Introduction 492
II. Redox Regulation of Ischemia-Reperfusion 493
III. Redox Regulation of Ischemic
Adaptation 496
IV. Activation of Multiple Transcription
Factors 503
V. Programed Cell Death in
Ischemia-Reperfusion 505
VI. Ischemic Adaptation and Apoptosis 507
VII. Summary and Conclusion 508
References 511
23 Oxidative Stress as a Governing Factor in
Physiological Aging
William C. On and Rajindar S. Sohal
I. Introduction 517
II. Reformulation of the Oxidative Stress Hypothesis of
Aging 518
III. Genetic Manipulations to Attenuate Oxidative
Damage 519
IV. Factors Affecting the Generation of Reactive Oxygen
Species 523
V. What Are the Targets of Oxidative Stress? 524
VI. Concluding Remarks 527
References 527
V Contents
24 Antioxidants in Senescence and Wasting
Wulf Droge, Volker Hack, Raoul Breitkreutz, Eggert Holm,
Stefanie Holm, and Rail Kinscherf
I. Introduction: Loss of Skeletal Muscle Mass and
Muscle Function as a Correlate of Senescence and
Wasting 531
II. Redox State as a Target for Therapeutic
Intervention 532
III. What Determines the Plasma Cystine Level? 539
IV. Diseases and Conditions Associated with Relatively
Low Plasma Cystine Levels (Low CG
Syndrome) 545
V. Plasma Glutamate and Intracellular Glutathione
Levels 549
VI. Summary and Conclusions 549
References 551
Index 557
|
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