Introduction to renal therapeutics:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London [u.a.]
Pharmaceutical Press
2008
|
| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis Klappentext |
| Physical Description: | XX, 300 S. Ill., graph. Darst. |
| ISBN: | 9780853696889 9783769243284 3769243285 |
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| 245 | 1 | 0 | |a Introduction to renal therapeutics |c ed. by Caroline Ashley ; Clare Morlidge |
| 250 | |a 1. publ. | ||
| 264 | 1 | |a London [u.a.] |b Pharmaceutical Press |c 2008 | |
| 300 | |a XX, 300 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a Reins - Maladies - Traitement | |
| 650 | 4 | |a Kidney Diseases |x drug therapy | |
| 650 | 4 | |a Kidneys |x Diseases |x Treatment | |
| 700 | 1 | |a Ashley, Caroline |e Sonstige |4 oth | |
| 700 | 1 | |a Morlidge, Clare |e Sonstige |4 oth | |
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Contents
Preface
x¡
About the editors
xiii
Contributors
xv
Abbreviations
xvii
What are
lhe
functions of the kidney?
1
The functional anatomy of the kidney
1
Other functions of the kidneys
5
Conclusion
7
Laboratory tests and investigations
9
Standard tests and investigations for the general adult patient
population
9
Haematological tests and investigations
13
Urine tests
14
Renal biopsy
15
immonological tests
15
Serum and urine electrophoresis
15
Radiological tests
16
Describing and measuring renal function
16
References
18
Acute renal failure
21
Definiiion
21
incidence
21
Clinicai
features
22
Causes
22
Syroptoms/signs
27
Distinguishing acute from chronic renal impairment
28
vi
Contents
Management
28
Additional points
31
Outcome
31
Conclusion
31
References
33
Further reading
34
4
Chronic renal failure
35
Definition
35
Clinical features
35
Incidence
37
Causes
37
Symptoms and consequences
38
Influence of chronic renal disease on drug handling
41
Renal replacement therapies
42
Conclusion
42
References
43
Further reading
44
5
Renal anaemia
45
Maintenance of serum haemoglobin in the healthy individual
45
The development and consequences of anaemia of chronic
kidney disease
47
Assessing the anaemia of chronic kidney disease
49
Iron and erythropoiesis-stimulating agents available for the correction
of renal anaemia
51
Iron preparations
53
Initiating iron and erythropoiesis-stimulating agents therapy
53
Failure to respond to therapy
54
Summary
54
References
55
6
Renal bone disease
57
Pathophysiology
57
Complications for the skeleton and progression of renal bone
disease
60
Treatment with phosphate binders
63
Treatment with vitamin
D
65
The role of parathyroidectomy
66
Conienis
vii
j
Therapeutic targets
68
New management
strategies and new therapeutic agents for renal
bone disease
69
References
74
Further reading
74
7
Hypertension and hyperlipidaemia
77
Hypertension
77
Hyperlipidaemia
81
References
84
8
Renal replacement therapy
85
Haemodialysis
85
Continuous renal replacement therapies
91
Haemodiafiltration
95
Peritoneal dialysis
96
References
105
9
Renal transplantation
107
The donor organ
107
Transplant rejection and its prevention
108
Transplant immunosuppression
109
Post-transplant complications
117
The pharmacist's role in caring for transplant patients
121
References
124
10
Drug dosing in patients with renal impairment and during
renal replacement therapy
127
Drug handling considerations in patients with renal impairment
127
Assessment of renal function
129
Adjusting doses for patients with renal impairment
132
Drug handling considerations in patients undergoing renal replacement
therapy
133
Adjusting drug doses for patients undergoing renal replacement
therapy
135
Summary
136
References
137
Further reading
137
'
vîîî
Contents
11
Drug-induced kidney disease
Ί
39
Pre-renal (or haemodynamic) acute renal failure
139
Intrinsic renal
toxicity
141
Post-renal damage (obstructive uropathy)
142
Conclusion
143
References
144
12
Autoimmune kidney disease
145
Pathogenesis
145
Clinical manifestations
145
Principles of treatment
147
Antineutrophil cytoplasmic autoantibody (ANCAJ-associated
vasculitis
148
Goodpasture's syndrome
153
Systemic lupus erythematosus
154
Ig
A nephropathy
156
Membranous glomerulonephritis
158
Membranoproliferative glomerulonephritis
159
Cryoglobulinaemic glomerulonephritis
159
Conclusions
160
References
161
13
Paediatric kidney disease
163
Creatinine and glomerular filtration rate
163
Monitoring and treatment of children with chronic renal failure
164
Transplantation
169
Dialysis
173
Drug prescribing in renal disease
178
References
179
Further reading
180
14
Renal pharmacy in critical care
181
Preventing acute renal failure
181
Renal replacement therapy in the intensive care unit
182
Drug therapies specific to critical care areas
184
General comments on administering drugs to patients with
renal impairment
188
References
189
Contents
Їх
15
Pain control in renal impairment
191
Assessing pain
191
The analgesic ladder
191
Analgesics and renal impairment
191
Individual agents
192
References
201
Further reading
204
16
Diabetes management in kidney disease
205
Definitions of diabetic renal disease
205
The actual structural changes that occur in the diabetic kidney
206
The diagnosis of diabetic renal disease
20ό
The prevention of diabetic renal disease
206
The screening and referral process for diabetic renal disease
207
The management of diabetes in kidney disease
207
References
216
17
Myeloma and kidney disease
217
Clinical presentation of multiple myeloma
218
Investigation and diagnosis of myeloma
218
Myeloma kidney
218
Treatment options
219
Summary
223
References
224
18
Palliative care
225
Prescribing for symptom control in patients with stage
5
chronic
kidney disease managed without dialysis
226
Prescribing in the last few days of life
233
Conclusions
235
References
237
19
Dietary management of kidney disease
239
Historic pre-dialysis dietary intervention
239
Pre-dialysis dietary management
239
Dietary management of renal replacement therapy
244
Vitamin and minerals
247
χ
Contents
Malnutrition
248
References
252
20
Travelling and vaccines
253
Planning holidays
253
General travel health advice
254
Travelling abroad with medication
257
Malaria
259
Travel vaccinations
261
Conclusion
263
References
264
Further information
265
Case study answers
267
Glossary
289
Index
295
Edited by Caroline Ashley and Clare Morlidge
Introduction to Renal Therapeutics is an introduction to all aspects of drug use
in renal failure. Covering various diseases affecting the kidneys, each chapter
discusses the disease process and treatment. It also addresses the role of the
pharmacist in patient care. Case studies and questions and answers are
included at the end of each chapter.
Topics include:
•
Laboratory tests and investigations
•
Acute and chronic renal failure
•
Renal bone disease
•
Renal anaemia
•
Renal replacement therapy
•
Autoimmune kidney disease
•
Drug-induced renal failure
•
Renal transplantation
•
Pain control
•
Paediatrics.
Written by members of the UK Renal Pharmacy Group, this book will be of
particular interest to anyone new to, or planning a career in, renal pharmacy.
It will also be of interest to non-specialists who deal with renal patients and
to pharmacy students, and to any healthcare professional with an interest in
renal medicine.
Caroline Ashley is the Lead Specialist Pharmacist (Renal Unit) at the Royal Free
Hospital, London, UK.
Clare Morlidge is a Cardiothoradc Directorate Pharmacist for the East and
North Hertfordshire NHS Trust, Hertfordshire, UK. |
| adam_txt |
Contents
Preface
x¡
About the editors
xiii
Contributors
xv
Abbreviations
xvii
What are
lhe
functions of the kidney?
1
The functional anatomy of the kidney
1
Other functions of the kidneys
5
Conclusion
7
Laboratory tests and investigations
9
Standard tests and investigations for the general adult patient
population
9
Haematological tests and investigations
13
Urine tests
14
Renal biopsy
15
immonological tests
15
Serum and urine electrophoresis
15
Radiological tests
16
Describing and measuring renal function
16
References
18
Acute renal failure
21
Definiiion
21
incidence
21
Clinicai
features
22
Causes
22
Syroptoms/signs
27
Distinguishing acute from chronic renal impairment
28
vi
Contents
Management
28
Additional points
31
Outcome
31
Conclusion
31
References
33
Further reading
34
4
Chronic renal failure
35
Definition
35
Clinical features
35
Incidence
37
Causes
37
Symptoms and consequences
38
Influence of chronic renal disease on drug handling
41
Renal replacement therapies
42
Conclusion
42
References
43
Further reading
44
5
Renal anaemia
45
Maintenance of serum haemoglobin in the healthy individual
45
The development and consequences of anaemia of chronic
kidney disease
47
Assessing the anaemia of chronic kidney disease
49
Iron and erythropoiesis-stimulating agents available for the correction
of renal anaemia
51
Iron preparations
53
Initiating iron and erythropoiesis-stimulating agents therapy
53
Failure to respond to therapy
54
Summary
54
References
55
6
Renal bone disease
57
Pathophysiology
57
Complications for the skeleton and progression of renal bone
disease
60
Treatment with phosphate binders
63
Treatment with vitamin
D
65
The role of parathyroidectomy
66
Conienis
vii
j
Therapeutic targets
68
New management
strategies and new therapeutic agents for renal
bone disease
69
References
74
Further reading
74
7
Hypertension and hyperlipidaemia
77
Hypertension
77
Hyperlipidaemia
81
References
84
8
Renal replacement therapy
85
Haemodialysis
85
Continuous renal replacement therapies
91
Haemodiafiltration
95
Peritoneal dialysis
96
References
105
9
Renal transplantation
107
The donor organ
107
Transplant rejection and its prevention
108
Transplant immunosuppression
109
Post-transplant complications
117
The pharmacist's role in caring for transplant patients
121
References
124
10
Drug dosing in patients with renal impairment and during
renal replacement therapy
127
Drug handling considerations in patients with renal impairment
127
Assessment of renal function
129
Adjusting doses for patients with renal impairment
132
Drug handling considerations in patients undergoing renal replacement
therapy
133
Adjusting drug doses for patients undergoing renal replacement
therapy
135
Summary
136
References
137
Further reading
137
'
vîîî
Contents
11
Drug-induced kidney disease
Ί
39
Pre-renal (or haemodynamic) acute renal failure
139
Intrinsic renal
toxicity
141
Post-renal damage (obstructive uropathy)
142
Conclusion
143
References
144
12
Autoimmune kidney disease
145
Pathogenesis
145
Clinical manifestations
145
Principles of treatment
147
Antineutrophil cytoplasmic autoantibody (ANCAJ-associated
vasculitis
148
Goodpasture's syndrome
153
Systemic lupus erythematosus
154
Ig
A nephropathy
156
Membranous glomerulonephritis
158
Membranoproliferative glomerulonephritis
159
Cryoglobulinaemic glomerulonephritis
159
Conclusions
160
References
161
13
Paediatric kidney disease
163
Creatinine and glomerular filtration rate
163
Monitoring and treatment of children with chronic renal failure
164
Transplantation
169
Dialysis
173
Drug prescribing in renal disease
178
References
179
Further reading
180
14
Renal pharmacy in critical care
181
Preventing acute renal failure
181
Renal replacement therapy in the intensive care unit
182
Drug therapies specific to critical care areas
184
General comments on administering drugs to patients with
renal impairment
188
References
189
Contents
Їх
15
Pain control in renal impairment
191
Assessing pain
191
The analgesic ladder
191
Analgesics and renal impairment
191
Individual agents
192
References
201
Further reading
204
16
Diabetes management in kidney disease
205
Definitions of diabetic renal disease
205
The actual structural changes that occur in the diabetic kidney
206
The diagnosis of diabetic renal disease
20ό
The prevention of diabetic renal disease
206
The screening and referral process for diabetic renal disease
207
The management of diabetes in kidney disease
207
References
216
17
Myeloma and kidney disease
217
Clinical presentation of multiple myeloma
218
Investigation and diagnosis of myeloma
218
Myeloma kidney
218
Treatment options
219
Summary
223
References
224
18
Palliative care
225
Prescribing for symptom control in patients with stage
5
chronic
kidney disease managed without dialysis
226
Prescribing in the last few days of life
233
Conclusions
235
References
237
19
Dietary management of kidney disease
239
Historic pre-dialysis dietary intervention
239
Pre-dialysis dietary management
239
Dietary management of renal replacement therapy
244
Vitamin and minerals
247
χ
Contents
Malnutrition
248
References
252
20
Travelling and vaccines
253
Planning holidays
253
General travel health advice
254
Travelling abroad with medication
257
Malaria
259
Travel vaccinations
261
Conclusion
263
References
264
Further information
265
Case study answers
267
Glossary
289
Index
295
Edited by Caroline Ashley and Clare Morlidge
Introduction to Renal Therapeutics is an introduction to all aspects of drug use
in renal failure. Covering various diseases affecting the kidneys, each chapter
discusses the disease process and treatment. It also addresses the role of the
pharmacist in patient care. Case studies and questions and answers are
included at the end of each chapter.
Topics include:
•
Laboratory tests and investigations
•
Acute and chronic renal failure
•
Renal bone disease
•
Renal anaemia
•
Renal replacement therapy
•
Autoimmune kidney disease
•
Drug-induced renal failure
•
Renal transplantation
•
Pain control
•
Paediatrics.
Written by members of the UK Renal Pharmacy Group, this book will be of
particular interest to anyone new to, or planning a career in, renal pharmacy.
It will also be of interest to non-specialists who deal with renal patients and
to pharmacy students, and to any healthcare professional with an interest in
renal medicine.
Caroline Ashley is the Lead Specialist Pharmacist (Renal Unit) at the Royal Free
Hospital, London, UK.
Clare Morlidge is a Cardiothoradc Directorate Pharmacist for the East and
North Hertfordshire NHS Trust, Hertfordshire, UK. |
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| id | DE-604.BV023276576 |
| illustrated | Illustrated |
| index_date | 2024-07-02T20:38:04Z |
| indexdate | 2024-07-20T09:38:34Z |
| institution | BVB |
| isbn | 9780853696889 9783769243284 3769243285 |
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| publisher | Pharmaceutical Press |
| record_format | marc |
| spelling | Introduction to renal therapeutics ed. by Caroline Ashley ; Clare Morlidge 1. publ. London [u.a.] Pharmaceutical Press 2008 XX, 300 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Reins - Maladies - Traitement Kidney Diseases drug therapy Kidneys Diseases Treatment Ashley, Caroline Sonstige oth Morlidge, Clare Sonstige oth text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2994769&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016461460&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016461460&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Introduction to renal therapeutics Reins - Maladies - Traitement Kidney Diseases drug therapy Kidneys Diseases Treatment |
| title | Introduction to renal therapeutics |
| title_auth | Introduction to renal therapeutics |
| title_exact_search | Introduction to renal therapeutics |
| title_exact_search_txtP | Introduction to renal therapeutics |
| title_full | Introduction to renal therapeutics ed. by Caroline Ashley ; Clare Morlidge |
| title_fullStr | Introduction to renal therapeutics ed. by Caroline Ashley ; Clare Morlidge |
| title_full_unstemmed | Introduction to renal therapeutics ed. by Caroline Ashley ; Clare Morlidge |
| title_short | Introduction to renal therapeutics |
| title_sort | introduction to renal therapeutics |
| topic | Reins - Maladies - Traitement Kidney Diseases drug therapy Kidneys Diseases Treatment |
| topic_facet | Reins - Maladies - Traitement Kidney Diseases drug therapy Kidneys Diseases Treatment |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2994769&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016461460&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016461460&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT ashleycaroline introductiontorenaltherapeutics AT morlidgeclare introductiontorenaltherapeutics |