From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies: report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007
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| Format: | Conference Proceeding Book |
|---|---|
| Language: | English |
| Published: |
Lengerich ; Berlin ; Bremen ; Miami ; Riga ; Viernheim ; Wien ; Zagreb
Pabst
2007
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| Series: | Autoimmunity, autoantigens, autoantibodies
5 |
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XX, 675 S. Ill., graph. Darst. |
| ISBN: | 9783899674095 389967409X |
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MARC
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| 245 | 1 | 0 | |a From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies |b report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 |c K. Conrad ... (ed.) |
| 264 | 1 | |a Lengerich ; Berlin ; Bremen ; Miami ; Riga ; Viernheim ; Wien ; Zagreb |b Pabst |c 2007 | |
| 300 | |a XX, 675 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Autoimmunity, autoantigens, autoantibodies |v 5 | |
| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Autoantibodies |v Congresses | |
| 650 | 4 | |a Autoantibodies |x diagnostic use |v Congresses | |
| 650 | 4 | |a Autoimmune Diseases |x diagnosis |v Congresses | |
| 650 | 4 | |a Autoimmune diseases |v Congresses | |
| 650 | 4 | |a Autoimmunity |v Congresses | |
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| 650 | 0 | 7 | |a Diagnose |0 (DE-588)4012040-5 |2 gnd |9 rswk-swf |
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Contents
Preface XIX
Chapter 1
Prediction of Autoimmune Diseases — Facts and Perspectives
1 Prediction of autoimmunity — more than just autoantibodies 2
Yehuda Shoenfeld
2 Predictive autoantibodies: Past, present and future 6
Noel R.Rose
3 The predictive relevance of autoantibodies 16
Karsten Conrad, Werner Schossler, Marvin J. Fritzler
Chapter 2
Induction of Autoantibodies
4 The role of Toll-like receptors in the induction of autoantibodies and the
development of autoimmune diseases 34
Maria Fischer, Alexander Stoehr, Jeffrey V. Ravetch, Marc Ehlers
5 Autoimmune responses in experimental models of rheumatoid arthritis 45
Giinter Steiner, Markus Hoffmann, Silvia Hayer, Ruth Fritsch, Josef Smolen
6 Origin of anti-neutrophil cytoplasmic antibodies (ANCA) — new insights 54
Elena Csernok, Julia Ulrike Holle, Wolfgang Ludwig Gross
Chapter 3
Effects of Autoantigens and Autoantibodies
7 Protective autoantibodies: Role in homeostasis, clinical importance and therapeutic
potential 62
Elias Toubi, Yehuda Shoenfeld
8 Catalytic autoantibodies: Role in immune homeostasis and clinical autoimmunity 77
Mikhail Paltsev, Aleksandr Gabibov, Sergey Suchkov
9 Catalytic autoantibodies in organ-specific autoimmunity: an update 127
Elena Tretyak, Sergey Suchkov
10 Antiphospholipid antibodies induce procoagulant cytokine activity stimulating the
TLR8 pathway 130
Philipp von Landenberg, Yvonne Doring, Maik D. Drechsler, Natascha Clemens, Ingrid
Obermeier, Stefan Bauer, Joab Chapman, Yehuda Shoenfeld, Miri Blank, KarlJ. Lackner
11 Clinical and pathological significance of autoantibodies against protective molecules 131
Martine Szyper Kravitz, Yehuda Shoenfeld
12 Are autoantibodies secreted by long-lived plasma cells pathogenic? 141
Falk Hiepe, Thomas Dorner, Rudolf Manz, Andreas Radbruch
13 LEDGFp75/DFS70, a stress response autoantigen with multiple functions and broad
clinical relevance 146
Melanie Mediavilla-Varela, Lai Sum Leoh, Anamika Basu, Vidya Ganapathy, Carlos A.
Casiano
Chapter 4
Autoantibodies to Macromolecular Complexes
14 Autoantibodies to key components of the RNA interference pathway 168
Keigo Ikeda, Kaleb M. Pauley, Andrew Jakymiw, Minoru Satoh, Marvin J. I'ritzier,
Edward K. L. Chan
15 Autoantibodies to cytoplasmic autoantigens in endosomes, exosomes and the Golgi
Complex 178
Marvin J. fritzier, Laura M. Stinton, Edward K. L. Chan
16 Novel aspects of autoantibodies to the human exosome (PM/Scl complex) 194
Michael Mahler, Marvin J. fritzier
17 The human interferon-inducible protein IFI16: a mediator of inflammation and a
target for autoimmunity 210
Pier Luigi Meroni, M. Mondini, Paolo Aim, Piersandro Riboldi, Yehuda Shoenfeld, Marisa
Gariglio, Santo Landolfo
Chapter 5
Receptors, Autoantibodies, and Disease
18 Autoimmunity and idiopathic dilated cardiomyopathy: Where we are? 216
Michael Fu
19 Functional autoantibodies against G-protein coupled receptors 222
Gerd Wallukat
Chapter 6
Autoantibodies in Organ Specific Autoimmune Diseases
6.1
Neuromuscular and Neurological Diseases
20 Pathogenic and diagnostic relevance of autoantibodies against ion channels 236
Bethan Lang, Angela Vincent
21 Surface-binding autoantibodies and B-cell activating factor (BAFF) in pediatric
opsoclonus-myoclonus syndrome 247
Sandra Bick, Stefanie Altenkdmper, Isabell Krasenbrink, Marlene Tschernatsch, Antje
Kirsten, Franz Blaes, Verena Fuhlhuber
22 Anti-neuropil antibody in a patient with limbic encephalitis and breast cancer 255
/?. Vitaliani, M. Zoccarato, S. Irani, Sergio Zanini, Gian Luigi Gigli, B. Giometto, A. Vincent
23 Paraneoplastic limbic encephalitis with anti-Ma2 and CV2 antibodies 257
B. Giometto, M. Zoccarato, L Zuliani, R. Vitaliani
24 Long term survival of two patients with small cell lung carcinoma and anti-Hu
antibodies. Relation to therapy and serial antibody determination. 258
U. Wurster, J. Tummler, E. Sindern, A. Borchert, M. Schilling
25 Possible implementation of diagnostic tools in paraneoplastic neurological disorders 261
D. Saccomanno, G. P. Comi, N. Bresolin, M. Carpo
26 Euroline neuronal antigens: A newly developed line immunoassay for the detection
of antibodies against neuronal antigens in paraneoplastic syndromes 263
T. Scheper, W. Meyer, P. Klatt, L. Komorowski, C Probst, W. Schlumberger, W. Stocker
27 Complex regional pain syndrome and autoantibodies against differentiation-depen¬
dent neuronal surface antigens 265
F. Blaes, D. Nascimento, K. Schmitz, 0. Matz, M. Tschernatsch, M. Kaps
28 Antineurofilament antibodies in cerebrospinal fluid and serum in patients with
amyotrophic lateral sclerosis 267
/. Malbohan, L. Fialova, J. Svarcova, A. Bartos, P. Ridzoh, R. Rusina
29 Avidity of antineurofilament antibodies determined by Elisa method 269
/. Malbohan, J. Svarcova, L Fialova, A. Bartos
30 Anti-ganglioside autoantibody profiling in patients with autoimmune peripheral
neuropathies by a new line immunoassay 271
Hauke Schneider, Karsten Conrad, Ulrich Canzler, Tjalf Ziemssen, Thomas Talaska, Dirk
Reinhold, Rene Louis Humbel, Dirk Roggenbuck
31 Detection of anti-MOG autoantibodies in acute disseminated encephalomyelitis
(ADEM) by FACS analysis using MOG-transfected LN18 cells 276
P. W. Modderman, L A. Aarden, R. Q. Hintzen, D. Hamann
32 Discovery and validation of novel multiple sclerosis associated biomarkers using
protein biochips 278
A. Lueking, C Gutjahr, K. Schulte, V. GruB, H. £ Meyer, C Huels, S. Muellner, J. Beator
33 Neurological complications in celiac disease: Could have an autoimmune origin? 279
M. Carpo, D. Saccomanno, M. T. Bordello, I Allaria, N. Bresolin, G. P. Comi
34 Spectrum of autoantibodies in patients with psychiatric manifestations 281
L Laadhar, 0. Sidhom, S. Masmoudi, M. Zitouni, M. Sellami-Kallel, H. Zouhei, S. Makni
6.2
Gastrointestinal and Liver Diseases
35 Anti-carbohydrate antibodies as new markers for inflammatory bowel disease 284
Karin Malickova, Peter Laszlo Lakatos, Robert DonovaI, PetraSandova, IvanaJanatkova,
Milan Lukas
36 Differential diagnosis between Crohn's disease vs non-CD patients using a
combination of antiglycan antibodies (gASCA, ALCA, ACCA and AMCA) 294
Margarida Franco, Monica Ramalho, Sara Alberto, Luis Novais, Germano de Sousa,
Joao Ramos de Deus
37 Aberrant expression of B cell-activating factor of the TNF family (BAFF) and its
receptor in duodenal biopsies of patients with celiac disease 297
M. Fabris, F. Barone, A. Lerussi, D. Visentini, A. Picierno, R. Maieron, D. Villalta. 5. De Vita,
N. Bizzaro, R. Tozzoli, 5. Pizzolitto, J. Spencer, E. Tonutti
38 Overexpression of B cell-activating factor of the TNF family (BAFF) in serum and
duodenal biopsy in celiac disease patients. 299
M. Fabris, A. Lerussi, F. Barone, J Spencer, D. Visentini, A. Picierno, R. Maieron, D. Villalta,
F. Curcio, 5. De Vita, N. Bizzaro, R. Tozzoli, E. Tonutti
39 Deamidated gliadin peptides are superior to native gliadin in Elisa for diagnosis of
childhood celiac disease 302
Christian Prause, Christian Probst, Conny Da'hnrich, Wolfgang Schlumberger, Winfried
Stocker, Thomas Richter, Almuth Christine Hauer, Martin Stern, Holm Uhlig, Martin
W. Laass, Klaus-Peter Zimmer, Thomas Mothes
40 Antibodies against deamidated gliadin peptides as novel biomarkers of childhood
celiac disease 308
Maria Ritter, Rudiger Lieske, Thomas Richter, Almuth Christine Hauer, Martin Stern,
Holm Uhlig, Martin W. Laass, Klaus-Peter Zimmer, Thomas Mothes
41 Screening for celiac disease in patients with Hashimoto thyroiditis 313
L Laadhar, F. Harzallah, A. Hassin, M. Zitouni, M. Kallel-Sellami, S. Masmoudi,
H. Slimane, S. Makni
42 Production of celiac disease autoantibodies after in vitro gliadin challenge is
dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits 315
5. Stenman, K. Lindfors, lima R. Korponay-Szabo, 0. Lohi, H. Wieser, Markku Maki, Katri
Kaukinen
43 Celiac disease-specific IgA class autoantibodies disturb angiogenesis 317
Essi Myrsky, Katri Kaukinen, Mari Syrjdnen, lima R. Korponay-Szabo, Markku Mdki,
Katri Lindfors
44 Detection of primary biliary cirrhosis-associated anti-mitochondrial antibodies
using an improved test system: Anti-M2/BP0 Elisa 319
L Komorowski, D. Bogdanos, C. Probst, C. Dahnrich, A. Rosemann, W. Schlumberger, W.
Stocker
45 An help on primary biliary cirrhosis diagnostics?
Comparison between a newly developed Elisa (PBC Screen) and the SplOO, gp21O
EllSAS 321
I Martins, I. Abreu, C. Cardoso, A. Bastos, H. Trindade, J. Chaves
46 A comprehensive line immunoassay for the detection of autoantibodies in primary
biliary cirrhosis (PBC) 323
W. Meyer, T. Scheper, N. Janssen, L. Komorowski, C. Probst, W. Schlumberger, D. Bogdanos,
W. Stocker
6.3
Endocrine Diseases
47 Autoantibody characteristics and combinations in the prediction of type 1 diabetes 326
Ezio Bonifacio, Peter Achenbach
48 Differentiation of type 1 diabetes risk by GAD antibody epitope analysis and insulin
antibody affinity in antibody positive children from a general population 338
Michael Schlosser, Wolfgang Kerner, Peter Achenbach, Christiane S. Hampe, Reinhard
Walther
49 Examination of the diabetes-associated autoantigen GAD65 in serum as a possible
early diagnostic marker of beta cell loss 340
U. Walschus, I. Kloting, R. Walther, M. Schlosser
6.4
Cutaneous Autoimmune Diseases
50 Prevalence of autoantibodies in patients with pemphigus 344
K. Mejri, M. Kallel-Sellami, L Laadhar, H. Lahmer, M. Zitouni, S. Makni
51 Successful anti-CD20 therapy in paraneoplastic pemphigus associated with a
follicular dendritic cell sarcoma 346
Romain Bailloud, Jacques Serratrice, Sophie Desplat-Jego, Pascal Thomas, Pierre-Jean
Weiller
52 Sensitive and specific detection of pemphigoid autoantibodies by an Enzyme-linked
immunosorbent assay using multimers of the NCI 6A domain of BP180 as antigen 348
C Probst, C. Ddhnrich, L Komorowski, I.M. Bloecker, £ Schmidt, W. Schlumberger, C.
Sitaru, C. Rose, W. Stocker, D. Zillikens
Chapter 7
Autoantibodies in Systemic Autoimmune Diseases
53 Autoantibodies, classification criteria and diagnosis of systemic autoimmune
rheumatic diseases 352
Jennifer G. Walker, Cheryl Barnabe, Marvin J. Fritzler
54 Anti-phospholipid antibodies as predictors of autoimmune disease manifestations 370
Yaniv Sherer, Yehuda Shoenfeld
7.1
Rheumatoid Arthritis and Other Arthropathies
55 Citrullination in the arthritic synovium; the citrullinome, the antibodies against
citrullinated proteins and their connection with RA pathogenesis 378
Joyce J. B. C. van Beers, Albert J. W. Zendman, Walther J. van Venrooij, Ger J. M. Pruijn
56 Differential prognostic impact of autoantibodies and inflammation markers in early
rheumatoid arthritis 389
Johan Ronnelid, Mohammed Mullazehi, Linda Mathsson
57 Clinical and pathophysiological relevance of the autoimmune response to
citrullinated proteins 401
Guy Serre
58 Should rheumatoid patients have flossed more? Maybe . 404
H. A. Menard, M. Lora, William V. Giannobile, J. Mobley, D. Grenier, C. Bodet
59 Comparison of anti-mutated citrullinated vimentin antibodies with anti-CCP
antibodies: Interest in RA diagnosis and during infliximab therapy 406
P. Nicaise-Roland, 5. Grootenboer-Mignot, A. Bruns, M. Hurtado, E. Palazzo, G. Hayem,
0. Meyer, 5. Chollet-Martin
60 Improvement of serological RA diagnostics by autoantibody profiling 408
Karsten Conrad, Babette Heschel, Andrea Thieme, Renate Christoph, Beate Roch, Kirsten
Luthke, Stefan Bornstein, Hans-Egbert Schroder
61 Cost effectiveness of autoantibodies against cyclic citrullinated peptide in the very
early diagnosis of rheumatoid arthritis 411
Alexander Konnopka, Karsten Conrad Christoph Baerwald, Hans-Helmut Konig
62 Characterization of cells expressing citrullinated proteins in synovial tissue
of patients with rheumatoid arthritis, reactive arthritis, psoriatic arthritis and
osteoarthritis 413
Christof Zimmermann, Makiyeh Tohidast-Akrad, Peter Zenz, Josef Smolen, Gunter
Sterner
63 Antibodies cross-reacting with a 28 kDa drosophila antigen for diagnosis of
ankylosing spondylitis? 415
C. Duftner, C Dejaco, H. J. Lakomek, M. Schirmer
64 Hypothesis-testing for etiopathogenesis, therapy and prevention of ankylosing
spondylitis, Klebsiella-reactive uveitis and rheumatoid arthritis 423
Frank Hartig, Roland Pechlaner
65 Autoantibody profile in Slovak patients with juvenile idiopathic arthritis 425
D. Kozakova, V. Bosak, E. Koskova, F. Mateicka
7.2
SLE and Antiphospholipid Syndrome
66 Antibodies against nucleosomes and DNA: Clinical and pathogenic significance 428
L. Cebecauer, I. Lochman, V. Krai, R. W. Burlingame, W. Schlumberger
67 Can anti-chromatin antibody Elisa replace FARR in a routine diagnostic laboratory? 440
Myfanwy Spellerberg, Matthew Hayman, Peter Chapman, Lisa Stamp, John O'Donnell
68 Evaluation of novel assay systems for the determination of autoantibodies to
double-stranded DNA in patients with SLE 442
Christof Zimmermann, Elisabeth Hoefler, Josef Smolen, Gunter Sterner
69 A novel dot assay for the detection of anti-dsDNA antibodies in SLE sera 444
Tanja Liittich, Petra EiBfeller, Christine Jauris, Arno Kromminga
70 Characterization of cellular and humoral autoimmune responses to histone H1 and
core histones in patients with SLE 446
Georg Stummvoll, Ruth Fritsch, Brigitte Meyer, Martin Aringer, Josef Smolen, Gunter
Steiner
71 Cryopreservation of crithidia luciliae 448
Sonia Carujo, Ana Belen Polonio, Petraki Munujos
72 High sensitive detection of double-stranded DNA autoantibodies by a modified
Crithidia luciliae immunofluorescence test (CLIFT) 450
Werner SchoBler, Dirk Roggenbuck, Thomas Buttner, Uta KieBling, Hans-Egbert
Schroder, Karsten Conrad
73 The association of anti-SS-A/Ro52 and anti-SS-A/Ro60 antibodies in different
connective tissue diseases 453
Petra Eilifeller, Birgit Pepperkok, Tanja Luettich, Michael Mahler, Christine Jauris,
Marvin J fritzier
74 Evaluation of novel chemiluminescence-based methods for the detection of
anti-cardiolipin antibodies in APS and SLE patients 463
Alexander W. Gotz, Francesco Capuano, Luca Pallavicini, Karsten Conrad, Kristin
Tausche, Hans-Egbert Schroder
75 Value of serum levels of autoantibodies for monitoring therapy with aphaeresis in
antiphospholipid syndrome (APS) 465
M. Tampoia, A. Ramunni, A. Zucano, P. Lisi, G. Pannarale, A. Fontana
7.3
Systemic Sclerosis
76 Evaluation of an enzyme immunoassay for the detection of scleroderma-related
autoantibodies 468
R. Tozzoli, G Kodermaz, N. Bizzaro, E. Tonutti, M. Tampoia, S. Platzgummer, A. Antico
77 RNA polymerase III antibodies in patients with systemic sclerosis: Validation of a
new Elisa method 471
R. Tozzoli, G Kodermaz, N. Bizzaro, E. Tonutti, M. Tampoia, S. Platzgummer, A. Antico, G.
Moroni, D. Bassetti
78 Anti-Scl70 antibody levels correlate with skin and organ fibrosis in patients with
systemic sclerosis — analysis from the Charite SSc cohort 475
Stefanie Uibel, Katharina Hanke, Cornelia Dahnrich, Claudia Bruckner, Karl Egerer, Falk
Hiepe, Wolfgang Schlumberger, Gabriela Riemekasten
79 Antibodies against CENP-B antigen identify a subset of systemic sclerosis patients
with sicca syndrome and missing lung fibrosis — analysis of the Charite SSc cohort 477
Katharina Hanke, Stefanie Uibel, Claudia Bruckner, Cornelia Dahnrich, Karl Egerer, Falk
Hiepe, Wolfgang Schlumberger, Gabriela Riemekasten
7.4
ANCA-associated Vasculitis
80 MPO and PR3 autoantibodies: Evaluation of a new indirect immunofluorescence
method 480
F. Gioia, D. De Francesco
81 A novel Elisa detects anti-neutrophil cytoplasm antibodies against proteinase 3
with superior sensitivity 482
Bernhard Hellmich, Elena Csernok, Gert Fredenhagen, Wolfgang L. Gross
82 Europlus™ ANCA Biochip Mosaic: MPO and PR3 antigen dots improve the detection
of ANCA by indirect immunofluorescence 485
J. Damoiseaux, M. Buschtez, U. Steller, B. Zerbe, A. Rosemann, K. Fechner, W. Schlum-
berger, J. W. Cohen Tervaert, W. Stocker
83 A newly developed Elisa using a mixture of native PR3 and recombinant PR3
expressed in human cells improves the serological investigation of ANCA-associated
vasculitis 487
J. Damoiseaux, C. Dahnrich, A. Rosemann, C. Probst, L Komorowski, W. Schlumberger,
E. Csernok, F. Hiepe, J. W. Cohen Tervaert
Chapter 8
Autoantibodies in Miscellaneous Diseases
84 Anti-GSTTI antibody mediated chronic renal allograft rejection 490
/. Wichmann, I. Aguilera, A. J. Alvarez-Marquez, M. A. Gentil, A. Nuhez-Roldan
85 The antinuclear autoantibodies in patients with chronic heart failure 492
N. Virstyuk, E. Cherkachuna
86 Determination of serum anti-SlOO autoantibodies in patients with acute ischemic
stroke 494
M. Cojocaru, I. M. Cojocaru, C. Burcin, A. Atanasiu
87 Prevalence and clinical significance of autoantibodies in 147 adult patients with
cystic fibrosis 4g6
Karine Nkana, Florence Lachenal, Raphaele Nove Josserand, Isabelle Durieu, Nicole
Fabien
88 High prevalence of autoantibodies in patients with sickle cell disease 498
A M. Rouquette, S. Obadia, P. M'Bappe, I. Hagege, F. Boussa-Khettab, L Tshilolo, R. Girot
Chapter 9
Methodical Aspects and Diagnostic Strategies
89 Strategies and algorithms to improve the early diagnosis of autoimmune rheumatic
diseases 502
Allan Wiik
90 Autoantibodies in individuals with no apparent autoimmune disease 510
Silvia Helena Barbosa, Danilo Mesquita Junior, Paulo Guilherme Leser, Alessandra
Dellavance, Luis Eduardo Coelho Andrade
91 Definition of reference intervals in autoantibody assays using indirect methods
based on current data 530
/?. Tozzoli, D. Giavarina, D. Villalta, N. Bizzaro
92 Lessons from autoantibody binding avidity 540
Arno Kromminga
9.1
Identification of Novel Autoantibodies
93 Systematic development of antibody profiles as biomarkers 544
Angelika Lueking, Axel Kowald, Helmut E. Meyer, Jens Beator
94 Identification of two new autoantigens in patients with high titres of antinuclear
autoantibodies using protein macro-array technology 551
Cindy Hempp, Friedrich Haag, Friedrich Koch-Nolte, Thorsten Krieger
95 Protein arrays as versatile tool for the characterization of antibodies 562
Axel Kowald
96 Anti-prostasome autoantibodies in serum of prostate cancer patients 563
Karl Goran Ronquist, Lena Carlsson, Gunnar Ronquist, Anders Larsson
97 Autoantibodies in patients with glaucoma 578
Stephanie C Joachim, Jan Rekhelt, Simone Berneiser, Norbert Pfeiffer, Franz H. Grus
9.2
Multiplex Assays for Autoantibody Analyses
98 Proteomics on a chip for monitoring autoimmune diseases 592
Angelique M. C. Lokate, J. Bianca Beusink, Richard B. M. Schasfoort, GerJ. M. Pruijn
99 Development of a novel multi-parameter platform for use in autoimmune
diseases — technical aspects and first results on ANA testing 602
U. Klause, M. Rothfuss, H. Eberl, M. Wanger, A. Nichtl, H.-J. Muller, B. Risse
100 Evaluation of ANA-EN A antibodies in sera of patients with Sjogren's syndrome using
two multiplexed immunoassays (AtheNA multi-lyte ana system and the FIDIS™
connective) and two conventional methods (Ouchterlony double immunodiffusion,
immunoblotting) 604
/. Abreu, H. Guimardes, A. Bastos, Vaz Pato, F. Barcelos, G. Sousa, H. Trindade
101 BioPlex™2200 system: Simultaneous detection of anti-dsDNA and anti-nucleosome
antibodies in patients with systemic lupus erythematosus 606
Nathalie Bardin, Sophie Desplat-Jego, Bruno Larida, Marielle Sanmarco
102 Comparison between UltraPlex™ barcoded microparticle technology and en¬
zyme-linked immunosorbent assay for the determination of antibodies to dsDNA
and extractable nuclear antigens 608
Torsten Witte, Jodie Smith, David Mosedale, Reinhold E. Schmidt
103 Evaluation of multiplexed fluorescence microsphere immunoassay for detection of
autoantibodies to nuclear antigens 611
A. Kozmar, M. Rudolf, I. Radic, Branko Malenica
104 Euroline Myositis Profile: A newly developed line immunoassay for the detection of
myositis specific autoantibodies 612
W. Meyer, T. Scheper, N. Janssen, S. Torkler, W. Schlumberger, W. Stbcker
105 Microblots for autoantibody differentiation 614
Kai Grolimann, Ulrich Wagner, Rico Hiemann, Stephan Milius, Elke Kalz, Thomas
Buttner, Karsten Conrad, Werner Lehmann
9.3
Improvement of Autoantibody Detection
106 Designer antigens as diagnostic targets for (auto)antibody determination 619
Chnstwn Probst, Lars Komorowski, Cornelia Ddhnrich, Anke Rosemann, Wolfgang
Schlumberger, Klaus-Peter Wandinger, Thomas Mothes, Winfried Stacker
107 HEp-2 cell preparation for automated analysis of autoantibodies 632
J. Michel, R. Hiemann, N. Hilger, K. Kaltschmidt, M. Weigert, U. Sack, U. Anderer
108 Autoantibody screening by indirect immunofluorescence on HEp-2 cells: Compari¬
son of a novel automated image processing with visual examination 634
Rico Hiemann, Nadja Hilger, Karsten Conrad, Dirk Roggenbuck, Joerg Michel, Ursula
Anderer, Martin Weigert, Ulrich Sack
Color Figures 636
Subject Index 665
Author Index 671 |
| adam_txt |
Contents
Preface XIX
Chapter 1
Prediction of Autoimmune Diseases — Facts and Perspectives
1 Prediction of autoimmunity — more than just autoantibodies 2
Yehuda Shoenfeld
2 Predictive autoantibodies: Past, present and future 6
Noel R.Rose
3 The predictive relevance of autoantibodies 16
Karsten Conrad, Werner Schossler, Marvin J. Fritzler
Chapter 2
Induction of Autoantibodies
4 The role of Toll-like receptors in the induction of autoantibodies and the
development of autoimmune diseases 34
Maria Fischer, Alexander Stoehr, Jeffrey V. Ravetch, Marc Ehlers
5 Autoimmune responses in experimental models of rheumatoid arthritis 45
Giinter Steiner, Markus Hoffmann, Silvia Hayer, Ruth Fritsch, Josef Smolen
6 Origin of anti-neutrophil cytoplasmic antibodies (ANCA) — new insights 54
Elena Csernok, Julia Ulrike Holle, Wolfgang Ludwig Gross
Chapter 3
Effects of Autoantigens and Autoantibodies
7 Protective autoantibodies: Role in homeostasis, clinical importance and therapeutic
potential 62
Elias Toubi, Yehuda Shoenfeld
8 Catalytic autoantibodies: Role in immune homeostasis and clinical autoimmunity 77
Mikhail Paltsev, Aleksandr Gabibov, Sergey Suchkov
9 Catalytic autoantibodies in organ-specific autoimmunity: an update 127
Elena Tretyak, Sergey Suchkov
10 Antiphospholipid antibodies induce procoagulant cytokine activity stimulating the
TLR8 pathway 130
Philipp von Landenberg, Yvonne Doring, Maik D. Drechsler, Natascha Clemens, Ingrid
Obermeier, Stefan Bauer, Joab Chapman, Yehuda Shoenfeld, Miri Blank, KarlJ. Lackner
11 Clinical and pathological significance of autoantibodies against protective molecules 131
Martine Szyper Kravitz, Yehuda Shoenfeld
12 Are autoantibodies secreted by long-lived plasma cells pathogenic? 141
Falk Hiepe, Thomas Dorner, Rudolf Manz, Andreas Radbruch
13 LEDGFp75/DFS70, a stress response autoantigen with multiple functions and broad
clinical relevance 146
Melanie Mediavilla-Varela, Lai Sum Leoh, Anamika Basu, Vidya Ganapathy, Carlos A.
Casiano
Chapter 4
Autoantibodies to Macromolecular Complexes
14 Autoantibodies to key components of the RNA interference pathway 168
Keigo Ikeda, Kaleb M. Pauley, Andrew Jakymiw, Minoru Satoh, Marvin J. I'ritzier,
Edward K. L. Chan
15 Autoantibodies to cytoplasmic autoantigens in endosomes, exosomes and the Golgi
Complex 178
Marvin J. fritzier, Laura M. Stinton, Edward K. L. Chan
16 Novel aspects of autoantibodies to the human exosome (PM/Scl complex) 194
Michael Mahler, Marvin J. fritzier
17 The human interferon-inducible protein IFI16: a mediator of inflammation and a
target for autoimmunity 210
Pier Luigi Meroni, M. Mondini, Paolo Aim, Piersandro Riboldi, Yehuda Shoenfeld, Marisa
Gariglio, Santo Landolfo
Chapter 5
Receptors, Autoantibodies, and Disease
18 Autoimmunity and idiopathic dilated cardiomyopathy: Where we are? 216
Michael Fu
19 Functional autoantibodies against G-protein coupled receptors 222
Gerd Wallukat
Chapter 6
Autoantibodies in Organ Specific Autoimmune Diseases
6.1
Neuromuscular and Neurological Diseases
20 Pathogenic and diagnostic relevance of autoantibodies against ion channels 236
Bethan Lang, Angela Vincent
21 Surface-binding autoantibodies and B-cell activating factor (BAFF) in pediatric
opsoclonus-myoclonus syndrome 247
Sandra Bick, Stefanie Altenkdmper, Isabell Krasenbrink, Marlene Tschernatsch, Antje
Kirsten, Franz Blaes, Verena Fuhlhuber
22 Anti-neuropil antibody in a patient with limbic encephalitis and breast cancer 255
/?. Vitaliani, M. Zoccarato, S. Irani, Sergio Zanini, Gian Luigi Gigli, B. Giometto, A. Vincent
23 Paraneoplastic limbic encephalitis with anti-Ma2 and CV2 antibodies 257
B. Giometto, M. Zoccarato, L Zuliani, R. Vitaliani
24 Long term survival of two patients with small cell lung carcinoma and anti-Hu
antibodies. Relation to therapy and serial antibody determination. 258
U. Wurster, J. Tummler, E. Sindern, A. Borchert, M. Schilling
25 Possible implementation of diagnostic tools in paraneoplastic neurological disorders 261
D. Saccomanno, G. P. Comi, N. Bresolin, M. Carpo
26 Euroline neuronal antigens: A newly developed line immunoassay for the detection
of antibodies against neuronal antigens in paraneoplastic syndromes 263
T. Scheper, W. Meyer, P. Klatt, L. Komorowski, C Probst, W. Schlumberger, W. Stocker
27 Complex regional pain syndrome and autoantibodies against differentiation-depen¬
dent neuronal surface antigens 265
F. Blaes, D. Nascimento, K. Schmitz, 0. Matz, M. Tschernatsch, M. Kaps
28 Antineurofilament antibodies in cerebrospinal fluid and serum in patients with
amyotrophic lateral sclerosis 267
/. Malbohan, L. Fialova, J. Svarcova, A. Bartos, P. Ridzoh, R. Rusina
29 Avidity of antineurofilament antibodies determined by Elisa method 269
/. Malbohan, J. Svarcova, L Fialova, A. Bartos
30 Anti-ganglioside autoantibody profiling in patients with autoimmune peripheral
neuropathies by a new line immunoassay 271
Hauke Schneider, Karsten Conrad, Ulrich Canzler, Tjalf Ziemssen, Thomas Talaska, Dirk
Reinhold, Rene Louis Humbel, Dirk Roggenbuck
31 Detection of anti-MOG autoantibodies in acute disseminated encephalomyelitis
(ADEM) by FACS analysis using MOG-transfected LN18 cells 276
P. W. Modderman, L A. Aarden, R. Q. Hintzen, D. Hamann
32 Discovery and validation of novel multiple sclerosis associated biomarkers using
protein biochips 278
A. Lueking, C Gutjahr, K. Schulte, V. GruB, H. £ Meyer, C Huels, S. Muellner, J. Beator
33 Neurological complications in celiac disease: Could have an autoimmune origin? 279
M. Carpo, D. Saccomanno, M. T. Bordello, I Allaria, N. Bresolin, G. P. Comi
34 Spectrum of autoantibodies in patients with psychiatric manifestations 281
L Laadhar, 0. Sidhom, S. Masmoudi, M. Zitouni, M. Sellami-Kallel, H. Zouhei, S. Makni
6.2
Gastrointestinal and Liver Diseases
35 Anti-carbohydrate antibodies as new markers for inflammatory bowel disease 284
Karin Malickova, Peter Laszlo Lakatos, Robert DonovaI, PetraSandova, IvanaJanatkova,
Milan Lukas
36 Differential diagnosis between Crohn's disease vs non-CD patients using a
combination of antiglycan antibodies (gASCA, ALCA, ACCA and AMCA) 294
Margarida Franco, Monica Ramalho, Sara Alberto, Luis Novais, Germano de Sousa,
Joao Ramos de Deus
37 Aberrant expression of B cell-activating factor of the TNF family (BAFF) and its
receptor in duodenal biopsies of patients with celiac disease 297
M. Fabris, F. Barone, A. Lerussi, D. Visentini, A. Picierno, R. Maieron, D. Villalta. 5. De Vita,
N. Bizzaro, R. Tozzoli, 5. Pizzolitto, J. Spencer, E. Tonutti
38 Overexpression of B cell-activating factor of the TNF family (BAFF) in serum and
duodenal biopsy in celiac disease patients. 299
M. Fabris, A. Lerussi, F. Barone, J Spencer, D. Visentini, A. Picierno, R. Maieron, D. Villalta,
F. Curcio, 5. De Vita, N. Bizzaro, R. Tozzoli, E. Tonutti
39 Deamidated gliadin peptides are superior to native gliadin in Elisa for diagnosis of
childhood celiac disease 302
Christian Prause, Christian Probst, Conny Da'hnrich, Wolfgang Schlumberger, Winfried
Stocker, Thomas Richter, Almuth Christine Hauer, Martin Stern, Holm Uhlig, Martin
W. Laass, Klaus-Peter Zimmer, Thomas Mothes
40 Antibodies against deamidated gliadin peptides as novel biomarkers of childhood
celiac disease 308
Maria Ritter, Rudiger Lieske, Thomas Richter, Almuth Christine Hauer, Martin Stern,
Holm Uhlig, Martin W. Laass, Klaus-Peter Zimmer, Thomas Mothes
41 Screening for celiac disease in patients with Hashimoto thyroiditis 313
L Laadhar, F. Harzallah, A. Hassin, M. Zitouni, M. Kallel-Sellami, S. Masmoudi,
H. Slimane, S. Makni
42 Production of celiac disease autoantibodies after in vitro gliadin challenge is
dependent on small-bowel mucosal transglutaminase 2-specific IgA deposits 315
5. Stenman, K. Lindfors, lima R. Korponay-Szabo, 0. Lohi, H. Wieser, Markku Maki, Katri
Kaukinen
43 Celiac disease-specific IgA class autoantibodies disturb angiogenesis 317
Essi Myrsky, Katri Kaukinen, Mari Syrjdnen, lima R. Korponay-Szabo, Markku Mdki,
Katri Lindfors
44 Detection of primary biliary cirrhosis-associated anti-mitochondrial antibodies
using an improved test system: Anti-M2/BP0 Elisa 319
L Komorowski, D. Bogdanos, C. Probst, C. Dahnrich, A. Rosemann, W. Schlumberger, W.
Stocker
45 An help on primary biliary cirrhosis diagnostics?
Comparison between a newly developed Elisa (PBC Screen) and the SplOO, gp21O
EllSAS 321
I Martins, I. Abreu, C. Cardoso, A. Bastos, H. Trindade, J. Chaves
46 A comprehensive line immunoassay for the detection of autoantibodies in primary
biliary cirrhosis (PBC) 323
W. Meyer, T. Scheper, N. Janssen, L. Komorowski, C. Probst, W. Schlumberger, D. Bogdanos,
W. Stocker
6.3
Endocrine Diseases
47 Autoantibody characteristics and combinations in the prediction of type 1 diabetes 326
Ezio Bonifacio, Peter Achenbach
48 Differentiation of type 1 diabetes risk by GAD antibody epitope analysis and insulin
antibody affinity in antibody positive children from a general population 338
Michael Schlosser, Wolfgang Kerner, Peter Achenbach, Christiane S. Hampe, Reinhard
Walther
49 Examination of the diabetes-associated autoantigen GAD65 in serum as a possible
early diagnostic marker of beta cell loss 340
U. Walschus, I. Kloting, R. Walther, M. Schlosser
6.4
Cutaneous Autoimmune Diseases
50 Prevalence of autoantibodies in patients with pemphigus 344
K. Mejri, M. Kallel-Sellami, L Laadhar, H. Lahmer, M. Zitouni, S. Makni
51 Successful anti-CD20 therapy in paraneoplastic pemphigus associated with a
follicular dendritic cell sarcoma 346
Romain Bailloud, Jacques Serratrice, Sophie Desplat-Jego, Pascal Thomas, Pierre-Jean
Weiller
52 Sensitive and specific detection of pemphigoid autoantibodies by an Enzyme-linked
immunosorbent assay using multimers of the NCI 6A domain of BP180 as antigen 348
C Probst, C. Ddhnrich, L Komorowski, I.M. Bloecker, £ Schmidt, W. Schlumberger, C.
Sitaru, C. Rose, W. Stocker, D. Zillikens
Chapter 7
Autoantibodies in Systemic Autoimmune Diseases
53 Autoantibodies, classification criteria and diagnosis of systemic autoimmune
rheumatic diseases 352
Jennifer G. Walker, Cheryl Barnabe, Marvin J. Fritzler
54 Anti-phospholipid antibodies as predictors of autoimmune disease manifestations 370
Yaniv Sherer, Yehuda Shoenfeld
7.1
Rheumatoid Arthritis and Other Arthropathies
55 Citrullination in the arthritic synovium; the citrullinome, the antibodies against
citrullinated proteins and their connection with RA pathogenesis 378
Joyce J. B. C. van Beers, Albert J. W. Zendman, Walther J. van Venrooij, Ger J. M. Pruijn
56 Differential prognostic impact of autoantibodies and inflammation markers in early
rheumatoid arthritis 389
Johan Ronnelid, Mohammed Mullazehi, Linda Mathsson
57 Clinical and pathophysiological relevance of the autoimmune response to
citrullinated proteins 401
Guy Serre
58 Should rheumatoid patients have flossed more? Maybe . 404
H. A. Menard, M. Lora, William V. Giannobile, J. Mobley, D. Grenier, C. Bodet
59 Comparison of anti-mutated citrullinated vimentin antibodies with anti-CCP
antibodies: Interest in RA diagnosis and during infliximab therapy 406
P. Nicaise-Roland, 5. Grootenboer-Mignot, A. Bruns, M. Hurtado, E. Palazzo, G. Hayem,
0. Meyer, 5. Chollet-Martin
60 Improvement of serological RA diagnostics by autoantibody profiling 408
Karsten Conrad, Babette Heschel, Andrea Thieme, Renate Christoph, Beate Roch, Kirsten
Luthke, Stefan Bornstein, Hans-Egbert Schroder
61 Cost effectiveness of autoantibodies against cyclic citrullinated peptide in the very
early diagnosis of rheumatoid arthritis 411
Alexander Konnopka, Karsten Conrad Christoph Baerwald, Hans-Helmut Konig
62 Characterization of cells expressing citrullinated proteins in synovial tissue
of patients with rheumatoid arthritis, reactive arthritis, psoriatic arthritis and
osteoarthritis 413
Christof Zimmermann, Makiyeh Tohidast-Akrad, Peter Zenz, Josef Smolen, Gunter
Sterner
63 Antibodies cross-reacting with a 28 kDa drosophila antigen for diagnosis of
ankylosing spondylitis? 415
C. Duftner, C Dejaco, H. J. Lakomek, M. Schirmer
64 Hypothesis-testing for etiopathogenesis, therapy and prevention of ankylosing
spondylitis, Klebsiella-reactive uveitis and rheumatoid arthritis 423
Frank Hartig, Roland Pechlaner
65 Autoantibody profile in Slovak patients with juvenile idiopathic arthritis 425
D. Kozakova, V. Bosak, E. Koskova, F. Mateicka
7.2
SLE and Antiphospholipid Syndrome
66 Antibodies against nucleosomes and DNA: Clinical and pathogenic significance 428
L. Cebecauer, I. Lochman, V. Krai, R. W. Burlingame, W. Schlumberger
67 Can anti-chromatin antibody Elisa replace FARR in a routine diagnostic laboratory? 440
Myfanwy Spellerberg, Matthew Hayman, Peter Chapman, Lisa Stamp, John O'Donnell
68 Evaluation of novel assay systems for the determination of autoantibodies to
double-stranded DNA in patients with SLE 442
Christof Zimmermann, Elisabeth Hoefler, Josef Smolen, Gunter Sterner
69 A novel dot assay for the detection of anti-dsDNA antibodies in SLE sera 444
Tanja Liittich, Petra EiBfeller, Christine Jauris, Arno Kromminga
70 Characterization of cellular and humoral autoimmune responses to histone H1 and
core histones in patients with SLE 446
Georg Stummvoll, Ruth Fritsch, Brigitte Meyer, Martin Aringer, Josef Smolen, Gunter
Steiner
71 Cryopreservation of crithidia luciliae 448
Sonia Carujo, Ana Belen Polonio, Petraki Munujos
72 High sensitive detection of double-stranded DNA autoantibodies by a modified
Crithidia luciliae immunofluorescence test (CLIFT) 450
Werner SchoBler, Dirk Roggenbuck, Thomas Buttner, Uta KieBling, Hans-Egbert
Schroder, Karsten Conrad
73 The association of anti-SS-A/Ro52 and anti-SS-A/Ro60 antibodies in different
connective tissue diseases 453
Petra Eilifeller, Birgit Pepperkok, Tanja Luettich, Michael Mahler, Christine Jauris,
Marvin J fritzier
74 Evaluation of novel chemiluminescence-based methods for the detection of
anti-cardiolipin antibodies in APS and SLE patients 463
Alexander W. Gotz, Francesco Capuano, Luca Pallavicini, Karsten Conrad, Kristin
Tausche, Hans-Egbert Schroder
75 Value of serum levels of autoantibodies for monitoring therapy with aphaeresis in
antiphospholipid syndrome (APS) 465
M. Tampoia, A. Ramunni, A. Zucano, P. Lisi, G. Pannarale, A. Fontana
7.3
Systemic Sclerosis
76 Evaluation of an enzyme immunoassay for the detection of scleroderma-related
autoantibodies 468
R. Tozzoli, G Kodermaz, N. Bizzaro, E. Tonutti, M. Tampoia, S. Platzgummer, A. Antico
77 RNA polymerase III antibodies in patients with systemic sclerosis: Validation of a
new Elisa method 471
R. Tozzoli, G Kodermaz, N. Bizzaro, E. Tonutti, M. Tampoia, S. Platzgummer, A. Antico, G.
Moroni, D. Bassetti
78 Anti-Scl70 antibody levels correlate with skin and organ fibrosis in patients with
systemic sclerosis — analysis from the Charite SSc cohort 475
Stefanie Uibel, Katharina Hanke, Cornelia Dahnrich, Claudia Bruckner, Karl Egerer, Falk
Hiepe, Wolfgang Schlumberger, Gabriela Riemekasten
79 Antibodies against CENP-B antigen identify a subset of systemic sclerosis patients
with sicca syndrome and missing lung fibrosis — analysis of the Charite SSc cohort 477
Katharina Hanke, Stefanie Uibel, Claudia Bruckner, Cornelia Dahnrich, Karl Egerer, Falk
Hiepe, Wolfgang Schlumberger, Gabriela Riemekasten
7.4
ANCA-associated Vasculitis
80 MPO and PR3 autoantibodies: Evaluation of a new indirect immunofluorescence
method 480
F. Gioia, D. De Francesco
81 A novel Elisa detects anti-neutrophil cytoplasm antibodies against proteinase 3
with superior sensitivity 482
Bernhard Hellmich, Elena Csernok, Gert Fredenhagen, Wolfgang L. Gross
82 Europlus™ ANCA Biochip Mosaic: MPO and PR3 antigen dots improve the detection
of ANCA by indirect immunofluorescence 485
J. Damoiseaux, M. Buschtez, U. Steller, B. Zerbe, A. Rosemann, K. Fechner, W. Schlum-
berger, J. W. Cohen Tervaert, W. Stocker
83 A newly developed Elisa using a mixture of native PR3 and recombinant PR3
expressed in human cells improves the serological investigation of ANCA-associated
vasculitis 487
J. Damoiseaux, C. Dahnrich, A. Rosemann, C. Probst, L Komorowski, W. Schlumberger,
E. Csernok, F. Hiepe, J. W. Cohen Tervaert
Chapter 8
Autoantibodies in Miscellaneous Diseases
84 Anti-GSTTI antibody mediated chronic renal allograft rejection 490
/. Wichmann, I. Aguilera, A. J. Alvarez-Marquez, M. A. Gentil, A. Nuhez-Roldan
85 The antinuclear autoantibodies in patients with chronic heart failure 492
N. Virstyuk, E. Cherkachuna
86 Determination of serum anti-SlOO autoantibodies in patients with acute ischemic
stroke 494
M. Cojocaru, I. M. Cojocaru, C. Burcin, A. Atanasiu
87 Prevalence and clinical significance of autoantibodies in 147 adult patients with
cystic fibrosis 4g6
Karine Nkana, Florence Lachenal, Raphaele Nove Josserand, Isabelle Durieu, Nicole
Fabien
88 High prevalence of autoantibodies in patients with sickle cell disease 498
A M. Rouquette, S. Obadia, P. M'Bappe, I. Hagege, F. Boussa-Khettab, L Tshilolo, R. Girot
Chapter 9
Methodical Aspects and Diagnostic Strategies
89 Strategies and algorithms to improve the early diagnosis of autoimmune rheumatic
diseases 502
Allan Wiik
90 Autoantibodies in individuals with no apparent autoimmune disease 510
Silvia Helena Barbosa, Danilo Mesquita Junior, Paulo Guilherme Leser, Alessandra
Dellavance, Luis Eduardo Coelho Andrade
91 Definition of reference intervals in autoantibody assays using indirect methods
based on current data 530
/?. Tozzoli, D. Giavarina, D. Villalta, N. Bizzaro
92 Lessons from autoantibody binding avidity 540
Arno Kromminga
9.1
Identification of Novel Autoantibodies
93 Systematic development of antibody profiles as biomarkers 544
Angelika Lueking, Axel Kowald, Helmut E. Meyer, Jens Beator
94 Identification of two new autoantigens in patients with high titres of antinuclear
autoantibodies using protein macro-array technology 551
Cindy Hempp, Friedrich Haag, Friedrich Koch-Nolte, Thorsten Krieger
95 Protein arrays as versatile tool for the characterization of antibodies 562
Axel Kowald
96 Anti-prostasome autoantibodies in serum of prostate cancer patients 563
Karl Goran Ronquist, Lena Carlsson, Gunnar Ronquist, Anders Larsson
97 Autoantibodies in patients with glaucoma 578
Stephanie C Joachim, Jan Rekhelt, Simone Berneiser, Norbert Pfeiffer, Franz H. Grus
9.2
Multiplex Assays for Autoantibody Analyses
98 Proteomics on a chip for monitoring autoimmune diseases 592
Angelique M. C. Lokate, J. Bianca Beusink, Richard B. M. Schasfoort, GerJ. M. Pruijn
99 Development of a novel multi-parameter platform for use in autoimmune
diseases — technical aspects and first results on ANA testing 602
U. Klause, M. Rothfuss, H. Eberl, M. Wanger, A. Nichtl, H.-J. Muller, B. Risse
100 Evaluation of ANA-EN A antibodies in sera of patients with Sjogren's syndrome using
two multiplexed immunoassays (AtheNA multi-lyte ana system and the FIDIS™
connective) and two conventional methods (Ouchterlony double immunodiffusion,
immunoblotting) 604
/. Abreu, H. Guimardes, A. Bastos, Vaz Pato, F. Barcelos, G. Sousa, H. Trindade
101 BioPlex™2200 system: Simultaneous detection of anti-dsDNA and anti-nucleosome
antibodies in patients with systemic lupus erythematosus 606
Nathalie Bardin, Sophie Desplat-Jego, Bruno Larida, Marielle Sanmarco
102 Comparison between UltraPlex™ barcoded microparticle technology and en¬
zyme-linked immunosorbent assay for the determination of antibodies to dsDNA
and extractable nuclear antigens 608
Torsten Witte, Jodie Smith, David Mosedale, Reinhold E. Schmidt
103 Evaluation of multiplexed fluorescence microsphere immunoassay for detection of
autoantibodies to nuclear antigens 611
A. Kozmar, M. Rudolf, I. Radic, Branko Malenica
104 Euroline Myositis Profile: A newly developed line immunoassay for the detection of
myositis specific autoantibodies 612
W. Meyer, T. Scheper, N. Janssen, S. Torkler, W. Schlumberger, W. Stbcker
105 Microblots for autoantibody differentiation 614
Kai Grolimann, Ulrich Wagner, Rico Hiemann, Stephan Milius, Elke Kalz, Thomas
Buttner, Karsten Conrad, Werner Lehmann
9.3
Improvement of Autoantibody Detection
106 Designer antigens as diagnostic targets for (auto)antibody determination 619
Chnstwn Probst, Lars Komorowski, Cornelia Ddhnrich, Anke Rosemann, Wolfgang
Schlumberger, Klaus-Peter Wandinger, Thomas Mothes, Winfried Stacker
107 HEp-2 cell preparation for automated analysis of autoantibodies 632
J. Michel, R. Hiemann, N. Hilger, K. Kaltschmidt, M. Weigert, U. Sack, U. Anderer
108 Autoantibody screening by indirect immunofluorescence on HEp-2 cells: Compari¬
son of a novel automated image processing with visual examination 634
Rico Hiemann, Nadja Hilger, Karsten Conrad, Dirk Roggenbuck, Joerg Michel, Ursula
Anderer, Martin Weigert, Ulrich Sack
Color Figures 636
Subject Index 665
Author Index 671 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author_GND | (DE-588)110452917 |
| building | Verbundindex |
| bvnumber | BV023065965 |
| ctrlnum | (OCoLC)229430445 (DE-599)DNB985916052 |
| dewey-full | 616.9780756 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.9780756 |
| dewey-search | 616.9780756 |
| dewey-sort | 3616.9780756 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Conference Proceeding Book |
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| genre | (DE-588)1071861417 Konferenzschrift 2007 Dresden gnd-content |
| genre_facet | Konferenzschrift 2007 Dresden |
| id | DE-604.BV023065965 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:30:50Z |
| indexdate | 2024-07-20T09:29:25Z |
| institution | BVB |
| institution_GND | (DE-588)10183017-8 |
| isbn | 9783899674095 389967409X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016269164 |
| oclc_num | 229430445 |
| open_access_boolean | |
| owner | DE-29 |
| owner_facet | DE-29 |
| physical | XX, 675 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Pabst |
| record_format | marc |
| series | Autoimmunity, autoantigens, autoantibodies |
| series2 | Autoimmunity, autoantigens, autoantibodies |
| spelling | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 K. Conrad ... (ed.) Lengerich ; Berlin ; Bremen ; Miami ; Riga ; Viernheim ; Wien ; Zagreb Pabst 2007 XX, 675 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Autoimmunity, autoantigens, autoantibodies 5 Literaturangaben Autoantibodies Congresses Autoantibodies diagnostic use Congresses Autoimmune Diseases diagnosis Congresses Autoimmune diseases Congresses Autoimmunity Congresses Autoantikörper (DE-588)4215429-7 gnd rswk-swf Autoaggressionskrankheit (DE-588)4003935-3 gnd rswk-swf Diagnose (DE-588)4012040-5 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2007 Dresden gnd-content Autoaggressionskrankheit (DE-588)4003935-3 s Diagnose (DE-588)4012040-5 s Autoantikörper (DE-588)4215429-7 s DE-604 Conrad, Karsten 1956- Sonstige (DE-588)110452917 oth Dresden Symposium on Autoantibodies 8 2007 Dresden Sonstige (DE-588)10183017-8 oth Autoimmunity, autoantigens, autoantibodies 5 (DE-604)BV014013293 5 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3011255&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016269164&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 Autoimmunity, autoantigens, autoantibodies Autoantibodies Congresses Autoantibodies diagnostic use Congresses Autoimmune Diseases diagnosis Congresses Autoimmune diseases Congresses Autoimmunity Congresses Autoantikörper (DE-588)4215429-7 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd Diagnose (DE-588)4012040-5 gnd |
| subject_GND | (DE-588)4215429-7 (DE-588)4003935-3 (DE-588)4012040-5 (DE-588)1071861417 |
| title | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 |
| title_auth | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 |
| title_exact_search | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 |
| title_exact_search_txtP | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 |
| title_full | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 K. Conrad ... (ed.) |
| title_fullStr | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 K. Conrad ... (ed.) |
| title_full_unstemmed | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 K. Conrad ... (ed.) |
| title_short | From etiopathogenesis to the prediction of autoimmune diseases: relevance of autoantibodies |
| title_sort | from etiopathogenesis to the prediction of autoimmune diseases relevance of autoantibodies report on the 8th dresden symposium on autoantibodies held in dresden on september 12 15 2007 |
| title_sub | report on the 8th Dresden Symposium on Autoantibodies, held in Dresden on September 12 - 15, 2007 |
| topic | Autoantibodies Congresses Autoantibodies diagnostic use Congresses Autoimmune Diseases diagnosis Congresses Autoimmune diseases Congresses Autoimmunity Congresses Autoantikörper (DE-588)4215429-7 gnd Autoaggressionskrankheit (DE-588)4003935-3 gnd Diagnose (DE-588)4012040-5 gnd |
| topic_facet | Autoantibodies Congresses Autoantibodies diagnostic use Congresses Autoimmune Diseases diagnosis Congresses Autoimmune diseases Congresses Autoimmunity Congresses Autoantikörper Autoaggressionskrankheit Diagnose Konferenzschrift 2007 Dresden |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3011255&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016269164&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV014013293 |
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