RNA interference:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2008
|
| Schriftenreihe: | Current topics in microbiology and immunology
320 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VIII, 273 S. Ill., graph. Darst. |
| ISBN: | 9783540751564 9783540751571 |
Internformat
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| 245 | 1 | 0 | |a RNA interference |c Patrick J. Paddison ..., ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a VIII, 273 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Current topics in microbiology and immunology |v 320 | |
| 650 | 4 | |a Gene Silencing | |
| 650 | 4 | |a Gene silencing | |
| 650 | 4 | |a MicroRNAs | |
| 650 | 4 | |a RNA | |
| 650 | 4 | |a RNA Interference | |
| 650 | 4 | |a RNA, Small Interfering | |
| 650 | 4 | |a Small interfering RNA | |
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Datensatz im Suchindex
| _version_ | 1804137450824531968 |
|---|---|
| adam_text | Contents
RNA
Interference in Mammalian Cell Systems
...................... 1
Patrick J. Paddison
RNAi Pathway in
C. elegans:
The
Argonautes
and Collaborators
....... 21
Marie-Eve L. Boisvert and Martin J. Simard
Genetics and Biochemistry of RNAi in
Drosophila
................... 37
Harsh H.
Kavi,
Harvey Fernandez, Weiwu Xie.
and James A. Birchler
Role of Dicer in Posttranscriptional
RNA
Silencing
.................. 77
Lukasz
Jaskiewicz and
Witold Filipowicz
The Mechanism of RNase III Action: How Dicer Dices
............... 99
Xinhua Ji
MicroRNA Metabolism in Plants
.................................. 117
Xuemei Chen
Structure-Function Relationships Among RNA-Dependent
RNA
Polymerases
............................................... 137
Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron
RNAi-Mediated Chromatin Silencing in Fission Yeast
................ 157
Sharon A. White and Robin
C. Allshire
A Role for RNAi in Heterochromatin Formation in
Drosophila
......... 185
Nicole
С
Riddle and Sarah C.R. Elgin
RNA
Mediated Transcriptional Gene Silencing in Human Cells
........ 211
Kevin V. Morris
vi
Contents
RNA
Silencing in Mammalian Oocytes and Early Embryos
........... 225
Petr Svoboda
Identifying Human MicroRNAs
................................... 257
Isaac Bentwich
Index
......................................................... 271
RNAi emerged out of the pioneering work of Andrew Fire and Craig
Mello
in
the nematode,
C. elegans.
Attempting to use antisense
RNA
to knock down
gene expression, they found synergistic effects on gene silencing when anti-
sense and sense
RNA
strands where delivered together. While at first RNAi
seemed a peculiarity of nematodes, dsRNA dependent gene silencing has since
become one of the biggest surprises in the past decade of research in eukaryotic
cells. The core machinery that underlies RNAi is conserved in virtually every
experimental eukaryotic system and has been co-opted in most of them to
trigger gene silencing.
With the advent of RNAi in mammals and the refinement of silencing triggers,
we have reached a point at which any gene in the human or mouse genome can
conceivably be targeted using small dsRNA gene silencing triggers
-
synthetic
small interfering RNAs (siRNAs) or expressed short hairpin RNAs (shRNAs).
In the next decade in the
biomedical
sciences, siRNAs and shRNAs win be em¬
ployed to validate disease models in vitro in
сеД
based systems and in vivo in
rodent and primate systems; to validate drug activities through the remove of
suspected targets; to identify new drug candidates in genome-wide, functional
genomic screens; and finally to combat disease directly, using siRNAs or
shRNAs as therapeutic molecules in the clinic. This volume highlights recent
progress in understanding dsRNA-dependent gene silencing phenomena in
eukaryotic systems ranging from yeast to mammals.
|
| adam_txt |
Contents
RNA
Interference in Mammalian Cell Systems
. 1
Patrick J. Paddison
RNAi Pathway in
C. elegans:
The
Argonautes
and Collaborators
. 21
Marie-Eve L. Boisvert and Martin J. Simard
Genetics and Biochemistry of RNAi in
Drosophila
. 37
Harsh H.
Kavi,
Harvey Fernandez, Weiwu Xie.
and James A. Birchler
Role of Dicer in Posttranscriptional
RNA
Silencing
. 77
Lukasz
Jaskiewicz and
Witold Filipowicz
The Mechanism of RNase III Action: How Dicer Dices
. 99
Xinhua Ji
MicroRNA Metabolism in Plants
. 117
Xuemei Chen
Structure-Function Relationships Among RNA-Dependent
RNA
Polymerases
. 137
Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron
RNAi-Mediated Chromatin Silencing in Fission Yeast
. 157
Sharon A. White and Robin
C. Allshire
A Role for RNAi in Heterochromatin Formation in
Drosophila
. 185
Nicole
С
Riddle and Sarah C.R. Elgin
RNA
Mediated Transcriptional Gene Silencing in Human Cells
. 211
Kevin V. Morris
vi
Contents
RNA
Silencing in Mammalian Oocytes and Early Embryos
. 225
Petr Svoboda
Identifying Human MicroRNAs
. 257
Isaac Bentwich
Index
. 271
RNAi emerged out of the pioneering work of Andrew Fire and Craig
Mello
in
the nematode,
C. elegans.
Attempting to use antisense
RNA
to knock down
gene expression, they found synergistic effects on gene silencing when anti-
sense and sense
RNA
strands where delivered together. While at first RNAi
seemed a peculiarity of nematodes, dsRNA dependent gene silencing has since
become one of the biggest surprises in the past decade of research in eukaryotic
cells. The core machinery that underlies RNAi is conserved in virtually every
experimental eukaryotic system and has been co-opted in most of them to
trigger gene silencing.
With the advent of RNAi in mammals and the refinement of silencing triggers,
we have reached a point at which any gene in the human or mouse genome can
conceivably be targeted using small dsRNA gene silencing triggers
-
synthetic
small interfering RNAs (siRNAs) or expressed short hairpin RNAs (shRNAs).
In the next decade in the
biomedical
sciences, siRNAs and shRNAs win be em¬
ployed to validate disease models in vitro in
сеД
based systems and in vivo in
rodent and primate systems; to validate drug activities through the remove of
suspected targets; to identify new drug candidates in genome-wide, functional
genomic screens; and finally to combat disease directly, using siRNAs or
shRNAs as therapeutic molecules in the clinic. This volume highlights recent
progress in understanding dsRNA-dependent gene silencing phenomena in
eukaryotic systems ranging from yeast to mammals. |
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| dewey-full | 572.88 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
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| discipline | Biologie |
| discipline_str_mv | Biologie |
| format | Book |
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| illustrated | Illustrated |
| index_date | 2024-07-02T20:02:04Z |
| indexdate | 2024-07-09T21:12:30Z |
| institution | BVB |
| isbn | 9783540751564 9783540751571 |
| language | English |
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| physical | VIII, 273 S. Ill., graph. Darst. |
| publishDate | 2008 |
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| series | Current topics in microbiology and immunology |
| series2 | Current topics in microbiology and immunology |
| spelling | RNA interference Patrick J. Paddison ..., ed. Berlin [u.a.] Springer 2008 VIII, 273 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in microbiology and immunology 320 Gene Silencing Gene silencing MicroRNAs RNA RNA Interference RNA, Small Interfering Small interfering RNA RNS-Interferenz (DE-588)4802706-6 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content RNS-Interferenz (DE-588)4802706-6 s DE-604 Paddison, Patrick J. Sonstige (DE-588)134024060 oth Current topics in microbiology and immunology 320 (DE-604)BV002527248 320 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016369271&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016369271&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | RNA interference Current topics in microbiology and immunology Gene Silencing Gene silencing MicroRNAs RNA RNA Interference RNA, Small Interfering Small interfering RNA RNS-Interferenz (DE-588)4802706-6 gnd |
| subject_GND | (DE-588)4802706-6 (DE-588)4143413-4 |
| title | RNA interference |
| title_auth | RNA interference |
| title_exact_search | RNA interference |
| title_exact_search_txtP | RNA interference |
| title_full | RNA interference Patrick J. Paddison ..., ed. |
| title_fullStr | RNA interference Patrick J. Paddison ..., ed. |
| title_full_unstemmed | RNA interference Patrick J. Paddison ..., ed. |
| title_short | RNA interference |
| title_sort | rna interference |
| topic | Gene Silencing Gene silencing MicroRNAs RNA RNA Interference RNA, Small Interfering Small interfering RNA RNS-Interferenz (DE-588)4802706-6 gnd |
| topic_facet | Gene Silencing Gene silencing MicroRNAs RNA RNA Interference RNA, Small Interfering Small interfering RNA RNS-Interferenz Aufsatzsammlung |
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