A handbook of mouse models of cardiovascular disease:
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| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Chichester
Wiley
2006
|
| Subjects: | |
| Online Access: | Table of contents only Publisher description Contributor biographical information Inhaltsverzeichnis |
| Physical Description: | XVI, 387 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| ISBN: | 9780470016107 0470016108 |
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Record in the Search Index
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| adam_text | Contents
Preface xi
List of Contributors xiii
1 Mice - general information 1
Hermann Dietrich
Historical perspective of house mice as laboratory animals 1
Maintaining and breeding of mice 3
Mouse genetics 5
Blood and bone marrow collection methods 7
Anesthesia and analgesia 7
Euthanasia 14
References 14
2 Naturally occurring variation among mouse strains 19
Weibin Shi and Aldons J. Lusis
Introduction 19
Mapping genes underlying quantitative traits 20
Dissecting QTLs using congenic strains 22
Testing candidate genes in QTL regions 24
Functional tests of candidate genes 26
From mouse to man 28
References 28
3 Transgenic and gene-targeted mice in the study of hyperlipidemia 33
Yadong Huang
Introduction 33
Generation of transgenic mouse models 34
Generation of gene-targeted mouse models 36
Application of transgenic and gene-targeted mouse models
in hyperlipidemia research 38
Acknowledgments 39
References 40
4 Bone marrow transplantation: the methodology and its
application in atherosclerosis research 43
Menno P.J. de Winther and Marten H Hofker
Introduction 43
Methods 45
v . CONTENTS
Discussion and application 48
Conclusions 50
References 5j
5 Hyperlipidemia-induced atherosclerosis 53
Alan Dougherty and Debra L. Rateri
Introduction 53
Induction of hyperlipidemia in mice 54
Mouse strain 56
Environmental factors 57
Gender 57
Analysis of atherosclerotic lesions 57
Determination of lesion composition 62
Statistical analysis 63
Conclusions 64
Acknowledgments 64
References 64
6 Magnetic resonance imaging evaluation
of atherosclerotic plaque 67
Martina A. McAteer, Jiirgen E. Schneider and Robin P. Choudhury
Introduction 67
Imaging atherosclerosis with MRI 68
Mouse MRI 68
Materials and methods 69
Discussion 75
Application 76
Acknowledgments 76
References 76
7 Plaque rupture 79
Christopher L. Jackson
Introduction 79
Animals 79
Husbandry and welfare °*
Termination 81
Tissue processing °2
Morphological analysis
Morphometric analysis °*
Study design considerations
Summary
Acknowledgment °
References 86
8 Perivascular cuff-, electronic and chemical injury-induced
QQ
stenosis °7
Nuno MM. Pires, Margreet R. de Vries, Abbey Schepers,
Daniel Eefting, Jan-Willem H.P. Lardenoye and Paul H.A. Quax
Introduction °
Materials and methods ^
Discussion
CONTENTS vii
Application 94
References 100
9 Flow-induced vascular remodeling 103
Vyacheslav A. Korshunov and Bradford C. Berk
Introduction 103
Materials and methods 104
Discussion 107
Applications 108
References 110
Movie legends 111
10 Vein graft atherosclerosis 113
Yanhua Hu and Qingbo Xu
Introduction 113
Materials and methods 114
Discussion 119
Applications 120
Acknowledgments 122
References 122
11 Angiotensin H-induced aortic aneurysms 125
Yi-Xin Wang, Lisa A. Cassis and Alan Dougherty
Introduction 125
Methods 126
Discussion 133
Acknowledgments 133
References 134
12 Carotidojugular fistula 137
Yves Castier, Alain Tedgui and Stephanie Lehoux
Introduction 137
Creation of the AVF 138
Hemodynamic and structural data 142
References 144
13 Applications to the study of stroke 147
Jacques Seylaz and Elisabeth Pinard
Introduction 147
Experimental preparation of mice 148
Methods 153
Applications 155
References 157
14 Identifying congenital heart defects in embryos using
high-resolution magnetic resonance imaging 159
Jtirgen E Schneider and Shoumo Bhattacharya
Introduction 159
Identifying mouse cardiac malformations 160
Magnetic resonance imaging 160
viii CONTENTS
Embryo MRI technique and analysis 161
Discussion 166
Applications 166
Pros and cons of ex vivo MRI 169
Acknowledgments 169
References 170
15 Allograft arteriopathy: heterotopic heart transplantation
and aortic interposition grafts 173
Koichi Shimizu and Richard N. Mitchell
Introduction 173
Murine models for A A 175
Murine heterotopic cardiac transplantation 177
Murine aortic interposition grafts 183
Translation to clinical investigation 187
References 189
16 Heart preconditioning analysis 193
Guang-Wu Wang, David A Liem, Steven Le and Peipei Ping
Introduction 193
Methods 194
Methodological considerations 198
References 200
17 Myocardial ischemia-reperfusion 203
Bernhard Metzler, Elisabetta Conci and Otmar Pachinger
Myocardial ischemia-reperfusion 203
Ischemia-reperfusion models 206
Measurement of infarction size 210
Electrocardiogram and in vivo left ventricular pressure-volume measurements 214
Different mouse types 215
Conclusion 217
References 217
18 Cardiac hypertrophy 221
David J. Grieve, Alison C. Cave and A jay M. Shah
Introduction 221
Materials and methods 222
Summary 231
Acknowledgments 231
References 231
19 The retrogradely perfused isolated heart model 235
Mihaela M. Mocanu and Derek M. Yellon
Introduction 235
Langendorff system 235
Preparation of hearts for perfusion 237
Experimental protocol 241
CONTENTS ix
Measurement of infarct size 242
Infarct size computation 243
General comments 244
Acknowledgments 244
References 244
20 Measurement of pulse wave velocity 245
Yi-Xin Wang
Introduction 245
Materials and methods 246
Discussion 249
Application 251
References 252
21 Gene transfer to dyslipidemic mice 255
Kazuhiro Oka, Andrew H. Baker and Lawrence Chan
Introduction 255
Mouse models of dyslipidemia 256
ApoB transgenic mice 263
Vectors for liver-directed gene transfer 263
Route or vector delivery 267
Conclusion 268
Acknowledgments 269
References 269
22 Hypertension 273
Daiana Weiss and W. Robert Taylor
Introduction 273
Pharmacological models of hypertension 275
Renal models of hypertension 278
Genetic models of hypertension 279
Measurement of blood pressure in mice 282
Summary 282
References 283
23 Ischemia-induced neovascularisation 287
Ken-ichiro Sasaki, Christopher Heeschen, Alexandra Aicher and
Stefanie Dimmeler
Introduction 287
Materials and methods 288
Discussion 296
Application 296
References 297
24 Angiogenesis in biomatrices and artificial materials 299
Pieter Koolwijk and Victor W.M. van Hinsburgh
Introduction 299
Materials and methods 300
Discussion 305
x CONTENTS
Application 307
Acknowledgments 308
References 308
25 Venous thrombosis 311
Alberto Smith, James Gossage, Matthew Waltham,
Bijan Modarai and Julie Humphries
Background 311
Models of thrombosis 313
The St Thomas model 314
References 319
26 Virus-induced vasculitis 321
Philippe Krebs and Burkhard Ludewig
Introduction 321
Materials and methods 322
Discussion 329
Application 329
References 330
27 Surgically induced chronic heart failure 333
Craig A. Lygate and Stefan Neubauer
Introduction 333
Materials and methods 336
Discussion 340
Applications 346
Conclusions 346
References 347
28 Cardiac electrophysiology 349
Sander Verheule, Toshiaki Sato and Jeffrey E. Olgin
Introduction 349
Anesthesia for adult mice 350
ECG recording and analysis 351
Transesophageal stimulation 352
Open chest epicardial measurements 354
Studies on Langendorff perfused hearts 357
Conclusion 360
References 361
29 Ligation- and wire injury-induced stenosis 363
Volkhard Lindner
Introduction 363
Materials and methods 364
Discussion 367
Acknowledgments 370
References 370
Index 373
|
| adam_txt |
Contents
Preface xi
List of Contributors xiii
1 Mice - general information 1
Hermann Dietrich
Historical perspective of house mice as laboratory animals 1
Maintaining and breeding of mice 3
Mouse genetics 5
Blood and bone marrow collection methods 7
Anesthesia and analgesia 7
Euthanasia 14
References 14
2 Naturally occurring variation among mouse strains 19
Weibin Shi and Aldons J. Lusis
Introduction 19
Mapping genes underlying quantitative traits 20
Dissecting QTLs using congenic strains 22
Testing candidate genes in QTL regions 24
Functional tests of candidate genes 26
From mouse to man 28
References 28
3 Transgenic and gene-targeted mice in the study of hyperlipidemia 33
Yadong Huang
Introduction 33
Generation of transgenic mouse models 34
Generation of gene-targeted mouse models 36
Application of transgenic and gene-targeted mouse models
in hyperlipidemia research 38
Acknowledgments 39
References 40
4 Bone marrow transplantation: the methodology and its
application in atherosclerosis research 43
Menno P.J. de Winther and Marten H Hofker
Introduction 43
Methods 45
v . CONTENTS
Discussion and application 48
Conclusions 50
References 5j
5 Hyperlipidemia-induced atherosclerosis 53
Alan Dougherty and Debra L. Rateri
Introduction 53
Induction of hyperlipidemia in mice 54
Mouse strain 56
Environmental factors 57
Gender 57
Analysis of atherosclerotic lesions 57
Determination of lesion composition 62
Statistical analysis 63
Conclusions 64
Acknowledgments 64
References 64
6 Magnetic resonance imaging evaluation
of atherosclerotic plaque 67
Martina A. McAteer, Jiirgen E. Schneider and Robin P. Choudhury
Introduction 67
Imaging atherosclerosis with MRI 68
Mouse MRI 68
Materials and methods 69
Discussion 75
Application 76
Acknowledgments 76
References 76
7 Plaque rupture 79
Christopher L. Jackson
Introduction 79
Animals 79
Husbandry and welfare °*
Termination 81
Tissue processing °2
Morphological analysis "
Morphometric analysis °*
Study design considerations "
Summary "
Acknowledgment "°
References 86
8 Perivascular cuff-, electronic and chemical injury-induced
QQ
stenosis °7
Nuno MM. Pires, Margreet R. de Vries, Abbey Schepers,
Daniel Eefting, Jan-Willem H.P. Lardenoye and Paul H.A. Quax
Introduction °
Materials and methods "^
Discussion
CONTENTS vii
Application 94
References 100
9 Flow-induced vascular remodeling 103
Vyacheslav A. Korshunov and Bradford C. Berk
Introduction 103
Materials and methods 104
Discussion 107
Applications 108
References 110
Movie legends 111
10 Vein graft atherosclerosis 113
Yanhua Hu and Qingbo Xu
Introduction 113
Materials and methods 114
Discussion 119
Applications 120
Acknowledgments 122
References 122
11 Angiotensin H-induced aortic aneurysms 125
Yi-Xin Wang, Lisa A. Cassis and Alan Dougherty
Introduction 125
Methods 126
Discussion 133
Acknowledgments 133
References 134
12 Carotidojugular fistula 137
Yves Castier, Alain Tedgui and Stephanie Lehoux
Introduction 137
Creation of the AVF 138
Hemodynamic and structural data 142
References 144
13 Applications to the study of stroke 147
Jacques Seylaz and Elisabeth Pinard
Introduction 147
Experimental preparation of mice 148
Methods 153
Applications 155
References 157
14 Identifying congenital heart defects in embryos using
high-resolution magnetic resonance imaging 159
Jtirgen E Schneider and Shoumo Bhattacharya
Introduction 159
Identifying mouse cardiac malformations 160
Magnetic resonance imaging 160
viii CONTENTS
Embryo MRI technique and analysis 161
Discussion 166
Applications 166
Pros and cons of ex vivo MRI 169
Acknowledgments 169
References 170
15 Allograft arteriopathy: heterotopic heart transplantation
and aortic interposition grafts 173
Koichi Shimizu and Richard N. Mitchell
Introduction 173
Murine models for A A 175
Murine heterotopic cardiac transplantation 177
Murine aortic interposition grafts 183
Translation to clinical investigation 187
References 189
16 Heart preconditioning analysis 193
Guang-Wu Wang, David A Liem, Steven Le and Peipei Ping
Introduction 193
Methods 194
Methodological considerations 198
References 200
17 Myocardial ischemia-reperfusion 203
Bernhard Metzler, Elisabetta Conci and Otmar Pachinger
Myocardial ischemia-reperfusion 203
Ischemia-reperfusion models 206
Measurement of infarction size 210
Electrocardiogram and in vivo left ventricular pressure-volume measurements 214
Different mouse types 215
Conclusion 217
References 217
18 Cardiac hypertrophy 221
David J. Grieve, Alison C. Cave and A jay M. Shah
Introduction 221
Materials and methods 222
Summary 231
Acknowledgments 231
References 231
19 The retrogradely perfused isolated heart model 235
Mihaela M. Mocanu and Derek M. Yellon
Introduction 235
Langendorff system 235
Preparation of hearts for perfusion 237
Experimental protocol 241
CONTENTS ix
Measurement of infarct size 242
Infarct size computation 243
General comments 244
Acknowledgments 244
References 244
20 Measurement of pulse wave velocity 245
Yi-Xin Wang
Introduction 245
Materials and methods 246
Discussion 249
Application 251
References 252
21 Gene transfer to dyslipidemic mice 255
Kazuhiro Oka, Andrew H. Baker and Lawrence Chan
Introduction 255
Mouse models of dyslipidemia 256
ApoB transgenic mice 263
Vectors for liver-directed gene transfer 263
Route or vector delivery 267
Conclusion 268
Acknowledgments 269
References 269
22 Hypertension 273
Daiana Weiss and W. Robert Taylor
Introduction 273
Pharmacological models of hypertension 275
Renal models of hypertension 278
Genetic models of hypertension 279
Measurement of blood pressure in mice 282
Summary 282
References 283
23 Ischemia-induced neovascularisation 287
Ken-ichiro Sasaki, Christopher Heeschen, Alexandra Aicher and
Stefanie Dimmeler
Introduction 287
Materials and methods 288
Discussion 296
Application 296
References 297
24 Angiogenesis in biomatrices and artificial materials 299
Pieter Koolwijk and Victor W.M. van Hinsburgh
Introduction 299
Materials and methods 300
Discussion 305
x CONTENTS
Application 307
Acknowledgments 308
References 308
25 Venous thrombosis 311
Alberto Smith, James Gossage, Matthew Waltham,
Bijan Modarai and Julie Humphries
Background 311
Models of thrombosis 313
The St Thomas' model 314
References 319
26 Virus-induced vasculitis 321
Philippe Krebs and Burkhard Ludewig
Introduction 321
Materials and methods 322
Discussion 329
Application 329
References 330
27 Surgically induced chronic heart failure 333
Craig A. Lygate and Stefan Neubauer
Introduction 333
Materials and methods 336
Discussion 340
Applications 346
Conclusions 346
References 347
28 Cardiac electrophysiology 349
Sander Verheule, Toshiaki Sato and Jeffrey E. Olgin
Introduction 349
Anesthesia for adult mice 350
ECG recording and analysis 351
Transesophageal stimulation 352
Open chest epicardial measurements 354
Studies on Langendorff perfused hearts 357
Conclusion 360
References 361
29 Ligation- and wire injury-induced stenosis 363
Volkhard Lindner
Introduction 363
Materials and methods 364
Discussion 367
Acknowledgments 370
References 370
Index 373 |
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| index_date | 2024-07-02T21:23:44Z |
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| isbn | 9780470016107 0470016108 |
| language | English |
| lccn | 2006016185 |
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| spelling | A handbook of mouse models of cardiovascular disease ed.: Qingbo Xu Chichester Wiley 2006 XVI, 387 S. Ill., graph. Darst. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Tiermodell (DE-588)4140660-6 gnd rswk-swf Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd rswk-swf Kardiovaskuläre Krankheit (DE-588)4024666-8 s Tiermodell (DE-588)4140660-6 s b DE-604 Xu, Qingbo Sonstige oth http://www.loc.gov/catdir/toc/ecip0614/2006016185.html Table of contents only http://www.loc.gov/catdir/enhancements/fy0648/2006016185-d.html Publisher description http://www.loc.gov/catdir/enhancements/fy0740/2006016185-b.html Contributor biographical information HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016583715&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | A handbook of mouse models of cardiovascular disease Tiermodell (DE-588)4140660-6 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4024666-8 |
| title | A handbook of mouse models of cardiovascular disease |
| title_auth | A handbook of mouse models of cardiovascular disease |
| title_exact_search | A handbook of mouse models of cardiovascular disease |
| title_exact_search_txtP | A handbook of mouse models of cardiovascular disease |
| title_full | A handbook of mouse models of cardiovascular disease ed.: Qingbo Xu |
| title_fullStr | A handbook of mouse models of cardiovascular disease ed.: Qingbo Xu |
| title_full_unstemmed | A handbook of mouse models of cardiovascular disease ed.: Qingbo Xu |
| title_short | A handbook of mouse models of cardiovascular disease |
| title_sort | a handbook of mouse models of cardiovascular disease |
| topic | Tiermodell (DE-588)4140660-6 gnd Kardiovaskuläre Krankheit (DE-588)4024666-8 gnd |
| topic_facet | Tiermodell Kardiovaskuläre Krankheit |
| url | http://www.loc.gov/catdir/toc/ecip0614/2006016185.html http://www.loc.gov/catdir/enhancements/fy0648/2006016185-d.html http://www.loc.gov/catdir/enhancements/fy0740/2006016185-b.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016583715&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT xuqingbo ahandbookofmousemodelsofcardiovasculardisease |