Chemistry and molecular aspects of drug design and action:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Boca Raton [u.a.]
CRC/Taylor & Francis
2008
|
| Subjects: | |
| Online Access: | Publisher description Inhaltsverzeichnis Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | XXII, 356 S. Ill., graph. Darst. |
| ISBN: | 0849390060 9780849390067 |
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| adam_text | Contents
Editors ix
Contributors xi
Rational Drug Design Based Mainly on the Pathobiochemistry of the Disease xv
E. A. Rekka, A. P. Kourounakis, and P. N. Kourounakis
PARTI
CHEMICAL, BIOCHEMICAL, AND BIOLOGICAL
ASPECTS OF PATHOPHYSIOLOGICAL CONDITIONS
Chapter 1 Inflammatory Mechanisms in Alzheimer s Disease and Other
Neurodegenerative Disorders 3
Joseph Rogers, Thomas Beach, Rena Li, Zhe Liang,
Lih-Fen Lue, Alexander Roher, Marwan Sabbagh, Yong Shen,
Ronald Strohmeyer, and Douglas Walker
Chapter 2 Treatment Development Strategies for Alzheimer s Disease 13
Ernst Wulfert
Chapter 3 Lipoprotein-Associated Phospholipase A2 as A New Prognostic
Factor for Coronary Artery Disease 35
Alexandros D. Tselepis
Chapter 4 New Molecular Targets for the Prevention and Treatment of
Gastrointestinal Ulcers and Inflammation 43
Sandor Szabo, Ganna Tolstanova, Lajos Nagy,
Longchuan Chen, Tetyana Khomenko, Xiaoming Deng, and
Zsuzsanna Sandor
Chapter 5 Stress Activates Corticotropin Releasing: Factor Signaling
Pathways: Implication in Functional Bowel Disorders 75
Yvette Tache
v
vi Chemistry and Molecular Aspects of Drug Design and Action
PART II
CLASSICAL MEDICINAL CHEMISTRY
Chapter 6 Design, Synthesis, and Pharmacological Evaluation of
High-Affinity and Selectivity Sigma-1 and Sigma-2 Receptor
Ligands 93
Jacques H. Poupaert
Chapter 7 Synthesis of Biologically Active Taxoids 101
K. C. Nicolaou and R. K. Guy
Chapter 8 From the Molecular Pharmacology to the Medicinal Chemistry
of Cannabinoids 109
Didier M. Lambert
Chapter 9 An Appraisal of Fomocaines: Current Situation and Outlook 123
Herbert Oelschldger and Andreas Seeling
Chapter 10 Ligands for the GABA Recognition Site at the GABAA
Receptor: Structure-Activity Studies 139
Bente Fr0lund, Uffe Kristiansen, Povl Krogsgaard-Larsen,
and Tommy Liljefors
Chapter 11 Strategies for Development of New Lead Structures for
Inhibition of Acetylcholinesterase 149
Petra Kapkova, Vildan Alptuzun, Eberhard Heller,
Eva Kugelmann, Gerd Folkers, and Ulrike Holzgrabe
PART III
DRUG DESIGN, CHEMICAL AND MOLECULAR
ASPECTS OF DRUG ACTION
Chapter 12 Discovery of Potent and Selective Inhibitors of Human
Aldosterone Synthase (CYP11B2): A New Target for the
Treatment of Congestive Heart Failure and Myocardial
Fibrosis—A Review 165
R. W. Hartmann, U. Miiller-Vieira, S. Ulmschneider,
and M. Voets
Contents vii
Chapter 13 Thiocarboxanilides: A New Class of Nonnucleoside Reverse
Transcriptase Inhibitors (NNRTIs) with Great Potential for the
Treatment of Human Immunodeficiency Virus Type 1 (HIV-1)
Infections 177
E. De Clercq, A. Karlsson, and J. Balzarini
Chapter 14 Histamine H3-Receptor Agonists and Antagonists: Chemical,
Pharmacological, and Clinical Aspects 199
Holger Stark and Walter Schunack
Chapter 15 Anti-Inflammatory Actions of Flavonoids and Structural
Requirements for New Design 215
Theoharis C. Theoharides
Chapter 16 Molecular Mechanisms of H2O2-Induced DNA Damage:
The Action of Desferrioxamine 227
M. Tenopoulou, P.-TDoulias, and D. Galaris
Chapter 17 LNA (Locked Nucleic Acid) and Functionalized LNA:
Toward Efficient Gene Targeting 239
Jesper Wengel
PART IV
DRUG - XENOBIOTIC METABOLISM
Chapter 18 The Effect of Diet on Drug Metabolism 247
K.J. Netter
Chapter 19 Cytochromes P450 in the Metabolism and Bioactivation of
Chemicals 253
Costas loannides
Chapter 20 In Vitro Methods to Measure Drug Metabolism and Drug
Interactions in Drug Discovery and Development 273
O. Pelkonen, M. Turpeinen, J. Uusitalo, P. Taavitsainen,
and H. Raunio
viii Chemistry and Molecular Aspects of Drug Design and Action
PARTV
PHYSICAL ORGANIC AND THEORETICAL
MEDICINAL CHEMISTRY
Chapter 21 How to Probe the Sites of Action of Drug Molecules 289
A. Makriyannis and F. Bitter
Chapter 22 Physicochemical Profiling in Early Drug Discovery:
New Challenges at the Age of High-Throughput Screen and
Combinatorial Chemistry 303
Bernard Faller
Chapter 23 Drug-Membrane Interaction and Its Importance for Drug
Efficacy 313
J.KSeydel, E.A. Coats, K. Visser, and M. Wiese
Chapter 24 The Fight Against AIDS: New Avenues for Inhibiting Reverse
Transcriptase (RT), an Old Target 325
Maurizio Botta, Lucilla Angeli, Marco Radi, and Giovanni Maga
Index 347
|
| adam_txt |
Contents
Editors ix
Contributors xi
Rational Drug Design Based Mainly on the Pathobiochemistry of the Disease xv
E. A. Rekka, A. P. Kourounakis, and P. N. Kourounakis
PARTI
CHEMICAL, BIOCHEMICAL, AND BIOLOGICAL
ASPECTS OF PATHOPHYSIOLOGICAL CONDITIONS
Chapter 1 Inflammatory Mechanisms in Alzheimer's Disease and Other
Neurodegenerative Disorders 3
Joseph Rogers, Thomas Beach, Rena Li, Zhe Liang,
Lih-Fen Lue, Alexander Roher, Marwan Sabbagh, Yong Shen,
Ronald Strohmeyer, and Douglas Walker
Chapter 2 Treatment Development Strategies for Alzheimer's Disease 13
Ernst Wulfert
Chapter 3 Lipoprotein-Associated Phospholipase A2 as A New Prognostic
Factor for Coronary Artery Disease 35
Alexandros D. Tselepis
Chapter 4 New Molecular Targets for the Prevention and Treatment of
Gastrointestinal Ulcers and Inflammation 43
Sandor Szabo, Ganna Tolstanova, Lajos Nagy,
Longchuan Chen, Tetyana Khomenko, Xiaoming Deng, and
Zsuzsanna Sandor
Chapter 5 Stress Activates Corticotropin Releasing: Factor Signaling
Pathways: Implication in Functional Bowel Disorders 75
Yvette Tache
v
vi Chemistry and Molecular Aspects of Drug Design and Action
PART II
CLASSICAL MEDICINAL CHEMISTRY
Chapter 6 Design, Synthesis, and Pharmacological Evaluation of
High-Affinity and Selectivity Sigma-1 and Sigma-2 Receptor
Ligands 93
Jacques H. Poupaert
Chapter 7 Synthesis of Biologically Active Taxoids 101
K. C. Nicolaou and R. K. Guy
Chapter 8 From the Molecular Pharmacology to the Medicinal Chemistry
of Cannabinoids 109
Didier M. Lambert
Chapter 9 An Appraisal of Fomocaines: Current Situation and Outlook 123
Herbert Oelschldger and Andreas Seeling
Chapter 10 Ligands for the GABA Recognition Site at the GABAA
Receptor: Structure-Activity Studies 139
Bente Fr0lund, Uffe Kristiansen, Povl Krogsgaard-Larsen,
and Tommy Liljefors
Chapter 11 Strategies for Development of New Lead Structures for
Inhibition of Acetylcholinesterase 149
Petra Kapkova, Vildan Alptuzun, Eberhard Heller,
Eva Kugelmann, Gerd Folkers, and Ulrike Holzgrabe
PART III
DRUG DESIGN, CHEMICAL AND MOLECULAR
ASPECTS OF DRUG ACTION
Chapter 12 Discovery of Potent and Selective Inhibitors of Human
Aldosterone Synthase (CYP11B2): A New Target for the
Treatment of Congestive Heart Failure and Myocardial
Fibrosis—A Review 165
R. W. Hartmann, U. Miiller-Vieira, S. Ulmschneider,
and M. Voets
Contents vii
Chapter 13 Thiocarboxanilides: A New Class of Nonnucleoside Reverse
Transcriptase Inhibitors (NNRTIs) with Great Potential for the
Treatment of Human Immunodeficiency Virus Type 1 (HIV-1)
Infections 177
E. De Clercq, A. Karlsson, and J. Balzarini
Chapter 14 Histamine H3-Receptor Agonists and Antagonists: Chemical,
Pharmacological, and Clinical Aspects 199
Holger Stark and Walter Schunack
Chapter 15 Anti-Inflammatory Actions of Flavonoids and Structural
Requirements for New Design 215
Theoharis C. Theoharides
Chapter 16 Molecular Mechanisms of H2O2-Induced DNA Damage:
The Action of Desferrioxamine 227
M. Tenopoulou, P.-TDoulias, and D. Galaris
Chapter 17 LNA (Locked Nucleic Acid) and Functionalized LNA:
Toward Efficient Gene Targeting 239
Jesper Wengel
PART IV
DRUG - XENOBIOTIC METABOLISM
Chapter 18 The Effect of Diet on Drug Metabolism 247
K.J. Netter
Chapter 19 Cytochromes P450 in the Metabolism and Bioactivation of
Chemicals 253
Costas loannides
Chapter 20 In Vitro Methods to Measure Drug Metabolism and Drug
Interactions in Drug Discovery and Development 273
O. Pelkonen, M. Turpeinen, J. Uusitalo, P. Taavitsainen,
and H. Raunio
viii Chemistry and Molecular Aspects of Drug Design and Action
PARTV
PHYSICAL ORGANIC AND THEORETICAL
MEDICINAL CHEMISTRY
Chapter 21 How to Probe the Sites of Action of Drug Molecules 289
A. Makriyannis and F. Bitter
Chapter 22 Physicochemical Profiling in Early Drug Discovery:
New Challenges at the Age of High-Throughput Screen and
Combinatorial Chemistry 303
Bernard Faller
Chapter 23 Drug-Membrane Interaction and Its Importance for Drug
Efficacy 313
J.KSeydel, E.A. Coats, K. Visser, and M. Wiese
Chapter 24 The Fight Against AIDS: New Avenues for Inhibiting Reverse
Transcriptase (RT), an Old Target 325
Maurizio Botta, Lucilla Angeli, Marco Radi, and Giovanni Maga
Index 347 |
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| spelling | Chemistry and molecular aspects of drug design and action E. A. Rekka ; P. N. Kourounakis [eds] Boca Raton [u.a.] CRC/Taylor & Francis 2008 XXII, 356 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Chemistry, Pharmaceutical Drug Design Drugs Design Pharmaceutical chemistry Pharmacological Phenomena Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 s Arzneimitteldesign (DE-588)4278218-1 s DE-604 Rekka, E. A. Sonstige oth Kourounakis, P. N Sonstige oth http://www.loc.gov/catdir/enhancements/fy0710/2007010012-d.html Publisher description lizenzfrei http://www.loc.gov/catdir/toc/ecip0712/2007010012.html lizenzfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016542133&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Chemistry and molecular aspects of drug design and action |
| title_auth | Chemistry and molecular aspects of drug design and action |
| title_exact_search | Chemistry and molecular aspects of drug design and action |
| title_exact_search_txtP | Chemistry and molecular aspects of drug design and action |
| title_full | Chemistry and molecular aspects of drug design and action E. A. Rekka ; P. N. Kourounakis [eds] |
| title_fullStr | Chemistry and molecular aspects of drug design and action E. A. Rekka ; P. N. Kourounakis [eds] |
| title_full_unstemmed | Chemistry and molecular aspects of drug design and action E. A. Rekka ; P. N. Kourounakis [eds] |
| title_short | Chemistry and molecular aspects of drug design and action |
| title_sort | chemistry and molecular aspects of drug design and action |
| topic | Chemistry, Pharmaceutical Drug Design Drugs Design Pharmaceutical chemistry Pharmacological Phenomena Pharmazeutische Chemie (DE-588)4132158-3 gnd Arzneimitteldesign (DE-588)4278218-1 gnd |
| topic_facet | Chemistry, Pharmaceutical Drug Design Drugs Design Pharmaceutical chemistry Pharmacological Phenomena Pharmazeutische Chemie Arzneimitteldesign |
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