Aminoglycoside antibiotics: from chemical biology to drug discovery
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Hoboken, NJ
Wiley-Interscience
2007
|
| Series: | Wiley series in drug discovery and development
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | X, 319 S. Ill., graph. Darst. |
| ISBN: | 9780471743026 |
Staff View
MARC
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| 650 | 4 | |a Antibiotics | |
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Record in the Search Index
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| adam_text | CONTENTS
Preface vii
Contributors
ix
1.
In
the Beginning There Was Streptomycin
1
Julian Davies
2.
The Biochemistry and Genetics of Aminoglycoside Producers
15
Wolfgang
Piepersberg,
Khaled M. Aboshanab,
Heike Schmidt-Beißner,
and
Udo F. Wehmeier
3.
Mechanisms of Aminoglycoside Antibiotic Resistance
119
Tushar Shakya and Gerard D. Wright
4.
Design, Chemical Synthesis, and Antibacterial Activity
of Kanamycin and Neomycin Class Aminoglycoside
Antibiotics
141
Jinhua Wang and Cheng-Wei Tom Chang
5.
NMR Structural Studies of Aminoglycoside:
RNA
Interaction
181
R. Andrew Marshall and Joseph D. Puglisi
vi
CONTENTS
6.
Structural Comparisons Between Prokaryotic and Eukaryotic
Ribosomal Decoding A Sites Free and Complexed with
Aminoglycosides
209
Jiro
Kondo and Eric Westhof
7.
Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial
Ribosome
225
Dale
Kling,
Christine Chow, and Shahriar Mobashery
8.
Metalloaminoglycosides: Chemistry and Biological Relevance
235
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan
9.
Adverse Effects of Aminoglycoside Therapy
255
Atidra
E.
Talaska
and
Jochen Schacht
10. Targeting HIV-1
RNA
with
Aminoglycoside
Antibiotics and
Their Derivatives
267
Lev Ebon-Schwab and Yitzhak Tor
11.
Novel Targets for Aminoglycosides
289
Der
P. Arya, Nicholas Shaw, and Hongjuan
Xi
Index
315
Advances that open new avenues in
developing aminoglycoside antibiotics
During the last twenty years, there have been numerous advances in
the understanding of the chemistry, biochemistry, and recognition of
aminoglycosides. This has led to the development of novel antibiotics
and opened up new therapeutic targets for intervention. This is the first
book to provide a complete overview of recent advances in the field and
explore their tremendous potential for drug discovery and rational drug
design. With chapters written by one or more leading experts in their
specialty areas, the book addresses the chemistry, biology, and toxicol¬
ogy of aminoglycosides.
Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery
is a great resource for academic and industrial researchers in drug
design and mechanism studies and for researchers studying antibiotic
resistance, antibiotic design and synthesis, and the discovery of novel
Pharmaceuticals. It is also a valuable reference for graduate students
in pharmacy, pharmaceutical science, biophysics, medicinal chemistry,
and chemical biology.
DEV P. ARYA is an Associate Professor of Chemistry and Director of the
Laboratory of Medicinal Chemistry at Clemson University. He is a mem¬
ber of the ACS, and currently serves as the Program Chair of the Division
of Carbohydrate Chemistry. His research interests lie in the development
of nucleic acid targeted drugs.
|
| adam_txt |
CONTENTS
Preface vii
Contributors
ix
1.
In
the Beginning There Was Streptomycin
1
Julian Davies
2.
The Biochemistry and Genetics of Aminoglycoside Producers
15
Wolfgang
Piepersberg,
Khaled M. Aboshanab,
Heike Schmidt-Beißner,
and
Udo F. Wehmeier
3.
Mechanisms of Aminoglycoside Antibiotic Resistance
119
Tushar Shakya and Gerard D. Wright
4.
Design, Chemical Synthesis, and Antibacterial Activity
of Kanamycin and Neomycin Class Aminoglycoside
Antibiotics
141
Jinhua Wang and Cheng-Wei Tom Chang
5.
NMR Structural Studies of Aminoglycoside:
RNA
Interaction
181
R. Andrew Marshall and Joseph D. Puglisi
vi
CONTENTS
6.
Structural Comparisons Between Prokaryotic and Eukaryotic
Ribosomal Decoding A Sites Free and Complexed with
Aminoglycosides
209
Jiro
Kondo and Eric Westhof
7.
Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial
Ribosome
225
Dale
Kling,
Christine Chow, and Shahriar Mobashery
8.
Metalloaminoglycosides: Chemistry and Biological Relevance
235
Nikhil Gokhale, Anjali Patwardhan, and J. A. Cowan
9.
Adverse Effects of Aminoglycoside Therapy
255
Atidra
E.
Talaska
and
Jochen Schacht
10. Targeting HIV-1
RNA
with
Aminoglycoside
Antibiotics and
Their Derivatives
267
Lev Ebon-Schwab and Yitzhak Tor
11.
Novel Targets for Aminoglycosides
289
Der
P. Arya, Nicholas Shaw, and Hongjuan
Xi
Index
315
Advances that open new avenues in
developing aminoglycoside antibiotics
During the last twenty years, there have been numerous advances in
the understanding of the chemistry, biochemistry, and recognition of
aminoglycosides. This has led to the development of novel antibiotics
and opened up new therapeutic targets for intervention. This is the first
book to provide a complete overview of recent advances in the field and
explore their tremendous potential for drug discovery and rational drug
design. With chapters written by one or more leading experts in their
specialty areas, the book addresses the chemistry, biology, and toxicol¬
ogy of aminoglycosides.
Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery
is a great resource for academic and industrial researchers in drug
design and mechanism studies and for researchers studying antibiotic
resistance, antibiotic design and synthesis, and the discovery of novel
Pharmaceuticals. It is also a valuable reference for graduate students
in pharmacy, pharmaceutical science, biophysics, medicinal chemistry,
and chemical biology.
DEV P. ARYA is an Associate Professor of Chemistry and Director of the
Laboratory of Medicinal Chemistry at Clemson University. He is a mem¬
ber of the ACS, and currently serves as the Program Chair of the Division
of Carbohydrate Chemistry. His research interests lie in the development
of nucleic acid targeted drugs. |
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| illustrated | Illustrated |
| index_date | 2024-07-02T18:56:48Z |
| indexdate | 2024-07-09T21:08:03Z |
| institution | BVB |
| isbn | 9780471743026 |
| language | English |
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| physical | X, 319 S. Ill., graph. Darst. |
| publishDate | 2007 |
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| series2 | Wiley series in drug discovery and development |
| spelling | Aminoglycoside antibiotics from chemical biology to drug discovery [ed. by] Dev P. Arya Hoboken, NJ Wiley-Interscience 2007 X, 319 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Wiley series in drug discovery and development Aminoglycosides Physiological effect Aminoglycosides Structure-activity relationships Aminoglycosides chemistry Antibiotics Drug Design Drug development Structure-Activity Relationship Arya, Dev P. Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016141325&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016141325&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Aminoglycoside antibiotics from chemical biology to drug discovery Aminoglycosides Physiological effect Aminoglycosides Structure-activity relationships Aminoglycosides chemistry Antibiotics Drug Design Drug development Structure-Activity Relationship |
| title | Aminoglycoside antibiotics from chemical biology to drug discovery |
| title_auth | Aminoglycoside antibiotics from chemical biology to drug discovery |
| title_exact_search | Aminoglycoside antibiotics from chemical biology to drug discovery |
| title_exact_search_txtP | Aminoglycoside antibiotics from chemical biology to drug discovery |
| title_full | Aminoglycoside antibiotics from chemical biology to drug discovery [ed. by] Dev P. Arya |
| title_fullStr | Aminoglycoside antibiotics from chemical biology to drug discovery [ed. by] Dev P. Arya |
| title_full_unstemmed | Aminoglycoside antibiotics from chemical biology to drug discovery [ed. by] Dev P. Arya |
| title_short | Aminoglycoside antibiotics |
| title_sort | aminoglycoside antibiotics from chemical biology to drug discovery |
| title_sub | from chemical biology to drug discovery |
| topic | Aminoglycosides Physiological effect Aminoglycosides Structure-activity relationships Aminoglycosides chemistry Antibiotics Drug Design Drug development Structure-Activity Relationship |
| topic_facet | Aminoglycosides Physiological effect Aminoglycosides Structure-activity relationships Aminoglycosides chemistry Antibiotics Drug Design Drug development Structure-Activity Relationship |
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