Basic bioinformatics:
"This book is intended to give the basics of biological concepts, biological database and internet based bioinformatic tools. We are hopeful that this book will cater to the immediate needs of students, researchers, faculty members and pharmaceutical industries."--Pref.
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Harrow
Alpha Science Internat.
2005
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | "This book is intended to give the basics of biological concepts, biological database and internet based bioinformatic tools. We are hopeful that this book will cater to the immediate needs of students, researchers, faculty members and pharmaceutical industries."--Pref. |
| Beschreibung: | Literaturverz. S. [170] - 172 |
| Beschreibung: | XIII, 190 S. Ill., graph. Darst. |
| ISBN: | 1842652311 9781842652312 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV023347308 | ||
| 003 | DE-604 | ||
| 005 | 20081219 | ||
| 007 | t | ||
| 008 | 080616s2005 ad|| |||| 00||| eng d | ||
| 020 | |a 1842652311 |9 1-8426-5231-1 | ||
| 020 | |a 9781842652312 |9 978-1-8426-5231-2 | ||
| 035 | |a (OCoLC)60365640 | ||
| 035 | |a (DE-599)GBV527902942 | ||
| 040 | |a DE-604 |b ger | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-91G |a DE-20 | ||
| 050 | 0 | |a QH324.2 | |
| 082 | 0 | |a 570.28 |2 bio01 | |
| 084 | |a ST 640 |0 (DE-625)143686: |2 rvk | ||
| 084 | |a WC 7700 |0 (DE-625)148144: |2 rvk | ||
| 084 | |a BIO 110f |2 stub | ||
| 100 | 1 | |a Ignacimuthu, Savarimuthu |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Basic bioinformatics |c S. Ignacimuthu |
| 264 | 1 | |a Harrow |b Alpha Science Internat. |c 2005 | |
| 300 | |a XIII, 190 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Literaturverz. S. [170] - 172 | ||
| 520 | 3 | |a "This book is intended to give the basics of biological concepts, biological database and internet based bioinformatic tools. We are hopeful that this book will cater to the immediate needs of students, researchers, faculty members and pharmaceutical industries."--Pref. | |
| 650 | 4 | |a Bioinformatics | |
| 650 | 4 | |a Computational Biology | |
| 650 | 0 | 7 | |a Bioinformatik |0 (DE-588)4611085-9 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4151278-9 |a Einführung |2 gnd-content | |
| 689 | 0 | 0 | |a Bioinformatik |0 (DE-588)4611085-9 |D s |
| 689 | 0 | |5 DE-604 | |
| 856 | 4 | 2 | |m HEBIS Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016530972&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016530972 | ||
Datensatz im Suchindex
| _version_ | 1804137703218872320 |
|---|---|
| adam_text | Basic
Bioinformatics
S Ignadmuthu, s j
Alpha Science International Ltd
Harrow, U K
CONTENTS
Preface
Acknowledgements
History, Scope and Importance
Important Contributions
Sequencing Development
Aims and Tasks of Bioinformatics
Applications of Bioinformatics
Sequence Homology Analysis
Drug Design
Predictive Functions
Medical Areas
Intellectual Property Rights
Challenges and Opportunities
Study Questions
Computers, Internet, World Wide Web and NCBI
Computers and Programs
Internet
World Wide Web
Browsers
EMBnet and SRS
NCBI
Study Questions
DNA, RNA and Proteins
Background
DNA
RNA
Transcription and Translation
Proteins
Study Questions
DNA and Protein Sequencing and Analysis
Genomics and Proteomics
Genome Mapping
DNA Sequencing Methods
Open Reading Frame
Determining Sequence of a Clone
Expressed Sequence Tags
IX
nii
4 7 Protein Sequencing 57
4 8 Gene and Protein expression analysis 57
481 DNA Microarrays 58
482 Protein Expression Analysis 62
483 Gene Discovery 64
4 9 Human Genome Project 66
Study Questions 70
5 Databases, Tools and their Uses 71
51I mportance of Databases 71
5 2 Nucleic acid Sequence Databases 75
5 3 Protein Sequence Databases 78
5 4 Structure Databases 80
5 5 Bibliographic Databases and Virtual Library 86
5 6 Specialized Analysis Packages 87
5 7 Use of Databases 91
Study Questions 91
6 Sequence Alignment 92
6 1 Algorithm 92
6 2 Goals and Types of Alignment 93
6 3 Study of Similarities 94
6 4 Scoring Mutations, Deletions and Substitutions 97
6 5 Sequence Alignment Methods 100
6 6 Pairwise Alignment 101
6 7 Multiple Sequence Alignment 105
6 8 Algorithms for Identifying Domains within a Protein Structure 109
6 9 Algorithms for Structural Comparison 109
6 10 Carrying out a Sequence Search 110
Study Questions 113
7 Predictive Methods using DNA and Protein Sequences 114
7 1 Gene Prediction Strategies 114
711 Gene Prediction Programs 116
7 2 Protein Prediction Strategies 117
721 Secondary Structure Prediction 118
722 Intrinsic Tendency of Amino acids to form (3-turns 121
723 Rotamer Libraries 121
724 Three-Dimensional Structure Prediction 121
725 Comparative Modeling 122
726 Threading 123
siii
727 Energy-based Prediction of Protein Structure 123
728 Protein Function Prediction 124
7 3 Protein Prediction Programs 125
7 4 Molecular Visualization 126
Study Questions 127
8 Homology, Phylogeny and Evolutionary Trees 129
8 1 Homology and Similarity 129
8 2 Phylogeny and Relationships 131
821 Approaches used in Phylogenetic Analysis 132
822 Phylogenetic Trees 135
823 Tree-building Methods 136
8 3 Molecular Approaches to Phylogeny 13,9
8 4 Phylogenetic Analysis Databases 141
Study Questions 141
9 Drug Discovery and Pharmainformatics 142
9 1 Discovering a Drug 142
911 Target Identification and Validation 142
912 Identifying the Lead Compound 144
913 Optimization of Lead Compound 144
9 2 Pharmainformatics 146
921 Chemical Libraries 147
9 3 Search Programs 147
Study Questions 152
Appendix: List of Special Websites and Web Addresses 153
References 170
Glossary 173
Index 187
|
| adam_txt |
Basic
Bioinformatics
S Ignadmuthu, s j
Alpha Science International Ltd
Harrow, U K
CONTENTS
Preface
Acknowledgements
History, Scope and Importance
Important Contributions
Sequencing Development
Aims and Tasks of Bioinformatics
Applications of Bioinformatics
Sequence Homology Analysis
Drug Design
Predictive Functions
Medical Areas
Intellectual Property Rights
Challenges and Opportunities
Study Questions
Computers, Internet, World Wide Web and NCBI
Computers and Programs
Internet
World Wide Web
Browsers
EMBnet and SRS
NCBI
Study Questions
DNA, RNA and Proteins
Background
DNA
RNA
Transcription and Translation
Proteins
Study Questions
DNA and Protein Sequencing and Analysis
Genomics and Proteomics
Genome Mapping
DNA Sequencing Methods
Open Reading Frame
Determining Sequence of a Clone
Expressed Sequence Tags
IX
nii
4 7 Protein Sequencing 57
4 8 Gene and Protein expression analysis 57
481 DNA Microarrays 58
482 Protein Expression Analysis 62
483 Gene Discovery 64
4 9 Human Genome Project 66
Study Questions 70
5 Databases, Tools and their Uses 71
51I mportance of Databases 71
5 2 Nucleic acid Sequence Databases 75
5 3 Protein Sequence Databases 78
5 4 Structure Databases 80
5 5 Bibliographic Databases and Virtual Library 86
5 6 Specialized Analysis Packages 87
5 7 Use of Databases 91
Study Questions 91
6 Sequence Alignment 92
6 1 Algorithm 92
6 2 Goals and Types of Alignment 93
6 3 Study of Similarities 94
6 4 Scoring Mutations, Deletions and Substitutions 97
6 5 Sequence Alignment Methods 100
6 6 Pairwise Alignment 101
6 7 Multiple Sequence Alignment 105
6 8 Algorithms for Identifying Domains within a Protein Structure 109
6 9 Algorithms for Structural Comparison 109
6 10 Carrying out a Sequence Search 110
Study Questions 113
7 Predictive Methods using DNA and Protein Sequences 114
7 1 Gene Prediction Strategies 114
711 Gene Prediction Programs 116
7 2 Protein Prediction Strategies 117
721 Secondary Structure Prediction 118
722 Intrinsic Tendency of Amino acids to form (3-turns 121
723 Rotamer Libraries 121
724 Three-Dimensional Structure Prediction 121
725 Comparative Modeling 122
726 Threading 123
siii
727 Energy-based Prediction of Protein Structure 123
728 Protein Function Prediction 124
7 3 Protein Prediction Programs 125
7 4 Molecular Visualization 126
Study Questions 127
8 Homology, Phylogeny and Evolutionary Trees 129
8 1 Homology and Similarity 129
8 2 Phylogeny and Relationships 131
821 Approaches used in Phylogenetic Analysis 132
822 Phylogenetic Trees 135
823 Tree-building Methods 136
8 3 Molecular Approaches to Phylogeny 13,9
8 4 Phylogenetic Analysis Databases 141
Study Questions 141
9 Drug Discovery and Pharmainformatics 142
9 1 Discovering a Drug 142
911 Target Identification and Validation 142
912 Identifying the Lead Compound 144
913 Optimization of Lead Compound 144
9 2 Pharmainformatics 146
921 Chemical Libraries 147
9 3 Search Programs 147
Study Questions 152
Appendix: List of Special Websites and Web Addresses 153
References 170
Glossary 173
Index 187 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Ignacimuthu, Savarimuthu |
| author_facet | Ignacimuthu, Savarimuthu |
| author_role | aut |
| author_sort | Ignacimuthu, Savarimuthu |
| author_variant | s i si |
| building | Verbundindex |
| bvnumber | BV023347308 |
| callnumber-first | Q - Science |
| callnumber-label | QH324 |
| callnumber-raw | QH324.2 |
| callnumber-search | QH324.2 |
| callnumber-sort | QH 3324.2 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | ST 640 WC 7700 |
| classification_tum | BIO 110f |
| ctrlnum | (OCoLC)60365640 (DE-599)GBV527902942 |
| dewey-full | 570.28 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 570 - Biology |
| dewey-raw | 570.28 |
| dewey-search | 570.28 |
| dewey-sort | 3570.28 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Informatik |
| discipline_str_mv | Biologie Informatik |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01785nam a2200433 c 4500</leader><controlfield tag="001">BV023347308</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20081219 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">080616s2005 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">1842652311</subfield><subfield code="9">1-8426-5231-1</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9781842652312</subfield><subfield code="9">978-1-8426-5231-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)60365640</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBV527902942</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-91G</subfield><subfield code="a">DE-20</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH324.2</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">570.28</subfield><subfield code="2">bio01</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">ST 640</subfield><subfield code="0">(DE-625)143686:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 7700</subfield><subfield code="0">(DE-625)148144:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIO 110f</subfield><subfield code="2">stub</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ignacimuthu, Savarimuthu</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Basic bioinformatics</subfield><subfield code="c">S. Ignacimuthu</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Harrow</subfield><subfield code="b">Alpha Science Internat.</subfield><subfield code="c">2005</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIII, 190 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Literaturverz. S. [170] - 172</subfield></datafield><datafield tag="520" ind1="3" ind2=" "><subfield code="a">"This book is intended to give the basics of biological concepts, biological database and internet based bioinformatic tools. We are hopeful that this book will cater to the immediate needs of students, researchers, faculty members and pharmaceutical industries."--Pref.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Bioinformatics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Computational Biology</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Bioinformatik</subfield><subfield code="0">(DE-588)4611085-9</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4151278-9</subfield><subfield code="a">Einführung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Bioinformatik</subfield><subfield code="0">(DE-588)4611085-9</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HEBIS Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016530972&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016530972</subfield></datafield></record></collection> |
| genre | (DE-588)4151278-9 Einführung gnd-content |
| genre_facet | Einführung |
| id | DE-604.BV023347308 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:03:53Z |
| indexdate | 2024-07-09T21:16:30Z |
| institution | BVB |
| isbn | 1842652311 9781842652312 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016530972 |
| oclc_num | 60365640 |
| open_access_boolean | |
| owner | DE-91G DE-BY-TUM DE-20 |
| owner_facet | DE-91G DE-BY-TUM DE-20 |
| physical | XIII, 190 S. Ill., graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Alpha Science Internat. |
| record_format | marc |
| spelling | Ignacimuthu, Savarimuthu Verfasser aut Basic bioinformatics S. Ignacimuthu Harrow Alpha Science Internat. 2005 XIII, 190 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. [170] - 172 "This book is intended to give the basics of biological concepts, biological database and internet based bioinformatic tools. We are hopeful that this book will cater to the immediate needs of students, researchers, faculty members and pharmaceutical industries."--Pref. Bioinformatics Computational Biology Bioinformatik (DE-588)4611085-9 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Bioinformatik (DE-588)4611085-9 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016530972&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ignacimuthu, Savarimuthu Basic bioinformatics Bioinformatics Computational Biology Bioinformatik (DE-588)4611085-9 gnd |
| subject_GND | (DE-588)4611085-9 (DE-588)4151278-9 |
| title | Basic bioinformatics |
| title_auth | Basic bioinformatics |
| title_exact_search | Basic bioinformatics |
| title_exact_search_txtP | Basic bioinformatics |
| title_full | Basic bioinformatics S. Ignacimuthu |
| title_fullStr | Basic bioinformatics S. Ignacimuthu |
| title_full_unstemmed | Basic bioinformatics S. Ignacimuthu |
| title_short | Basic bioinformatics |
| title_sort | basic bioinformatics |
| topic | Bioinformatics Computational Biology Bioinformatik (DE-588)4611085-9 gnd |
| topic_facet | Bioinformatics Computational Biology Bioinformatik Einführung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016530972&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ignacimuthusavarimuthu basicbioinformatics |