Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2008
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| Subjects: | |
| Online Access: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-79914 Inhaltsverzeichnis |
| Physical Description: | III, 99 S. graph. Darst. |
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MARC
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Record in the Search Index
| _version_ | 1804137736795324416 |
|---|---|
| adam_text | Contents
1 Introduction 1
1.1 Allergic Sensitization and Allergic Diseases 1
1.1.1 Epidemiology of Allergic Diseases 3
1.1.2 Immune Mechanism and Pathology of Allergy and Atopy . 4
1.1.3 Allergen and Microbial Exposure - Environmental Risk /
Protective Factors for Allergic Diseases 5
1.2 Pet Ownership and Pet Contacts 8
1.2.1 Cats and Cat Allergen 8
1.2.2 Dog Ownership 10
1.3 Objectives 12
2 Study Populations and Designs 13
2.1 The LISA Study 13
2.1.1 Questionnaire Data 14
2.1.2 Collection and Analysis of Blood Samples 14
2.1.3 Collection and Analysis of Settled House Dust Samples . . 1C
2.1.4 Information on household density in the living area .... 17
2.2 The GINI Study 17
2.2.1 Questionnaire Data 18
2.2.2 Collection and Analysis of Blood Samples 18
2.2.3 Information on household density in the living area .... 20
2.3 The AIRALLERG Study 20
2.3.1 Serum Assays 21
2.3.2 Collection and Analysis of Settled House Dust Samples . . 22
I
3 Statistical Analysis 23
3.1 Descriptive Analysis 23
3.2 Analysis for Single Outcome Measurement 25
3.2.1 Logistic Regression Model 25
3.2.2 Generalized Additive Models 26
3.2.3 Ordinal Logistic Regression Model 27
3.3 Analysis for Repeated Outcome Measurements in Cohort Study
Design 28
3.3.1 Longitudinal analysis with marginal logistic regression model
(GEE) 28
3.3.2 Longitudinal analysis with random effects logistic regres¬
sion models 29
4 Study Results 31
4.1 Inequality of Domestic Cat Allergen and Endotoxin Distribution
between Families with Different Socioeconomic Status 32
4.2 Associations between Cat Allergen Exposure and the Development
of Allergy in Young Children-LISA Study 41
4.3 Domestic Cat Allergen Level and Allergic sensitization in Young
Children-AIRALLERG Study 50
4.4 Associations between Dog Ownership and Dog Contact and the
Development of Allergy in Young Children-LISA and GIXI Study 57
5 Discussion 65
5.1 Cat Exposure and Allergy in Young Children 65
5.1.1 Domestic Cat Allergen and Endotoxin Distribution between
Families with Different Socioeconomic Status 65
5.1.2 Associations between Cat Allergen Exposure and the De¬
velopment of Allergy in Young Children-German Longitu¬
dinal Study 67
5.1.3 Domestic Cat Allergen Level and Allergic sensitization in
Young Children-European Cross-sectional Study 70
5.2 Dog ownership and Dog Contact and Allergy in Young Children . 73
5.3 Conclusion 77
II
6 Summary 79
7 Zusammenfassung 81
Bibliography 84
Acknowledgements 99
III
|
| adam_txt |
Contents
1 Introduction 1
1.1 Allergic Sensitization and Allergic Diseases 1
1.1.1 Epidemiology of Allergic Diseases 3
1.1.2 Immune Mechanism and Pathology of Allergy and Atopy . 4
1.1.3 Allergen and Microbial Exposure - Environmental Risk /
Protective Factors for Allergic Diseases 5
1.2 Pet Ownership and Pet Contacts 8
1.2.1 Cats and Cat Allergen 8
1.2.2 Dog Ownership 10
1.3 Objectives 12
2 Study Populations and Designs 13
2.1 The LISA Study 13
2.1.1 Questionnaire Data 14
2.1.2 Collection and Analysis of Blood Samples 14
2.1.3 Collection and Analysis of Settled House Dust Samples . . 1C
2.1.4 Information on household density in the living area . 17
2.2 The GINI Study 17
2.2.1 Questionnaire Data 18
2.2.2 Collection and Analysis of Blood Samples 18
2.2.3 Information on household density in the living area . 20
2.3 The AIRALLERG Study 20
2.3.1 Serum Assays 21
2.3.2 Collection and Analysis of Settled House Dust Samples . . 22
I
3 Statistical Analysis 23
3.1 Descriptive Analysis 23
3.2 Analysis for Single Outcome Measurement 25
3.2.1 Logistic Regression Model 25
3.2.2 Generalized Additive Models 26
3.2.3 Ordinal Logistic Regression Model 27
3.3 Analysis for Repeated Outcome Measurements in Cohort Study
Design 28
3.3.1 Longitudinal analysis with marginal logistic regression model
(GEE) 28
3.3.2 Longitudinal analysis with random effects logistic regres¬
sion models 29
4 Study Results 31
4.1 Inequality of Domestic Cat Allergen and Endotoxin Distribution
between Families with Different Socioeconomic Status 32
4.2 Associations between Cat Allergen Exposure and the Development
of Allergy in Young Children-LISA Study 41
4.3 Domestic Cat Allergen Level and Allergic sensitization in Young
Children-AIRALLERG Study 50
4.4 Associations between Dog Ownership and Dog Contact and the
Development of Allergy in Young Children-LISA and GIXI Study 57
5 Discussion 65
5.1 Cat Exposure and Allergy in Young Children 65
5.1.1 Domestic Cat Allergen and Endotoxin Distribution between
Families with Different Socioeconomic Status 65
5.1.2 Associations between Cat Allergen Exposure and the De¬
velopment of Allergy in Young Children-German Longitu¬
dinal Study 67
5.1.3 Domestic Cat Allergen Level and Allergic sensitization in
Young Children-European Cross-sectional Study 70
5.2 Dog ownership and Dog Contact and Allergy in Young Children . 73
5.3 Conclusion 77
II
6 Summary 79
7 Zusammenfassung 81
Bibliography 84
Acknowledgements 99
III |
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| dewey-ones | 618 - Gynecology, obstetrics, pediatrics, geriatrics |
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| discipline | Medizin |
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| spelling | Chen, Chih-Mei 1978- Verfasser (DE-588)134242661 aut Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children from Chih-Mei Chen 2008 III, 99 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2008 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-79914 http://edoc.ub.uni-muenchen.de/7991/ Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:19-79914 Resolving-System HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016553088&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chen, Chih-Mei 1978- Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| subject_GND | (DE-588)4113937-9 |
| title | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| title_auth | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| title_exact_search | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| title_exact_search_txtP | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| title_full | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children from Chih-Mei Chen |
| title_fullStr | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children from Chih-Mei Chen |
| title_full_unstemmed | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children from Chih-Mei Chen |
| title_short | Epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| title_sort | epidemiological studies on the association between cat and dog exposure and atopic outcomes in young children |
| topic_facet | Hochschulschrift |
| url | http://edoc.ub.uni-muenchen.de/7991/ https://nbn-resolving.org/urn:nbn:de:bvb:19-79914 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016553088&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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