HIV-1: molecular biology and pathogenesis: [2] Clinical applications
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier
2008
|
| Edition: | 2. ed. |
| Series: | Advances in pharmacology
56 |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 593 S. Ill., graph. Darst., Kt. |
| ISBN: | 9780123736017 |
Staff View
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| 245 | 1 | 0 | |a HIV-1: molecular biology and pathogenesis |n [2] |p Clinical applications |c ed. by Kuan-Teh Jeang |
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| adam_text | Contents
Contributors xi
Preface written by Robin A. Weiss xv
Global Molecular Epidemiology of HIV: Understanding the
Genesis of AIDS Pandemic
Yutaka Takebe, Rie Uenishi, and Xiaojie Li
I. Chapter Overview 1
II. Introduction 2
III. Genotype Classification of HIVs 4
IV. Global Distribution of HIV Genotypes 9
V. Methods for Identifying HIV Genetic Forms 11
VI. Origin of HIVs and Genesis of HIV-1 Pandemic 13
VII. Biological Significance of HIV-1 Variability and Recombination 14
VIII. Conclusions 18
References 18
v
vi Contents
Current Clinical Treatments of AIDS
Erin-Margaret Murphy, Humberto R. Jimenez, and Stephen M. Smith
I. Chapter Overview 27
II. HIV Medications 28
III. HIV Treatment 52
IV. Conclusion 63
References 63
HIV-1-Specific Immune Response
Alexandre Harari and Giuseppe Pantaleo
I. Introduction 75
II. Humoral HIV-1-Specific Response 77
III. HIV-1-Specific T-Cell Responses 78
References 87
Targeting HIV Attachment and Entry for Therapy
Julie Strizki
I. Chapter Overview 93
II. Background 94
III. Inhibition of Viral Attachment 95
IV. Chemokine Receptors in HIV Infection 98
V. Targeting Coreceptor Binding 99
VI. Fusion Inhibitors 107
VII. Resistance to Inhibitors of Viral Entry 109
VIII. Use Entry Inhibitors as Microbicides 110
References 111
Inhibitors of HIV-1 Reverse Transcriptase
Tatiana Nina and Michael A. Parniak
I. Chapter Overview 121
II. Introduction 122
III. The Target 123
IV. Nucleoside RT Inhibitors 127
V. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) 140
VI. Other Inhibitors of HIV-1 RT 150
VII. Conclusion 154
References 154
Contents vii
Development of Protease Inhibitors and the Fight with
Drug-Resistant HIV-1 Variants
Hiroaki Mitsuya, Kenji Maeda, Debananda Das, and Arun K. Ghosh
I. Chapter Overview 169
II. Introduction 170
III. Targeting Viral Protease 170
IV. The Role of Pis and Challenges in HAART 174
V. Boosting : A Critical Modification of Clinical Efficacy of Pis 175
VI. Viral Resistance to Pis 176
VII. Pis with Activity Against Drug-Resistant HIV-1 182
VIII. Conclusions 189
References 191
HIV-1 Integrase Inhibitors: Update and Perspectives
Elena A. Semenova, Christophe Marchand, and Yves Pommier
I. Chapter Overview 199
II. Foreword 200
III. Integration: A Crucial Step in the HIV Life Cycle 200
IV. Approaches to Inhibit HIV Integration 210
V. Inhibitors in Clinical Trials 216
VI. Inhibitors in Preclinical Development 217
VII. Perspectives 218
References 219
Topical Microbicides: A Promising Approach for Controlling the
AIDS Pandemic via Retroviral Zinc Finger Inhibitors
Jim A. Turpin, Marco L. Schito, Lisa M. Miller Jenkins, John K. Inman, and Ettore Appella
I. Chapter Overview 229
II. The AIDS Pandemic and the Rationale for a Microbicide 230
III. Topical Microbicides in Preclinical Development 232
IV. Characteristics of an Ideal Microbicide 237
V. The Retroviral Zinc Fingers of HIV-1 NCp7 as a Potential
Microbicide Target 238
VI. Characteristics of the SAMT Chemotype 240
VII. Application of Thioesters for Microbicides 244
VIII. Target Specificity of the SAMT NCp7 Inhibitors 246
IX. Conclusions 249
X. Addendum 250
References 251
Viii Contents
Viral Drug Resistance and Fitness
Miguel E. Quinones-Mateu, Dawn M. Moore-Dudley, Oyebisi Jegede, Jan Weber, and Eric J. Arts
I. Chapter Overview 257
II. Introduction 258
References 283
Gene Therapy to Induce Cellular Resistance to HIV-1 Infection:
Lessons from Clinical Trials
Mauro Giacca
I. Chapter Overview 297
II. Introduction: Do We Need HIV-1 Gene Therapy? 298
III. Gene Therapy of HIV Infection: Lessons from Early
Clinical Trials 300
IV. Gene Therapy of HIV Infection: Current Developments 306
V. Gene Therapy for HIV Infection: Where Are We Heading? 314
References 317
Identification of Potential Drug Targets Using Genomics
and Proteomics: A Systems Approach
Zachary A. Klase, Rachel Van Duyne, and Fatah Kashanchi
I. Chapter Overview 327
II. Introduction 328
III. Viral Targets 329
IV. Cellular/Viral Protein-Protein Interactions 331
V. Viral-Induced Cellular Alterations 343
VI. Other Approaches 351
VII. Conclusion 354
References 355
Rapid Disease Progression to AIDS due to Simian
immunodeficiency virus Infection of Macaques: Host
and Viral Factors
Que Dang and Vanessa M. Hirsch
I. Chapter Overview 369
II. Introduction 370
III. SIV Strain Diversity 371
Contents IX
IV. Biology of SIV 371
V. Pathogenesis of SIV in Macaques 373
VI. Unique Immunologic, Virological, and Pathological Features
of Rapid Disease 377
VII. Host Factors That Influence Disease Progression 383
VIII. Role of Virus Genotype/Phenotype in Rapid
Disease Progression 384
IX. Summary 388
References 389
Nonprimate Models of HIV-1 Infection and Pathogenesis
Viet Hoang, Elizabeth Withers-Ward, and David Camerini
I. Chapter Overview 399
II. Introduction 400
III. SCID-Hu Thy/Liv Mice 401
IV. The hu-PBL-SCID Mouse 405
V. NOD/LtSz-SCID Mice 407
VI. Rag2^ yC and NOD-SCID yC - Mice 408
VII. Humanized Immune Competent Mice and Rats 409
VIII. HIV-1 Tg Mice 410
IX. Rabbit Model of HIV Pathogenesis 412
X. Conclusion 413
References 413
Perspectives for a Protective HIV-1 Vaccine
Marco Schiavone, lleana Quinto, and Giuseppe Scala
I. Chapter Overview 423
II. Introduction 424
III. Current Strategies in Developing an HIV-1 Vaccine 429
IV. Concluding Remarks 441
References 442
Molecular Mechanisms of HIV-1 Vertical Transmission
and Pathogenesis in Infants
Nafees Ahmad
I. Chapter Overview 453
II. Introduction 454
III. Timing and Mechanism of HIV-1 Vertical Transmission 456
X Contents
IV. Factors Associated with HIV-1 Vertical Transmission 458
V. HIV-1 Infection Diagnosis in Neonates and Infants 460
VI. Prevention of HIV-1 Vertical Transmission 460
VII. Characterization of HIV-1 Associated with Vertical
Transmission 462
VIII. Chemokine Receptors and HIV-1 Vertical Transmission 464
IX. Molecular Properties of HIV-1 from Mother-Infant Pairs Associated
with Vertical Transmission 465
X. Characterization of Functional Domains of HIV-1 Genes Associated
with Vertical Transmission 470
XI. Properties of HIV-1 Associated with Lack of Vertical
Transmission 478
XII. Analysis of Immunologically Relevant Mutations in HIV-1 Isolates
Associated with Vertical Transmission 481
XIII. Mechanisms of HIV-1 Pathogenesis and Disease
Progression in Infants 485
XIV. The Future 491
References 492
The Viral Etiology of AIDS-Associated Malignancies
Peter C. Angeletti, Luwen Zhang, and Charles Wood
I. Chapter Overview 509
II. Introduction 510
III. Kaposi s Sarcoma 512
IV. AIDS-Associated Lymphomas 520
V. AIDS-Associated NHL 524
VI. HPV-Associated Cancers 527
VII. HPV—The Causative Agent 529
VIII. Conclusions 538
References 539
Index 559
Contents of Previous Volumes 575
Color Plate Section at the end of the book
|
| adam_txt |
Contents
Contributors xi
Preface written by Robin A. Weiss xv
Global Molecular Epidemiology of HIV: Understanding the
Genesis of AIDS Pandemic
Yutaka Takebe, Rie Uenishi, and Xiaojie Li
I. Chapter Overview 1
II. Introduction 2
III. Genotype Classification of HIVs 4
IV. Global Distribution of HIV Genotypes 9
V. Methods for Identifying HIV Genetic Forms 11
VI. Origin of HIVs and Genesis of HIV-1 Pandemic 13
VII. Biological Significance of HIV-1 Variability and Recombination 14
VIII. Conclusions 18
References 18
v
vi Contents
Current Clinical Treatments of AIDS
Erin-Margaret Murphy, Humberto R. Jimenez, and Stephen M. Smith
I. Chapter Overview 27
II. HIV Medications 28
III. HIV Treatment 52
IV. Conclusion 63
References 63
HIV-1-Specific Immune Response
Alexandre Harari and Giuseppe Pantaleo
I. Introduction 75
II. Humoral HIV-1-Specific Response 77
III. HIV-1-Specific T-Cell Responses 78
References 87
Targeting HIV Attachment and Entry for Therapy
Julie Strizki
I. Chapter Overview 93
II. Background 94
III. Inhibition of Viral Attachment 95
IV. Chemokine Receptors in HIV Infection 98
V. Targeting Coreceptor Binding 99
VI. Fusion Inhibitors 107
VII. Resistance to Inhibitors of Viral Entry 109
VIII. Use Entry Inhibitors as Microbicides 110
References 111
Inhibitors of HIV-1 Reverse Transcriptase
Tatiana Nina and Michael A. Parniak
I. Chapter Overview 121
II. Introduction 122
III. The Target 123
IV. Nucleoside RT Inhibitors 127
V. Nonnucleoside Reverse Transcriptase Inhibitors (NNRTIs) 140
VI. Other Inhibitors of HIV-1 RT 150
VII. Conclusion 154
References 154
Contents vii
Development of Protease Inhibitors and the Fight with
Drug-Resistant HIV-1 Variants
Hiroaki Mitsuya, Kenji Maeda, Debananda Das, and Arun K. Ghosh
I. Chapter Overview 169
II. Introduction 170
III. Targeting Viral Protease 170
IV. The Role of Pis and Challenges in HAART 174
V. "Boosting": A Critical Modification of Clinical Efficacy of Pis 175
VI. Viral Resistance to Pis 176
VII. Pis with Activity Against Drug-Resistant HIV-1 182
VIII. Conclusions 189
References 191
HIV-1 Integrase Inhibitors: Update and Perspectives
Elena A. Semenova, Christophe Marchand, and Yves Pommier
I. Chapter Overview 199
II. Foreword 200
III. Integration: A Crucial Step in the HIV Life Cycle 200
IV. Approaches to Inhibit HIV Integration 210
V. Inhibitors in Clinical Trials 216
VI. Inhibitors in Preclinical Development 217
VII. Perspectives 218
References 219
Topical Microbicides: A Promising Approach for Controlling the
AIDS Pandemic via Retroviral Zinc Finger Inhibitors
Jim A. Turpin, Marco L. Schito, Lisa M. Miller Jenkins, John K. Inman, and Ettore Appella
I. Chapter Overview 229
II. The AIDS Pandemic and the Rationale for a Microbicide 230
III. Topical Microbicides in Preclinical Development 232
IV. Characteristics of an Ideal Microbicide 237
V. The Retroviral Zinc Fingers of HIV-1 NCp7 as a Potential
Microbicide Target 238
VI. Characteristics of the SAMT Chemotype 240
VII. Application of Thioesters for Microbicides 244
VIII. Target Specificity of the SAMT NCp7 Inhibitors 246
IX. Conclusions 249
X. Addendum 250
References 251
Viii Contents
Viral Drug Resistance and Fitness
Miguel E. Quinones-Mateu, Dawn M. Moore-Dudley, Oyebisi Jegede, Jan Weber, and Eric J. Arts
I. Chapter Overview 257
II. Introduction 258
References 283
Gene Therapy to Induce Cellular Resistance to HIV-1 Infection:
Lessons from Clinical Trials
Mauro Giacca
I. Chapter Overview 297
II. Introduction: Do We Need HIV-1 Gene Therapy? 298
III. Gene Therapy of HIV Infection: Lessons from Early
Clinical Trials 300
IV. Gene Therapy of HIV Infection: Current Developments 306
V. Gene Therapy for HIV Infection: Where Are We Heading? 314
References 317
Identification of Potential Drug Targets Using Genomics
and Proteomics: A Systems Approach
Zachary A. Klase, Rachel Van Duyne, and Fatah Kashanchi
I. Chapter Overview 327
II. Introduction 328
III. Viral Targets 329
IV. Cellular/Viral Protein-Protein Interactions 331
V. Viral-Induced Cellular Alterations 343
VI. Other Approaches 351
VII. Conclusion 354
References 355
Rapid Disease Progression to AIDS due to Simian
immunodeficiency virus Infection of Macaques: Host
and Viral Factors
Que Dang and Vanessa M. Hirsch
I. Chapter Overview 369
II. Introduction 370
III. SIV Strain Diversity 371
Contents IX
IV. Biology of SIV 371
V. Pathogenesis of SIV in Macaques 373
VI. Unique Immunologic, Virological, and Pathological Features
of Rapid Disease 377
VII. Host Factors That Influence Disease Progression 383
VIII. Role of Virus Genotype/Phenotype in Rapid
Disease Progression 384
IX. Summary 388
References 389
Nonprimate Models of HIV-1 Infection and Pathogenesis
Viet Hoang, Elizabeth Withers-Ward, and David Camerini
I. Chapter Overview 399
II. Introduction 400
III. SCID-Hu Thy/Liv Mice 401
IV. The hu-PBL-SCID Mouse 405
V. NOD/LtSz-SCID Mice 407
VI. Rag2^ yC' and NOD-SCID yC"'- Mice 408
VII. Humanized Immune Competent Mice and Rats 409
VIII. HIV-1 Tg Mice 410
IX. Rabbit Model of HIV Pathogenesis 412
X. Conclusion 413
References 413
Perspectives for a Protective HIV-1 Vaccine
Marco Schiavone, lleana Quinto, and Giuseppe Scala
I. Chapter Overview 423
II. Introduction 424
III. Current Strategies in Developing an HIV-1 Vaccine 429
IV. Concluding Remarks 441
References 442
Molecular Mechanisms of HIV-1 Vertical Transmission
and Pathogenesis in Infants
Nafees Ahmad
I. Chapter Overview 453
II. Introduction 454
III. Timing and Mechanism of HIV-1 Vertical Transmission 456
X Contents
IV. Factors Associated with HIV-1 Vertical Transmission 458
V. HIV-1 Infection Diagnosis in Neonates and Infants 460
VI. Prevention of HIV-1 Vertical Transmission 460
VII. Characterization of HIV-1 Associated with Vertical
Transmission 462
VIII. Chemokine Receptors and HIV-1 Vertical Transmission 464
IX. Molecular Properties of HIV-1 from Mother-Infant Pairs Associated
with Vertical Transmission 465
X. Characterization of Functional Domains of HIV-1 Genes Associated
with Vertical Transmission 470
XI. Properties of HIV-1 Associated with Lack of Vertical
Transmission 478
XII. Analysis of Immunologically Relevant Mutations in HIV-1 Isolates
Associated with Vertical Transmission 481
XIII. Mechanisms of HIV-1 Pathogenesis and Disease
Progression in Infants 485
XIV. The Future 491
References 492
The Viral Etiology of AIDS-Associated Malignancies
Peter C. Angeletti, Luwen Zhang, and Charles Wood
I. Chapter Overview 509
II. Introduction 510
III. Kaposi's Sarcoma 512
IV. AIDS-Associated Lymphomas 520
V. AIDS-Associated NHL 524
VI. HPV-Associated Cancers 527
VII. HPV—The Causative Agent 529
VIII. Conclusions 538
References 539
Index 559
Contents of Previous Volumes 575
Color Plate Section at the end of the book |
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| index_date | 2024-07-02T18:32:25Z |
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| isbn | 9780123736017 |
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| series | Advances in pharmacology |
| series2 | Advances in pharmacology |
| spelling | HIV-1: molecular biology and pathogenesis [2] Clinical applications ed. by Kuan-Teh Jeang 2. ed. Amsterdam [u.a.] Elsevier 2008 XVII, 593 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Advances in pharmacology 56 Advances in pharmacology ... Jeang, Kuan-Teh Sonstige oth (DE-604)BV022942588 2 Advances in pharmacology 56 (DE-604)BV002534644 56 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015960912&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | HIV-1: molecular biology and pathogenesis Advances in pharmacology |
| title | HIV-1: molecular biology and pathogenesis |
| title_auth | HIV-1: molecular biology and pathogenesis |
| title_exact_search | HIV-1: molecular biology and pathogenesis |
| title_exact_search_txtP | HIV-1: molecular biology and pathogenesis |
| title_full | HIV-1: molecular biology and pathogenesis [2] Clinical applications ed. by Kuan-Teh Jeang |
| title_fullStr | HIV-1: molecular biology and pathogenesis [2] Clinical applications ed. by Kuan-Teh Jeang |
| title_full_unstemmed | HIV-1: molecular biology and pathogenesis [2] Clinical applications ed. by Kuan-Teh Jeang |
| title_short | HIV-1: molecular biology and pathogenesis |
| title_sort | hiv 1 molecular biology and pathogenesis clinical applications |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015960912&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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