Molecular mechanisms of basal cell and squamous cell carcinomas:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Georgetown, Tex.
Landes Bioscience [u.a.]
2006
|
| Series: | Medical intelligence unit
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 137 S. Ill., graph. Darst. |
| ISBN: | 9780387260464 0387260463 |
Staff View
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| 245 | 1 | 0 | |a Molecular mechanisms of basal cell and squamous cell carcinomas |c [ed. by] Jörg Reichrath |
| 264 | 1 | |a Georgetown, Tex. |b Landes Bioscience [u.a.] |c 2006 | |
| 300 | |a 137 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Medical intelligence unit | |
| 650 | 4 | |a Skin |x Cancer |x Genetic aspects | |
| 650 | 4 | |a Basal cell carcinoma |x Genetic aspects | |
| 650 | 4 | |a Squamous cell carcinoma |x Genetic aspects | |
| 650 | 4 | |a Carcinoma, Basal Cell |x genetics | |
| 650 | 4 | |a Carcinoma, Basal Cell |x physiopathology | |
| 650 | 4 | |a Carcinoma, Squamous Cell |x genetics | |
| 650 | 4 | |a Carcinoma, Squamous Cell |x physiopathology | |
| 650 | 4 | |a Cytogenetics |x methods | |
| 650 | 4 | |a Papillomavirus Infections |x complications | |
| 650 | 0 | 7 | |a Basaliom |0 (DE-588)4220831-2 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Squamöser Krebs |0 (DE-588)4284825-8 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Basaliom |0 (DE-588)4220831-2 |D s |
| 689 | 0 | 1 | |a Squamöser Krebs |0 (DE-588)4284825-8 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Reichrath, Jörg |d 1962- |e Sonstige |0 (DE-588)172479150 |4 oth | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-016161936 | ||
Record in the Search Index
| _version_ | 1804137202573115392 |
|---|---|
| adam_text | CONTENTS
Preface
. xv
1.
The Epidemiology of Basal Cell and Squamous Cell Carcinoma
............1
Hao Wang and Thomas L.
Diepgen
Incidence of Nonmelanoma Skin Cancer (NMSC)
...............................1
Trends in Incidence of BCC and SCC
..................................................3
Risk Factors
...........................................................................................3
Ultraviolet Radiation (UVR)
.................................................................3
Ageing
...................................................................................................4
Smoking
................................................................................................4
Alcohol
..................................................................................................4
Diet
.......................................................................................................4
Medical Conditions
...............................................................................5
Ionizing Radiation
.........................................................................,.......5
Occupation
...........................................................................................5
Chemical Carcinogens
...........................................................................6
History and Precursor Lesions
...............................................................6
Skin Cancer Prevention Strategies
.........................................................6
2.
Histology of Epithelial Skin Tumors
....................................................10
Jörg Reichrath
and
Kerstin Querings
Squamous Cell Carcinoma
..................................................................10
Basal Cell Carcinoma
..........................................................................15
Basosquamous Carcinoma
...................................................................16
3.
UV Damage and
DNA
Repair in Basal Cell
and Squamous Cell Carcinomas
...........................................................18
Knuth Rass
UV
Damage and
DNA
Repair
............................................................19
UV-Induced Carcinogenesis in Squamous Cell Carcinoma (SCC)
......23
UV-Induced Carcinogenesis in Basal Cell Carcinoma (BCC)
..............25
4.
Papillomavitus Infections and Cancerogenesis of Squamous Cell
and Basal Cell Carcinomas
...................................................................31
Guido
Bem
Basal Cell Carcinomas
.........................................................................39
5.
The Immune System and Nonmelanoma Skin Cancers
.......................43
Elma D.
Baron
Epidemiologie
Evidence from Organ Transplant Recipients
................43
Evidence from Studies on UV-Induced Immune Suppression
and Nonmelanoma Cancer Formation
............................................44
Mechanisms Involved in Immune Suppression and Carcinogenesis
of Nonmelanoma Skin Tumors
.......................................................45
6.
Cytogenetics
of Basal Cell Carcinoma
and Squamous Ceil Carcinomas
...........................................................49
MehnieA. Carless, Kevin
J
.
Ashton andLyn
R
Griffiths
Cytogenetic Analysis
............................................................................49
Ploidy Analysis
....................................................................................50
Classical Karyotypic Analysis
...............................................................51
Fluorescence in Situ Hybridization Analysis
and Comparative Genomic Hybridization Analysis
.........................51
Implications of Cytogenetic Findings and Future Developments
.........53
7.
The Hedgehog Signaling Pathway and Epithelial Skin Cancer
.............58
Julia Reifenberger
The Hedgehog Signaling Pathway
.......................................................59
Alterations of Hedgehog Signaling in Skin Tumors
.............................60
Mouse Models for Basal Cell Carcinoma
.............................................62
Novel Pathogenesis-Based Approaches for Prevention
and Therapy of Basal Cell Carcinomas
............................................63
8.
p53 Protein and Nonmelanoma Skin Cancer
.......................................66
Vladislava
О.
Melnikova and Honnavara
N.
Ananthaswamy
p53 Tumor Suppressor Gene
..............................................................66
Induction of p53 Protein by UV and Biologic Consequences
..............69
A Model of UV-Induced Initiation and Progression
of Squamous Cell Carcinomas
.........................................................69
p53 Mutations in Nonmelanoma Skin Cancers
...................................69
p53 Mutations in Mouse Skin Cancers
................................................72
9. TGF-ß
Pathway and Cancerogenesis of Epithelial Skin Tumors
..........80
Miguel Quintanilla,
Eduardo
Pérez-Gómez,
Diana Romero,
Mar
Pons
and Jaime Renart
TGF-ß
Signalling
................................................................................80
Role of
TGF-ß in
Epidermal Development
.........................................82
Role of
TGF-ß in
Epidermal Proliferation and Homeostasis
...............84
Role of
TGF-ß in
Epithelial Skin Cancer
............................................86
10.
PDGF Pathways and Growth of Basal Cell
and Squamous Cell Carcinomas
...........................................................94
Jingwu Xie
Signal Transduction by PDGFs and Their Receptors
..........................94
In Vivo Functions of PDGFs and Their Receptors
..............................95
PDGF Alterations in Cancer
...............................................................97
The Role of PDGF for Cell Proliferation in BCCs
..............................99
The Role of PDGF/VEGF Signaling in Angiogenesis of SCCs
..........102
PDGF Signaling in Dermatofibrosarcoma Protuberans
and Giant Cell Fibroblastoma
.......................................................104
Perspectives
.......................................................................................104
11.
Apoptosis and Cancerogenesis of Basal Cell
and Squamous Cell Carcinoma
..........................................................108
Peter
Erb,
Jingmin Ji, Marion Wemli and
StanisUw
A.
Büchner
Gene Mutations Lead to NMSCs
......................................................109
Apoptosis Is Pivotal for the Removal of
DNA
Damaged
and Transformed Cells
..................................................................110
UV-Light Changes the Expression Pattern of Apoptosis-Inducing
and -Preventing Molecules in Skin Epidermis
...............................110
FasL, the Double-Edged Sword
.........................................................
Ill
Downregulation of FasL on BCC by Antisense Oligonucleotides
or Small Interfering RNAs (siRNAs)
.............................................112
Outlook
............................................................................................113
12.
The Role of Telomerase for Cancerogenesis of Basal Cell
and Squamous Cell Carcinomas
.........................................................115
Eva-Maria Fabricius
Interaction of Telomeres and Telomerase
..........................................116
Telomerase Activating in Normal Skin
..............................................119
Telomerase Activation in the Nonmelanoma Skin Tumors BCC
and SCC and in Their Tumor-Free Margins
.................................121
Index
..................................................................................................135
|
| adam_txt |
CONTENTS
Preface
. xv
1.
The Epidemiology of Basal Cell and Squamous Cell Carcinoma
.1
Hao Wang and Thomas L.
Diepgen
Incidence of Nonmelanoma Skin Cancer (NMSC)
.1
Trends in Incidence of BCC and SCC
.3
Risk Factors
.3
Ultraviolet Radiation (UVR)
.3
Ageing
.4
Smoking
.4
Alcohol
.4
Diet
.4
Medical Conditions
.5
Ionizing Radiation
.,.5
Occupation
.5
Chemical Carcinogens
.6
History and Precursor Lesions
.6
Skin Cancer Prevention Strategies
.6
2.
Histology of Epithelial Skin Tumors
.10
Jörg Reichrath
and
Kerstin Querings
Squamous Cell Carcinoma
.10
Basal Cell Carcinoma
.15
Basosquamous Carcinoma
.16
3.
UV Damage and
DNA
Repair in Basal Cell
and Squamous Cell Carcinomas
.18
Knuth Rass
UV
Damage and
DNA
Repair
.19
UV-Induced Carcinogenesis in Squamous Cell Carcinoma (SCC)
.23
UV-Induced Carcinogenesis in Basal Cell Carcinoma (BCC)
.25
4.
Papillomavitus Infections and Cancerogenesis of Squamous Cell
and Basal Cell Carcinomas
.31
Guido
Bem
Basal Cell Carcinomas
.39
5.
The Immune System and Nonmelanoma Skin Cancers
.43
Elma D.
Baron
Epidemiologie
Evidence from Organ Transplant Recipients
.43
Evidence from Studies on UV-Induced Immune Suppression
and Nonmelanoma Cancer Formation
.44
Mechanisms Involved in Immune Suppression and Carcinogenesis
of Nonmelanoma Skin Tumors
.45
6.
Cytogenetics
of Basal Cell Carcinoma
and Squamous Ceil Carcinomas
.49
MehnieA. Carless, Kevin
J
.
Ashton andLyn
R
Griffiths
Cytogenetic Analysis
.49
Ploidy Analysis
.50
Classical Karyotypic Analysis
.51
Fluorescence in Situ Hybridization Analysis
and Comparative Genomic Hybridization Analysis
.51
Implications of Cytogenetic Findings and Future Developments
.53
7.
The Hedgehog Signaling Pathway and Epithelial Skin Cancer
.58
Julia Reifenberger
The Hedgehog Signaling Pathway
.59
Alterations of Hedgehog Signaling in Skin Tumors
.60
Mouse Models for Basal Cell Carcinoma
.62
Novel Pathogenesis-Based Approaches for Prevention
and Therapy of Basal Cell Carcinomas
.63
8.
p53 Protein and Nonmelanoma Skin Cancer
.66
Vladislava
О.
Melnikova and Honnavara
N.
Ananthaswamy
p53 Tumor Suppressor Gene
.66
Induction of p53 Protein by UV and Biologic Consequences
.69
A Model of UV-Induced Initiation and Progression
of Squamous Cell Carcinomas
.69
p53 Mutations in Nonmelanoma Skin Cancers
.69
p53 Mutations in Mouse Skin Cancers
.72
9. TGF-ß
Pathway and Cancerogenesis of Epithelial Skin Tumors
.80
Miguel Quintanilla,
Eduardo
Pérez-Gómez,
Diana Romero,
Mar
Pons
and Jaime Renart
TGF-ß
Signalling
.80
Role of
TGF-ß in
Epidermal Development
.82
Role of
TGF-ß in
Epidermal Proliferation and Homeostasis
.84
Role of
TGF-ß in
Epithelial Skin Cancer
.86
10.
PDGF Pathways and Growth of Basal Cell
and Squamous Cell Carcinomas
.94
Jingwu Xie
Signal Transduction by PDGFs and Their Receptors
.94
In Vivo Functions of PDGFs and Their Receptors
.95
PDGF Alterations in Cancer
.97
The Role of PDGF for Cell Proliferation in BCCs
.99
The Role of PDGF/VEGF Signaling in Angiogenesis of SCCs
.102
PDGF Signaling in Dermatofibrosarcoma Protuberans
and Giant Cell Fibroblastoma
.104
Perspectives
.104
11.
Apoptosis and Cancerogenesis of Basal Cell
and Squamous Cell Carcinoma
.108
Peter
Erb,
Jingmin Ji, Marion Wemli and
StanisUw
A.
Büchner
Gene Mutations Lead to NMSCs
.109
Apoptosis Is Pivotal for the Removal of
DNA
Damaged
and Transformed Cells
.110
UV-Light Changes the Expression Pattern of Apoptosis-Inducing
and -Preventing Molecules in Skin Epidermis
.110
FasL, the Double-Edged Sword
.
Ill
Downregulation of FasL on BCC by Antisense Oligonucleotides
or Small Interfering RNAs (siRNAs)
.112
Outlook
.113
12.
The Role of Telomerase for Cancerogenesis of Basal Cell
and Squamous Cell Carcinomas
.115
Eva-Maria Fabricius
Interaction of Telomeres and Telomerase
.116
Telomerase Activating in Normal Skin
.119
Telomerase Activation in the Nonmelanoma Skin Tumors BCC
and SCC and in Their Tumor-Free Margins
.121
Index
.135 |
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| id | DE-604.BV022957526 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:03:25Z |
| indexdate | 2024-07-09T21:08:33Z |
| institution | BVB |
| isbn | 9780387260464 0387260463 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016161936 |
| oclc_num | 209909222 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | 137 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Landes Bioscience [u.a.] |
| record_format | marc |
| series2 | Medical intelligence unit |
| spelling | Molecular mechanisms of basal cell and squamous cell carcinomas [ed. by] Jörg Reichrath Georgetown, Tex. Landes Bioscience [u.a.] 2006 137 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medical intelligence unit Skin Cancer Genetic aspects Basal cell carcinoma Genetic aspects Squamous cell carcinoma Genetic aspects Carcinoma, Basal Cell genetics Carcinoma, Basal Cell physiopathology Carcinoma, Squamous Cell genetics Carcinoma, Squamous Cell physiopathology Cytogenetics methods Papillomavirus Infections complications Basaliom (DE-588)4220831-2 gnd rswk-swf Squamöser Krebs (DE-588)4284825-8 gnd rswk-swf Basaliom (DE-588)4220831-2 s Squamöser Krebs (DE-588)4284825-8 s b DE-604 Reichrath, Jörg 1962- Sonstige (DE-588)172479150 oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016161936&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Molecular mechanisms of basal cell and squamous cell carcinomas Skin Cancer Genetic aspects Basal cell carcinoma Genetic aspects Squamous cell carcinoma Genetic aspects Carcinoma, Basal Cell genetics Carcinoma, Basal Cell physiopathology Carcinoma, Squamous Cell genetics Carcinoma, Squamous Cell physiopathology Cytogenetics methods Papillomavirus Infections complications Basaliom (DE-588)4220831-2 gnd Squamöser Krebs (DE-588)4284825-8 gnd |
| subject_GND | (DE-588)4220831-2 (DE-588)4284825-8 |
| title | Molecular mechanisms of basal cell and squamous cell carcinomas |
| title_auth | Molecular mechanisms of basal cell and squamous cell carcinomas |
| title_exact_search | Molecular mechanisms of basal cell and squamous cell carcinomas |
| title_exact_search_txtP | Molecular mechanisms of basal cell and squamous cell carcinomas |
| title_full | Molecular mechanisms of basal cell and squamous cell carcinomas [ed. by] Jörg Reichrath |
| title_fullStr | Molecular mechanisms of basal cell and squamous cell carcinomas [ed. by] Jörg Reichrath |
| title_full_unstemmed | Molecular mechanisms of basal cell and squamous cell carcinomas [ed. by] Jörg Reichrath |
| title_short | Molecular mechanisms of basal cell and squamous cell carcinomas |
| title_sort | molecular mechanisms of basal cell and squamous cell carcinomas |
| topic | Skin Cancer Genetic aspects Basal cell carcinoma Genetic aspects Squamous cell carcinoma Genetic aspects Carcinoma, Basal Cell genetics Carcinoma, Basal Cell physiopathology Carcinoma, Squamous Cell genetics Carcinoma, Squamous Cell physiopathology Cytogenetics methods Papillomavirus Infections complications Basaliom (DE-588)4220831-2 gnd Squamöser Krebs (DE-588)4284825-8 gnd |
| topic_facet | Skin Cancer Genetic aspects Basal cell carcinoma Genetic aspects Squamous cell carcinoma Genetic aspects Carcinoma, Basal Cell genetics Carcinoma, Basal Cell physiopathology Carcinoma, Squamous Cell genetics Carcinoma, Squamous Cell physiopathology Cytogenetics methods Papillomavirus Infections complications Basaliom Squamöser Krebs |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016161936&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT reichrathjorg molecularmechanismsofbasalcellandsquamouscellcarcinomas |