Stroke genomics: methods and reviews
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Totowa, NJ
Humana Press
2005
|
| Series: | Methods in molecular medicine
104 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | X, 351 S. Ill., graph. Darst. |
| ISBN: | 1588293335 9781588293336 |
Staff View
MARC
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| 245 | 1 | 0 | |a Stroke genomics |b methods and reviews |c ed. by Simon J. Read ... |
| 264 | 1 | |a Totowa, NJ |b Humana Press |c 2005 | |
| 300 | |a X, 351 S. |b Ill., graph. Darst. | ||
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| 650 | 4 | |a aCerebrovascular disease |a xGenetic aspects | |
| 650 | 4 | |a aCerebrovascular disease |a xMolecular aspects | |
| 650 | 4 | |a aGenomics | |
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Record in the Search Index
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| adam_text | Contents
Preface
Contributors
Part I. Introduction
1
Simon]. Read and Frank
Part
2
Stroke Models: The Search for Clinical Relevance
David Virley
3
The Stroke-Prone Spontaneously Hypertensive Rat
Hilary V. O. Carswell, Martin W. McBride, Delyth Graham,
Anna F. Dominiczak, and I. Mhairi Macrae
4
Midori A. Yenari and Robert M. Sapoisky
5
Paul Stroemer and Helen Hodges
6
Models, Gene Expression, and Mechanisms
Frank C.
7
Alex
8
Assessment by Magnetic Resonance Imaging
Toby John Roberts
Part III. Clinical Paradigms
9
Ahamad Hassan and Hugh S.
10
in Stroke
Zoltán Szolnoki.................................................................................
vii
viii Contents
Part IV. Assessing Differential Expression
11
Using Preclinical Models of Stroke
XinkangWang
12
Using Real-Time RT-PCR
David C. Harrison and Brian C. Bond
13
Paul R. Nelson, Andrew B. Coulter, and Richard}. Davis
14
From Novel Sequence Data
David Michalovich and Richard
15
to Functionally Defined Drug Target: The lnterleukin-1 Story
Stuart McRae Allan
Index
Although numerous genomic studies of stroke have examined such factors as stroke inheritance,
chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain
injury, repair, and recovery, much work to determine the precise role of gene function in human
neurological pathophysiology remains ahead. In Stroke Genomics: Methods and Reviews, leading
•experts in the field explore the pragmatic application of the tools of genomic and molecular biology
research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and
preclinical genomics, the authors relate changes in gene expression to physiological end points-
such as functional imaging paradigms-to produce a more holistic approach in which molecular
biology goes hand in hand with stroke pathophysiology. Topics of special interest include stem cell
transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery.
Readily reproducible techniques are provided, along with ancillary methods (imaging, animal
models, human genetic study design, and transgenic animal production) that can be effectively
applied to gene discovery. The protocols follow the successful Methods in Molecular Medicine1
series format, each offering step-by-step laboratory instructions, an introduction outlining the
principle behind the technique, lists of the necessary equipment and reagents, and tips on trouble¬
shooting and avoiding known pitfalls.
Cutting-edge and highly practical, Stroke Genomics: Methods and Reviews shows how to success¬
fully design, execute, and interpret preclinical and clinical molecular biological studies of stroke,
workthatwill greatly advance its understanding, as well as rapid development of the next generation
of stroke therapeutics.
Cutting-edge reviews of the clinical and
preclinical genomics of stroke researchers and research institutions
Detailed clinical and preclinical
methodologies successful results
Readily reproducible techniques to study
the molecular biology of stroke shooting and avoiding known pitfalls
Complimentary techniques that can be
applied to gene discovery
Coverage
therapy, and cytokine drag discovery
|
| adam_txt |
Contents
Preface
Contributors
Part I. Introduction
1
Simon]. Read and Frank
Part
2
Stroke Models: The Search for Clinical Relevance
David Virley
3
The Stroke-Prone Spontaneously Hypertensive Rat
Hilary V. O. Carswell, Martin W. McBride, Delyth Graham,
Anna F. Dominiczak, and I. Mhairi Macrae
4
Midori A. Yenari and Robert M. Sapoisky
5
Paul Stroemer and Helen Hodges
6
Models, Gene Expression, and Mechanisms
Frank C.
7
Alex
8
Assessment by Magnetic Resonance Imaging
Toby John Roberts
Part III. Clinical Paradigms
9
Ahamad Hassan and Hugh S.
10
in Stroke
Zoltán Szolnoki.
vii
viii Contents
Part IV. Assessing Differential Expression
11
Using Preclinical Models of Stroke
XinkangWang
12
Using Real-Time RT-PCR
David C. Harrison and Brian C. Bond
13
Paul R. Nelson, Andrew B. Coulter, and Richard}. Davis
14
From Novel Sequence Data
David Michalovich and Richard
15
to Functionally Defined Drug Target: The lnterleukin-1 Story
Stuart McRae Allan
Index
Although numerous genomic studies of stroke have examined such factors as stroke inheritance,
chromosomal loci of risk, preclinical models of stroke, and differential gene expression of brain
injury, repair, and recovery, much work to determine the precise role of gene function in human
neurological pathophysiology remains ahead. In Stroke Genomics: Methods and Reviews, leading
•experts in the field explore the pragmatic application of the tools of genomic and molecular biology
research to the treatment of stroke. Providing the reader with cutting-edge reviews of clinical and
preclinical genomics, the authors relate changes in gene expression to physiological end points-
such as functional imaging paradigms-to produce a more holistic approach in which molecular
biology goes hand in hand with stroke pathophysiology. Topics of special interest include stem cell
transplantation, gene therapy, clinical gene/gene interaction studies, and cytokine drug discovery.
Readily reproducible techniques are provided, along with ancillary methods (imaging, animal
models, human genetic study design, and transgenic animal production) that can be effectively
applied to gene discovery. The protocols follow the successful Methods in Molecular Medicine1"
series format, each offering step-by-step laboratory instructions, an introduction outlining the
principle behind the technique, lists of the necessary equipment and reagents, and tips on trouble¬
shooting and avoiding known pitfalls.
Cutting-edge and highly practical, Stroke Genomics: Methods and Reviews shows how to success¬
fully design, execute, and interpret preclinical and clinical molecular biological studies of stroke,
workthatwill greatly advance its understanding, as well as rapid development of the next generation
of stroke therapeutics.
Cutting-edge reviews of the clinical and
preclinical genomics of stroke researchers and research institutions
Detailed clinical and preclinical
methodologies successful results
Readily reproducible techniques to study
the molecular biology of stroke shooting and avoiding known pitfalls
Complimentary techniques that can be
applied to gene discovery
Coverage
therapy, and cytokine drag discovery |
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| id | DE-604.BV022526684 |
| illustrated | Illustrated |
| index_date | 2024-07-02T18:05:06Z |
| indexdate | 2024-07-09T20:59:31Z |
| institution | BVB |
| isbn | 1588293335 9781588293336 |
| language | English |
| lccn | 2004012019 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015733343 |
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| physical | X, 351 S. Ill., graph. Darst. |
| publishDate | 2005 |
| publishDateSearch | 2005 |
| publishDateSort | 2005 |
| publisher | Humana Press |
| record_format | marc |
| series | Methods in molecular medicine |
| series2 | Methods in molecular medicine |
| spelling | Stroke genomics methods and reviews ed. by Simon J. Read ... Totowa, NJ Humana Press 2005 X, 351 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in molecular medicine 104 aCerebrovascular disease xGenetic aspects aCerebrovascular disease xMolecular aspects aGenomics aCerebrovascular Accident xgenetics Molekulare Medizin (DE-588)4543844-4 gnd rswk-swf Schlaganfall (DE-588)4052588-0 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Schlaganfall (DE-588)4052588-0 s Genanalyse (DE-588)4200230-8 s Molekulare Medizin (DE-588)4543844-4 s b DE-604 Read, Simon J. Sonstige oth Erscheint auch als Online-Ausgabe 1-592-59836-6 Methods in molecular medicine 104 (DE-604)BV011334960 104 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015733343&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015733343&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Stroke genomics methods and reviews Methods in molecular medicine aCerebrovascular disease xGenetic aspects aCerebrovascular disease xMolecular aspects aGenomics aCerebrovascular Accident xgenetics Molekulare Medizin (DE-588)4543844-4 gnd Schlaganfall (DE-588)4052588-0 gnd Genanalyse (DE-588)4200230-8 gnd |
| subject_GND | (DE-588)4543844-4 (DE-588)4052588-0 (DE-588)4200230-8 |
| title | Stroke genomics methods and reviews |
| title_auth | Stroke genomics methods and reviews |
| title_exact_search | Stroke genomics methods and reviews |
| title_exact_search_txtP | Stroke genomics methods and reviews |
| title_full | Stroke genomics methods and reviews ed. by Simon J. Read ... |
| title_fullStr | Stroke genomics methods and reviews ed. by Simon J. Read ... |
| title_full_unstemmed | Stroke genomics methods and reviews ed. by Simon J. Read ... |
| title_short | Stroke genomics |
| title_sort | stroke genomics methods and reviews |
| title_sub | methods and reviews |
| topic | aCerebrovascular disease xGenetic aspects aCerebrovascular disease xMolecular aspects aGenomics aCerebrovascular Accident xgenetics Molekulare Medizin (DE-588)4543844-4 gnd Schlaganfall (DE-588)4052588-0 gnd Genanalyse (DE-588)4200230-8 gnd |
| topic_facet | aCerebrovascular disease xGenetic aspects aCerebrovascular disease xMolecular aspects aGenomics aCerebrovascular Accident xgenetics Molekulare Medizin Schlaganfall Genanalyse |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015733343&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015733343&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT readsimonj strokegenomicsmethodsandreviews |