The subthalamic nucleus: 2 Modelling and simulation of activity
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2008
|
| Series: | Advances in anatomy, embryology and cell biology
199 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XIV, 88 S. Ill., graph. Darst. |
| ISBN: | 9783540794615 |
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MARC
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| 245 | 1 | 0 | |a The subthalamic nucleus |n 2 |p Modelling and simulation of activity |c Enrico Marani ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a XIV, 88 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in anatomy, embryology and cell biology |v 199 | |
| 490 | 0 | |a Advances in anatomy, embryology and cell biology |v ... | |
| 650 | 4 | |a Basal Ganglia |x anatomy & histology | |
| 650 | 4 | |a Basal ganglia | |
| 650 | 4 | |a Models, Neurological | |
| 650 | 4 | |a Neural networks (Neurobiology) | |
| 650 | 4 | |a Subthalamic Nucleus |x anatomy & histology | |
| 650 | 4 | |a Subthalamus | |
| 650 | 4 | |a Subthalamus |x Cytology | |
| 700 | 1 | |a Marani, Enrico |d 1946- |e Sonstige |0 (DE-588)110852990 |4 oth | |
| 700 | 1 | |a Heida, Tjitske |e Sonstige |4 oth | |
| 700 | 1 | |a Usunov, Kamen G. |e Sonstige |4 oth | |
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| 830 | 0 | |a Advances in anatomy, embryology and cell biology |v 199 |w (DE-604)BV002528506 |9 199 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-016607961 | ||
Record in the Search Index
| _version_ | 1804137820344811520 |
|---|---|
| adam_text | List of
Contents
1
Introduction
........................................................ 1
2
The Basal Ganglia
................................................... 1
2.1
Pathways Within the Basal Ganglia
..................................... 2
2.1.1
Direct Pathway
...................................................... 2
2.1.2
Indirect Pathway
.................................................... 2
2.1.3
Hyperdirect Pathway
................................................. 4
2.1.4
Role of the Direct, Indirect, and Hyperdirect Pathways
.................... 4
2.1.5
Role of Dopamine in the Direct arid Indirect Pathways
.................... 6
2.1.6
Conduction Times of Pathways
........................................ 6
2.2
Parkinson s Disease
.................................................. 6
2.2.1
Direct and Indirect Pathways in PD
.................................... 7
2.2.2
Changes in
Neuronal
Firing Rate in PD
................................. 8
2.2.3
Changes in
Neuronal
Firing Pattern in PD
............................... 9
2.3
Deep Brain Stimulation
............................................... 9
2.3.1
Which
Neuronal
Elements Are Influenced by DBS?
....................... 11
2.3.2
Mechanisms of DBS: Hypotheses
...................................... 11
3
STN Activity Recorded in Vitro: Brain Slices
............................ 14
3.1
Spontaneous Activity
................................................. 15
3.1.1
Single-Spike Mode
................................................... 15
3.1.2
Burst-Firing Mode
................................................... 17
3.2
Depolarizing and Hyperpolarizing Inputs
............................... 19
3.2.1
Plateau Potential
..................................................... 21
3.2.2
Low-Threshold Spike
................................................. 22
3.3
Ionic Mechanisms of a Plateau Potential
................................ 23
3.4
Synaptic Inputs
...................................................... 25
3.5
High-Frequency Stimulation of STN Cells
............................... 26
3.6
Intrinsic Versus Extrinsic Properties: Bursts
............................. 27
3.6.1
Definition of Bursts
.................................................. 27
3.6.2
Burst Detection Algorithms
........................................... 28
3.6.3
Network Bursts Using Burst and Phase Profiles
.......................... 30
4
STN Activity Recorded in Vitro: Dissociated Cell Cultures
................ 31
4.1
Experimental Set-up
................................................. 31
4.1.1
Cell Culture
......................................................... 33
4.1.2
Measurement Set-up
................................................. 33
4.2
Spontaneous Activity
................................................. 33
List of Contents
4.3
Addition of Acetylcholine
............................................. 35
4.4
Electrical Stimulation
................................................ 37
5
STN Cell Models and Simulation of
Neuronal
Networks
.................. 40
5.1
Otsuka s Model
...................................................... 40
5.1.1
Membrane Dynamics
................................................ 41
5.1.2
Spontaneous Activity
................................................. 43
5.1.3
Plateau Potential Generation
.......................................... 45
5.2
Termán
and Rubin s Model
............................................ 52
5.2.1
Membrane Dynamics
................................................ 52
5.2.2
Spontaneous Activity
................................................. 53
5.2.3
Rebound Bursts
..................................................... 56
5.3
Comparison of the Otsuka Model with the Terman/Rubin Model
........... 58
5.4
The Multi-compartment STN Model of Gillies and
Willshaw............... 63
5.4.1
Membrane Dynamics
................................................ 63
5.4.2
Activity Patterns
..................................................... 64
5.5
Intra-nudear Network Models
......................................... 66
5.6
Inter-nuclear Network Models
......................................... 67
5.6.1
GPe-STN Network
................................................... 67
5.6.2
GPe-STN-GPi-Thalamus Network
...................................... 71
6
Comparison of Part I and Part II
...................................... 75
6.1
Recurrent STN
Axons
................................................ 75
6.2
Inter-neurons in the STN
............................................. 75
6.3
Fibre Tracts around and in the STN
.................................... 75
6.4
Ca2+ Receptors
...................................................... 76
6.5
Three-Dimensional Modelling
......................................... 76
6.6
Types of Projection Neurons
.......................................... 76
6.7
Neurotransmitter
Input Versus Receptors in the STN
..................... 77
6.8
The Pedunculopontine Nucleus
........................................ 77
6.9
Nigro-subthalamic Connections
....................................... 77
6.10
Another Cortico-subthalamic Loop
.................................... 78
6.11
Nissl-Based Subdivision of the STN
.................................... 78
Appendix
1
Model Parameter Values Otsuka
et al.
2004......................... 78
Appendix
2
Model Parameter Values
Termán
et al.
2002;
Rubin
and
Termán
(2004)............................................. 79
References
................................................................. 81
Index
......................................................................... 87
|
| adam_txt |
List of
Contents
1
Introduction
. 1
2
The Basal Ganglia
. 1
2.1
Pathways Within the Basal Ganglia
. 2
2.1.1
Direct Pathway
. 2
2.1.2
Indirect Pathway
. 2
2.1.3
Hyperdirect Pathway
. 4
2.1.4
Role of the Direct, Indirect, and Hyperdirect Pathways
. 4
2.1.5
Role of Dopamine in the Direct arid Indirect Pathways
. 6
2.1.6
Conduction Times of Pathways
. 6
2.2
Parkinson's Disease
. 6
2.2.1
Direct and Indirect Pathways in PD
. 7
2.2.2
Changes in
Neuronal
Firing Rate in PD
. 8
2.2.3
Changes in
Neuronal
Firing Pattern in PD
. 9
2.3
Deep Brain Stimulation
. 9
2.3.1
Which
Neuronal
Elements Are Influenced by DBS?
. 11
2.3.2
Mechanisms of DBS: Hypotheses
. 11
3
STN Activity Recorded in Vitro: Brain Slices
. 14
3.1
Spontaneous Activity
. 15
3.1.1
Single-Spike Mode
. 15
3.1.2
Burst-Firing Mode
. 17
3.2
Depolarizing and Hyperpolarizing Inputs
. 19
3.2.1
Plateau Potential
. 21
3.2.2
Low-Threshold Spike
. 22
3.3
Ionic Mechanisms of a Plateau Potential
. 23
3.4
Synaptic Inputs
. 25
3.5
High-Frequency Stimulation of STN Cells
. 26
3.6
Intrinsic Versus Extrinsic Properties: Bursts
. 27
3.6.1
Definition of Bursts
. 27
3.6.2
Burst Detection Algorithms
. 28
3.6.3
Network Bursts Using Burst and Phase Profiles
. 30
4
STN Activity Recorded in Vitro: Dissociated Cell Cultures
. 31
4.1
Experimental Set-up
. 31
4.1.1
Cell Culture
. 33
4.1.2
Measurement Set-up
. 33
4.2
Spontaneous Activity
. 33
List of Contents
4.3
Addition of Acetylcholine
. 35
4.4
Electrical Stimulation
. 37
5
STN Cell Models and Simulation of
Neuronal
Networks
. 40
5.1
Otsuka's Model
. 40
5.1.1
Membrane Dynamics
. 41
5.1.2
Spontaneous Activity
. 43
5.1.3
Plateau Potential Generation
. 45
5.2
Termán
and Rubin's Model
. 52
5.2.1
Membrane Dynamics
. 52
5.2.2
Spontaneous Activity
. 53
5.2.3
Rebound Bursts
. 56
5.3
Comparison of the Otsuka Model with the Terman/Rubin Model
. 58
5.4
The Multi-compartment STN Model of Gillies and
Willshaw. 63
5.4.1
Membrane Dynamics
. 63
5.4.2
Activity Patterns
. 64
5.5
Intra-nudear Network Models
. 66
5.6
Inter-nuclear Network Models
. 67
5.6.1
GPe-STN Network
. 67
5.6.2
GPe-STN-GPi-Thalamus Network
. 71
6
Comparison of Part I and Part II
. 75
6.1
Recurrent STN
Axons
. 75
6.2
Inter-neurons in the STN
. 75
6.3
Fibre Tracts around and in the STN
. 75
6.4
Ca2+ Receptors
. 76
6.5
Three-Dimensional Modelling
. 76
6.6
Types of Projection Neurons
. 76
6.7
Neurotransmitter
Input Versus Receptors in the STN
. 77
6.8
The Pedunculopontine Nucleus
. 77
6.9
Nigro-subthalamic Connections
. 77
6.10
Another Cortico-subthalamic Loop
. 78
6.11
Nissl-Based Subdivision of the STN
. 78
Appendix
1
Model Parameter Values Otsuka
et al.
2004. 78
Appendix
2
Model Parameter Values
Termán
et al.
2002;
Rubin
and
Termán
(2004). 79
References
. 81
Index
. 87 |
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| index_date | 2024-07-02T21:32:42Z |
| indexdate | 2024-07-09T21:18:22Z |
| institution | BVB |
| isbn | 9783540794615 |
| language | English |
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| physical | XIV, 88 S. Ill., graph. Darst. |
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| series | Advances in anatomy, embryology and cell biology |
| series2 | Advances in anatomy, embryology and cell biology |
| spelling | The subthalamic nucleus 2 Modelling and simulation of activity Enrico Marani ... Berlin [u.a.] Springer 2008 XIV, 88 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in anatomy, embryology and cell biology 199 Advances in anatomy, embryology and cell biology ... Basal Ganglia anatomy & histology Basal ganglia Models, Neurological Neural networks (Neurobiology) Subthalamic Nucleus anatomy & histology Subthalamus Subthalamus Cytology Marani, Enrico 1946- Sonstige (DE-588)110852990 oth Heida, Tjitske Sonstige oth Usunov, Kamen G. Sonstige oth (DE-604)BV023425551 2 Advances in anatomy, embryology and cell biology 199 (DE-604)BV002528506 199 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016607961&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The subthalamic nucleus Advances in anatomy, embryology and cell biology Basal Ganglia anatomy & histology Basal ganglia Models, Neurological Neural networks (Neurobiology) Subthalamic Nucleus anatomy & histology Subthalamus Subthalamus Cytology |
| title | The subthalamic nucleus |
| title_auth | The subthalamic nucleus |
| title_exact_search | The subthalamic nucleus |
| title_exact_search_txtP | The subthalamic nucleus |
| title_full | The subthalamic nucleus 2 Modelling and simulation of activity Enrico Marani ... |
| title_fullStr | The subthalamic nucleus 2 Modelling and simulation of activity Enrico Marani ... |
| title_full_unstemmed | The subthalamic nucleus 2 Modelling and simulation of activity Enrico Marani ... |
| title_short | The subthalamic nucleus |
| title_sort | the subthalamic nucleus modelling and simulation of activity |
| topic | Basal Ganglia anatomy & histology Basal ganglia Models, Neurological Neural networks (Neurobiology) Subthalamic Nucleus anatomy & histology Subthalamus Subthalamus Cytology |
| topic_facet | Basal Ganglia anatomy & histology Basal ganglia Models, Neurological Neural networks (Neurobiology) Subthalamic Nucleus anatomy & histology Subthalamus Subthalamus Cytology |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016607961&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV023425551 (DE-604)BV002528506 |
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