The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Aachen
Shaker
2008
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| Schriftenreihe: | Berichte aus der Medizin
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Zugl.: Berlin, Univ., Diss., 2008 |
| Beschreibung: | 101 S. Ill., graph. Darst. |
| ISBN: | 9783832271497 |
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| adam_text | GESCANNT DURCH TABLE OF CONTENTS TABLE OF CONTENTS TABLE OF CONTENTS 1.
INTRODUCTION 1 1.1. CLASSIFICATION OF PAPILLOMAVIRUSES 2 1.2.
HPV-TNDUCED DISEASES 3 1.2.1. NON CANCEROUS LESIONS 1.2.1.1. SKIN-TYPE
WARTS 1.2.1.2. MUCOSA-TYPE WARTS OF THE GENITAL TRACT 1.2.1.3.
MUCOSA-TYPE WARTS OF THE AERODIGESTIVE TRACT 1.2.2. CANCEROUS LESIONS
1.2.2.1. EPIDEMIOLOGY OF CERVICAL CANCER 1.2.2.2. PATHOPHYSIOLOGY
1.2.2.3. SIGNS AND SYMPTOMS 1.2.2.4. MICROSCOPIC ANATOMY 1.2.2.5.
DIAGNOSIS 1.2.2.6. STAGING OF CERVICAL CANCER 1.2.2.7. TREATMENT
1.2.2.8. VACCINE 1.3. PAPILLOMAVIRUS STRUCTURE 12 1.4. PAPILLOMAVIRUS
LIFE CYCLE 13 1.4.1. THE PAPILLOMAVIRAL E2 PROTEIN 1.4.2. THE CELLULAR
BROMODOMAIN PROTEIN BRD4 1.4.3. INTERACTION BETWEEN BRD4 AND TTIEVIRAL
E2 PROTEIN 2. RESEARCH QUESTION 21 3. RESULTS 23 3.1. DLSRUPTIONOF THE
BRD4-E2 INTERACTION BY BRD4-CTD INDUCES PHENOTYPIC REVERSION OF BPV1 -
TRANSFORMED CELLS DUE TO A LOSS OF VIRAI GENOMES 23 3.1.1. PHENOTYPIC
REVERSION OF BPV1-TRANSFORMED CELLS 3.1.2. BRD4-CTD INDUCES LOSS OF
PAPILLOMAVIRAL GENOMES 3.1.3. DETECTION AND CHARACTERIZATIONOFINTEGRATED
VERSUS EXTRACHROMOSOMAL VIRAL DNA 3.1.4. BPV STATUS OF TRANSFORMED AND
PHENOTYPIC REVERTEDH2 CELLS BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/988311747 DIGITALISIERT DURCH * * * * * TABLE OF
CONTENTS 6.3. PROTEIN CHEMICAL METHODS 79 6.3.1.
SDS-GELELECTROPHORESISAFTER LAEMMLI (1970) 6.3.2. WESTERN BLOTTING AND
IMMUNOSTAINING OF PROTEINS 6.3.3. DETERMINATION OF PROTEIN
CONCENTRATIONS 6.3.4. EXTRACTION AND WESTEM BLOTTING OF BRD4 6.4. CELL
BIOLOGICAL METHODS 85 6.4.1. 6.4.2. 6.4.3. 6.4.4. 6.4.5. 6.4.6. 6.4.7.
6.4.8. 6.4.9. 7. 7.1. 7.2. 8. CELL LINES PROPAGATION OF CELLS
TRANSFECTION OF CELLS RETROVIRAL INFECTION OF CELLS GROWTH REPRESSION
ASSAY COLONY REDUCTION ASSAY LUCIFERASE ASSAY CHLORAMPHENICOL
ACETYLTRANSFERASE (CAT) ASSAY SIRNA KNOCK DOWN WITH THE PSUPER.RETRO
VECTOR SYSTEM APPENDIX ABBREVIATIONS REFERENCES CURRICUIUM VITAE 91 101
9. ACKNOWLEDGEMENT 103
|
| adam_txt |
GESCANNT DURCH TABLE OF CONTENTS TABLE OF CONTENTS TABLE OF CONTENTS 1.
INTRODUCTION 1 1.1. CLASSIFICATION OF PAPILLOMAVIRUSES 2 1.2.
HPV-TNDUCED DISEASES 3 1.2.1. NON CANCEROUS LESIONS 1.2.1.1. SKIN-TYPE
WARTS 1.2.1.2. MUCOSA-TYPE WARTS OF THE GENITAL TRACT 1.2.1.3.
MUCOSA-TYPE WARTS OF THE AERODIGESTIVE TRACT 1.2.2. CANCEROUS LESIONS
1.2.2.1. EPIDEMIOLOGY OF CERVICAL CANCER 1.2.2.2. PATHOPHYSIOLOGY
1.2.2.3. SIGNS AND SYMPTOMS 1.2.2.4. MICROSCOPIC ANATOMY 1.2.2.5.
DIAGNOSIS 1.2.2.6. STAGING OF CERVICAL CANCER 1.2.2.7. TREATMENT
1.2.2.8. VACCINE 1.3. PAPILLOMAVIRUS STRUCTURE 12 1.4. PAPILLOMAVIRUS
LIFE CYCLE 13 1.4.1. THE PAPILLOMAVIRAL E2 PROTEIN 1.4.2. THE CELLULAR
BROMODOMAIN PROTEIN BRD4 1.4.3. INTERACTION BETWEEN BRD4 AND TTIEVIRAL
E2 PROTEIN 2. RESEARCH QUESTION 21 3. RESULTS 23 3.1. DLSRUPTIONOF THE
BRD4-E2 INTERACTION BY BRD4-CTD INDUCES PHENOTYPIC REVERSION OF BPV1 -
TRANSFORMED CELLS DUE TO A LOSS OF VIRAI GENOMES 23 3.1.1. PHENOTYPIC
REVERSION OF BPV1-TRANSFORMED CELLS 3.1.2. BRD4-CTD INDUCES LOSS OF
PAPILLOMAVIRAL GENOMES 3.1.3. DETECTION AND CHARACTERIZATIONOFINTEGRATED
VERSUS EXTRACHROMOSOMAL VIRAL DNA 3.1.4. BPV STATUS OF TRANSFORMED AND
PHENOTYPIC REVERTEDH2 CELLS BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/988311747 DIGITALISIERT DURCH * * * * * TABLE OF
CONTENTS 6.3. PROTEIN CHEMICAL METHODS 79 6.3.1.
SDS-GELELECTROPHORESISAFTER LAEMMLI (1970) 6.3.2. WESTERN BLOTTING AND
IMMUNOSTAINING OF PROTEINS 6.3.3. DETERMINATION OF PROTEIN
CONCENTRATIONS 6.3.4. EXTRACTION AND WESTEM BLOTTING OF BRD4 6.4. CELL
BIOLOGICAL METHODS 85 6.4.1. 6.4.2. 6.4.3. 6.4.4. 6.4.5. 6.4.6. 6.4.7.
6.4.8. 6.4.9. 7. 7.1. 7.2. 8. CELL LINES PROPAGATION OF CELLS
TRANSFECTION OF CELLS RETROVIRAL INFECTION OF CELLS GROWTH REPRESSION
ASSAY COLONY REDUCTION ASSAY LUCIFERASE ASSAY CHLORAMPHENICOL
ACETYLTRANSFERASE (CAT) ASSAY SIRNA KNOCK DOWN WITH THE PSUPER.RETRO
VECTOR SYSTEM APPENDIX ABBREVIATIONS REFERENCES CURRICUIUM VITAE 91 101
9. ACKNOWLEDGEMENT 103 |
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| language | English |
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| spelling | Schweiger, Michal-Ruth 1976- Verfasser (DE-588)1146834802 aut The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis Michal-Ruth Schweiger Aachen Shaker 2008 101 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Medizin Zugl.: Berlin, Univ., Diss., 2008 Protein-Protein-Wechselwirkung (DE-588)4745193-2 gnd rswk-swf Gebärmutterhalskrebs (DE-588)4131512-1 gnd rswk-swf Papillomaviren (DE-588)4219886-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Gebärmutterhalskrebs (DE-588)4131512-1 s Papillomaviren (DE-588)4219886-0 s DE-604 Protein-Protein-Wechselwirkung (DE-588)4745193-2 s DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016493082&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schweiger, Michal-Ruth 1976- The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis Protein-Protein-Wechselwirkung (DE-588)4745193-2 gnd Gebärmutterhalskrebs (DE-588)4131512-1 gnd Papillomaviren (DE-588)4219886-0 gnd |
| subject_GND | (DE-588)4745193-2 (DE-588)4131512-1 (DE-588)4219886-0 (DE-588)4113937-9 |
| title | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis |
| title_auth | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis |
| title_exact_search | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis |
| title_exact_search_txtP | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis |
| title_full | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis Michal-Ruth Schweiger |
| title_fullStr | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis Michal-Ruth Schweiger |
| title_full_unstemmed | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis Michal-Ruth Schweiger |
| title_short | The interaction between the papillomaviral protein E2 and the cellular bromodomain protein Brd4 is important for the viral life cycle and viral oncogenesis |
| title_sort | the interaction between the papillomaviral protein e2 and the cellular bromodomain protein brd4 is important for the viral life cycle and viral oncogenesis |
| topic | Protein-Protein-Wechselwirkung (DE-588)4745193-2 gnd Gebärmutterhalskrebs (DE-588)4131512-1 gnd Papillomaviren (DE-588)4219886-0 gnd |
| topic_facet | Protein-Protein-Wechselwirkung Gebärmutterhalskrebs Papillomaviren Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016493082&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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