Bisphosphonates in medical practice: actions, side effects, indications, strategies
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2007
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | XX, 265 S. zahlr. Ill., graph. Darst. |
| ISBN: | 3540698698 9783540698692 |
Staff View
MARC
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| 020 | |a 3540698698 |c kart. : EUR 53.45 (freier Pr.), ca. sfr 88.50 (freier Pr.) |9 3-540-69869-8 | ||
| 020 | |a 9783540698692 |c kart. : EUR 53.45 (freier Pr.), ca. sfr 88.50 (freier Pr.) |9 978-3-540-69869-2 | ||
| 024 | 3 | |a 9783540698692 | |
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| 245 | 1 | 0 | |a Bisphosphonates in medical practice |b actions, side effects, indications, strategies |c Reiner Bartl ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2007 | |
| 300 | |a XX, 265 S. |b zahlr. Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Bones |x Diseases | |
| 650 | 4 | |a Diphosphonates |x Side effects | |
| 650 | 4 | |a Diphosphonates |x Therapeutic use | |
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Record in the Search Index
| _version_ | 1804137685224259584 |
|---|---|
| adam_text | Contents
Chapter
1
The Skeleton
Functions of the Skeleton
.............................................. 1
Structure of the Skeleton
............................................... 2
Modelling and Remodelling
............................................ 3
Bone Cells
..............................................................
б
Steps (or Phases) of Bone Remodelling
................................ 10
Regulation of Bone Remodelling
....................................... 12
The RANK/RANKL/Osteoprotegerin System
........................... 18
Age and Bone Mass
.................................................... 20
Chapter
2
Disorders of Bone
Manifestations of Abnormalities in Remodelling
....................... 23
Osteoclasts: The Leading Actors in Disorders of Bone
.................. 23
Classification of Osteopathies According to Spread (Topography)
..... 25
Classification According to Underlying Pathologic Anatomy
of the Bones Involved
............................................... 26
Diagnostic Investigation
............................................... 28
Chapter
3
Bisphosphonates
Historical Review
....................................................... 33
Chemistry
.............................................................. 34
Pharmacodynamics
.................................................... 35
Actions of Bisphosphonates
............................................ 46
Structure-Related Actions
.............................................. 58
Side Effects
............................................................. 61
Practical Recommendations and Guidelines
........................... 68
XII Contents______________________________________________________________
Chapter
4
Osteoporotic Syndrome
Definition
............................................................ 71
Classification According to Extent of Spread
......................... 72
Classification According to Rate of Bone Turnover
................... 72
Classification According to Age and Sex
............................. 72
Secondary Osteoporoses
............................................. 73
Diagnosis
............................................................ 76
Therapeutic Strategies
............................................... 82
Bisphosphonates
..................................................... 86
Intravenous Therapy of Osteoporosis
................................ 89
Practical Recommendations
......................................... 95
Chapter
5
Glucocorticoid Induced Osteoporosis
Definition
............................................................ 99
Diseases Treated with Glucocorticoids
............................... 99
Pathophysiology
..................................................... 100
Prevention
........................................................... 101
Treatment Strategies
................................................. 101
Bisphosphonates
..................................................... 102
Chapter
6
Tumor and Chemotherapy Induced Osteoporosis
Definition
............................................................ 103
Pathophysiology
..................................................... 103
Types of Tumor Therapy with Direct Effects on Bone
................. 104
Treatment Strategies
................................................. 107
Bisphosphonates
..................................................... 107
Chapter
7
Transplantation Osteoporosis
Definition
............................................................ 109
Pathogenesis
......................................................... 109
Treatment Strategies
................................................. 110
Bisphosphonates
..................................................... 110
Contents XIII
Chapter
8
Immobilisation Osteoporosis
Examples of Bone Loss
............................................... 111
Therapy of Immobilisation Osteoporosis
............................. 112
Chapter
9
Pregnancy Associated Osteoporosis
Pathogenesis
......................................................... 115
Prevention and Therapy
.............................................. 115
Chapter
10
Osteogenesis
Imperfecta
(01)
Definition
............................................................ 117
Pathophysiology
..................................................... 117
Diagnosis
............................................................ 118
Treatment Strategies
................................................. 118
Bisphosphonates
..................................................... 119
Osteopenia of Prematurity
........................................... 120
Chapter
11
AIDS Osteopathy
Clinical Settings of Disorders of Bone in AIDS
........................ 123
Manifestations of AIDS Osteopathy
.................................. 123
Diagnosis
............................................................ 124
Treatment Strategies
................................................. 125
Chapter
12
Renal Osteopathy
Definition
............................................................ 127
Pathophysiology
..................................................... 127
Diagnosis
............................................................ 128
Treatment Strategies
................................................. 129
Bisphosphonates
..................................................... 130
XIV Contents
Chapter
13
Paget s Disease of Bone
Definition
............................................................ 131
Clinical Findings
...................................................... 131
Diagnosis
............................................................ 132
Treatment Strategies
................................................. 135
Bisphosphonates
..................................................... 136
Chapter
14
Complex Regional Pain Syndrome (CRPS)
Definition
............................................................ 139
Clinical Findings
...................................................... 139
Diagnosis
............................................................ 139
Course of Disease
.................................................... 140
Treatment Strategies
................................................. 141
Bisphosphonates
..................................................... 141
Chapter
15
Transient Osteoporosis
and the Bone Marrow Edema Syndrome (BMES)
Transient Osteoporosis
............................................... 143
Diagnosis
............................................................ 143
Treatment Strategies
................................................. 144
Bisphosphonates
..................................................... 145
Bone Marrow Edema Syndrome {BMES)
.............................. 145
Diagnosis
............................................................ 146
Treatment Strategies
................................................. 147
Bisphosphonates
..................................................... 147
Chapter
16
Vanishing Bone Disease
(Gorham-Stout Syndrome)
Definition
............................................................ 151
Etiology and Pathophysiology
....................................... 151
Clinical Findings
...................................................... 151
Diagnosis
............................................................ 153
Treatment Strategies
................................................. 153
Bisphosphonates
..................................................... 153
Contents
XV
Chapter
17
Fibrous
Dysplasie
Definition
............................................................ 155
Clinical Findings
...................................................... 156
Treatment Strategies
................................................. 156
Bisphosphonates
..................................................... 157
Chapter
18
SAPHO Syndrome
Definition
............................................................ 159
Diagnosis
............................................................ 159
Therapy
.............................................................. 160
Chapter^
Heterotopic Calcification and Ossification
Definition
............................................................ 163
Sites and Conditions of Occurrence
.................................. 163
Treatment Strategies
................................................. 163
Bisphosphonates
..................................................... 164
Chapter
20
Periprosthetic Osteolysis and Aseptic Loosening
of
Prostheses
in Total Joint Arthroplasty
Pathogenesis
......................................................... 165
Diagnosis
............................................................ 167
Treatment Strategies
................................................. 168
Bisphosphonates
..................................................... 169
Chapter
21
Alveolar Bone Loss due to Periodontitis
Definition
............................................................ 173
Pathogenesis
......................................................... 173
Clinical Findings
...................................................... 173
Treatment Strategies
................................................. 173
Bisphosphonates
..................................................... 174
Necrosis of the Jaw Bones and Non-traumatic Avascular Necrosis
of the Femoral Head
............................................... 175
XVI Contents
Chapter
22
Hypercalcemia
Definition
............................................................ 177
Frequency
............................................................ 177
Differential Diagnosis
................................................ 178
Symptoms
........................................................... 179
Treatment Strategies
................................................. 179
Bisphosphonates
..................................................... 179
Hypercalcemia of Malignancy
........................................ 180
Chapter
23
Bone Pain
Frequency
............................................................ 183
Differential Diagnosis
................................................ 183
Pathogenesis
......................................................... 184
Diagnosis
............................................................ 185
Treatment Strategies
................................................. 186
Bisphosphonates
..................................................... 186
Chapter
24
Multiple Myeloma
Definition
............................................................ 189
Frequency
............................................................ 189
Pathogenesis
......................................................... 189
Clinical Findings
...................................................... 190
Diagnosis of Skeletal Manifestations
................................. 192
Myeloma Variants
.................................................... 193
Treatment Strategies
................................................. 194
Bisphosphonates
..................................................... 195
Chapter
25
Bone
Métastases
Introduction
......................................................... 199
Frequency
............................................................ 199
Regional Distribution within the Skeleton
........................... 201
Development of Skeletal
Métastases
................................. 201
Osseous Reactions
................................................... 203
Bisphosphonates
..................................................... 205
__________________________________________________________________Contents XVII
Chapter
26
Skeletal
Métastases
of Breast Cancer
Frequency
............................................................ 209
Circulating Tumor Cells
............................................... 209
Complications
........................................................ 209
Treatment Strategies
................................................. 210
Bisphosphonates for Prevention of Metastasis
....................... 210
Bisphosphonates for Prevention of Skeletal Complications
.......... 212
Bisphosphonates for Treatment of Skeletal Complications
........... 212
Chapter
27
Other Carcinomas with Osteotropic
Métastases
Prostatic Carcinoma
.................................................. 215
Bronchial Carcinoma, Lung Cancer
................................... 217
Renal Cell Carcinoma
................................................. 217
Other Malignancies with Implications for Skeletal Involvement
...... 218
Chapter
28
Bisphosphonates from A-Z
List of Indications
.................................................... 221
List of Subgroups of Bisphosphonates
............................... 226
List According to Different Modes of Action
.......................... 227
List of Commercial Bisphosphonate Preparations from A to
Z
........ 227
List of Authorised Bisphosphonates from A to
Z
..................... 228
Chapter
29
Summary and Perspectives
................................. 229
Chapter
30
Literature Survey
............................................ 235
Subject Index
................................................ 259
Clinical osteology is now an independent
specialty which nevertheless encompasses
all branches of medicine and effects each
and every one of us: Bone is Every Body s
Business: This book has been designed as an
up-to-date manual to deal with the currently
recognized indications for bisphospho-
nates, to outline situations and conditions
for prevention of skeletal disorders, and to
provide practical guidelines for treatment.
It is intended for doctors who seek precise
information on bisphosphonates in medical
practice to enable them to treat patients with
disorders of bone or better still to avoid their
occurrence
-
as the age-old saying has it
prevention is better than cure! Significant
advances have already been made in the first
6
years of the Bone and Joint Decade of
the new century, and it is our hope that this
book will contribute to more progress in the
same direction.
Bartl
Frisch
vonTresckow
Bartl
Bisphosphonates
in Medical
Practice
Actions
Side Effects
Indications
Strategies
|
| adam_txt |
Contents
Chapter
1
The Skeleton
Functions of the Skeleton
. 1
Structure of the Skeleton
. 2
Modelling and Remodelling
. 3
Bone Cells
.
б
Steps (or Phases) of Bone Remodelling
. 10
Regulation of Bone Remodelling
. 12
The RANK/RANKL/Osteoprotegerin System
. 18
Age and Bone Mass
. 20
Chapter
2
Disorders of Bone
Manifestations of Abnormalities in Remodelling
. 23
Osteoclasts: The Leading Actors in Disorders of Bone
. 23
Classification of Osteopathies According to Spread (Topography)
. 25
Classification According to Underlying Pathologic Anatomy
of the Bones Involved
. 26
Diagnostic Investigation
. 28
Chapter
3
Bisphosphonates
Historical Review
. 33
Chemistry
. 34
Pharmacodynamics
. 35
Actions of Bisphosphonates
. 46
Structure-Related Actions
. 58
Side Effects
. 61
Practical Recommendations and Guidelines
. 68
XII Contents_
Chapter
4
Osteoporotic Syndrome
Definition
. 71
Classification According to Extent of Spread
. 72
Classification According to Rate of Bone Turnover
. 72
Classification According to Age and Sex
. 72
Secondary Osteoporoses
. 73
Diagnosis
. 76
Therapeutic Strategies
. 82
Bisphosphonates
. 86
Intravenous Therapy of Osteoporosis
. 89
Practical Recommendations
. 95
Chapter
5
Glucocorticoid Induced Osteoporosis
Definition
. 99
Diseases Treated with Glucocorticoids
. 99
Pathophysiology
. 100
Prevention
. 101
Treatment Strategies
. 101
Bisphosphonates
. 102
Chapter
6
Tumor and Chemotherapy Induced Osteoporosis
Definition
. 103
Pathophysiology
. 103
Types of Tumor Therapy with Direct Effects on Bone
. 104
Treatment Strategies
. 107
Bisphosphonates
. 107
Chapter
7
Transplantation Osteoporosis
Definition
. 109
Pathogenesis
. 109
Treatment Strategies
. 110
Bisphosphonates
. 110
Contents XIII
Chapter
8
Immobilisation Osteoporosis
Examples of Bone Loss
. 111
Therapy of Immobilisation Osteoporosis
. 112
Chapter
9
Pregnancy Associated Osteoporosis
Pathogenesis
. 115
Prevention and Therapy
. 115
Chapter
10
Osteogenesis
Imperfecta
(01)
Definition
. 117
Pathophysiology
. 117
Diagnosis
. 118
Treatment Strategies
. 118
Bisphosphonates
. 119
Osteopenia of Prematurity
. 120
Chapter
11
AIDS Osteopathy
Clinical Settings of Disorders of Bone in AIDS
. 123
Manifestations of AIDS Osteopathy
. 123
Diagnosis
. 124
Treatment Strategies
. 125
Chapter
12
Renal Osteopathy
Definition
. 127
Pathophysiology
. 127
Diagnosis
. 128
Treatment Strategies
. 129
Bisphosphonates
. 130
XIV Contents
Chapter
13
Paget's Disease of Bone
Definition
. 131
Clinical Findings
. 131
Diagnosis
. 132
Treatment Strategies
. 135
Bisphosphonates
. 136
Chapter
14
Complex Regional Pain Syndrome (CRPS)
Definition
. 139
Clinical Findings
. 139
Diagnosis
. 139
Course of Disease
. 140
Treatment Strategies
. 141
Bisphosphonates
. 141
Chapter
15
Transient Osteoporosis
and the Bone Marrow Edema Syndrome (BMES)
Transient Osteoporosis
. 143
Diagnosis
. 143
Treatment Strategies
. 144
Bisphosphonates
. 145
Bone Marrow Edema Syndrome {BMES)
. 145
Diagnosis
. 146
Treatment Strategies
. 147
Bisphosphonates
. 147
Chapter
16
Vanishing Bone Disease
(Gorham-Stout Syndrome)
Definition
. 151
Etiology and Pathophysiology
. 151
Clinical Findings
. 151
Diagnosis
. 153
Treatment Strategies
. 153
Bisphosphonates
. 153
Contents
XV
Chapter
17
Fibrous
Dysplasie
Definition
. 155
Clinical Findings
. 156
Treatment Strategies
. 156
Bisphosphonates
. 157
Chapter
18
SAPHO Syndrome
Definition
. 159
Diagnosis
. 159
Therapy
. 160
Chapter^
Heterotopic Calcification and Ossification
Definition
. 163
Sites and Conditions of Occurrence
. 163
Treatment Strategies
. 163
Bisphosphonates
. 164
Chapter
20
Periprosthetic Osteolysis and Aseptic Loosening
of
Prostheses
in Total Joint Arthroplasty
Pathogenesis
. 165
Diagnosis
. 167
Treatment Strategies
. 168
Bisphosphonates
. 169
Chapter
21
Alveolar Bone Loss due to Periodontitis
Definition
. 173
Pathogenesis
. 173
Clinical Findings
. 173
Treatment Strategies
. 173
Bisphosphonates
. 174
Necrosis of the Jaw Bones and Non-traumatic Avascular Necrosis
of the Femoral Head
. 175
XVI Contents
Chapter
22
Hypercalcemia
Definition
. 177
Frequency
. 177
Differential Diagnosis
. 178
Symptoms
. 179
Treatment Strategies
. 179
Bisphosphonates
. 179
Hypercalcemia of Malignancy
. 180
Chapter
23
Bone Pain
Frequency
. 183
Differential Diagnosis
. 183
Pathogenesis
. 184
Diagnosis
. 185
Treatment Strategies
. 186
Bisphosphonates
. 186
Chapter
24
Multiple Myeloma
Definition
. 189
Frequency
. 189
Pathogenesis
. 189
Clinical Findings
. 190
Diagnosis of Skeletal Manifestations
. 192
Myeloma Variants
. 193
Treatment Strategies
. 194
Bisphosphonates
. 195
Chapter
25
Bone
Métastases
Introduction
. 199
Frequency
. 199
Regional Distribution within the Skeleton
. 201
Development of Skeletal
Métastases
. 201
Osseous Reactions
. 203
Bisphosphonates
. 205
_Contents XVII
Chapter
26
Skeletal
Métastases
of Breast Cancer
Frequency
. 209
Circulating Tumor Cells
. 209
Complications
. 209
Treatment Strategies
. 210
Bisphosphonates for Prevention of Metastasis
. 210
Bisphosphonates for Prevention of Skeletal Complications
. 212
Bisphosphonates for Treatment of Skeletal Complications
. 212
Chapter
27
Other Carcinomas with Osteotropic
Métastases
Prostatic Carcinoma
. 215
Bronchial Carcinoma, Lung Cancer
. 217
Renal Cell Carcinoma
. 217
Other Malignancies with Implications for Skeletal Involvement
. 218
Chapter
28
Bisphosphonates from A-Z
List of Indications
. 221
List of Subgroups of Bisphosphonates
. 226
List According to Different Modes of Action
. 227
List of Commercial Bisphosphonate Preparations from A to
Z
. 227
List of Authorised Bisphosphonates from A to
Z
. 228
Chapter
29
Summary and Perspectives
. 229
Chapter
30
Literature Survey
. 235
Subject Index
. 259
Clinical osteology is now an independent
specialty which nevertheless encompasses
all branches of medicine and effects each
and every one of us: Bone is Every Body's
Business: This book has been designed as an
up-to-date manual to deal with the currently
recognized indications for bisphospho-
nates, to outline situations and conditions
for prevention of skeletal disorders, and to
provide practical guidelines for treatment.
It is intended for doctors who seek precise
information on bisphosphonates in medical
practice to enable them to treat patients with
disorders of bone or better still to avoid their
occurrence
-
as the age-old saying has it
"prevention is better than cure!" Significant
advances have already been made in the first
6
years of the "Bone and Joint Decade" of
the new century, and it is our hope that this
book will contribute to more progress in the
same direction.
Bartl
Frisch
vonTresckow
Bartl
Bisphosphonates
in Medical
Practice
Actions
Side Effects
Indications
Strategies |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author_GND | (DE-588)106851322 |
| building | Verbundindex |
| bvnumber | BV023335181 |
| classification_rvk | YK 2000 YK 2015 |
| ctrlnum | (OCoLC)185027061 (DE-599)BVBBV023335181 |
| dewey-full | 616.71061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.71061 |
| dewey-search | 616.71061 |
| dewey-sort | 3616.71061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Book |
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| id | DE-604.BV023335181 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:59:20Z |
| indexdate | 2024-07-09T21:16:13Z |
| institution | BVB |
| isbn | 3540698698 9783540698692 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016519060 |
| oclc_num | 185027061 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| owner_facet | DE-355 DE-BY-UBR DE-19 DE-BY-UBM |
| physical | XX, 265 S. zahlr. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Springer |
| record_format | marc |
| spelling | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl ... Berlin [u.a.] Springer 2007 XX, 265 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Bones Diseases Diphosphonates Side effects Diphosphonates Therapeutic use Diphosphonate (DE-588)4150083-0 gnd rswk-swf Knochenkrankheit (DE-588)4120576-5 gnd rswk-swf Knochenkrankheit (DE-588)4120576-5 s Diphosphonate (DE-588)4150083-0 s DE-604 Bartl, Reiner 1944- Sonstige (DE-588)106851322 oth Erscheint auch als Online-Ausgabe 978-3-540-69870-8 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016519060&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016519060&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Bisphosphonates in medical practice actions, side effects, indications, strategies Bones Diseases Diphosphonates Side effects Diphosphonates Therapeutic use Diphosphonate (DE-588)4150083-0 gnd Knochenkrankheit (DE-588)4120576-5 gnd |
| subject_GND | (DE-588)4150083-0 (DE-588)4120576-5 |
| title | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_auth | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_exact_search | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_exact_search_txtP | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_full | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl ... |
| title_fullStr | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl ... |
| title_full_unstemmed | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl ... |
| title_short | Bisphosphonates in medical practice |
| title_sort | bisphosphonates in medical practice actions side effects indications strategies |
| title_sub | actions, side effects, indications, strategies |
| topic | Bones Diseases Diphosphonates Side effects Diphosphonates Therapeutic use Diphosphonate (DE-588)4150083-0 gnd Knochenkrankheit (DE-588)4120576-5 gnd |
| topic_facet | Bones Diseases Diphosphonates Side effects Diphosphonates Therapeutic use Diphosphonate Knochenkrankheit |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016519060&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016519060&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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