In vivo models of HIV disease and control:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
New York, NY
Springer
2006
|
| Series: | Infectious diseases and pathogenesis
|
| Subjects: | |
| Online Access: | UBR01 Volltext Inhaltsverzeichnis |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 0387257411 9780387257402 9780387257419 |
| DOI: | 10.1007/b135975 |
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Record in the Search Index
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|---|---|
| adam_text | Contents
1. Historical Perspective 1
MURRAY B. GARDNER
1. Introduction 1
2. The Virus Cancer Program (VCP) Era 1
3. Discovery of HIV 7
4. Sheep, Goat, Horse, and Cow Lentiviruses 8
5. Animal Models of HIV Infection 9
6. Macaque Retrovirus Models of AIDS 10
7. SRV: Type D Virus 10
8. SIV: Lentivirus 11
9. FIV: Lentivirus 14
10. Summary 15
References 16
2. Animal Model Systems of
HIV Diseases 19
ERIC R. ANDERSON, HUANGUI XIONG, and
HOWARD E. GENDELMAN
1. Introduction 19
2. HIV 1 Pathogenesis 21
3. Animal Models for HIV 1 Infection: Overview 23
4. Mouse Models 25
5. Ungulates 27
6. Immunodeficiency Lentiviruses 30
7. Conclusion 33
References 35
xiii
xjy CONTENTS
3. Chemoldnes and Their Receptors and the Neuropathogenesis
of HIV 1 Infection 45
HOWARD E. GENDELMAN, ERIC R. ANDERSON,
LOYDA MELENDEZ, and JIALIN ZHENG
1. Introduction 45
2. HIV Neuropathogenesis 48
3. Chemokines: An Overview 55
4. Conclusion 65
Acknowledgments 65
References 66
4. SCID Mice Transplanted With Human Cells as Small Animal
Models in AIDS Research 81
CATERINA LAPENTA, STEFANO M. SANTINI,
MASSIMO SPADA, and FILIPPO BELARDELLI
1. Introduction 81
2. The HU PBLrSCID Mouse Model:
Major Technical Aspects 82
3. HIV Infection in the HU PBL SCID Mouse Model 84
4. Therapy and Immunization Studies 89
5. Final Remarks 94
Acknowledgments 95
References 95
5. SIV as a Model for AIDS Pathogenesis Studies 101
ULRIKE SAUERMANN and SIEGHART SOPPER
1. Introduction 101
2. Viruses 102
3. Monkey Species 102
4. Natural Course of SIV Infection 104
5. Selected Aspects of SIV Pathogenicity 109
6. Conclusion and Perspective 115
References 116
CONTENTS xv
6. SIV Infection of Macaques as a Model for
AIDS Drug Studies 121
KOEN K. A. VAN ROMPAY, RAMAN P. SINGH, and
MARTA L. MARTHAS
1. Introduction: The Need for an Animal Model 121
2. SIV Infection of Macaques: Animal Model of
HIV and AIDS 123
3. Macaque Species and Virus Isolates Used in
Antiviral Drug Studies 124
4. Development of the Animal Model:
Initial Obstacles and Solutions 125
5. Overview of Drug Studies in Nonhuman Primates 127
6. Conclusions 137
References 138
7. JTV as a Model for HIV: An Overview 149
ELLEN E. SPARGER
1. Introduction 149
2. FIV Genome, Structure, and Gene Function 150
3. FIV Tropism 166
4. Epidemiology and Transmission 170
5. Virus Infection and Host Responses 173
6. FIV Vaccine Development 184
7. FIV and Antiviral Therapies 191
8. FIV as a Viral Vector 193
9. Feline Lentiviruses of Nondomestic Cats 195
10. Outlook for the FIV Animal Model 198
Acknowledgments 199
References 199
8. FIV as a Model for AIDS Pathogenesis Studies 239
THOMAS W. VAHLENKAMP, MARY B. TOMPKINS,
and WAYNE A. F. TOMPKINS
1. Introduction 239
2. Course of the Disease 240
xvi CONTENTS
3. Feline Immunodeficiency Virus (FIV) 242
4. Immune Response to FIV 246
5. Immunopathogenesis of FIV Infection 251
6. Conclusion 261
References 261
9. Drugs of Abuse, AIDS, and the FIV Model 275
MARGARET C. BARR, MARIA PIA TESTA,
and TOM R. PHILLIPS
1. Introduction 275
2. The FIV/Cat Model for AIDS Pathogenesis
and Drug Abuse 276
3. Opiates and the FlV/Cat Model 280
4. Methamphetamine and the FIV/Cat Model 283
5. Conclusion 287
References 287
10. FIV as a Model for AIDS Vaccine Studies 293
STEPHEN DUNHAM and OSWALD JARRETT
1. Introduction 293
2. Relevance of FIV to HIV Vaccination 294
3. Crucial Factors in FIV Vaccine Development Strategies . . 298
4. Examples of FIV Vaccines 317
5. Conclusions 326
Acknowledgments 327
References 327
11. FTV as a Model for HIV Treatment 333
KATRIN HARTMANN and CHRISTIANE STENGEL
1. Introduction . 333
2. Development of the FIV/Cat Model 334
3. Treatment Studies in FIV Infected Cats 341
References 358
CONTENTS xvii
12. Equine Infectious Anemia Virus as a Model for
Lentiviral Pathogenesis 365
SUSAN L. PAYNE, WAH SENG LIM,
FREDERICK J. FULLER, and JUDITH M. BALL
1. Introduction 365
2. Disease Induction by EIAV 370
3. Immune Responses That Control EIAV Replication 374
4. Vaccines 376
5. Molecular Characterization of Virulence
Determinants 378
References 386
13. Studies of the Structure of Caprine Arthritis Encephalitis
Virus Surface Envelope Glycoprotein 391
ISIDRO HOTZEL and WILLIAM P. CHEEVERS
1. Introduction 391
2. Primary Structure of CAEV SU 392
3. Comparative Structural Model of CAEV SU 394
4. Summary 400
References 401
14. Ethical Issues in the Use of Animal Models of Infection and
Some Practical Refinements 405
DAVID B. MORTON
1. Introduction 405
2. Should We Use Animals in Research on HIV? 406
3. The Three Rs: An Ethical Framework to Develop
Research Strategies and Project Evaluation 407
4. Guidance for Ethics Committees and
Publication of Data 420
5. Conclusion 421
References 422
xviii CONTENTS
15. Future Perspectives 425
MAURO PISTELLO
Index 429
|
| adam_txt |
Contents
1. Historical Perspective 1
MURRAY B. GARDNER
1. Introduction 1
2. The Virus Cancer Program (VCP) Era 1
3. Discovery of HIV 7
4. Sheep, Goat, Horse, and Cow Lentiviruses 8
5. Animal Models of HIV Infection 9
6. Macaque Retrovirus Models of AIDS 10
7. SRV: Type D Virus 10
8. SIV: Lentivirus 11
9. FIV: Lentivirus 14
10. Summary 15
References 16
2. Animal Model Systems of
HIV Diseases 19
ERIC R. ANDERSON, HUANGUI XIONG, and
HOWARD E. GENDELMAN
1. Introduction 19
2. HIV 1 Pathogenesis 21
3. Animal Models for HIV 1 Infection: Overview 23
4. Mouse Models 25
5. Ungulates 27
6. Immunodeficiency Lentiviruses 30
7. Conclusion 33
References 35
xiii
xjy CONTENTS
3. Chemoldnes and Their Receptors and the Neuropathogenesis
of HIV 1 Infection 45
HOWARD E. GENDELMAN, ERIC R. ANDERSON,
LOYDA MELENDEZ, and JIALIN ZHENG
1. Introduction 45
2. HIV Neuropathogenesis 48
3. Chemokines: An Overview 55
4. Conclusion 65
Acknowledgments 65
References 66
4. SCID Mice Transplanted With Human Cells as Small Animal
Models in AIDS Research 81
CATERINA LAPENTA, STEFANO M. SANTINI,
MASSIMO SPADA, and FILIPPO BELARDELLI
1. Introduction 81
2. The HU PBLrSCID Mouse Model:
Major Technical Aspects 82
3. HIV Infection in the HU PBL SCID Mouse Model 84
4. Therapy and Immunization Studies 89
5. Final Remarks 94
Acknowledgments 95
References 95
5. SIV as a Model for AIDS Pathogenesis Studies 101
ULRIKE SAUERMANN and SIEGHART SOPPER
1. Introduction 101
2. Viruses 102
3. Monkey Species 102
4. Natural Course of SIV Infection 104
5. Selected Aspects of SIV Pathogenicity 109
6. Conclusion and Perspective 115
References 116
CONTENTS xv
6. SIV Infection of Macaques as a Model for
AIDS Drug Studies 121
KOEN K. A. VAN ROMPAY, RAMAN P. SINGH, and
MARTA L. MARTHAS
1. Introduction: The Need for an Animal Model 121
2. SIV Infection of Macaques: Animal Model of
HIV and AIDS 123
3. Macaque Species and Virus Isolates Used in
Antiviral Drug Studies 124
4. Development of the Animal Model:
Initial Obstacles and Solutions 125
5. Overview of Drug Studies in Nonhuman Primates 127
6. Conclusions 137
References 138
7. JTV as a Model for HIV: An Overview 149
ELLEN E. SPARGER
1. Introduction 149
2. FIV Genome, Structure, and Gene Function 150
3. FIV Tropism 166
4. Epidemiology and Transmission 170
5. Virus Infection and Host Responses 173
6. FIV Vaccine Development 184
7. FIV and Antiviral Therapies 191
8. FIV as a Viral Vector 193
9. Feline Lentiviruses of Nondomestic Cats 195
10. Outlook for the FIV Animal Model 198
Acknowledgments 199
References 199
8. FIV as a Model for AIDS Pathogenesis Studies 239
THOMAS W. VAHLENKAMP, MARY B. TOMPKINS,
and WAYNE A. F. TOMPKINS
1. Introduction 239
2. Course of the Disease 240
xvi CONTENTS
3. Feline Immunodeficiency Virus (FIV) 242
4. Immune Response to FIV 246
5. Immunopathogenesis of FIV Infection 251
6. Conclusion 261
References 261
9. Drugs of Abuse, AIDS, and the FIV Model 275
MARGARET C. BARR, MARIA PIA TESTA,
and TOM R. PHILLIPS
1. Introduction 275
2. The FIV/Cat Model for AIDS Pathogenesis
and Drug Abuse 276
3. Opiates and the FlV/Cat Model 280
4. Methamphetamine and the FIV/Cat Model 283
5. Conclusion 287
References 287
10. FIV as a Model for AIDS Vaccine Studies 293
STEPHEN DUNHAM and OSWALD JARRETT
1. Introduction 293
2. Relevance of FIV to HIV Vaccination 294
3. Crucial Factors in FIV Vaccine Development Strategies . . 298
4. Examples of FIV Vaccines 317
5. Conclusions 326
Acknowledgments 327
References 327
11. FTV as a Model for HIV Treatment 333
KATRIN HARTMANN and CHRISTIANE STENGEL
1. Introduction . 333
2. Development of the FIV/Cat Model 334
3. Treatment Studies in FIV Infected Cats 341
References 358
CONTENTS xvii
12. Equine Infectious Anemia Virus as a Model for
Lentiviral Pathogenesis 365
SUSAN L. PAYNE, WAH SENG LIM,
FREDERICK J. FULLER, and JUDITH M. BALL
1. Introduction 365
2. Disease Induction by EIAV 370
3. Immune Responses That Control EIAV Replication 374
4. Vaccines 376
5. Molecular Characterization of Virulence
Determinants 378
References 386
13. Studies of the Structure of Caprine Arthritis Encephalitis
Virus Surface Envelope Glycoprotein 391
ISIDRO HOTZEL and WILLIAM P. CHEEVERS
1. Introduction 391
2. Primary Structure of CAEV SU 392
3. Comparative Structural Model of CAEV SU 394
4. Summary 400
References 401
14. Ethical Issues in the Use of Animal Models of Infection and
Some Practical Refinements 405
DAVID B. MORTON
1. Introduction 405
2. Should We Use Animals in Research on HIV? 406
3. The Three Rs: An Ethical Framework to Develop
Research Strategies and Project Evaluation 407
4. Guidance for Ethics Committees and
Publication of Data 420
5. Conclusion 421
References 422
xviii CONTENTS
15. Future Perspectives 425
MAURO PISTELLO
Index 429 |
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| spelling | In vivo models of HIV disease and control ed. by Herman Friedman ... New York, NY Springer 2006 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Infectious diseases and pathogenesis Tiermodell (DE-588)4140660-6 gnd rswk-swf HIV-Infektion (DE-588)4203852-2 gnd rswk-swf HIV-Infektion (DE-588)4203852-2 s Tiermodell (DE-588)4140660-6 s DE-604 Friedman, Herman Sonstige oth Erscheint auch als Druck-Ausgabe, Hardcover 0-387-25740-3 https://doi.org/10.1007/b135975 Verlag Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016086532&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | In vivo models of HIV disease and control Tiermodell (DE-588)4140660-6 gnd HIV-Infektion (DE-588)4203852-2 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4203852-2 |
| title | In vivo models of HIV disease and control |
| title_auth | In vivo models of HIV disease and control |
| title_exact_search | In vivo models of HIV disease and control |
| title_exact_search_txtP | In vivo models of HIV disease and control |
| title_full | In vivo models of HIV disease and control ed. by Herman Friedman ... |
| title_fullStr | In vivo models of HIV disease and control ed. by Herman Friedman ... |
| title_full_unstemmed | In vivo models of HIV disease and control ed. by Herman Friedman ... |
| title_short | In vivo models of HIV disease and control |
| title_sort | in vivo models of hiv disease and control |
| topic | Tiermodell (DE-588)4140660-6 gnd HIV-Infektion (DE-588)4203852-2 gnd |
| topic_facet | Tiermodell HIV-Infektion |
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