Bisphosphonates in medical practice: actions, side effects, indications, strategies
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Berlin ; Heidelberg ; New York
Springer
2007
|
| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis |
| Physical Description: | 1 Online-Ressource (xx, 265 Seiten) Illustrationen, Diagramme |
| ISBN: | 9783540698708 |
| DOI: | 10.1007/978-3-540-69870-8 |
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Record in the Search Index
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| adam_text | Chapter 1
The Skeleton
Functions of the Skeleton 1
Structure of the Skeleton 2
Modelling and Remodelling 3
Bone Cells 6
Steps (or Phases) of Bone Remodelling 10
Regulation of Bone Remodelling 12
The RANK/RANKL/Osteoprotegerin System 18
Age and Bone Mass 20
Chapter 2
Disorders of Bone
Manifestations of Abnormalities in Remodelling 23
Osteoclasts:The Leading Actors in Disorders of Bone 23
Classification of Osteopathies According to Spread (Topography) 25
Classification According to Underlying Pathologic Anatomy
of the Bones Involved 26
Diagnostic Investigation 28
Chapter 3
Bisphosphonates
Historical Review 33
Chemistry 34
Pharmacodynamics 35
Actions of Bisphosphonates 46
Structure Related Actions 58
Side Effects 61
Practical Recommendations and Guidelines 68
XII Contents
Chapter 4
Osteoporotic Syndrome
Definition 71
Classification According to Extent of Spread 72
Classification According to Rate of Bone Turnover 72
Classification According to Age and Sex 72
Secondary Osteoporoses 73
Diagnosis 76
Therapeutic Strategies 82
Bisphosphonates 86
Intravenous Therapy of Osteoporosis 89
Practical Recommendations 95
Chapter 5
Glucocorticoid Induced Osteoporosis
Definition 99
Diseases Treated with Glucocorticoids 99
Pathophysiology 100
Prevention 101
Treatment Strategies 101
Bisphosphonates 102
Chapter 6
Tumor and Chemotherapy Induced Osteoporosis
Definition 103
Pathophysiology 103
Types of TumorTherapy with Direct Effects on Bone 104
Treatment Strategies 107
Bisphosphonates 107
Chapter 7
Transplantation Osteoporosis
Definition 109
Pathogenesis 109
Treatment Strategies 110
Bisphosphonates 110
Contents XIII
Chapter 8
Immobilisation Osteoporosis
Examples of Bone Loss Ill
Therapy of Immobilisation Osteoporosis 112
Chapter 9
Pregnancy Associated Osteoporosis
Pathogenesis 115
Prevention and Therapy 115
Chapter 10
Osteogenesis Imperfecta (Ol)
Definition 117
Pathophysiology 117
Diagnosis 118
Treatment Strategies 118
Bisphosphonates 119
Osteopenia of Prematurity 120
Chapter 11
AIDS Osteopathy
Clinical Settings of Disorders of Bone in AIDS 123
Manifestations of AIDS Osteopathy 123
Diagnosis 124
Treatment Strategies 125
Chapter 12
Renal Osteopathy
Definition 127
Pathophysiology 127
Diagnosis 128
Treatment Strategies 129
Bisphosphonates 130
XIV Contents
Chapter 13
Paget s Disease of Bone
Definition 131
Clinical Findings 131
Diagnosis 132
Treatment Strategies 135
Bisphosphonates 136
Chapter 14
Complex Regional Pain Syndrome (CRPS)
Definition 139
Clinical Findings 139
Diagnosis 139
Course of Disease 140
Treatment Strategies 141
Bisphosphonates 141
Chapter 15
Transient Osteoporosis
and the Bone Marrow Edema Syndrome (BMES)
Transient Osteoporosis 143
Diagnosis 143
Treatment Strategies 144
Bisphosphonates 145
Bone Marrow Edema Syndrome (BMES) 145
Diagnosis 146
Treatment Strategies 147
Bisphosphonates 147
Chapter 16
Vanishing Bone Disease
(Gorham Stout Syndrome)
Definition 151
Etiology and Pathophysiology 151
Clinical Findings 151
Diagnosis 153
Treatment Strategies 153
Bisphosphonates 153
Contents XV
Chapter 17
Fibrous Dysplasia
Definition 155
Clinical Findings 156
Treatment Strategies 156
Bisphosphonates 157
Chapter 18
SAPHO Syndrome
Definition 159
Diagnosis 159
Therapy 160
Chapter 19
Heterotopic Calcification and Ossification
Definition 163
Sites and Conditions of Occurrence 163
Treatment Strategies 163
Bisphosphonates 164
Chapter 20
Periprosthetic Osteolysis and Aseptic Loosening
of Prostheses in Total Joint Arthroplasty
Pathogenesis 165
Diagnosis 167
Treatment Strategies 168
Bisphosphonates 169
Chapter 21
Alveolar Bone Loss due to Periodontitis
Definition 173
Pathogenesis 173
Clinical Findings 173
Treatment Strategies 173
Bisphosphonates 174
Necrosis of the Jaw Bones and Non traumatic Avascular Necrosis
of the Femoral Head 175
XVI Contents
Chapter 22
Hypercalcemia
Definition 177
Frequency 177
Differential Diagnosis 178
Symptoms 179
Treatment Strategies 179
Bisphosphonates 179
Hypercalcemia of Malignancy 180
Chapter 23
Bone Pain
Frequency 183
Differential Diagnosis 183
Pathogenesis 184
Diagnosis 185
Treatment Strategies 186
Bisphosphonates 186
Chapter 24
Multiple Myeloma
Definition 189
Frequency 189
Pathogenesis 189
Clinical Findings 190
Diagnosis of Skeletal Manifestations 192
Myeloma Variants 193
Treatment Strategies 194
Bisphosphonates 195
Chapter 25
Bone Metastases
Introduction 199
Frequency 199
Regional Distribution within the Skeleton 201
Development of Skeletal Metastases 201
Osseous Reactions 203
Bisphosphonates 205
Contents XVII
Chapter 26
Skeletal Metastases of Breast Cancer
Frequency 209
Circulating Tumor Cells 209
Complications 209
Treatment Strategies 210
Bisphosphonates for Prevention of Metastasis 210
Bisphosphonatesfor Prevention of Skeletal Complications 212
Bisphosphonates for Treatment of Skeletal Complications 212
Chapter 27
Other Carcinomas with Osteotropic Metastases
Prostatic Carcinoma 215
Bronchial Carcinoma, Lung Cancer 217
Renal Cell Carcinoma 217
Other Malignancies with Implications for Skeletal Involvement 218
Chapter 28
Bisphosphonates from A Z
List of Indications 221
List of Subgroups of Bisphosphonates 226
List According to Different Modes of Action 227
List of Commercial Bisphosphonate Preparations from A to Z 227
List of Authorised Bisphosphonates from A to Z 228
Chapter 29
Summary and Perspectives 229
Chapter 30
Literature Survey 235
Subject Index 259
|
| adam_txt |
Chapter 1
The Skeleton
Functions of the Skeleton 1
Structure of the Skeleton 2
Modelling and Remodelling 3
Bone Cells 6
Steps (or Phases) of Bone Remodelling 10
Regulation of Bone Remodelling 12
The RANK/RANKL/Osteoprotegerin System 18
Age and Bone Mass 20
Chapter 2
Disorders of Bone
Manifestations of Abnormalities in Remodelling 23
Osteoclasts:The Leading Actors in Disorders of Bone 23
Classification of Osteopathies According to Spread (Topography) 25
Classification According to Underlying Pathologic Anatomy
of the Bones Involved 26
Diagnostic Investigation 28
Chapter 3
Bisphosphonates
Historical Review 33
Chemistry 34
Pharmacodynamics 35
Actions of Bisphosphonates 46
Structure Related Actions 58
Side Effects 61
Practical Recommendations and Guidelines 68
XII Contents
Chapter 4
Osteoporotic Syndrome
Definition 71
Classification According to Extent of Spread 72
Classification According to Rate of Bone Turnover 72
Classification According to Age and Sex 72
Secondary Osteoporoses 73
Diagnosis 76
Therapeutic Strategies 82
Bisphosphonates 86
Intravenous Therapy of Osteoporosis 89
Practical Recommendations 95
Chapter 5
Glucocorticoid Induced Osteoporosis
Definition 99
Diseases Treated with Glucocorticoids 99
Pathophysiology 100
Prevention 101
Treatment Strategies 101
Bisphosphonates 102
Chapter 6
Tumor and Chemotherapy Induced Osteoporosis
Definition 103
Pathophysiology 103
Types of TumorTherapy with Direct Effects on Bone 104
Treatment Strategies 107
Bisphosphonates 107
Chapter 7
Transplantation Osteoporosis
Definition 109
Pathogenesis 109
Treatment Strategies 110
Bisphosphonates 110
Contents XIII
Chapter 8
Immobilisation Osteoporosis
Examples of Bone Loss Ill
Therapy of Immobilisation Osteoporosis 112
Chapter 9
Pregnancy Associated Osteoporosis
Pathogenesis 115
Prevention and Therapy 115
Chapter 10
Osteogenesis Imperfecta (Ol)
Definition 117
Pathophysiology 117
Diagnosis 118
Treatment Strategies 118
Bisphosphonates 119
Osteopenia of Prematurity 120
Chapter 11
AIDS Osteopathy
Clinical Settings of Disorders of Bone in AIDS 123
Manifestations of AIDS Osteopathy 123
Diagnosis 124
Treatment Strategies 125
Chapter 12
Renal Osteopathy
Definition 127
Pathophysiology 127
Diagnosis 128
Treatment Strategies 129
Bisphosphonates 130
XIV Contents
Chapter 13
Paget's Disease of Bone
Definition 131
Clinical Findings 131
Diagnosis 132
Treatment Strategies 135
Bisphosphonates 136
Chapter 14
Complex Regional Pain Syndrome (CRPS)
Definition 139
Clinical Findings 139
Diagnosis 139
Course of Disease 140
Treatment Strategies 141
Bisphosphonates 141
Chapter 15
Transient Osteoporosis
and the Bone Marrow Edema Syndrome (BMES)
Transient Osteoporosis 143
Diagnosis 143
Treatment Strategies 144
Bisphosphonates 145
Bone Marrow Edema Syndrome (BMES) 145
Diagnosis 146
Treatment Strategies 147
Bisphosphonates 147
Chapter 16
Vanishing Bone Disease
(Gorham Stout Syndrome)
Definition 151
Etiology and Pathophysiology 151
Clinical Findings 151
Diagnosis 153
Treatment Strategies 153
Bisphosphonates 153
Contents XV
Chapter 17
Fibrous Dysplasia
Definition 155
Clinical Findings 156
Treatment Strategies 156
Bisphosphonates 157
Chapter 18
SAPHO Syndrome
Definition 159
Diagnosis 159
Therapy 160
Chapter 19
Heterotopic Calcification and Ossification
Definition 163
Sites and Conditions of Occurrence 163
Treatment Strategies 163
Bisphosphonates 164
Chapter 20
Periprosthetic Osteolysis and Aseptic Loosening
of Prostheses in Total Joint Arthroplasty
Pathogenesis 165
Diagnosis 167
Treatment Strategies 168
Bisphosphonates 169
Chapter 21
Alveolar Bone Loss due to Periodontitis
Definition 173
Pathogenesis 173
Clinical Findings 173
Treatment Strategies 173
Bisphosphonates 174
Necrosis of the Jaw Bones and Non traumatic Avascular Necrosis
of the Femoral Head 175
XVI Contents
Chapter 22
Hypercalcemia
Definition 177
Frequency 177
Differential Diagnosis 178
Symptoms 179
Treatment Strategies 179
Bisphosphonates 179
Hypercalcemia of Malignancy 180
Chapter 23
Bone Pain
Frequency 183
Differential Diagnosis 183
Pathogenesis 184
Diagnosis 185
Treatment Strategies 186
Bisphosphonates 186
Chapter 24
Multiple Myeloma
Definition 189
Frequency 189
Pathogenesis 189
Clinical Findings 190
Diagnosis of Skeletal Manifestations 192
Myeloma Variants 193
Treatment Strategies 194
Bisphosphonates 195
Chapter 25
Bone Metastases
Introduction 199
Frequency 199
Regional Distribution within the Skeleton 201
Development of Skeletal Metastases 201
Osseous Reactions 203
Bisphosphonates 205
Contents XVII
Chapter 26
Skeletal Metastases of Breast Cancer
Frequency 209
Circulating Tumor Cells 209
Complications 209
Treatment Strategies 210
Bisphosphonates for Prevention of Metastasis 210
Bisphosphonatesfor Prevention of Skeletal Complications 212
Bisphosphonates for Treatment of Skeletal Complications 212
Chapter 27
Other Carcinomas with Osteotropic Metastases
Prostatic Carcinoma 215
Bronchial Carcinoma, Lung Cancer 217
Renal Cell Carcinoma 217
Other Malignancies with Implications for Skeletal Involvement 218
Chapter 28
Bisphosphonates from A Z
List of Indications 221
List of Subgroups of Bisphosphonates 226
List According to Different Modes of Action 227
List of Commercial Bisphosphonate Preparations from A to Z 227
List of Authorised Bisphosphonates from A to Z 228
Chapter 29
Summary and Perspectives 229
Chapter 30
Literature Survey 235
Subject Index 259 |
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| author | Bartl, Reiner 1944- Frisch, Bertha Tresckow, Emmo von 1944- Bartl, Christoph 1972- |
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| author_facet | Bartl, Reiner 1944- Frisch, Bertha Tresckow, Emmo von 1944- Bartl, Christoph 1972- |
| author_role | aut aut aut aut |
| author_sort | Bartl, Reiner 1944- |
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| ctrlnum | (OCoLC)699660812 (DE-599)DNB982646801 |
| dewey-full | 616.71061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.71061 |
| dewey-search | 616.71061 |
| dewey-sort | 3616.71061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| doi_str_mv | 10.1007/978-3-540-69870-8 |
| format | Electronic eBook |
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| id | DE-604.BV022955334 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T19:03:02Z |
| indexdate | 2025-02-20T07:03:26Z |
| institution | BVB |
| isbn | 9783540698708 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016159761 |
| oclc_num | 699660812 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-20 DE-706 DE-1046 DE-1047 DE-1102 DE-858 DE-1028 DE-573 DE-859 DE-860 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-2070s DE-521 DE-522 DE-526 DE-11 DE-83 DE-70 DE-634 |
| owner_facet | DE-355 DE-BY-UBR DE-188 DE-12 DE-384 DE-473 DE-BY-UBG DE-703 DE-29 DE-19 DE-BY-UBM DE-91 DE-BY-TUM DE-739 DE-20 DE-706 DE-1046 DE-1047 DE-1102 DE-858 DE-1028 DE-573 DE-859 DE-860 DE-M347 DE-1049 DE-92 DE-898 DE-BY-UBR DE-863 DE-BY-FWS DE-862 DE-BY-FWS DE-128 DE-54 DE-22 DE-BY-UBG DE-150 DE-155 DE-BY-UBR DE-2070s DE-521 DE-522 DE-526 DE-11 DE-83 DE-70 DE-634 |
| physical | 1 Online-Ressource (xx, 265 Seiten) Illustrationen, Diagramme |
| psigel | ZDB-2-SME ZDB-1-SMI |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Springer |
| record_format | marc |
| spellingShingle | Bartl, Reiner 1944- Frisch, Bertha Tresckow, Emmo von 1944- Bartl, Christoph 1972- Bisphosphonates in medical practice actions, side effects, indications, strategies Diphosphonate (DE-588)4150083-0 gnd Knochenkrankheit (DE-588)4120576-5 gnd |
| subject_GND | (DE-588)4150083-0 (DE-588)4120576-5 |
| title | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_auth | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_exact_search | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_exact_search_txtP | Bisphosphonates in medical practice actions, side effects, indications, strategies |
| title_full | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl, Bertha Frisch, Emmo von Tresckow, Christoph Bartl |
| title_fullStr | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl, Bertha Frisch, Emmo von Tresckow, Christoph Bartl |
| title_full_unstemmed | Bisphosphonates in medical practice actions, side effects, indications, strategies Reiner Bartl, Bertha Frisch, Emmo von Tresckow, Christoph Bartl |
| title_short | Bisphosphonates in medical practice |
| title_sort | bisphosphonates in medical practice actions side effects indications strategies |
| title_sub | actions, side effects, indications, strategies |
| topic | Diphosphonate (DE-588)4150083-0 gnd Knochenkrankheit (DE-588)4120576-5 gnd |
| topic_facet | Diphosphonate Knochenkrankheit |
| url | https://doi.org/10.1007/978-3-540-69870-8 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016159761&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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