Chlamydia atherosclerosis lesion: discovery, diagnosis and treatment
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| Format: | Book |
| Language: | English |
| Published: |
London
Springer
2007
|
| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Physical Description: | XII, 170 S. zahlr. Ill. |
| ISBN: | 9781846288098 1846288096 |
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| 020 | |a 9781846288098 |c Gb. : ca. EUR 117.70 (freier Pr.) |9 978-1-84628-809-8 | ||
| 020 | |a 1846288096 |c Gb. : ca. EUR 117.70 (freier Pr.) |9 1-84628-809-6 | ||
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| 100 | 1 | |a Shor, Allan |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Chlamydia atherosclerosis lesion |b discovery, diagnosis and treatment |c Allan Shor |
| 264 | 1 | |a London |b Springer |c 2007 | |
| 300 | |a XII, 170 S. |b zahlr. Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Atherosclerosis | |
| 650 | 4 | |a Atherosclerosis |x pathology | |
| 650 | 4 | |a Atherosclerosis |x therapy | |
| 650 | 4 | |a Chlamydia Infections |x pathology | |
| 650 | 4 | |a Chlamydia infections | |
| 650 | 0 | 7 | |a Chlamydienkrankheit |0 (DE-588)4132401-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Arteriosklerose |0 (DE-588)4068866-5 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Arteriosklerose |0 (DE-588)4068866-5 |D s |
| 689 | 0 | 1 | |a Chlamydienkrankheit |0 (DE-588)4132401-8 |D s |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-016161928 | |
Record in the Search Index
| _version_ | 1805089609673080832 |
|---|---|
| adam_text |
Contents
Preface
.
vii
Chapter
1
Introduction
. 1
1.1
Killer Germs That Clog Arteries
. 1
Chapter
2
The Germ's Story
. 3
2.1
A Life of Infection and Destruction
. 3
Chapter
3
The Deadly Disease
. 6
3.1
A Very Common Disease
. 6
3.2
A Little Bit of History
. 8
3.3
Research
. 10
3.4
Cholesterol
. 10
3.5
Other Components
. 11
3.6
Molecular Biology of the Lesion
. 12
3.7
The Age of Statistics
. 12
3.8
Animal Studies
. 13
3.9
Modern View of the Lesion
. 13
Chapter
4
Atheroma Gruel
. 17
4.1
Study of Fatty Gruel That Clogs Arteries
. 17
4.2
Electron Microscope
. 19
4.3
Electron Microscopic Features of Atheroma Gruel
. 20
Chapter
5
Discovery
. 29
5.1
Does Atheroma Gruel Consist of Fat or Germs?
. 29
5.2
Which Germ?
. 30
5.3
A Chlamydia Germ
. 31
Chapter
6
Which Chlamydia Species?
. 35
6.1
Some Unique Features of the Chlamydia Germ in Atheroma
_ 35
6.2
Not Conventional Chlamydia Species
. 36
χ
Contents
6.3
A New Chlamydia Species
. 37
6.4
Other Chlamydia Species
. 41
Chapter
7
Identification of the Atheroma Germ
. 43
7.1
Attempts at Identification of the Germ
. 43
7.2
Positive Identification of Chlamydia TWAR
. 45
7.3
Methods of Identification
. 45
Chapter
8
Publications, Presentations, and Confirmation
. 48
8.1
Publications
. 48
8.2
Presentations
. 49
8.3
Confirmation
. 50
8.4
Possible Special Strain of Chlamydia pneumoniae
. 50
Chapter
9
Chlamydia Are Inherent Components of Atheroma
. 54
9.1
Serology Not Helpful
. 54
9.2
Previous Journal Articles on Atheroma Contain Pictures of
Unrecognized Chlamydia Germs
. 55
9.3
Persons with Congenital Raised Cholesterol Contain
Chlamydia pneumoniae Germs in Atheroma
. 56
9.4
Are There Other Germs in Atheroma?
. 57
Chapter
10
Do Chlamydia Germs Cause Atherosclerosis?
. 60
10.1
Determining Causality
. 60
10.2
Statistical Criteria
. 61
10.3
Koch's Postulates
. 62
10.4
Does Eradication of Germ Prove Causality?
. 62
10.5
No Disease Without Causal Agent
. 63
Chapter
11
Pathological Lesion Diagnosis
. 64
11.1
Lesion Examination
. 64
11.2
Lesion Diagnosis
. 65
11.3
Inability to Diagnose Atheroma Lesion
. 65
Chapter
12
Study of Atheroma Lesions
. 67
12.1
Steps in Atheroma Lesion Formation
. 67
12.2
Aspects Requiring Reexamination
. 68
12.3
Addressing the Problem of Atheroma Lesion Formation
. 68
Chapter
13
New Findings Concerning the
Initial
Lesion
. 71
13.1
Initial Lesion
. 71
13.2
Primary Muscle Damage
. 72
13.3
Chlamydia Cause Muscle Cell Damage
. 80
Contents xi
Chapter
14
Fatty Streak Lesion
. 82
14.1
Macrophage
Infiltration
. 82
14.2
Macrophages Phagocytose Fat,
Germs, and Muscle
. 82
14.3
Macrophage
Reaction Resulting from Germs
and Muscle Damage
. 87
Chapter
15
Formation of Fibronecrotic Plaque
. 89
15.1
Formation of Atheroma Gruel
. 89
15.2
Ceroid or Blighted
Chlamy
dia
Vacuoles?
. 95
15.3
Cholesterol Crystallization
. 98
15.4
Late Sequelae: Fibrosis, Calcification, and Angiogenesis
. 101
Chapter
16
Interpretation of Lesion
. 104
16.1
Another Way to Look at the Lesion
. 104
16.2
Assessment of Evidence
. 109
16.3
What Do We Call the Lesion?
.
Ill
Chapter
17
Confirmatory Molecular Biological Studies
. 112
17.1
Is Lymphocytic Infiltrate Caused by Chlamydia7.
. 112
17.2
Intimai
Smooth Muscle Cell Damage
. 113
17.3
Monocyte and
Macrophage
Infiltrate
. 113
17.4
Endothelial Changes
. 114
17.5
Collagen Formation
. 114
Chapter
18
Derivation of
Lipid
in Lesion
. 117
18.1
Atheroma
Lipid
. 117
18.2
Chlamydia
Lipid
. 119
18.3
Cholesterol: Friend or Foe?
. 121
Chapter
19
Acceptance
. 124
19.1
Old Ideas Do Not Change
. 124
19.2
Rejection of New Ideas
. 125
Chapter
20
Diagnosis of Atheroma Lesions
. 127
20.1
Serology
. 128
20.2
Heat Shock Protein
. 128
20.3
C-Reactive Protein
. 128
20.4
Detection of Chlamydia in White Blood Cells and Blood
. 129
20.5
Other Possible Tests
. 129
20.6
Pathological Diagnosis
. 129
20.7
Chlamydia Inclusion Bodies
. 129
20.8
Electron Microscopy
. 130
20.9
Immunohistochemical Detection
. 130
20.10
Polymerase Chain Reaction
. 130
20.11
Culture
. 130
xii Contents
Chapter
21
Treatment
. 132
21.1
Antibiotic Sensitivity
. 133
21.2
What Happens to the Lesion?
. 134
21.3
Does the Lesion Change in Size?
. 134
21.4
Does the Lesion Change in Character?
. 135
Chapter
22
Pathological Study
. 137
22.1
Eradication of Germ
. 138
22.2
Size of Lesion
. 139
22.3
Stage of Lesion
. 139
22.4
Decrease in Inflammation
. 139
22.5
Fibrosis and Scar Formation
. 139
22.6
Regeneration
. 142
22.7
Does Treatment Increase Healing?
. 142
Chapter
23
Other Studies
. 144
23.1
Animal Studies
. 144
23.2
Retrospective Studies
. 144
23.3
Secondary Prevention Trials
. 145
23.4
Meta-Analysis
. 147
23.5
Relevance of Clinical Trials
. 147
23.6
Unconsidered Aspects
. 147
23.7
Noncardiac Treatment Trials
. 148
Chapter
24
What Do We Know About Treatment of
Atheroma Lesions?
. 151
24.1
Physiology of the Heart
. 151
24.2
What Causes a Heart Attack?
. 152
24.3
Atherosclerosis Is Not the Same as
Ischemie
Heart Disease
_ 153
Chapter
25
Other Treatment Possibilities
. 155
25.1
Statins
. 155
25.2
Aspirin
. 156
25.3
Antihypertensive Agents
. 157
25.4
New Innovative Agents
. 157
25.5
Immunization
. 158
Chapter
26
Conclusion
. 160
Glossary of Terms
. 161
Index
. 163 |
| adam_txt |
Contents
Preface
.
vii
Chapter
1
Introduction
. 1
1.1
Killer Germs That Clog Arteries
. 1
Chapter
2
The Germ's Story
. 3
2.1
A Life of Infection and Destruction
. 3
Chapter
3
The Deadly Disease
. 6
3.1
A Very Common Disease
. 6
3.2
A Little Bit of History
. 8
3.3
Research
. 10
3.4
Cholesterol
. 10
3.5
Other Components
. 11
3.6
Molecular Biology of the Lesion
. 12
3.7
The Age of Statistics
. 12
3.8
Animal Studies
. 13
3.9
Modern View of the Lesion
. 13
Chapter
4
Atheroma Gruel
. 17
4.1
Study of Fatty Gruel That Clogs Arteries
. 17
4.2
Electron Microscope
. 19
4.3
Electron Microscopic Features of Atheroma Gruel
. 20
Chapter
5
Discovery
. 29
5.1
Does Atheroma Gruel Consist of Fat or Germs?
. 29
5.2
Which Germ?
. 30
5.3
A Chlamydia Germ
. 31
Chapter
6
Which Chlamydia Species?
. 35
6.1
Some Unique Features of the Chlamydia Germ in Atheroma
_ 35
6.2
Not Conventional Chlamydia Species
. 36
χ
Contents
6.3
A New Chlamydia Species
. 37
6.4
Other Chlamydia Species
. 41
Chapter
7
Identification of the Atheroma Germ
. 43
7.1
Attempts at Identification of the Germ
. 43
7.2
Positive Identification of Chlamydia TWAR
. 45
7.3
Methods of Identification
. 45
Chapter
8
Publications, Presentations, and Confirmation
. 48
8.1
Publications
. 48
8.2
Presentations
. 49
8.3
Confirmation
. 50
8.4
Possible Special Strain of Chlamydia pneumoniae
. 50
Chapter
9
Chlamydia Are Inherent Components of Atheroma
. 54
9.1
Serology Not Helpful
. 54
9.2
Previous Journal Articles on Atheroma Contain Pictures of
Unrecognized Chlamydia Germs
. 55
9.3
Persons with Congenital Raised Cholesterol Contain
Chlamydia pneumoniae Germs in Atheroma
. 56
9.4
Are There Other Germs in Atheroma?
. 57
Chapter
10
Do Chlamydia Germs Cause Atherosclerosis?
. 60
10.1
Determining Causality
. 60
10.2
Statistical Criteria
. 61
10.3
Koch's Postulates
. 62
10.4
Does Eradication of Germ Prove Causality?
. 62
10.5
No Disease Without Causal Agent
. 63
Chapter
11
Pathological Lesion Diagnosis
. 64
11.1
Lesion Examination
. 64
11.2
Lesion Diagnosis
. 65
11.3
Inability to Diagnose Atheroma Lesion
. 65
Chapter
12
Study of Atheroma Lesions
. 67
12.1
Steps in Atheroma Lesion Formation
. 67
12.2
Aspects Requiring Reexamination
. 68
12.3
Addressing the Problem of Atheroma Lesion Formation
. 68
Chapter
13
New Findings Concerning the
Initial
Lesion
. 71
13.1
Initial Lesion
. 71
13.2
Primary Muscle Damage
. 72
13.3
Chlamydia Cause Muscle Cell Damage
. 80
Contents xi
Chapter
14
Fatty Streak Lesion
. 82
14.1
Macrophage
Infiltration
. 82
14.2
Macrophages Phagocytose Fat,
Germs, and Muscle
. 82
14.3
Macrophage
Reaction Resulting from Germs
and Muscle Damage
. 87
Chapter
15
Formation of Fibronecrotic Plaque
. 89
15.1
Formation of Atheroma Gruel
. 89
15.2
Ceroid or Blighted
Chlamy
dia
Vacuoles?
. 95
15.3
Cholesterol Crystallization
. 98
15.4
Late Sequelae: Fibrosis, Calcification, and Angiogenesis
. 101
Chapter
16
Interpretation of Lesion
. 104
16.1
Another Way to Look at the Lesion
. 104
16.2
Assessment of Evidence
. 109
16.3
What Do We Call the Lesion?
.
Ill
Chapter
17
Confirmatory Molecular Biological Studies
. 112
17.1
Is Lymphocytic Infiltrate Caused by Chlamydia7.
. 112
17.2
Intimai
Smooth Muscle Cell Damage
. 113
17.3
Monocyte and
Macrophage
Infiltrate
. 113
17.4
Endothelial Changes
. 114
17.5
Collagen Formation
. 114
Chapter
18
Derivation of
Lipid
in Lesion
. 117
18.1
Atheroma
Lipid
. 117
18.2
Chlamydia
Lipid
. 119
18.3
Cholesterol: Friend or Foe?
. 121
Chapter
19
Acceptance
. 124
19.1
Old Ideas Do Not Change
. 124
19.2
Rejection of New Ideas
. 125
Chapter
20
Diagnosis of Atheroma Lesions
. 127
20.1
Serology
. 128
20.2
Heat Shock Protein
. 128
20.3
C-Reactive Protein
. 128
20.4
Detection of Chlamydia in White Blood Cells and Blood
. 129
20.5
Other Possible Tests
. 129
20.6
Pathological Diagnosis
. 129
20.7
Chlamydia Inclusion Bodies
. 129
20.8
Electron Microscopy
. 130
20.9
Immunohistochemical Detection
. 130
20.10
Polymerase Chain Reaction
. 130
20.11
Culture
. 130
xii Contents
Chapter
21
Treatment
. 132
21.1
Antibiotic Sensitivity
. 133
21.2
What Happens to the Lesion?
. 134
21.3
Does the Lesion Change in Size?
. 134
21.4
Does the Lesion Change in Character?
. 135
Chapter
22
Pathological Study
. 137
22.1
Eradication of Germ
. 138
22.2
Size of Lesion
. 139
22.3
Stage of Lesion
. 139
22.4
Decrease in Inflammation
. 139
22.5
Fibrosis and Scar Formation
. 139
22.6
Regeneration
. 142
22.7
Does Treatment Increase Healing?
. 142
Chapter
23
Other Studies
. 144
23.1
Animal Studies
. 144
23.2
Retrospective Studies
. 144
23.3
Secondary Prevention Trials
. 145
23.4
Meta-Analysis
. 147
23.5
Relevance of Clinical Trials
. 147
23.6
Unconsidered Aspects
. 147
23.7
Noncardiac Treatment Trials
. 148
Chapter
24
What Do We Know About Treatment of
Atheroma Lesions?
. 151
24.1
Physiology of the Heart
. 151
24.2
What Causes a Heart Attack?
. 152
24.3
Atherosclerosis Is Not the Same as
Ischemie
Heart Disease
_ 153
Chapter
25
Other Treatment Possibilities
. 155
25.1
Statins
. 155
25.2
Aspirin
. 156
25.3
Antihypertensive Agents
. 157
25.4
New Innovative Agents
. 157
25.5
Immunization
. 158
Chapter
26
Conclusion
. 160
Glossary of Terms
. 161
Index
. 163 |
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| id | DE-604.BV022957518 |
| illustrated | Illustrated |
| index_date | 2024-07-02T19:03:24Z |
| indexdate | 2024-07-20T09:26:38Z |
| institution | BVB |
| isbn | 9781846288098 1846288096 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016161928 |
| oclc_num | 86168223 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XII, 170 S. zahlr. Ill. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Springer |
| record_format | marc |
| spelling | Shor, Allan Verfasser aut Chlamydia atherosclerosis lesion discovery, diagnosis and treatment Allan Shor London Springer 2007 XII, 170 S. zahlr. Ill. txt rdacontent n rdamedia nc rdacarrier Atherosclerosis Atherosclerosis pathology Atherosclerosis therapy Chlamydia Infections pathology Chlamydia infections Chlamydienkrankheit (DE-588)4132401-8 gnd rswk-swf Arteriosklerose (DE-588)4068866-5 gnd rswk-swf Arteriosklerose (DE-588)4068866-5 s Chlamydienkrankheit (DE-588)4132401-8 s b DE-604 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2896034&prov=M&dok_var=1&dok_ext=htm Inhaltstext Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016161928&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Shor, Allan Chlamydia atherosclerosis lesion discovery, diagnosis and treatment Atherosclerosis Atherosclerosis pathology Atherosclerosis therapy Chlamydia Infections pathology Chlamydia infections Chlamydienkrankheit (DE-588)4132401-8 gnd Arteriosklerose (DE-588)4068866-5 gnd |
| subject_GND | (DE-588)4132401-8 (DE-588)4068866-5 |
| title | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment |
| title_auth | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment |
| title_exact_search | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment |
| title_exact_search_txtP | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment |
| title_full | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment Allan Shor |
| title_fullStr | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment Allan Shor |
| title_full_unstemmed | Chlamydia atherosclerosis lesion discovery, diagnosis and treatment Allan Shor |
| title_short | Chlamydia atherosclerosis lesion |
| title_sort | chlamydia atherosclerosis lesion discovery diagnosis and treatment |
| title_sub | discovery, diagnosis and treatment |
| topic | Atherosclerosis Atherosclerosis pathology Atherosclerosis therapy Chlamydia Infections pathology Chlamydia infections Chlamydienkrankheit (DE-588)4132401-8 gnd Arteriosklerose (DE-588)4068866-5 gnd |
| topic_facet | Atherosclerosis Atherosclerosis pathology Atherosclerosis therapy Chlamydia Infections pathology Chlamydia infections Chlamydienkrankheit Arteriosklerose |
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