Biology in space and life on earth: effects of spaceflight on biological systems
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| Language: | English |
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Weinheim
Wiley-VCH
2007
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| Subjects: | |
| Online Access: | Inhaltstext Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XVII, 277 S. Ill., graph. Darst. 25 cm |
| ISBN: | 9783527406685 |
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MARC
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| 245 | 1 | 0 | |a Biology in space and life on earth |b effects of spaceflight on biological systems |c ed. by Enno Brinckmann |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2007 | |
| 300 | |a XVII, 277 S. |b Ill., graph. Darst. |c 25 cm | ||
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| 500 | |a Literaturangaben | ||
| 650 | 4 | |a Cosmic Radiation |x adverse effects | |
| 650 | 4 | |a Extraterrestrial Environment | |
| 650 | 4 | |a Space Flight | |
| 650 | 4 | |a Space biology | |
| 650 | 4 | |a Space medicine | |
| 650 | 4 | |a Weightlessness |x adverse effects | |
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Contents
Foreword XI
Preface XIII
List of Contributors XV
Introduction 1
Enno Brinckmann
(with contributions from Rent Demets and Wolfgang Herfs)
1 Flight Mission Scenarios 1
2 Sounding Rocket Experiments 4
3 Biobox on Foton and in the Space Shuttle 6
3.1 Biobox 1 7
3.2 Biobox 2 8
3.3 Biobox 3 8
3.4 Biobox 4 9
4 Biorack in Spacelab and Spacehab 9
1 The Gravity Environment in Space Experiments 17
JackJ. W. A. van Loon
1.1 Introduction to Gravity Research 17
1.1.1 Principle of Equivalence 18
1.1.2 Microgravity 19
1.1.3 Artificial Gravity 21
1.2 Gravity Phenomena on Small Objects 24
1.2.1 Sedimentation 24
1.2.2 Hydrostatic Pressure 25
1.2.3 Diffusion 26
1.2.4 Convection 27
1.2.5 Diffusion/Convection 27
1.2.6 Buoyancy 28
1.2.7 Coriolis Acceleration 30
Biology in Space and Life on Earth. Effects ofSpacefiight on Biological Systems. Edited by Enno Brinckmann
Copyright © 2007 W1LEY VCH Verlag GmbH Co. KGaA, Weinheim
ISBN: 978 3 527 40668 5
VI I Contents
2 Primary Responses of Gravity Sensing in Plants 33
Markus Braun
2.1 Introduction and Historical Background 33
2.2 Evolution of Gravity Sensing Mechanisms under the Earth's Gravity
Conditions 35
2.3 Specific Location and Unique Features of Gravity Sensing Cells 36
2.4 Correlation between Statolith Sedimentation and Gravitropic
Responses 37
2.5 Is the Actin Cytoskeleton Involved in Gravity Sensing? 39
2.6 Gravireceptors 41
2.7 Second Messengers in Gravisignalling 44
2.8 Modifying Gravitational Acceleration Forces Versatile Tools for
Studying Plant Gravity Sensing Mechanisms 45
2.9 Conclusions and Perspectives 48
3 Physiological Responses of Higher Plants 53
Dieter Volkmann and Frantisek Baluika
3.1 Introduction: Historical Overview 53
3.2 Terminological Aspects 54
3.3 Microgravity as a Tool 55
3.3.1 Equipment 55
3.3.2 Testable Hypotheses 55
3.3.2.1 Gravisensitivity 56
3.3.2.2 Stimulus Transformation: Role of the Actomyosin System 56
3.3.2.3 Extracellular Matrix as Anti gravitational Material 57
3.3.2.4 Existence of Gravity (Microgravity) Related Genes 58
3.3.2.5 Autonomous versus Directed Movements 58
3.4 Microgravity as Stress Factor 59
3.4.1 Cellular Level 59
3.4.2 Developmental Aspects 60
3.5 Gravity related Paradoxes 61
3.6 Gravity and Evolution 63
3.7 Conclusion and Perspectives 65
4 Development and Gravitropism of Lentil Seedling Roots Crown in
Microgravity 71
Ge'rald Perbal and Dominique Driss Ecole
4.1 Introduction 71
4.1.1 Development of Lentil Seedlings on the Ground 72
4.1.1.1 Functional Zones of the Primary Root 72
4.1.1.2 Role of the Root Cap 72
4.1.1.3 Meristematic Activity 73
4.1.1.4 Cell Elongation 74
4.1.2 Root Gravitropism on Earth 75
4.1.2.1 Perception of Gravity 75
Contents I VII
4.1.2.2 The Root Statocyte 77
4.1.2.3 Gravisensitivity: The Presentation Time 78
4.1.2.4 Gravitropic Reaction SO
4.2 Basic Hardware Used to Perform Space Experiments 82
4.2.1 Plant Growth Chambers: The Minicontainers 82
4.2.1.1 Seed Set up 83
4.2.1.2 Hydration of the Seeds 84
4.2.2 The Glutaraldehyde Fixer 84
4.3 Development in Space 85
4.3.1 Root Orientation in Microgravity 85
4.3.2 Root Growth 88
4.3.3 Cell Elongation 89
4.3.4 Meristematic Activity 89
4.3.4.1 Mitotic Activity 89
4.3.4.2 Cell Cycle 92
4.4 Root Gravitropism in Space 93
4.4.1 Organelle Distribution within the Statocyte 93
4.4.1.1 Statocyte Polarity 93
4.4.1.2 Positioning of the Nucleus and of the Endoplasmic Reticulum 94
4.4.1.3 Amyloplasts Positioning 96
4.4.2 Gravisensitivity 99
4.4.2.1 Presentation Time 99
4.4.2.2 Models for Dose Response Curves 104
4.4.2.3 Difference in Gravisensitivity 105
4.4.2.4 Cause of the Difference in Gravisensitivity 107
4.4.2.5 Model of Gravisensing 108
4.4.3 Gravitropic Response 111
4.4.3.1 Absence of Counter reaction 111
4.4.3.2 Comparison with the Effect of Cytochalasin Treatments 112
4.5 Conclusion 113
4.5.1 Action of Microgravity on Root Growth 113
4.5.2 Gravisensing Cells and Perception of Gravity by Roots 115
4.5.2.1 Statocyte Polarity and Movement of Organelles 115
4.5.2.2 Gravisensing 116
5 Biology of Adherent Cells in Microgravity 123
Charles A. Lambert, Charles M. Lapiere, and Betty V. Nusgens
5.1 Why Cell Biology Research in Microgravity? 123
5.2 Medical Disturbances in Astronauts 124
5.2.1 Similarity to Diseases on Earth 324
5.2.2 Cell Types Potentially Involved 125
5.3 Mechano receptivity and reactivity of Adherent Cells in
Culture 126
5.3.1 Mechano transducrion at the Cell Matrix Contacts 127
5.3.2 Mechano transduction at the Cell Cell Contacts 129
VIII I Contents
5.3.3 The Cytoskeleton Network and its Control by the Small
RhoGTPases 129
5.3.4 Cells React to Mechanical Stress and Relaxation 132
5.4 Microgravity, the Loss of a Force, Leading to Cellular
Disturbances 133
5.4.1 Biological View of the Biophysical Concepts 133
5.4.2 Short Time Microgravity and Space Flights 134
5.4.3 Modelled Altered Gravity 140
5.4.3.1 Averaging the g Vector 140
5.4.3.2 Free fall Simulation 145
5.4.3.3 Diamagnetic Levitation 146
5.4.3.4 Hypergravity 146
5.5 From Ground Research to Investigations in Microgravity 146
5.5.1 Testable Hypotheses 147
5.5.2 Experimental Strategy and Constraints 147
5.5.3 The Future 148
6 Microgravity and Bone Cell Mechanosensitivity 157
Rommel C. Bacabac, JackJ. W. A. van Loon, andjenneke Klein Nulend
6.1 Overview 157
6.2 Introduction 157
6.3 Mechanotransduction in Bone 162
6.4 Signal Transduction in Mechanosensing 162
6.5 Single Cell Response to Mechanical Loading 163
6.6 Rate dependent Response by Bone Cells 164
6.7 Implications of Threshold Activation: Enhanced Response to Stochastic
Stress 167
6.8 Stress Response and Cellular Deformation 168
6.9 Towards a Quantitative Description of Bone Cell
Mechanosensitivity 169
6.10 Implications for the Extreme Condition of Unloading
Microgravity 172
7 Bone Cell Biology in Microgravity 179
Geert Carmeliet, Lieve Coenegrachts, and Roger Bouillon
7.1 Overview 179
7.2 Introduction 179
7.3 Bone Remodelling: An Equilibrium between Osteoblasts and
Osteoclasts 180
7.4 Human Studies: Response of Bone to Space Flight 181
7.5 Space Flight and Unloading in the Rat Mimics Human Bone
Loss 182
7.6 Mechanisms of Decreased Bone Formation Induced by Unloading or
Space Flight 182
Contents I IX
7.7 Are Osteoblastic Cells In Vitro Responding to Altered Gravity
Conditions? 184
7.7.1 Proliferation and Apoptosis 184
7.7.2 Differentiation: Matrix Production 185
7.7.3 Differentiation: Growth Factors 186
7.8 Potential Mechanisms of Altered Osteoblastic Behaviour 186
7.9 Conclusion 188
8 Cells of the Immune System in Space (Lymphocytes) 193
Augusto Cogoli and Marianne Cogoli Greuter
8.1 Introduction 193
8.2 Activation of T Cells 195
8.3 Earliest Data 196
8.4 Spacelab 1, 1983 197
8.5 Spacelab D l, 1985 197
8.6 Stratospheric Balloon, 1986 200
8.7 Sounding Rockets Maser 3, 1989, and Maser 4, 1990 200
8.8 Spacelab Life Sciences SLS 1, 1991 203
8.9 Russian MIR Station, Missions 7, 8, 9, 1988 1990 203
8.10 Spacelab IML 1, 1992 204
8.11 Sounding Rockets Maxus IB, 1992, and Maxus 2, 1995 205
8.12 Spacelab IML 2, 1994 209
8.13 Sounding Rocket Maser 9, 2002 211
8.14 Shuttle Flight STS 107, Biopack, 2003 212
8.15 Ground Simulations 212
8.15.1 Marathon Run and Head down Tilt Test 213
8.15.2 Clinostats 214
8.16 Conclusion 219
9 Evaluation of Environmental Radiation Effects at the Single Cell
Level in Space and on Earth 223
Patrick Van Oostveldt, Ceert Meesen, Philippe Baert, and kndri Poffjn
9.1 Introduction 223
9.2 The Space Radiation Environment 224
9.3 HZE Track Detection 225
9.3.1 Confocal Scanning Laser Microscopy for Track Analysis in PADC 226
9.3.2 Time resolved Track Detection 227
9.4 Results of the RAMIROS Experiment on board of the Soyuz Taxi Flight
to the ISS 229
9.4.1 Methods 229
9.4.2 Results and Discussion 230
9.4.2.1 Retrieval of Cell Cultures 230
9.4.2.2 Number of HZE Tracks 230
9.4.2.3 Correlation between HZE Hit and DNA Damage at Single Cell
Level 231
X Contents
9.4.2.4 Space versus Ground Samples 234
9.4.2.5 HZE Hits Before and After Fixation 235
9.4.2.6 Conclusions 235
9.5 Combination of Radiation with other Biological Stress in Space
Travel 236
9.6 Interactions between Radiation and Gravity 237
9.7 General Conclusions and Perspectives 239
10 Space Radiation Biology 243
Gerda Horneck
10.1 Radiation Scenario in Space 243
10.1.1 Cosmic Ionizing Radiation 244
10.1.2 Solar Electromagnetic Radiation 247
10.2 Questions Tackled in Space Radiation Biology 248
10.3 Results of Radiobiological Experiments in Space 250
10.3.1 Life and Cosmic Radiation 250
10.3.1.1 Radiation Dosimetry 250
10.3.1.2 Biological Effects of Cosmic Radiation 254
10.3.1.3 Interaction of Radiation with other Space Flight Factors 259
10.3.1.4 Radiation Protection Guidelines for Astronauts in LEO 262
10.3.2 Life and Solar Electromagnetic Radiation 263
10.3.2.1 Biological effects of Extraterrestrial Solar UV Radiation 264
10.3.2.2 Role of Solar UV Radiation in Evolutionary Processes Related to
Life 266
10.4 Outlook: Radiation Biology and Future Exploratory Missions in the
Solar System 268
10.4.1 Habitability of Mars 268
10.4.2 Radiation Protection Guidelines for Astronauts during Exploratory
Missions 269
Index 275 |
| adam_txt |
r
Contents
Foreword XI
Preface XIII
List of Contributors XV
Introduction 1
Enno Brinckmann
(with contributions from Rent Demets and Wolfgang Herfs)
1 Flight Mission Scenarios 1
2 Sounding Rocket Experiments 4
3 Biobox on Foton and in the Space Shuttle 6
3.1 Biobox 1 7
3.2 Biobox 2 8
3.3 Biobox 3 8
3.4 Biobox 4 9
4 Biorack in Spacelab and Spacehab 9
1 The Gravity Environment in Space Experiments 17
JackJ. W. A. van Loon
1.1 Introduction to Gravity Research 17
1.1.1 Principle of Equivalence 18
1.1.2 Microgravity 19
1.1.3 Artificial Gravity 21
1.2 Gravity Phenomena on Small Objects 24
1.2.1 Sedimentation 24
1.2.2 Hydrostatic Pressure 25
1.2.3 Diffusion 26
1.2.4 Convection 27
1.2.5 Diffusion/Convection 27
1.2.6 Buoyancy 28
1.2.7 Coriolis Acceleration 30
Biology in Space and Life on Earth. Effects ofSpacefiight on Biological Systems. Edited by Enno Brinckmann
Copyright © 2007 W1LEY VCH Verlag GmbH Co. KGaA, Weinheim
ISBN: 978 3 527 40668 5
VI I Contents
2 Primary Responses of Gravity Sensing in Plants 33
Markus Braun
2.1 Introduction and Historical Background 33
2.2 Evolution of Gravity Sensing Mechanisms under the Earth's Gravity
Conditions 35
2.3 Specific Location and Unique Features of Gravity Sensing Cells 36
2.4 Correlation between Statolith Sedimentation and Gravitropic
Responses 37
2.5 Is the Actin Cytoskeleton Involved in Gravity Sensing? 39
2.6 Gravireceptors 41
2.7 Second Messengers in Gravisignalling 44
2.8 Modifying Gravitational Acceleration Forces Versatile Tools for
Studying Plant Gravity Sensing Mechanisms 45
2.9 Conclusions and Perspectives 48
3 Physiological Responses of Higher Plants 53
Dieter Volkmann and Frantisek Baluika
3.1 Introduction: Historical Overview 53
3.2 Terminological Aspects 54
3.3 Microgravity as a Tool 55
3.3.1 Equipment 55
3.3.2 Testable Hypotheses 55
3.3.2.1 Gravisensitivity 56
3.3.2.2 Stimulus Transformation: Role of the Actomyosin System 56
3.3.2.3 Extracellular Matrix as Anti gravitational Material 57
3.3.2.4 Existence of Gravity (Microgravity) Related Genes 58
3.3.2.5 Autonomous versus Directed Movements 58
3.4 Microgravity as Stress Factor 59
3.4.1 Cellular Level 59
3.4.2 Developmental Aspects 60
3.5 Gravity related Paradoxes 61
3.6 Gravity and Evolution 63
3.7 Conclusion and Perspectives 65
4 Development and Gravitropism of Lentil Seedling Roots Crown in
Microgravity 71
Ge'rald Perbal and Dominique Driss Ecole
4.1 Introduction 71
4.1.1 Development of Lentil Seedlings on the Ground 72
4.1.1.1 Functional Zones of the Primary Root 72
4.1.1.2 Role of the Root Cap 72
4.1.1.3 Meristematic Activity 73
4.1.1.4 Cell Elongation 74
4.1.2 Root Gravitropism on Earth 75
4.1.2.1 Perception of Gravity 75
Contents I VII
4.1.2.2 The Root Statocyte 77
4.1.2.3 Gravisensitivity: The Presentation Time 78
4.1.2.4 Gravitropic Reaction SO
4.2 Basic Hardware Used to Perform Space Experiments 82
4.2.1 Plant Growth Chambers: The Minicontainers 82
4.2.1.1 Seed Set up 83
4.2.1.2 Hydration of the Seeds 84
4.2.2 The Glutaraldehyde Fixer 84
4.3 Development in Space 85
4.3.1 Root Orientation in Microgravity 85
4.3.2 Root Growth 88
4.3.3 Cell Elongation 89
4.3.4 Meristematic Activity 89
4.3.4.1 Mitotic Activity 89
4.3.4.2 Cell Cycle 92
4.4 Root Gravitropism in Space 93
4.4.1 Organelle Distribution within the Statocyte 93
4.4.1.1 Statocyte Polarity 93
4.4.1.2 Positioning of the Nucleus and of the Endoplasmic Reticulum 94
4.4.1.3 Amyloplasts Positioning 96
4.4.2 Gravisensitivity 99
4.4.2.1 Presentation Time 99
4.4.2.2 Models for Dose Response Curves 104
4.4.2.3 Difference in Gravisensitivity 105
4.4.2.4 Cause of the Difference in Gravisensitivity 107
4.4.2.5 Model of Gravisensing 108
4.4.3 Gravitropic Response 111
4.4.3.1 Absence of Counter reaction 111
4.4.3.2 Comparison with the Effect of Cytochalasin Treatments 112
4.5 Conclusion 113
4.5.1 Action of Microgravity on Root Growth 113
4.5.2 Gravisensing Cells and Perception of Gravity by Roots 115
4.5.2.1 Statocyte Polarity and Movement of Organelles 115
4.5.2.2 Gravisensing 116
5 Biology of Adherent Cells in Microgravity 123
Charles A. Lambert, Charles M. Lapiere, and Betty V. Nusgens
5.1 Why Cell Biology Research in Microgravity? 123
5.2 Medical Disturbances in Astronauts 124
5.2.1 Similarity to Diseases on Earth 324
5.2.2 Cell Types Potentially Involved 125
5.3 Mechano receptivity and reactivity of Adherent Cells in
Culture 126
5.3.1 Mechano transducrion at the Cell Matrix Contacts 127
5.3.2 Mechano transduction at the Cell Cell Contacts 129
VIII I Contents
5.3.3 The Cytoskeleton Network and its Control by the Small
RhoGTPases 129
5.3.4 Cells React to Mechanical Stress and Relaxation 132
5.4 Microgravity, the Loss of a Force, Leading to Cellular
Disturbances 133
5.4.1 Biological View of the Biophysical Concepts 133
5.4.2 Short Time Microgravity and Space Flights 134
5.4.3 Modelled Altered Gravity 140
5.4.3.1 Averaging the g Vector 140
5.4.3.2 Free fall Simulation 145
5.4.3.3 Diamagnetic Levitation 146
5.4.3.4 Hypergravity 146
5.5 From Ground Research to Investigations in Microgravity 146
5.5.1 Testable Hypotheses 147
5.5.2 Experimental Strategy and Constraints 147
5.5.3 The Future 148
6 Microgravity and Bone Cell Mechanosensitivity 157
Rommel C. Bacabac, JackJ. W. A. van Loon, andjenneke Klein Nulend
6.1 Overview 157
6.2 Introduction 157
6.3 Mechanotransduction in Bone 162
6.4 Signal Transduction in Mechanosensing 162
6.5 Single Cell Response to Mechanical Loading 163
6.6 Rate dependent Response by Bone Cells 164
6.7 Implications of Threshold Activation: Enhanced Response to Stochastic
Stress 167
6.8 Stress Response and Cellular Deformation 168
6.9 Towards a Quantitative Description of Bone Cell
Mechanosensitivity 169
6.10 Implications for the Extreme Condition of Unloading
Microgravity 172
7 Bone Cell Biology in Microgravity 179
Geert Carmeliet, Lieve Coenegrachts, and Roger Bouillon
7.1 Overview 179
7.2 Introduction 179
7.3 Bone Remodelling: An Equilibrium between Osteoblasts and
Osteoclasts 180
7.4 Human Studies: Response of Bone to Space Flight 181
7.5 Space Flight and Unloading in the Rat Mimics Human Bone
Loss 182
7.6 Mechanisms of Decreased Bone Formation Induced by Unloading or
Space Flight 182
Contents I IX
7.7 Are Osteoblastic Cells In Vitro Responding to Altered Gravity
Conditions? 184
7.7.1 Proliferation and Apoptosis 184
7.7.2 Differentiation: Matrix Production 185
7.7.3 Differentiation: Growth Factors 186
7.8 Potential Mechanisms of Altered Osteoblastic Behaviour 186
7.9 Conclusion 188
8 Cells of the Immune System in Space (Lymphocytes) 193
Augusto Cogoli and Marianne Cogoli Greuter
8.1 Introduction 193
8.2 Activation of T Cells 195
8.3 Earliest Data 196
8.4 Spacelab 1, 1983 197
8.5 Spacelab D l, 1985 197
8.6 Stratospheric Balloon, 1986 200
8.7 Sounding Rockets Maser 3, 1989, and Maser 4, 1990 200
8.8 Spacelab Life Sciences SLS 1, 1991 203
8.9 Russian MIR Station, Missions 7, 8, 9, 1988 1990 203
8.10 Spacelab IML 1, 1992 204
8.11 Sounding Rockets Maxus IB, 1992, and Maxus 2, 1995 205
8.12 Spacelab IML 2, 1994 209
8.13 Sounding Rocket Maser 9, 2002 211
8.14 Shuttle Flight STS 107, Biopack, 2003 212
8.15 Ground Simulations 212
8.15.1 Marathon Run and Head down Tilt Test 213
8.15.2 Clinostats 214
8.16 Conclusion 219
9 Evaluation of Environmental Radiation Effects at the Single Cell
Level in Space and on Earth 223
Patrick Van Oostveldt, Ceert Meesen, Philippe Baert, and kndri Poffjn
9.1 Introduction 223
9.2 The Space Radiation Environment 224
9.3 HZE Track Detection 225
9.3.1 Confocal Scanning Laser Microscopy for Track Analysis in PADC 226
9.3.2 Time resolved Track Detection 227
9.4 Results of the RAMIROS Experiment on board of the Soyuz Taxi Flight
to the ISS 229
9.4.1 Methods 229
9.4.2 Results and Discussion 230
9.4.2.1 Retrieval of Cell Cultures 230
9.4.2.2 Number of HZE Tracks 230
9.4.2.3 Correlation between HZE Hit and DNA Damage at Single Cell
Level 231
X Contents
9.4.2.4 Space versus Ground Samples 234
9.4.2.5 HZE Hits Before and After Fixation 235
9.4.2.6 Conclusions 235
9.5 Combination of Radiation with other Biological Stress in Space
Travel 236
9.6 Interactions between Radiation and Gravity 237
9.7 General Conclusions and Perspectives 239
10 Space Radiation Biology 243
Gerda Horneck
10.1 Radiation Scenario in Space 243
10.1.1 Cosmic Ionizing Radiation 244
10.1.2 Solar Electromagnetic Radiation 247
10.2 Questions Tackled in Space Radiation Biology 248
10.3 Results of Radiobiological Experiments in Space 250
10.3.1 Life and Cosmic Radiation 250
10.3.1.1 Radiation Dosimetry 250
10.3.1.2 Biological Effects of Cosmic Radiation 254
10.3.1.3 Interaction of Radiation with other Space Flight Factors 259
10.3.1.4 Radiation Protection Guidelines for Astronauts in LEO 262
10.3.2 Life and Solar Electromagnetic Radiation 263
10.3.2.1 Biological effects of Extraterrestrial Solar UV Radiation 264
10.3.2.2 Role of Solar UV Radiation in Evolutionary Processes Related to
Life 266
10.4 Outlook: Radiation Biology and Future Exploratory Missions in the
Solar System 268
10.4.1 Habitability of Mars 268
10.4.2 Radiation Protection Guidelines for Astronauts during Exploratory
Missions 269
Index 275 |
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| id | DE-604.BV022937004 |
| illustrated | Illustrated |
| index_date | 2024-07-02T18:56:57Z |
| indexdate | 2024-07-20T09:25:49Z |
| institution | BVB |
| isbn | 9783527406685 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016141736 |
| oclc_num | 170033197 |
| open_access_boolean | |
| owner | DE-29T |
| owner_facet | DE-29T |
| physical | XVII, 277 S. Ill., graph. Darst. 25 cm |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Biology in space and life on earth effects of spaceflight on biological systems ed. by Enno Brinckmann Weinheim Wiley-VCH 2007 XVII, 277 S. Ill., graph. Darst. 25 cm txt rdacontent n rdamedia nc rdacarrier Literaturangaben Cosmic Radiation adverse effects Extraterrestrial Environment Space Flight Space biology Space medicine Weightlessness adverse effects Raumfahrtbiologie (DE-588)4435195-1 gnd rswk-swf Raumfahrtmedizin (DE-588)4177057-2 gnd rswk-swf Raumfahrtbiologie (DE-588)4435195-1 s DE-604 Raumfahrtmedizin (DE-588)4177057-2 s 1\p DE-604 Brinckmann, Enno Sonstige oth text/html http://deposit.dnb.de/cgi-bin/dokserv?id=2945675&prov=M&dok_var=1&dok_ext=htm Inhaltstext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016141736&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Biology in space and life on earth effects of spaceflight on biological systems Cosmic Radiation adverse effects Extraterrestrial Environment Space Flight Space biology Space medicine Weightlessness adverse effects Raumfahrtbiologie (DE-588)4435195-1 gnd Raumfahrtmedizin (DE-588)4177057-2 gnd |
| subject_GND | (DE-588)4435195-1 (DE-588)4177057-2 |
| title | Biology in space and life on earth effects of spaceflight on biological systems |
| title_auth | Biology in space and life on earth effects of spaceflight on biological systems |
| title_exact_search | Biology in space and life on earth effects of spaceflight on biological systems |
| title_exact_search_txtP | Biology in space and life on earth effects of spaceflight on biological systems |
| title_full | Biology in space and life on earth effects of spaceflight on biological systems ed. by Enno Brinckmann |
| title_fullStr | Biology in space and life on earth effects of spaceflight on biological systems ed. by Enno Brinckmann |
| title_full_unstemmed | Biology in space and life on earth effects of spaceflight on biological systems ed. by Enno Brinckmann |
| title_short | Biology in space and life on earth |
| title_sort | biology in space and life on earth effects of spaceflight on biological systems |
| title_sub | effects of spaceflight on biological systems |
| topic | Cosmic Radiation adverse effects Extraterrestrial Environment Space Flight Space biology Space medicine Weightlessness adverse effects Raumfahrtbiologie (DE-588)4435195-1 gnd Raumfahrtmedizin (DE-588)4177057-2 gnd |
| topic_facet | Cosmic Radiation adverse effects Extraterrestrial Environment Space Flight Space biology Space medicine Weightlessness adverse effects Raumfahrtbiologie Raumfahrtmedizin |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=2945675&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016141736&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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