Scientific errors and controversies in the U.S. HIV/AIDS epidemic: how they slowed advances and were resolved
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Westport, Conn. [u.a.]
Praeger
2008
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | X, 228 S. graph. Darst. |
| ISBN: | 9780313347177 |
Staff View
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| 245 | 1 | 0 | |a Scientific errors and controversies in the U.S. HIV/AIDS epidemic |b how they slowed advances and were resolved |c Scott D. Holmberg |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a Westport, Conn. [u.a.] |b Praeger |c 2008 | |
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| 648 | 7 | |a Geschichte 1980-2007 |2 gnd |9 rswk-swf | |
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| 650 | 4 | |a AIDS (Disease) |x Research |z United States |x History | |
| 650 | 4 | |a HIV infections |x Research |z United States |x History | |
| 650 | 4 | |a AIDS (Disease) |z United States |x Epidemiology | |
| 650 | 4 | |a HIV infections |z United States |x Epidemiology | |
| 650 | 4 | |a Errors, Scientific | |
| 650 | 4 | |a Medical errors | |
| 650 | 4 | |a HIV Infections |x epidemiology |z United States | |
| 650 | 4 | |a HIV Infections |x history |z United States | |
| 650 | 4 | |a Epidemiologic Methods |z United States | |
| 650 | 4 | |a Medical Errors |x prevention & control |z United States | |
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| adam_text | Contents
Preface ix
1 Background 1
About Teamwork 1
Sources of Error and Epidemiologic Thinking 3
Interpreting the Relative Value of Studies 10
The HIV/AIDS Epidemic Today 16
2 Causes and Sources of AIDS 21
Cytomegalovirus 21
Human T-Cell Lymphotropic Virus Type III (HTLV-III) 23
HIV-2, HTLV-IV (and... SIV and STLV...) 27
Does HIV-2 Protect against HIV-1 ? 29
Poppers and Kaposi s Sarcoma 31
African Swine Fever Virus 33
HIV Does Not Cause AIDS 35
The Source of HIV and AIDS 36
The River 38
Other Theories 40
3 Counting Cases 47
What Is the Future of AIDS? Modeling the Past to Estimate the
Future 53
Estimating the Impact of AIDS 54
Idiopathic CD4-Lymphocytopenia (ICL), or the AIDS, Not!
Syndrome 62
HIV Reporting 64
vj Contents
4 Epidemiologic Controversies 75
Issues in Sexual Transmission 77
Blood and Blood Products 81
Silent Sequences 85
A Florida Dentist 88
Safe Insemination 90
5 Unusual and Unproven Modes of HIV Transmission 99
No Identified Risk 100
Health Care Workers 102
The Environment 103
Insects 105
Belle Glade 107
Saliva and Biting 109
Food HI
Sweat, Tears, and Urine 112
Household Transmission 113
6 Issues in Prevention 121
HIV Testing 122
The Person at Risk, or the Person Known to Be HIV-Infected? 128
Preventing Mother-to-Infant Spread 131
Needle and Syringe Exchange; Condom Provision 133
Circumcision 136
7 Early Drugs and Biomedical Interventions 147
The Pre-Zidovudine Drugs 147
Experimental Antiretroviral Therapies Now Largely
Abandoned 154
Zidovudine 156
After Zidovudine 160
8 The Modern Therapeutic Era (after 1995) 171
When to Start Therapy in HIV-Infected People widiout
Symptoms 173
Iipodystrophy 179
Protease Inhibitors and Cardiovascular Disease 182
Early Vaccines and Microbicides 184
Strategic Treatment Interruptions 185
9 Errors, Their Consequences, and Their Management 199
Types of Errors and Their Consequences 200
Human Bias 205
Contents vii
Bureaucracy, the Killer Bees, and Other Considerations
about Retarding Research 208
Journals 213
Higher Education 215
Appendix: Antiretroviral Drugs Approved by the U.S. Food and Drug
Administration, 2007 221
Index 223
|
| adam_txt |
Contents
Preface ix
1 Background 1
About Teamwork 1
Sources of Error and Epidemiologic Thinking 3
Interpreting the Relative Value of Studies 10
The HIV/AIDS Epidemic Today 16
2 Causes and Sources of AIDS 21
Cytomegalovirus 21
Human T-Cell Lymphotropic Virus Type III (HTLV-III) 23
HIV-2, HTLV-IV (and. SIV and STLV.) 27
Does HIV-2 Protect against HIV-1 ? 29
"Poppers" and Kaposi's Sarcoma 31
African Swine Fever Virus 33
HIV Does Not Cause AIDS 35
The Source of HIV and AIDS 36
The River 38
Other Theories 40
3 Counting Cases 47
What Is the Future of AIDS? Modeling the Past to Estimate the
Future 53
Estimating the Impact of AIDS 54
Idiopathic CD4-Lymphocytopenia (ICL), or the "AIDS, Not!"
Syndrome 62
HIV Reporting 64
vj Contents
4 Epidemiologic Controversies 75
Issues in Sexual Transmission 77
Blood and Blood Products 81
"Silent Sequences" 85
A Florida Dentist 88
"Safe" Insemination 90
5 Unusual and Unproven Modes of HIV Transmission 99
"No Identified Risk" 100
Health Care Workers 102
The Environment 103
Insects 105
Belle Glade 107
Saliva and Biting 109
Food HI
Sweat, Tears, and Urine 112
Household Transmission 113
6 Issues in Prevention 121
HIV Testing 122
The Person at Risk, or the Person Known to Be HIV-Infected? 128
Preventing Mother-to-Infant Spread 131
Needle and Syringe Exchange; Condom Provision 133
Circumcision 136
7 Early Drugs and Biomedical Interventions 147
The "Pre-Zidovudine" Drugs 147
Experimental Antiretroviral Therapies Now Largely
Abandoned 154
Zidovudine 156
After Zidovudine 160
8 The Modern Therapeutic Era (after 1995) 171
When to Start Therapy in HIV-Infected People widiout
Symptoms 173
Iipodystrophy 179
Protease Inhibitors and Cardiovascular Disease 182
Early Vaccines and Microbicides 184
Strategic Treatment Interruptions 185
9 Errors, Their Consequences, and Their Management 199
Types of Errors and Their Consequences 200
Human Bias 205
Contents vii
Bureaucracy, the "Killer Bees," and Other Considerations
about Retarding Research 208
Journals 213
Higher Education 215
Appendix: Antiretroviral Drugs Approved by the U.S. Food and Drug
Administration, 2007 221
Index 223 |
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| spelling | Holmberg, Scott D. Verfasser aut Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved Scott D. Holmberg 1. publ. Westport, Conn. [u.a.] Praeger 2008 X, 228 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Geschichte 1980-2007 gnd rswk-swf Geschichte AIDS (Disease) Research United States History HIV infections Research United States History AIDS (Disease) United States Epidemiology HIV infections United States Epidemiology Errors, Scientific Medical errors HIV Infections epidemiology United States HIV Infections history United States Epidemiologic Methods United States Medical Errors prevention & control United States Forschung (DE-588)4017894-8 gnd rswk-swf HIV-Infektion (DE-588)4203852-2 gnd rswk-swf USA USA (DE-588)4078704-7 gnd rswk-swf USA (DE-588)4078704-7 g HIV-Infektion (DE-588)4203852-2 s Forschung (DE-588)4017894-8 s Geschichte 1980-2007 z b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016533775&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Holmberg, Scott D. Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved Geschichte AIDS (Disease) Research United States History HIV infections Research United States History AIDS (Disease) United States Epidemiology HIV infections United States Epidemiology Errors, Scientific Medical errors HIV Infections epidemiology United States HIV Infections history United States Epidemiologic Methods United States Medical Errors prevention & control United States Forschung (DE-588)4017894-8 gnd HIV-Infektion (DE-588)4203852-2 gnd |
| subject_GND | (DE-588)4017894-8 (DE-588)4203852-2 (DE-588)4078704-7 |
| title | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved |
| title_auth | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved |
| title_exact_search | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved |
| title_exact_search_txtP | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved |
| title_full | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved Scott D. Holmberg |
| title_fullStr | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved Scott D. Holmberg |
| title_full_unstemmed | Scientific errors and controversies in the U.S. HIV/AIDS epidemic how they slowed advances and were resolved Scott D. Holmberg |
| title_short | Scientific errors and controversies in the U.S. HIV/AIDS epidemic |
| title_sort | scientific errors and controversies in the u s hiv aids epidemic how they slowed advances and were resolved |
| title_sub | how they slowed advances and were resolved |
| topic | Geschichte AIDS (Disease) Research United States History HIV infections Research United States History AIDS (Disease) United States Epidemiology HIV infections United States Epidemiology Errors, Scientific Medical errors HIV Infections epidemiology United States HIV Infections history United States Epidemiologic Methods United States Medical Errors prevention & control United States Forschung (DE-588)4017894-8 gnd HIV-Infektion (DE-588)4203852-2 gnd |
| topic_facet | Geschichte AIDS (Disease) Research United States History HIV infections Research United States History AIDS (Disease) United States Epidemiology HIV infections United States Epidemiology Errors, Scientific Medical errors HIV Infections epidemiology United States HIV Infections history United States Epidemiologic Methods United States Medical Errors prevention & control United States Forschung HIV-Infektion USA |
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