HPLC method development for pharmaceuticals:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam ; Heidelberg [u.a.]
Elsevier Academic Press
2007
|
| Series: | Separation science and technology
8 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes index |
| Physical Description: | XVII, 513 S. Ill., graph. Darst. |
| ISBN: | 0123705401 9780123705402 |
Staff View
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| 245 | 1 | 0 | |a HPLC method development for pharmaceuticals |c ed. by Satinder Ahuja ... |
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| 650 | 4 | |a Médicaments - Développement | |
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| adam_text | HPLC METHOD DEVELOPMENT FOR PHARMACEUTICALS SATINDER AHUJA HENRIK
RASMUSSEN - -R,-- *» *» * : *-, 11 SR N K /-.;*:: V; - / ./;* V ; -
^.;V. :: ICONTENTS PREFACE XIII CONTRIBUTORS XV I. OVERVIEW OF HPLC
METHOD DEVELOPMENT FOR PHARMACEUTICALS SATINDERAHUJA I. INTRODUCTION 1
II. THEORETICAL CONSIDERATIONS 2 III. HPLC COLUMNS AND COLUMN PACKINGS 2
IV. COLUMN SELECTION 3 V. CHIRAL SEPARATIONS 3 VI. CONTEMPORARY HPLC 4
VII. HYPHENATED METHODS 5 VIII. SAMPLE PREPARATION 5 IX. INSTRUMENT
QUALIFICATION AND SOFTWARE VALIDATION 6 X. PHARMACEUTICAL DEVELOPMENT 6
XL DRUG DISCOVERY 7 XII. EARLY PHASE METHOD DEVELOPMENT 8 XIII. LATE
PHASE DEVELOPMENT 8 XIV. IN-PROCESS TESTING 9 XV. METHOD DEVELOPMENT FOR
BIOMOLECULES 9 XVI. METHOD VALIDATION 10 XVII. TROUBLESHOOTING 10 XVIII.
MOLECULARLY IMPRINTED POLYMERS 10 REFERENCES 11 CONTENTS 2. HPLC THEORY
YV KAZAKEVICH ABSTRACT 13 I. INTRODUCTION 13 II. BASIC CHROMATOGRAPHIC
DESCRIPTORS 14 III. EFFICIENCY 15 IV. RESOLUTION 20 V. MAIN COMPONENTS
OF THE RETENTION MECHANISM 22 VI. GENERAL COLUMN MASS BALANCE 24 VII.
PARTITIONING MODEL 27 VIII. ADSORPTION MODEL 28 IX. VOID VOLUME
CONSIDERATIONS 29 X. THERMODYNAMIC RELATIONSHIPS 31 XL SECONDARY
EQUILIBRIA 35 XII. SALT EFFECT 37 XIII. EFFECT OF DIFFERENT
COUNTERANIONS 38 XIV. INCLUSION OF SECONDARY EQUILIBRIA IN THE MASS
BALANCE 40 XV. CONCLUSIONS 43 REFERENCES 43 3. HPLC COLUMNS AND PACKINGS
UWE D. NEUE, BONNIE A. ALDEN, EDWARD R. GROVER, ERIC S. GRUMBACH, PAMELA
C. IRANETA, AND ALBERTO MENDEZ ABSTRACT 45 I. INTRODUCTION 46 II. COLUMN
CHEMISTRY 47 III. SPEED AND RESOLUTION 68 IV. SPECIALTY COLUMNS FROM
NANOBORE TO PREPARATIVE CHROMATOGRAPHY 77 V. SUMMARY 80 REFERENCES 80 4.
COLUMN CHARACTERIZATION AND SELECTION DORAVISKY ABSTRACT 85 I.
INTRODUCTION 86 II. CHARACTERISTICS OF RP-HPLC COLUMNS AND
CHROMATOGRAPHIC TESTS 90 III. COLUMN CLASSIFICATION AND SELECTION 101
IV. CONCLUSIONS 104 ACKNOWLEDGMENT 105 REFERENCES 105 CONTENTS VM 5.
CHIRAL SEPARATIONS XIANDE WANG.WEIYONG LI, AND HENRIK RASMUSSEN ABSTRACT
111 I. INTRODUCTION 112 II. SEPARATION OF ENANTIOMERS ON HPLC CHIRAL
STATIONARY PHASES 115 III. PRACTICAL GUIDELINES TO CHIRAL HPLC OF
PHARMACEUTICALS 135 IV. CONCLUSIONS 137 REFERENCES 138 6. CONTEMPORARY
LIQUID CHROMATOGRAPHIC SYSTEMS FOR METHOD DEVELOPMENT MICHAEL E. SWARTZ
ABSTRACT 145 I. INTRODUCTION 146 II. TRADITIONAL INSTRUMENTATION FOR
HPLC METHOD DEVELOPMENT 147 III. CONTEMPORARY METHOD DEVELOPMENT SYSTEMS
153 IV. MIGRATING METHODS FROM HPLC TO UPLC 169 V. UPLC APPLICATIONS IN
PHARMACEUTICAL ANALYSIS 174 VI. SUMMARY AND CONCLUSIONS 183
ACKNOWLEDGMENTS 184 REFERENCES 185 FURTHER READING 186 7. HYPHENATED
TECHNIQUES DANIEL L NORWOOD, JAMES O. MULLIS, AND THOMAS N. FEINBERG
ABSTRACT 189 I. INTRODUCTION AND BACKGROUND 190 II. COMBINED LIQUID
CHROMATOGRAPHY/MASS SPECTROMETRY 191 III. COMBINED LIQUID
CHROMATOGRAPHY/NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 218 IV.
CONCLUSIONS 231 ACKNOWLEDGMENTS 231 REFERENCES 232 8. HPLC SAMPLE
PREPARATION GREGORY C. SLACK AND NICHOLAS H. SNOW ABSTRACT 237 I.
INTRODUCTION 238 II. FUNDAMENTALS OF EXTRACTION AND CHEMICAL EQUILIBRIUM
239 III. CHOICE OF SAMPLES PREPARATION 245 V JJJ CONTENTS IV. DIRECT
INJECTION 246 V. LIQUID-LIQUID EXTRACTION 247 VI. SOLID-PHASE EXTRACTION
248 VII. SOLID SAMPLES 254 VIII. ADDITIONAL SAMPLE PREPARATION METHODS
256 IX. CONCLUSIONS 263 REFERENCES 263 9. INSTRUMENT QUALIFICATION AND
SOFTWARE VALIDATION DAVE VAN GEEL ABSTRACT 270 I. INTRODUCTION 270 II.
DEFINITIONS 271 III. QUALIFICATION MODEL 278 IV. DISCUSSION: CASE STUDY
HPLC 291 V. SUMMARY AND CONCLUSIONS 294 ACKNOWLEDGMENTS 295 REFERENCES
295 10. PHARMACEUTICAL DEVELOPMENT: FROM PRE-CLINICAL TO POST APPROVAL
KEVIN C. BYNUM ABSTRACT 297 I. INTRODUCTION 298 II. THE ROLE OF HPLC IN
DRUG DISCOVERY 300 III. THE ROLE OF HPLC IN PRE-CLINICAL DEVELOPMENT 303
IV. THE ROLE OF HPLC IN CLINICAL DEVELOPMENT 307 V. POST APPROVAL 312
VI. CONCLUSIONS 315 REFERENCES 315 11. HPLC METHOD DEVELOPMENT FOR DRUG
DISCOVERY LC-MS ASSAYS IN RAPID PK APPLICATIONS XIAOYING XU I. II. III.
IV. ABSTRACT 318 INTRODUCTION 318 TANDEM MS SELECTED REACTION
DEVELOPMENT 319 HPLC METHOD DEVELOPMENT SAMPLE PREPARATION 324
MONITORING (SRM) 322 CONTENTS IX V. MATRIX EFFECTS 329 VI. BACKGROUND
INTERFERENCE: ENHANCED MASS RESOLUTION STRATEGY 334 VII. LIMIT OF
QUANTITATION, DYNAMIC RANGE AND LINEARITY 340 VIII. ASSAY SAMPLES AND
GENERATE PHARMACOKINETIC REPORTS 344 IX. CONCLUSIONS 345 ACKNOWLEDGMENT
345 REFERENCES 345 12. HPLC METHOD DEVELOPMENT IN EARLY PHASE
PHARMACEUTICAL DEVELOPMENT HENRIK T. RASMUSSEN, KELLY A. SWINNEY AND
SHEETAL GAIKI ABSTRACT 353 I. INTRODUCTION 354 II. FORCED DECOMPOSITION
AND IMPURITY PROFILING 355 III. ORTHOGONAL SCREENING 357 IV. METHOD
SELECTION AND OPTIMIZATION 362 V. ADDITIONAL METHODS 366 VI. SETTING THE
STAGE FOR LATE PHASE HPLC METHOD DEVELOPMENTS 367 VII. CONCLUSIONS 369
ACKNOWLEDGMENTS 369 REFERENCES 369 13. HPLC METHOD DEVELOPMENT IN LATE
PHASE PHARMACEUTICAL DEVELOPMENT M. WAS JIMIDAR AND MAURITS DE SMET
ABSTRACT 373 I. INTRODUCTION 374 II. GOALS OF DEVELOPMENT 375 III.
PLANNING PHASE 377 IV. METHOD DEVELOPMENT PHASE 382 V. METHOD EVALUATION
PHASE 394 VI. METHOD TRANSFER PHASE 398 VII. METHOD PERFORMANCE
MONITORING AND FEEDBACK 400 VIII. METHOD DEVELOPMENT CYCLE TIMES AND
DOCUMENTATION 403 IX. CONCLUSIONS 403 REFERENCES 404 14. USE OF HPLC FOR
IN-PROCESS TESTING CHRISTINE F. RICHARDSON ABSTRACT 407 I. INTRODUCTION
407 CONTENTS II. VARIOUS EXAMPLES OF IN-PROCESS TESTING IN DRUG
SUBSTANCE DEVELOPMENT 409 III. FAST HPLC 419 IV. IN-PROCESS TESTING IN
CHEMICAL PRODUCTION 420 V. IN-PROCESS TESTING IN PHARMACEUTICAL
PRODUCTION 422 VI. CONCLUSIONS AND FUTURE DIRECTIONS 423 ACKNOWLEDGMENTS
423 REFERENCES 423 15. METHOD DEVELOPMENT FOR BIOMOLECULES JULEE L
DRIVER AND DOUGLAS E. RAYNIE ABSTRACT 425 I. INTRODUCTION 426 II.
PROTEIN AND PEPTIDE SEPARATIONS BY HPLC 430 III. CASE STUDIES 434 IV.
SUMMARY AND CONCLUSIONS 437 ABBREVIATIONS 438 REFERENCES 438 16. METHOD
VALIDATION M. WAS JIMIDAR, PATRICK HEYLEN, AND MAURITS DE SMET ABSTRACT
441 I. INTRODUCTION 442 II. VALIDATION PROCESS 444 III. VALIDATION
CHARACTERISTICS 444 IV. ADDITIONAL VALIDATION CHARACTERISTICS 450 V.
ROBUSTNESS TESTING 452 VI. CONCLUSIONS 457 REFERENCES 457 17.
TROUBLESHOOTING IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY HAROLD MCNAIR
AND LEE N. POLITE ABSTRACT 459 I. INTRODUCTION 460 II. PROBLEMS OBSERVED
IN CHROMATOGRAMS 460 III. OPERATING PARAMETERS 468 IV. LEAKS 472 V.
PRESSURE PROBLEMS 474 VI. TROUBLESHOOTING ACTION PLAN 475 VII.
CONCLUSIONS 477 REFERENCES 477 INTERNET RESOURCES 477 CONTENTS XI 18.
MOLECULARLY IMPRINTED POLYMERS AS SORBENTS FOR SEPARATIONS AND
EXTRACTIONS MYRA T KOESDJOJO, YOLANDA H. TENNICO, AND VINCENT T.REMCHO
ABSTRACT 479 I. INTRODUCTION 479 II. MIP THEORY 481 III. SYNTHESIS 487
IV. USE OF IMPRINTED POLYMERS IN SEPARATION SCIENCE 491 V.
PHARMACEUTICAL APPLICATION FOR MIPS 493 VI. PROS AND CONS OF MIP
SORBENTS 495 VII. CONCLUSIONS AND FUTURE OUTLOOK 496 REFERENCES 497
|
| adam_txt |
HPLC METHOD DEVELOPMENT FOR PHARMACEUTICALS SATINDER AHUJA HENRIK
RASMUSSEN -'-R,-- *» *» ' *': *-, 11 SR\N K /-.;*:: V;'- / ./;* V ; -
^.;V. :: ICONTENTS PREFACE XIII CONTRIBUTORS XV I. OVERVIEW OF HPLC
METHOD DEVELOPMENT FOR PHARMACEUTICALS SATINDERAHUJA I. INTRODUCTION 1
II. THEORETICAL CONSIDERATIONS 2 III. HPLC COLUMNS AND COLUMN PACKINGS 2
IV. COLUMN SELECTION 3 V. CHIRAL SEPARATIONS 3 VI. CONTEMPORARY HPLC 4
VII. HYPHENATED METHODS 5 VIII. SAMPLE PREPARATION 5 IX. INSTRUMENT
QUALIFICATION AND SOFTWARE VALIDATION 6 X. PHARMACEUTICAL DEVELOPMENT 6
XL DRUG DISCOVERY 7 XII. EARLY PHASE METHOD DEVELOPMENT 8 XIII. LATE
PHASE DEVELOPMENT 8 XIV. IN-PROCESS TESTING 9 XV. METHOD DEVELOPMENT FOR
BIOMOLECULES 9 XVI. METHOD VALIDATION 10 XVII. TROUBLESHOOTING 10 XVIII.
MOLECULARLY IMPRINTED POLYMERS 10 REFERENCES 11 CONTENTS 2. HPLC THEORY
YV KAZAKEVICH ABSTRACT 13 I. INTRODUCTION 13 II. BASIC CHROMATOGRAPHIC
DESCRIPTORS 14 III. EFFICIENCY 15 IV. RESOLUTION 20 V. MAIN COMPONENTS
OF THE RETENTION MECHANISM 22 VI. GENERAL COLUMN MASS BALANCE 24 VII.
PARTITIONING MODEL 27 VIII. ADSORPTION MODEL 28 IX. VOID VOLUME
CONSIDERATIONS 29 X. THERMODYNAMIC RELATIONSHIPS 31 XL SECONDARY
EQUILIBRIA 35 XII. SALT EFFECT 37 XIII. EFFECT OF DIFFERENT
COUNTERANIONS 38 XIV. INCLUSION OF SECONDARY EQUILIBRIA IN THE MASS
BALANCE 40 XV. CONCLUSIONS 43 REFERENCES 43 3. HPLC COLUMNS AND PACKINGS
UWE D. NEUE, BONNIE A. ALDEN, EDWARD R. GROVER, ERIC S. GRUMBACH, PAMELA
C. IRANETA, AND ALBERTO MENDEZ ABSTRACT 45 I. INTRODUCTION 46 II. COLUMN
CHEMISTRY 47 III. SPEED AND RESOLUTION 68 IV. SPECIALTY COLUMNS FROM
NANOBORE TO PREPARATIVE CHROMATOGRAPHY 77 V. SUMMARY 80 REFERENCES 80 4.
COLUMN CHARACTERIZATION AND SELECTION DORAVISKY ABSTRACT 85 I.
INTRODUCTION 86 II. CHARACTERISTICS OF RP-HPLC COLUMNS AND
CHROMATOGRAPHIC TESTS 90 III. COLUMN CLASSIFICATION AND SELECTION 101
IV. CONCLUSIONS 104 ACKNOWLEDGMENT 105 REFERENCES 105 CONTENTS VM 5.
CHIRAL SEPARATIONS XIANDE WANG.WEIYONG LI, AND HENRIK RASMUSSEN ABSTRACT
111 I. INTRODUCTION 112 II. SEPARATION OF ENANTIOMERS ON HPLC CHIRAL
STATIONARY PHASES 115 III. PRACTICAL GUIDELINES TO CHIRAL HPLC OF
PHARMACEUTICALS 135 IV. CONCLUSIONS 137 REFERENCES 138 6. CONTEMPORARY
LIQUID CHROMATOGRAPHIC SYSTEMS FOR METHOD DEVELOPMENT MICHAEL E. SWARTZ
ABSTRACT 145 I. INTRODUCTION 146 II. TRADITIONAL INSTRUMENTATION FOR
HPLC METHOD DEVELOPMENT 147 III. CONTEMPORARY METHOD DEVELOPMENT SYSTEMS
153 IV. MIGRATING METHODS FROM HPLC TO UPLC 169 V. UPLC APPLICATIONS IN
PHARMACEUTICAL ANALYSIS 174 VI. SUMMARY AND CONCLUSIONS 183
ACKNOWLEDGMENTS 184 REFERENCES 185 FURTHER READING 186 7. HYPHENATED
TECHNIQUES DANIEL L NORWOOD, JAMES O. MULLIS, AND THOMAS N. FEINBERG
ABSTRACT 189 I. INTRODUCTION AND BACKGROUND 190 II. COMBINED LIQUID
CHROMATOGRAPHY/MASS SPECTROMETRY 191 III. COMBINED LIQUID
CHROMATOGRAPHY/NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 218 IV.
CONCLUSIONS 231 ACKNOWLEDGMENTS 231 REFERENCES 232 8. HPLC SAMPLE
PREPARATION GREGORY C. SLACK AND NICHOLAS H. SNOW ABSTRACT 237 I.
INTRODUCTION 238 II. FUNDAMENTALS OF EXTRACTION AND CHEMICAL EQUILIBRIUM
239 III. CHOICE OF SAMPLES PREPARATION 245 V JJJ CONTENTS IV. DIRECT
INJECTION 246 V. LIQUID-LIQUID EXTRACTION 247 VI. SOLID-PHASE EXTRACTION
248 VII. SOLID SAMPLES 254 VIII. ADDITIONAL SAMPLE PREPARATION METHODS
256 IX. CONCLUSIONS 263 REFERENCES 263 9. INSTRUMENT QUALIFICATION AND
SOFTWARE VALIDATION DAVE VAN GEEL ABSTRACT 270 I. INTRODUCTION 270 II.
DEFINITIONS 271 III. QUALIFICATION MODEL 278 IV. DISCUSSION: CASE STUDY
HPLC 291 V. SUMMARY AND CONCLUSIONS 294 ACKNOWLEDGMENTS 295 REFERENCES
295 10. PHARMACEUTICAL DEVELOPMENT: FROM PRE-CLINICAL TO POST APPROVAL
KEVIN C. BYNUM ABSTRACT 297 I. INTRODUCTION 298 II. THE ROLE OF HPLC IN
DRUG DISCOVERY 300 III. THE ROLE OF HPLC IN PRE-CLINICAL DEVELOPMENT 303
IV. THE ROLE OF HPLC IN CLINICAL DEVELOPMENT 307 V. POST APPROVAL 312
VI. CONCLUSIONS 315 REFERENCES 315 11. HPLC METHOD DEVELOPMENT FOR DRUG
DISCOVERY LC-MS ASSAYS IN RAPID PK APPLICATIONS XIAOYING XU I. II. III.
IV. ABSTRACT 318 INTRODUCTION 318 TANDEM MS SELECTED REACTION
DEVELOPMENT 319 HPLC METHOD DEVELOPMENT SAMPLE PREPARATION 324
MONITORING (SRM) 322 CONTENTS IX V. MATRIX EFFECTS 329 VI. BACKGROUND
INTERFERENCE: ENHANCED MASS RESOLUTION STRATEGY 334 VII. LIMIT OF
QUANTITATION, DYNAMIC RANGE AND LINEARITY 340 VIII. ASSAY SAMPLES AND
GENERATE PHARMACOKINETIC REPORTS 344 IX. CONCLUSIONS 345 ACKNOWLEDGMENT
345 REFERENCES 345 12. HPLC METHOD DEVELOPMENT IN EARLY PHASE
PHARMACEUTICAL DEVELOPMENT HENRIK T. RASMUSSEN, KELLY A. SWINNEY AND
SHEETAL GAIKI ABSTRACT 353 I. INTRODUCTION 354 II. FORCED DECOMPOSITION
AND IMPURITY PROFILING 355 III. ORTHOGONAL SCREENING 357 IV. METHOD
SELECTION AND OPTIMIZATION 362 V. ADDITIONAL METHODS 366 VI. SETTING THE
STAGE FOR LATE PHASE HPLC METHOD DEVELOPMENTS 367 VII. CONCLUSIONS 369
ACKNOWLEDGMENTS 369 REFERENCES 369 13. HPLC METHOD DEVELOPMENT IN LATE
PHASE PHARMACEUTICAL DEVELOPMENT M. WAS JIMIDAR AND MAURITS DE SMET
ABSTRACT 373 I. INTRODUCTION 374 II. GOALS OF DEVELOPMENT 375 III.
PLANNING PHASE 377 IV. METHOD DEVELOPMENT PHASE 382 V. METHOD EVALUATION
PHASE 394 VI. METHOD TRANSFER PHASE 398 VII. METHOD PERFORMANCE
MONITORING AND FEEDBACK 400 VIII. METHOD DEVELOPMENT CYCLE TIMES AND
DOCUMENTATION 403 IX. CONCLUSIONS 403 REFERENCES 404 14. USE OF HPLC FOR
IN-PROCESS TESTING CHRISTINE F. RICHARDSON ABSTRACT 407 I. INTRODUCTION
407 CONTENTS II. VARIOUS EXAMPLES OF IN-PROCESS TESTING IN DRUG
SUBSTANCE DEVELOPMENT 409 III. FAST HPLC 419 IV. IN-PROCESS TESTING IN
CHEMICAL PRODUCTION 420 V. IN-PROCESS TESTING IN PHARMACEUTICAL
PRODUCTION 422 VI. CONCLUSIONS AND FUTURE DIRECTIONS 423 ACKNOWLEDGMENTS
423 REFERENCES 423 15. METHOD DEVELOPMENT FOR BIOMOLECULES JULEE L
DRIVER AND DOUGLAS E. RAYNIE ABSTRACT 425 I. INTRODUCTION 426 II.
PROTEIN AND PEPTIDE SEPARATIONS BY HPLC 430 III. CASE STUDIES 434 IV.
SUMMARY AND CONCLUSIONS 437 ABBREVIATIONS 438 REFERENCES 438 16. METHOD
VALIDATION M. WAS JIMIDAR, PATRICK HEYLEN, AND MAURITS DE SMET ABSTRACT
441 I. INTRODUCTION 442 II. VALIDATION PROCESS 444 III. VALIDATION
CHARACTERISTICS 444 IV. ADDITIONAL VALIDATION CHARACTERISTICS 450 V.
ROBUSTNESS TESTING 452 VI. CONCLUSIONS 457 REFERENCES 457 17.
TROUBLESHOOTING IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY HAROLD MCNAIR
AND LEE N. POLITE ABSTRACT 459 I. INTRODUCTION 460 II. PROBLEMS OBSERVED
IN CHROMATOGRAMS 460 III. OPERATING PARAMETERS 468 IV. LEAKS 472 V.
PRESSURE PROBLEMS 474 VI. TROUBLESHOOTING ACTION PLAN 475 VII.
CONCLUSIONS 477 REFERENCES 477 INTERNET RESOURCES 477 CONTENTS XI 18.
MOLECULARLY IMPRINTED POLYMERS AS SORBENTS FOR SEPARATIONS AND
EXTRACTIONS MYRA T KOESDJOJO, YOLANDA H. TENNICO, AND VINCENT T.REMCHO
ABSTRACT 479 I. INTRODUCTION 479 II. MIP THEORY 481 III. SYNTHESIS 487
IV. USE OF IMPRINTED POLYMERS IN SEPARATION SCIENCE 491 V.
PHARMACEUTICAL APPLICATION FOR MIPS 493 VI. PROS AND CONS OF MIP
SORBENTS 495 VII. CONCLUSIONS AND FUTURE OUTLOOK 496 REFERENCES 497 |
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| callnumber-subject | RS - Pharmacy |
| classification_rvk | VS 5300 |
| ctrlnum | (OCoLC)144220768 (DE-599)BSZ266952674 |
| dewey-full | 615.1901 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
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| dewey-search | 615.1901 |
| dewey-sort | 3615.1901 |
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| discipline | Chemie / Pharmazie Medizin |
| discipline_str_mv | Chemie / Pharmazie Medizin |
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| id | DE-604.BV023283606 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:40:41Z |
| indexdate | 2024-07-09T21:14:55Z |
| institution | BVB |
| isbn | 0123705401 9780123705402 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016468354 |
| oclc_num | 144220768 |
| open_access_boolean | |
| owner | DE-19 DE-BY-UBM |
| owner_facet | DE-19 DE-BY-UBM |
| physical | XVII, 513 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Elsevier Academic Press |
| record_format | marc |
| series | Separation science and technology |
| series2 | Separation science and technology |
| spelling | HPLC method development for pharmaceuticals ed. by Satinder Ahuja ... Amsterdam ; Heidelberg [u.a.] Elsevier Academic Press 2007 XVII, 513 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Separation science and technology 8 Includes index Chromatographie en phase liquide à hautes performances - Méthodologie Médicaments - Analyse Médicaments - Développement Chromatographic analysis Separation Technology Chromatographie (DE-588)4010153-8 gnd rswk-swf Trennverfahren (DE-588)4078395-9 gnd rswk-swf Trennverfahren (DE-588)4078395-9 s Chromatographie (DE-588)4010153-8 s DE-604 Ahuja, Satinder Sonstige oth Separation science and technology 8 (DE-604)BV011987396 8 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016468354&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | HPLC method development for pharmaceuticals Separation science and technology Chromatographie en phase liquide à hautes performances - Méthodologie Médicaments - Analyse Médicaments - Développement Chromatographic analysis Separation Technology Chromatographie (DE-588)4010153-8 gnd Trennverfahren (DE-588)4078395-9 gnd |
| subject_GND | (DE-588)4010153-8 (DE-588)4078395-9 |
| title | HPLC method development for pharmaceuticals |
| title_auth | HPLC method development for pharmaceuticals |
| title_exact_search | HPLC method development for pharmaceuticals |
| title_exact_search_txtP | HPLC method development for pharmaceuticals |
| title_full | HPLC method development for pharmaceuticals ed. by Satinder Ahuja ... |
| title_fullStr | HPLC method development for pharmaceuticals ed. by Satinder Ahuja ... |
| title_full_unstemmed | HPLC method development for pharmaceuticals ed. by Satinder Ahuja ... |
| title_short | HPLC method development for pharmaceuticals |
| title_sort | hplc method development for pharmaceuticals |
| topic | Chromatographie en phase liquide à hautes performances - Méthodologie Médicaments - Analyse Médicaments - Développement Chromatographic analysis Separation Technology Chromatographie (DE-588)4010153-8 gnd Trennverfahren (DE-588)4078395-9 gnd |
| topic_facet | Chromatographie en phase liquide à hautes performances - Méthodologie Médicaments - Analyse Médicaments - Développement Chromatographic analysis Separation Technology Chromatographie Trennverfahren |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016468354&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV011987396 |
| work_keys_str_mv | AT ahujasatinder hplcmethoddevelopmentforpharmaceuticals |