Stress-activated protein kinases: with 12 tables
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2008
|
| Series: | Topics in current genetics
20 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XVIII, 312 S. graph. Darst. 24 cm |
| ISBN: | 9783540755685 3540755683 |
Staff View
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV023378955 | ||
| 003 | DE-604 | ||
| 005 | 20100624 | ||
| 007 | t | ||
| 008 | 080704s2008 gw d||| |||| 00||| eng d | ||
| 015 | |a 08,N05,1247 |2 dnb | ||
| 015 | |a 08,A19,1194 |2 dnb | ||
| 016 | 7 | |a 987106791 |2 DE-101 | |
| 020 | |a 9783540755685 |c Pp. : EUR 171.15 (freier Pr.), sfr 278.50 (freier Pr.) |9 978-3-540-75568-5 | ||
| 020 | |a 3540755683 |c Pp. : EUR 171.15 (freier Pr.), sfr 278.50 (freier Pr.) |9 3-540-75568-3 | ||
| 035 | |a (OCoLC)227008228 | ||
| 035 | |a (DE-599)DNB987106791 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 044 | |a gw |c XA-DE-BE | ||
| 049 | |a DE-355 |a DE-11 | ||
| 082 | 0 | |a 571.74 |2 22/ger | |
| 082 | 0 | |a 572.792 |2 22/ger | |
| 084 | |a WD 5060 |0 (DE-625)148187: |2 rvk | ||
| 084 | |a 570 |2 sdnb | ||
| 245 | 1 | 0 | |a Stress-activated protein kinases |b with 12 tables |c Francesc Posas ...(eds.) |
| 246 | 1 | 3 | |a Stress activated protein kinases |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a XVIII, 312 S. |b graph. Darst. |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Topics in current genetics |v 20 | |
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Stressreaktion |0 (DE-588)4138565-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Proteinkinasen |0 (DE-588)4175996-5 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Proteinkinasen |0 (DE-588)4175996-5 |D s |
| 689 | 0 | 1 | |a Stressreaktion |0 (DE-588)4138565-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Posas, Francesc |4 edt | |
| 830 | 0 | |a Topics in current genetics |v 20 |w (DE-604)BV035420113 |9 20 | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016562089&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016562089 | ||
Record in the Search Index
| _version_ | 1804137750570467328 |
|---|---|
| adam_text | Titel: Stress activated protein kinases
Autor: Posas, Francesc
Jahr: 2008
Table of contents
MAPK kinase kinase regulation of SAPK/JNK pathways 1
Lisa Stalheim and Gary L. Johnson 1
Abstract 1
1 Introduction 1
2 Organization of the MKKK-MKK4/7-JNK1/2/3 signaling module 3
3 MKKKs as signaling hubs controlling JNK activation 4
3.1 MLKs (mixed lineage kinases) 5
3.2 MEKKs (MAPK-ERK kinase kinases) 5
3.3 ASK1 (apoptosis signal-regulating kinase 1) 6
3.4 TAK1 (JGFP-activated kinase 1) 6
3.5 TAO1 (thousand and one-amino acid kinase 1) 6
4 Insight into the function of MKKKs regulating the JNK pathway from
targeted gene knockouts 7
4.1MEKK1 7
4.2MEKK2 8
4.3MEKK4 9
4.4ASK1 9
4.5TAK1 10
4.6MLK3 10
5 Conclusions 10
References 11
Alternative p38 MAPK pathways 17
Francisco Inesta-Vaquera, Guadalupe Sabio, Yvonne Kuma,
and AnaCuenda 17
Abstract 17
1 Introduction 17
2 The p38y and p385 MAPK pathways 19
2. Ip38y and p388 substrates 20
3 Biological roles of p38y and p388 MAPK pathways 21
3.1 Cell cycle and cellular transformation 21
3.2 Cellular differentiation 22
3.3 Cytoskeletal organization 24
4 More alternative p38MAPK pathways? 25
5 Concluding remarks 25
Acknowledgments 26
References 26
VIII Table of contents
The regulation of stress-activated MAP kinase signalling by protein
phosphatases 33
Stephen M. Keyse 33
Abstract 33
1 Introduction 33
2 Regulation of stress-activated MAPKs by protein phosphatases in S.
cerevisiae 34
3 Regulation of JNK andp38 MAPKs in Drosophila and C. elegans 37
3.1 The Drosophila phosphatase/?wcA:era/plays key roles in
development, stress responses and ageing 37
3.2 The vhp-1 phosphatase plays key roles in regulating stress
responses and immunity in C. elegans 37
4 Mammalian MKPs play essential roles in the regulation of both
JNK and p38 MAP kinase signalling 39
4.1 A subset of mammalian MKPs can regulate stress-activated
MAPK pathways 39
4.2 DUSP10/MKP-5 plays a key role in adaptive and innate immunity. 39
5 Inducible nuclear MKPs play key roles in stress resistance, immune
function, and metabolic homeostasis 41
5.1 DUSP1/MKP-1 is a key regulator of stress resistance 41
5.2 DUSP1/MKP-1 regulates both immune and metabolic function 42
5.3 DUSP2/PAC-1 is a positive regulator of certain inflammatory
responses 43
6 Summary 44
Acknowledgements 45
References 45
Transcriptional regulation by the p38 MAPK signaling pathway in
mammalian cells 51
Eusebio Perdiguero and Pura Munoz-Canoves 51
Abstract 51
1 Transcription in mammalian cells 51
1.1 Regulatory DNA elements 52
1.2 Chromatin modifying activities 52
1.3 Transcription factors 52
2 The p38 MAPK signaling pathway 53
2.1 MAPK pathways 53
2.2 p38 MAPKs 53
2.3 Upstream kinases 53
2.4 Downstream substrates 54
2.5 Downregulators 57
3 Consequences of p38 MAPK activation on growth and differentiation
of mammalian cells 57
3.1 Skeletal muscle proliferation and differentiation 58
3.2 Adipocyte differentiation 61
Table of contents IX
3.3 Cardiomyocyte hypertrophy 65
4 Conclusions and perspectives 68
Acknowledgements 70
References 70
Regulation of gene expression in response to osmostress by the yeast
stress-activated protein kinase Hogl 81
Eulalia de Nadal and Francesc Posas 81
Abstract 81
1 Introduction 81
2 Regulation of HOG signaling 82
3 The Hogl MAPK as a central component of transcription activation
upon osmostress 84
4 Transcriptional regulators downstream of the HOG pathway 84
4.1 The bZIP protein Skol 85
4.2 The MADS box protein Smpl 85
4.3 The zinc finger proteins Msn2 and Msn4 86
4.4 The Hotl transcription factor 86
5 Hogl is part of the transcription complexes at the promoters of
osmostress genes 87
6 Regulation of chromatin remodeling by the Hogl MAPK 88
7 Hogl MAPK and transcription elongation 89
8 Conclusions and perspectives 90
Acknowledgement 92
References 92
Regulation of tumorigenesis by p38a MAP kinase 99
Ignacio Dolado and Angel R. Nebreda 99
Abstract 99
1 Introduction 99
2 Cell cycle regulation 100
2.1 Inhibition of the Gl/S transition 101
2.2 Inhibition of the G2/M transition 101
2.3 Stimulation of cell cycle progression 103
3 Regulation of cell survival and apoptosis 104
3.1 Apoptosis induction 107
3.2 Anti-apoptotic roles 108
3.3 Reconciling pro- and anti-apoptotic functions 110
4 Regulation of cell differentiation 111
5 Inflammation 112
6 Cell migration and invasion 113
7 Concluding remarks 114
Acknowledgments 115
References 115
List of abbreviations 128
X Table of contents
Control of cell cycle by SAPKs in budding and fission yeast 129
Sandra Lopez-Aviles and Rosa M. Aligue 129
Abstract 129
1 Introduction 129
2 Cell cycle control by SAPKs in Saccharomyces cerevisiae 130
2.1 Cell cycle regulation 130
2.2 Stress-activated protein kinase pathway and cell cycle control 130
3 Cell cycle control by SAPKs in Schizosaccharomyces pombe 132
3.1 Cell cycle regulation 132
3.2 Stress-activated protein kinase pathway and cell cycle control 133
4 Concluding remarks 136
Acknowledgements 137
References 137
Hogl-mediated metabolic adjustments following hyperosmotic shock in
the yeast Saccharomyces cerevisiae 141
Bodil Nordlander, Marcus Krantz, Stefan Hohmann 141
Abstract 141
1 Yeast osmoregulation and carbon metabolism 141
2 Osmolytes: glycerol and trehalose as cell protectants 144
3 Flux control and potential direct effects on metabolism by
Hogl:PFK2 147
4 Glycerol export and import 151
5 Integration: a potential timeline of adjustments under osmo-stress 153
Acknowledgements 153
References 153
Control of mRNA stability by SAPKs 159
Miguel A. Rodriguez-Gabriel and Paul Russell 159
Abstract 159
1 Introduction 159
2. Eukaryotic mRNA turnover 160
2.1. Proteins involved 160
2.2 Localization 161
3 mRNA cis acting elements 162
4 Control of mRNA stability by SAPKs 162
4.1 RNA binding proteins involved in SAPK regulation of mRNA
stability 163
5 Concluding remarks 165
Acknowledgement 166
References 166
Intrinsically active (MKK- independent) variants of SAPKs - How do
they work? 171
Inbal Maayan and David Engelberg 171
Abstract 171
Table of contents XI
1 Introduction 171
2 Intrinsically active variants of SAPKs - bypassing their natural
mode of activation 173
3 Mechanism of activation of native SAPKs and of intrinsically active
SAPKs 176
3.1 The role of the phosphoacceptors in the intrinsically active
variants 176
3.2 The mutants acquired an auto-phosphorylation capability 178
3.3 Structural changes due to activation 179
4 Discussion 180
References 182
Regulation of MAPK signaling in yeast 187
Fabian Rudolf, Serge Pelet, Matthias Peter 187
Abstract 187
1 Introduction to MAPK signaling during mating and high osmolarity
conditions in yeast 187
2 Quantifying signaling at the single cell level 189
3 Regulation of mating signaling 191
3.1 Pathway activation 191
3.2 Spatial/temporal regulation 193
4 Regulation of mating signaling by internal and external factors 196
5 The Osmotic stress pathway 197
5.1 Pathway activation by stress signals 197
5.2 Internal regulation of the HOG pathway 198
6 Specificity/crosstalk between the two pathways 199
7 General principles for yeast MAPK regulation 199
8 Single cell measurement - future research 200
Acknowledgments 201
References 201
Modeling the dynamics of stress activated protein kinases (SAPK) in
cellular stress response 205
Edda Klipp and Jorg Schaber 205
Abstract 205
1 Introduction 205
2 Mathematical modeling in systems biology 206
2.1 Purpose of modeling 206
2.2 Model development in five steps 206
2.3 Mathematical modeling of biochemical reaction networks 209
2.4 Analysis of models 212
3 Studied phenomena 214
3.1 Dynamic behavior and parameters 214
3.2 Ultrasensitivity, amplification, and robustness 216
3.3 Relative importance of kinases and phosphatases 217
3.4 Regulation of MAPK cascade by receptor activity 218
XII Table of contents
3.5 Regulation of MAPK cascade by downstream processes -
feedback 219
3.6 Crosstalk and dynamics 220
4 Discussion/Summary 221
Acknowledgement 221
References 222
Stress-activated protein kinase signaling in Drosophila 225
Gerasimos P. Sykiotis and Dirk Bohmann 225
Abstract 225
1 Introduction 225
2 Structural conservation of the JNK and p38 pathways in Drosophila ...226
3 JNK signaling in Drosophila 228
3.1 Morphogenesis, wound healing, and immunity 228
3.2 Oxidative stress defense and lifespan regulation 229
3.3 JNK-dependent apoptosis during development 229
3.4 JNK in TNF- and irradiation-induced apoptosis 230
4 p38 signaling in Drosophila 232
4.1 Identification of the fruit fly p38 homologues 232
4.2 p38 in Drosophila development 232
4.3 Genetic analysis of the fruit fly p38 pathway 234
4.4 RNA interference in cultured Drosophila cells 235
4.5 Downstream effectors and upstream components of Drosophila
p38 signaling 236
5 Outlook 237
References 237
Protein kinases as substrates for SAPKs 243
Alexey Kotlyarov and Matthias Gaestel 243
Abstract 243
1 Definition of kinases downstream to SAPKs 243
2 Primary structure and overview 245
3 SAPK-regulated kinases in detail 245
3.1MSKs 245
3.2MNKs 248
3.3MK2/3 251
4 Summary and Perspectives 253
Acknowledgement 253
References 253
List of abbreviations 260
Functions of stress-activated MAP kinases in the immune response 261
Mercedes Rincon and Roger J. Davis 261
Abstract 261
1 Introduction 261
2 SAPK Functions in macrophages and dendritic cells 261
Table of contents XIII
2.1 RoleofJNK 261
2.2 Role of p38 MAPK 263
3 SAPK functions in B cells 264
3.1 RoleofJNK 264
3.2 Role of p38 MAPK 264
4 SAPK Functions in T cell development 265
4.1 RoleofJNK 265
4.2 Role of p38 MAPK 265
5 SAPK functions in CD4+T cells 266
5.1 RoleofJNK 266
5.2 Role of p38 MAPK 268
6 SAPK functions in CD8+ T cells 269
6.1 RoleofJNK 269
6.2 Role of p38 MAPK 271
7 SAPK functions in other T cell populations 272
8 SAPK functions during an in vivo immune response 273
9 Concluding remarks 275
References 275
Stress-activated MAP kinases in chromatin and transcriptional
complexes 283
Nicholas T. Crump, Ya Ting Han, and Louis C. Mahadevan 283
Abstract 283
1 Introduction 283
1.1 SAPK cascades in yeast and mammals 284
2 Phosphorylation of sequence-specific transcription factors and
recruitment of histone-modifying enzymes 286
3 Phosphorylation of general transcription factors 288
4 Phosphorylation of nucleosomal proteins 288
4.1 Inducible histone H3 phosphorylation is mediated by MSK1/2 289
4.2 Molecular function of histone H3 phosphorylation 290
5 SAPKs may also act independently of their kinase activity 291
5.1 A role for mammalian SAPKs in transcriptional and elongation
complexes? 293
6 Concluding remarks 293
References 294
SAPK and translational control 299
Malin Hult and Per Sunnerhagen 299
Abstract 299
1 Background and paradigms for control of translation 299
2 Global controls of translation 300
2.1 Global control of initiation by phosphorylation of eIF2a 300
2.2 Global control of initiation by phosphorylation of eIF4E/4E-BP ...300
2.3 Global control of elongation 301
3 Individual control of mRNA species - AREs 302
XIV Table of contents
3.1 ARE-binding proteins under SAPK control 303
3.2 MAPK-activated protein kinases in signalling through AREs 303
4 Links between translation and mRNA degradation 304
5 IRES 304
6 Indirect effects on translation through transcriptional and
posttranscriptional regulation 305
7 Concluding remarks 306
Acknowledgements 307
References 307
Index 311
|
| adam_txt |
Titel: Stress activated protein kinases
Autor: Posas, Francesc
Jahr: 2008
Table of contents
MAPK kinase kinase regulation of SAPK/JNK pathways 1
Lisa Stalheim and Gary L. Johnson 1
Abstract 1
1 Introduction 1
2 Organization of the MKKK-MKK4/7-JNK1/2/3 signaling module 3
3 MKKKs as signaling hubs controlling JNK activation 4
3.1 MLKs (mixed lineage kinases) 5
3.2 MEKKs (MAPK-ERK kinase kinases) 5
3.3 ASK1 (apoptosis signal-regulating kinase 1) 6
3.4 TAK1 (JGFP-activated kinase 1) 6
3.5 TAO1 (thousand and one-amino acid kinase 1) 6
4 Insight into the function of MKKKs regulating the JNK pathway from
targeted gene knockouts 7
4.1MEKK1 7
4.2MEKK2 8
4.3MEKK4 9
4.4ASK1 9
4.5TAK1 10
4.6MLK3 10
5 Conclusions 10
References 11
Alternative p38 MAPK pathways 17
Francisco Inesta-Vaquera, Guadalupe Sabio, Yvonne Kuma,
and AnaCuenda 17
Abstract 17
1 Introduction 17
2 The p38y and p385 MAPK pathways 19
2. Ip38y and p388 substrates 20
3 Biological roles of p38y and p388 MAPK pathways 21
3.1 Cell cycle and cellular transformation 21
3.2 Cellular differentiation 22
3.3 Cytoskeletal organization 24
4 More alternative p38MAPK pathways? 25
5 Concluding remarks 25
Acknowledgments 26
References 26
VIII Table of contents
The regulation of stress-activated MAP kinase signalling by protein
phosphatases 33
Stephen M. Keyse 33
Abstract 33
1 Introduction 33
2 Regulation of stress-activated MAPKs by protein phosphatases in S.
cerevisiae 34
3 Regulation of JNK andp38 MAPKs in Drosophila and C. elegans 37
3.1 The Drosophila phosphatase/?wcA:era/plays key roles in
development, stress responses and ageing 37
3.2 The vhp-1 phosphatase plays key roles in regulating stress
responses and immunity in C. elegans 37
4 Mammalian MKPs play essential roles in the regulation of both
JNK and p38 MAP kinase signalling 39
4.1 A subset of mammalian MKPs can regulate stress-activated
MAPK pathways 39
4.2 DUSP10/MKP-5 plays a key role in adaptive and innate immunity. 39
5 Inducible nuclear MKPs play key roles in stress resistance, immune
function, and metabolic homeostasis 41
5.1 DUSP1/MKP-1 is a key regulator of stress resistance 41
5.2 DUSP1/MKP-1 regulates both immune and metabolic function 42
5.3 DUSP2/PAC-1 is a positive regulator of certain inflammatory
responses 43
6 Summary 44
Acknowledgements 45
References 45
Transcriptional regulation by the p38 MAPK signaling pathway in
mammalian cells 51
Eusebio Perdiguero and Pura Munoz-Canoves 51
Abstract 51
1 Transcription in mammalian cells 51
1.1 Regulatory DNA elements 52
1.2 Chromatin modifying activities 52
1.3 Transcription factors 52
2 The p38 MAPK signaling pathway 53
2.1 MAPK pathways 53
2.2 p38 MAPKs 53
2.3 Upstream kinases 53
2.4 Downstream substrates 54
2.5 Downregulators 57
3 Consequences of p38 MAPK activation on growth and differentiation
of mammalian cells 57
3.1 Skeletal muscle proliferation and differentiation 58
3.2 Adipocyte differentiation 61
Table of contents IX
3.3 Cardiomyocyte hypertrophy 65
4 Conclusions and perspectives 68
Acknowledgements 70
References 70
Regulation of gene expression in response to osmostress by the yeast
stress-activated protein kinase Hogl 81
Eulalia de Nadal and Francesc Posas 81
Abstract 81
1 Introduction 81
2 Regulation of HOG signaling 82
3 The Hogl MAPK as a central component of transcription activation
upon osmostress 84
4 Transcriptional regulators downstream of the HOG pathway 84
4.1 The bZIP protein Skol 85
4.2 The MADS box protein Smpl 85
4.3 The zinc finger proteins Msn2 and Msn4 86
4.4 The Hotl transcription factor 86
5 Hogl is part of the transcription complexes at the promoters of
osmostress genes 87
6 Regulation of chromatin remodeling by the Hogl MAPK 88
7 Hogl MAPK and transcription elongation 89
8 Conclusions and perspectives 90
Acknowledgement 92
References 92
Regulation of tumorigenesis by p38a MAP kinase 99
Ignacio Dolado and Angel R. Nebreda 99
Abstract 99
1 Introduction 99
2 Cell cycle regulation 100
2.1 Inhibition of the Gl/S transition 101
2.2 Inhibition of the G2/M transition 101
2.3 Stimulation of cell cycle progression 103
3 Regulation of cell survival and apoptosis 104
3.1 Apoptosis induction 107
3.2 Anti-apoptotic roles 108
3.3 Reconciling pro- and anti-apoptotic functions 110
4 Regulation of cell differentiation 111
5 Inflammation 112
6 Cell migration and invasion 113
7 Concluding remarks 114
Acknowledgments 115
References 115
List of abbreviations 128
X Table of contents
Control of cell cycle by SAPKs in budding and fission yeast 129
Sandra Lopez-Aviles and Rosa M. Aligue 129
Abstract 129
1 Introduction 129
2 Cell cycle control by SAPKs in Saccharomyces cerevisiae 130
2.1 Cell cycle regulation 130
2.2 Stress-activated protein kinase pathway and cell cycle control 130
3 Cell cycle control by SAPKs in Schizosaccharomyces pombe 132
3.1 Cell cycle regulation 132
3.2 Stress-activated protein kinase pathway and cell cycle control 133
4 Concluding remarks 136
Acknowledgements 137
References 137
Hogl-mediated metabolic adjustments following hyperosmotic shock in
the yeast Saccharomyces cerevisiae 141
Bodil Nordlander, Marcus Krantz, Stefan Hohmann 141
Abstract 141
1 Yeast osmoregulation and carbon metabolism 141
2 Osmolytes: glycerol and trehalose as cell protectants 144
3 Flux control and potential direct effects on metabolism by
Hogl:PFK2 147
4 Glycerol export and import 151
5 Integration: a potential timeline of adjustments under osmo-stress 153
Acknowledgements 153
References 153
Control of mRNA stability by SAPKs 159
Miguel A. Rodriguez-Gabriel and Paul Russell 159
Abstract 159
1 Introduction 159
2. Eukaryotic mRNA turnover 160
2.1. Proteins involved 160
2.2 Localization 161
3 mRNA cis acting elements 162
4 Control of mRNA stability by SAPKs 162
4.1 RNA binding proteins involved in SAPK regulation of mRNA
stability 163
5 Concluding remarks 165
Acknowledgement 166
References 166
Intrinsically active (MKK- independent) variants of SAPKs - How do
they work? 171
Inbal Maayan and David Engelberg 171
Abstract 171
Table of contents XI
1 Introduction 171
2 Intrinsically active variants of SAPKs - bypassing their natural
mode of activation 173
3 Mechanism of activation of native SAPKs and of intrinsically active
SAPKs 176
3.1 The role of the phosphoacceptors in the intrinsically active
variants 176
3.2 The mutants acquired an auto-phosphorylation capability 178
3.3 Structural changes due to activation 179
4 Discussion 180
References 182
Regulation of MAPK signaling in yeast 187
Fabian Rudolf, Serge Pelet, Matthias Peter 187
Abstract 187
1 Introduction to MAPK signaling during mating and high osmolarity
conditions in yeast 187
2 Quantifying signaling at the single cell level 189
3 Regulation of mating signaling 191
3.1 Pathway activation 191
3.2 Spatial/temporal regulation 193
4 Regulation of mating signaling by internal and external factors 196
5 The Osmotic stress pathway 197
5.1 Pathway activation by stress signals 197
5.2 Internal regulation of the HOG pathway 198
6 Specificity/crosstalk between the two pathways 199
7 General principles for yeast MAPK regulation 199
8 Single cell measurement - future research 200
Acknowledgments 201
References 201
Modeling the dynamics of stress activated protein kinases (SAPK) in
cellular stress response 205
Edda Klipp and Jorg Schaber 205
Abstract 205
1 Introduction 205
2 Mathematical modeling in systems biology 206
2.1 Purpose of modeling 206
2.2 Model development in five steps 206
2.3 Mathematical modeling of biochemical reaction networks 209
2.4 Analysis of models 212
3 Studied phenomena 214
3.1 Dynamic behavior and parameters 214
3.2 Ultrasensitivity, amplification, and robustness 216
3.3 Relative importance of kinases and phosphatases 217
3.4 Regulation of MAPK cascade by receptor activity 218
XII Table of contents
3.5 Regulation of MAPK cascade by downstream processes -
feedback 219
3.6 Crosstalk and dynamics 220
4 Discussion/Summary 221
Acknowledgement 221
References 222
Stress-activated protein kinase signaling in Drosophila 225
Gerasimos P. Sykiotis and Dirk Bohmann 225
Abstract 225
1 Introduction 225
2 Structural conservation of the JNK and p38 pathways in Drosophila .226
3 JNK signaling in Drosophila 228
3.1 Morphogenesis, wound healing, and immunity 228
3.2 Oxidative stress defense and lifespan regulation 229
3.3 JNK-dependent apoptosis during development 229
3.4 JNK in TNF- and irradiation-induced apoptosis 230
4 p38 signaling in Drosophila 232
4.1 Identification of the fruit fly p38 homologues 232
4.2 p38 in Drosophila development 232
4.3 Genetic analysis of the fruit fly p38 pathway 234
4.4 RNA interference in cultured Drosophila cells 235
4.5 Downstream effectors and upstream components of Drosophila
p38 signaling 236
5 Outlook 237
References 237
Protein kinases as substrates for SAPKs 243
Alexey Kotlyarov and Matthias Gaestel 243
Abstract 243
1 Definition of kinases downstream to SAPKs 243
2 Primary structure and overview 245
3 SAPK-regulated kinases in detail 245
3.1MSKs 245
3.2MNKs 248
3.3MK2/3 251
4 Summary and Perspectives 253
Acknowledgement 253
References 253
List of abbreviations 260
Functions of stress-activated MAP kinases in the immune response 261
Mercedes Rincon and Roger J. Davis 261
Abstract 261
1 Introduction 261
2 SAPK Functions in macrophages and dendritic cells 261
Table of contents XIII
2.1 RoleofJNK 261
2.2 Role of p38 MAPK 263
3 SAPK functions in B cells 264
3.1 RoleofJNK 264
3.2 Role of p38 MAPK 264
4 SAPK Functions in T cell development 265
4.1 RoleofJNK 265
4.2 Role of p38 MAPK 265
5 SAPK functions in CD4+T cells 266
5.1 RoleofJNK 266
5.2 Role of p38 MAPK 268
6 SAPK functions in CD8+ T cells 269
6.1 RoleofJNK 269
6.2 Role of p38 MAPK 271
7 SAPK functions in other T cell populations 272
8 SAPK functions during an in vivo immune response 273
9 Concluding remarks 275
References 275
Stress-activated MAP kinases in chromatin and transcriptional
complexes 283
Nicholas T. Crump, Ya Ting Han, and Louis C. Mahadevan 283
Abstract 283
1 Introduction 283
1.1 SAPK cascades in yeast and mammals 284
2 Phosphorylation of sequence-specific transcription factors and
recruitment of histone-modifying enzymes 286
3 Phosphorylation of general transcription factors 288
4 Phosphorylation of nucleosomal proteins 288
4.1 Inducible histone H3 phosphorylation is mediated by MSK1/2 289
4.2 Molecular function of histone H3 phosphorylation 290
5 SAPKs may also act independently of their kinase activity 291
5.1 A role for mammalian SAPKs in transcriptional and elongation
complexes? 293
6 Concluding remarks 293
References 294
SAPK and translational control 299
Malin Hult and Per Sunnerhagen 299
Abstract 299
1 Background and paradigms for control of translation 299
2 Global controls of translation 300
2.1 Global control of initiation by phosphorylation of eIF2a 300
2.2 Global control of initiation by phosphorylation of eIF4E/4E-BP .300
2.3 Global control of elongation 301
3 Individual control of mRNA species - AREs 302
XIV Table of contents
3.1 ARE-binding proteins under SAPK control 303
3.2 MAPK-activated protein kinases in signalling through AREs 303
4 Links between translation and mRNA degradation 304
5 IRES 304
6 Indirect effects on translation through transcriptional and
posttranscriptional regulation 305
7 Concluding remarks 306
Acknowledgements 307
References 307
Index 311 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author2 | Posas, Francesc |
| author2_role | edt |
| author2_variant | f p fp |
| author_facet | Posas, Francesc |
| building | Verbundindex |
| bvnumber | BV023378955 |
| classification_rvk | WD 5060 |
| ctrlnum | (OCoLC)227008228 (DE-599)DNB987106791 |
| dewey-full | 571.74 572.792 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects 572 - Biochemistry |
| dewey-raw | 571.74 572.792 |
| dewey-search | 571.74 572.792 |
| dewey-sort | 3571.74 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01927nam a2200493 cb4500</leader><controlfield tag="001">BV023378955</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20100624 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">080704s2008 gw d||| |||| 00||| eng d</controlfield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">08,N05,1247</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="015" ind1=" " ind2=" "><subfield code="a">08,A19,1194</subfield><subfield code="2">dnb</subfield></datafield><datafield tag="016" ind1="7" ind2=" "><subfield code="a">987106791</subfield><subfield code="2">DE-101</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783540755685</subfield><subfield code="c">Pp. : EUR 171.15 (freier Pr.), sfr 278.50 (freier Pr.)</subfield><subfield code="9">978-3-540-75568-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3540755683</subfield><subfield code="c">Pp. : EUR 171.15 (freier Pr.), sfr 278.50 (freier Pr.)</subfield><subfield code="9">3-540-75568-3</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)227008228</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)DNB987106791</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">gw</subfield><subfield code="c">XA-DE-BE</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield><subfield code="a">DE-11</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">571.74</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.792</subfield><subfield code="2">22/ger</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 5060</subfield><subfield code="0">(DE-625)148187:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">570</subfield><subfield code="2">sdnb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Stress-activated protein kinases</subfield><subfield code="b">with 12 tables</subfield><subfield code="c">Francesc Posas ...(eds.)</subfield></datafield><datafield tag="246" ind1="1" ind2="3"><subfield code="a">Stress activated protein kinases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin [u.a.]</subfield><subfield code="b">Springer</subfield><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XVIII, 312 S.</subfield><subfield code="b">graph. Darst.</subfield><subfield code="c">24 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="1" ind2=" "><subfield code="a">Topics in current genetics</subfield><subfield code="v">20</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Literaturangaben</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Stressreaktion</subfield><subfield code="0">(DE-588)4138565-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Proteinkinasen</subfield><subfield code="0">(DE-588)4175996-5</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Proteinkinasen</subfield><subfield code="0">(DE-588)4175996-5</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2="1"><subfield code="a">Stressreaktion</subfield><subfield code="0">(DE-588)4138565-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Posas, Francesc</subfield><subfield code="4">edt</subfield></datafield><datafield tag="830" ind1=" " ind2="0"><subfield code="a">Topics in current genetics</subfield><subfield code="v">20</subfield><subfield code="w">(DE-604)BV035420113</subfield><subfield code="9">20</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016562089&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016562089</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV023378955 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:15:38Z |
| indexdate | 2024-07-09T21:17:15Z |
| institution | BVB |
| isbn | 9783540755685 3540755683 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016562089 |
| oclc_num | 227008228 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-355 DE-BY-UBR DE-11 |
| physical | XVIII, 312 S. graph. Darst. 24 cm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer |
| record_format | marc |
| series | Topics in current genetics |
| series2 | Topics in current genetics |
| spelling | Stress-activated protein kinases with 12 tables Francesc Posas ...(eds.) Stress activated protein kinases Berlin [u.a.] Springer 2008 XVIII, 312 S. graph. Darst. 24 cm txt rdacontent n rdamedia nc rdacarrier Topics in current genetics 20 Literaturangaben Stressreaktion (DE-588)4138565-2 gnd rswk-swf Proteinkinasen (DE-588)4175996-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Proteinkinasen (DE-588)4175996-5 s Stressreaktion (DE-588)4138565-2 s DE-604 Posas, Francesc edt Topics in current genetics 20 (DE-604)BV035420113 20 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016562089&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Stress-activated protein kinases with 12 tables Topics in current genetics Stressreaktion (DE-588)4138565-2 gnd Proteinkinasen (DE-588)4175996-5 gnd |
| subject_GND | (DE-588)4138565-2 (DE-588)4175996-5 (DE-588)4143413-4 |
| title | Stress-activated protein kinases with 12 tables |
| title_alt | Stress activated protein kinases |
| title_auth | Stress-activated protein kinases with 12 tables |
| title_exact_search | Stress-activated protein kinases with 12 tables |
| title_exact_search_txtP | Stress-activated protein kinases with 12 tables |
| title_full | Stress-activated protein kinases with 12 tables Francesc Posas ...(eds.) |
| title_fullStr | Stress-activated protein kinases with 12 tables Francesc Posas ...(eds.) |
| title_full_unstemmed | Stress-activated protein kinases with 12 tables Francesc Posas ...(eds.) |
| title_short | Stress-activated protein kinases |
| title_sort | stress activated protein kinases with 12 tables |
| title_sub | with 12 tables |
| topic | Stressreaktion (DE-588)4138565-2 gnd Proteinkinasen (DE-588)4175996-5 gnd |
| topic_facet | Stressreaktion Proteinkinasen Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016562089&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV035420113 |
| work_keys_str_mv | AT posasfrancesc stressactivatedproteinkinaseswith12tables AT posasfrancesc stressactivatedproteinkinases |