Practical statistics for experimental biologists:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley
2000
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Contributor biographical information Publisher description Table of Contents Inhaltsverzeichnis |
| Beschreibung: | VII, 249 S. Ill., graph. Darst. |
| ISBN: | 0471988219 0471988227 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804137557917696000 |
|---|---|
| adam_text | Chromatin
Structure and Function
Third Edition
A WOLFFE
National Institutes of Health,
Bethesda, Maryland, USA
ACADEMIC PRESS
San Diego London Boston
New York Sydney Tokyo Toronto
Contents
Preface to the first edition ix
Preface to the second edition xi
Preface to the third edition xiii
1 Overview 1
1 1 Introductory comments 1
1 2 Development of research into chromatin structure and
function 2
2 Chromatin Structure 7
2 1 DNA and histones 7
211 DNA structure 8
212 The histones 15
2 2 The nucleosome 19
221 The nucleosome hypothesis 19
222 The organization of DNA and histones in the
nucleosome 20
223 The structure of DNA in the nucleosome 26
224 The position of the core histones in the nucleosome 30
225 DNA sequence-directed positioning of nucleosomes 41
2 3 The organization of nucleosomes into the chromatin fibre 50
231 Histone HI and the compaction of nucleosomal
arrays 50
232 The chromatin fibre 58
vi Contents
2 4 Chromosomal architecture 66
241 The radial loop and helical folding models of
chromosome structure 67
242 The nuclear infrastructure, the centromere,
telomeres, protein components and their function 71
243 Lampbrush and polytene chromosomes 84
2 5 Modulation of chromosomal structure 87
251 Histone variants 88
252 Post-translational modification of core histones 97
253 Linker histone phosphorylation 108
254 Activators and repressors that make use of
chromatin modifications to regulate transcription 111
255 Remodelling of chromatin during spermatogenesis 126
256 Heterochromatin, position effect, locus control
regions and insulators 128
257 DNA methylation and chromatin 141
258 The HMGs and related proteins 151
259 Functional compartmentalization of the nucleus 157
Chromatin and Nuclear Assembly 173
3 1 Interactions between nuclear structure and cytoplasm 173
311 Nuclear transplantation, remodelling and assembly 174
312 Heterokaryons 187
3 2 Chromatin assembly 189
321 Chromatin assembly on replicating endogenous
chromosomal DNA in vivo 190
322 Chromatin assembly in vitro 195
3 3 Experimental approaches towards the reconstitution of
transcriptionally active and silent states 203
331 Purified systems 203
332 Chromatin assembly and transcription in Xenopus
eggs and oocytes 206
333 Chromatin assembly on DNA introduced into
somatic cells 215
334 Yeast minichromosomes 220
3 4 Modulation of the chromosomal environment during
development 224
341 Tetrahymena 224
342 Xenopus and sea urchin 226
343 The mouse 232
344 Developmental regulation of long-range chromatin
structure 234
Contents vii
4 How do Nuclear Processes Occur in Chromatin? 240
4 1 Overview of nuclear processes 240
411 The problem of specificity 241
412 Action at a distance 246
413 The transcriptional machinery 249
414 Stable and unstable transcription complexes 260
415 Regulation of gene activity 266
416 Sequence-specific DNA-binding proteins 269
417 Problems for nuclear processes in chromatin 274
4 2 Interaction of frans-acting factors with chromatin 275
421 Non-specific interactions 276
422 Specific trans-acting factors and non-specific
chromatin 279
423 Specific trans-acting factors and specific chromatin 286
424 Trans-acting factors, DNase I sensitivity, DNase I
hypersensitive sites and chromosomal architecture 299
425 Trans-acting factors and the local organization of
chromatin structure 311
4 3 Processive enzyme complexes and chromatin structure 315
431 Replication and the access of transcription factors
to DNA 316
432 The fate of nucleosomes and transcription
complexes during replication 320
433 Chromatin structure and DNA replication 326
434 Transcription and chromatin integrity in vivo 328
435 Transcription and chromatin integrity in vitro 333
4 4 Chromatin structure and DNA repair 337
441 Influence of chromatin structure on DNA damage 338
442 Repairing DNA and chromatin 339
5 Future Prospects 342
5 1 Local chromatin structure 342
5 2 Long-range chromatin and chromosomal structure 345
References 348
Index 434
|
| adam_txt |
Chromatin
Structure and Function
Third Edition
A WOLFFE
National Institutes of Health,
Bethesda, Maryland, USA
ACADEMIC PRESS
San Diego London Boston
New York Sydney Tokyo Toronto
Contents
Preface to the first edition ix
Preface to the second edition xi
Preface to the third edition xiii
1 Overview 1
1 1 Introductory comments 1
1 2 Development of research into chromatin structure and
function 2
2 Chromatin Structure 7
2 1 DNA and histones 7
211 DNA structure 8
212 The histones 15
2 2 The nucleosome 19
221 The nucleosome hypothesis 19
222 The organization of DNA and histones in the
nucleosome 20
223 The structure of DNA in the nucleosome 26
224 The position of the core histones in the nucleosome 30
225 DNA sequence-directed positioning of nucleosomes 41
2 3 The organization of nucleosomes into the chromatin fibre 50
231 Histone HI and the compaction of nucleosomal
arrays 50
232 The chromatin fibre 58
vi Contents
2 4 Chromosomal architecture 66
241 The radial loop and helical folding models of
chromosome structure 67
242 The nuclear infrastructure, the centromere,
telomeres, protein components and their function 71
243 Lampbrush and polytene chromosomes 84
2 5 Modulation of chromosomal structure 87
251 Histone variants 88
252 Post-translational modification of core histones 97
253 Linker histone phosphorylation 108
254 Activators and repressors that make use of
chromatin modifications to regulate transcription 111
255 Remodelling of chromatin during spermatogenesis 126
256 Heterochromatin, position effect, locus control
regions and insulators 128
257 DNA methylation and chromatin 141
258 The HMGs and related proteins 151
259 Functional compartmentalization of the nucleus 157
Chromatin and Nuclear Assembly 173
3 1 Interactions between nuclear structure and cytoplasm 173
311 Nuclear transplantation, remodelling and assembly 174
312 Heterokaryons 187
3 2 Chromatin assembly 189
321 Chromatin assembly on replicating endogenous
chromosomal DNA in vivo 190
322 Chromatin assembly in vitro 195
3 3 Experimental approaches towards the reconstitution of
transcriptionally active and silent states 203
331 Purified systems 203
332 Chromatin assembly and transcription in Xenopus
eggs and oocytes 206
333 Chromatin assembly on DNA introduced into
somatic cells 215
334 Yeast minichromosomes 220
3 4 Modulation of the chromosomal environment during
development 224
341 Tetrahymena 224
342 Xenopus and sea urchin 226
343 The mouse 232
344 Developmental regulation of long-range chromatin
structure 234
Contents vii
4 How do Nuclear Processes Occur in Chromatin? 240
4 1 Overview of nuclear processes 240
411 The problem of specificity 241
412 Action at a distance 246
413 The transcriptional machinery 249
414 Stable and unstable transcription complexes 260
415 Regulation of gene activity 266
416 Sequence-specific DNA-binding proteins 269
417 Problems for nuclear processes in chromatin 274
4 2 Interaction of frans-acting factors with chromatin 275
421 Non-specific interactions 276
422 Specific trans-acting factors and non-specific
chromatin 279
423 Specific trans-acting factors and specific chromatin 286
424 Trans-acting factors, DNase I sensitivity, DNase I
hypersensitive sites and chromosomal architecture 299
425 Trans-acting factors and the local organization of
chromatin structure 311
4 3 Processive enzyme complexes and chromatin structure 315
431 Replication and the access of transcription factors
to DNA 316
432 The fate of nucleosomes and transcription
complexes during replication 320
433 Chromatin structure and DNA replication 326
434 Transcription and chromatin integrity in vivo 328
435 Transcription and chromatin integrity in vitro 333
4 4 Chromatin structure and DNA repair 337
441 Influence of chromatin structure on DNA damage 338
442 Repairing DNA and chromatin 339
5 Future Prospects 342
5 1 Local chromatin structure 342
5 2 Long-range chromatin and chromosomal structure 345
References 348
Index 434 |
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| language | English |
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| spelling | Wardlaw, Alastair C. Verfasser aut Practical statistics for experimental biologists Alastair C. Wardlaw 2. ed. Chichester [u.a.] Wiley 2000 VII, 249 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologie expérimentale - Méthodes statistiques Biométrie aBiometry aBiology, Experimental xStatistical methods Statistik (DE-588)4056995-0 gnd rswk-swf Biostatistik (DE-588)4729990-3 gnd rswk-swf Experimentelle Biologie (DE-588)4308402-3 gnd rswk-swf Biostatistik (DE-588)4729990-3 s DE-604 Statistik (DE-588)4056995-0 s Experimentelle Biologie (DE-588)4308402-3 s 1\p DE-604 http://www.loc.gov/catdir/bios/wiley047/99035926.html Contributor biographical information http://www.loc.gov/catdir/description/wiley031/99035926.html Publisher description http://www.loc.gov/catdir/toc/onix01/99035926.html Table of Contents HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016438913&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Wardlaw, Alastair C. Practical statistics for experimental biologists Biologie expérimentale - Méthodes statistiques Biométrie aBiometry aBiology, Experimental xStatistical methods Statistik (DE-588)4056995-0 gnd Biostatistik (DE-588)4729990-3 gnd Experimentelle Biologie (DE-588)4308402-3 gnd |
| subject_GND | (DE-588)4056995-0 (DE-588)4729990-3 (DE-588)4308402-3 |
| title | Practical statistics for experimental biologists |
| title_auth | Practical statistics for experimental biologists |
| title_exact_search | Practical statistics for experimental biologists |
| title_exact_search_txtP | Practical statistics for experimental biologists |
| title_full | Practical statistics for experimental biologists Alastair C. Wardlaw |
| title_fullStr | Practical statistics for experimental biologists Alastair C. Wardlaw |
| title_full_unstemmed | Practical statistics for experimental biologists Alastair C. Wardlaw |
| title_short | Practical statistics for experimental biologists |
| title_sort | practical statistics for experimental biologists |
| topic | Biologie expérimentale - Méthodes statistiques Biométrie aBiometry aBiology, Experimental xStatistical methods Statistik (DE-588)4056995-0 gnd Biostatistik (DE-588)4729990-3 gnd Experimentelle Biologie (DE-588)4308402-3 gnd |
| topic_facet | Biologie expérimentale - Méthodes statistiques Biométrie aBiometry aBiology, Experimental xStatistical methods Statistik Biostatistik Experimentelle Biologie |
| url | http://www.loc.gov/catdir/bios/wiley047/99035926.html http://www.loc.gov/catdir/description/wiley031/99035926.html http://www.loc.gov/catdir/toc/onix01/99035926.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016438913&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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