Drug bioavailability: estimation of solubility, permeability, absorption and bioavailability
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Weinheim
Wiley-VCH
2007
|
| Edition: | 4th repr. |
| Series: | Methods and principles in medicinal chemistry
18 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Literaturangaben |
| Physical Description: | XXIV, 579 S. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Drug bioavailability |b estimation of solubility, permeability, absorption and bioavailability |c ed. by Han van de Waterbeemd ... |
| 250 | |a 4th repr. | ||
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2007 | |
| 300 | |a XXIV, 579 S. |b Ill., graph. Darst. | ||
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| 490 | 1 | |a Methods and principles in medicinal chemistry |v 18 | |
| 500 | |a Literaturangaben | ||
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Record in the Search Index
| _version_ | 1804136599013818368 |
|---|---|
| adam_text | Contents
Preface
Foreword
List of Authors
1 Studies of Membrane Permeability and Oral Absorption
Ί
Han van
Abbreviations
Symbols
1.1
1.2
1.3
1.3.1
1.4
1.5
1.5.1
1.6
1.6.1
1.7
1.7.1
1.8
1.9
1.9.1
1.9.2
1.9.3
1.9.4
1.9.5
References
2
John
Abbreviations
Symbols
vi
2.1
2.2
2.3
2.3.1
2.3.2
2.3.3
2.3.3.1 Chromatographie Hydrophobicity
2.3.3.2 Microemulsion Electrokinetic
2.3.3.3
2.3.3.4
2.3.3.5
2.4
2.4.1
2.4.2
2.4.3
2.4.4
2.4.5
2.4.6 pH
2.5
Acknowledgments
References
3
Alex Avdeef
Abbreviations
Symbols
3.1
3.2
Measurement
3.3
3.3.1
3.3.2
3.3.3
3.3.4
3.3.5
3.4
3.4.1
3.4.2
3.4.3
Solutions
3.4.4
free Solutions
3.4.5
3.4.6
Conditions
Contents
3.4.7
Retention
3.4.8
3.4.9
3.4.10
3.4.11
20%
Acknowledgments
References
4
A General Overview
Per
Abbreviations
Symbols
4.1
4.2
4.2.1
4.2.2
4.3
4.3.1
43.2
4.3.2.1
4.3.2.2
4.4
Acknowledgements
References
5
Anna-Lena Ungell and
Abbreviations
Symbols
5.1
5.2
5.3
5.3.1
5.3.2
5.3.3 2/4/
5.3.4
5.3.5
5.4
5.4.1
5.4.2
5.4.3
5.4.4
viii
5.4.5
5.4.6
5.5
5.5.1
5.5.2
5.5.3
5.5.4
5.5.5
5.5.6
5.6
References
6
Chris Logan
Abbreviations
Symbols
6.1
6.1.1
6.1.2
6.2
6.3
6.4
6.4.1 Radiolabels 139
6.4.2
6.4.2.1
6.4.2.2
6.4.3
6.5
6.5.1
6.5.2
6.5.3
6.6
6.7
6.7.1
6.7.2
6.8
6.8.1
6.8.2
6.8.3
6.9
References
7
Nielas
Abbreviations
Symbols
Contents
7.1
7.2
Metabolism (Eg and Eh) and Absolute unavailability (F) of Drugs
Administered Orally to Humans
7.3
Techniques
7.4
7.5
7.6
7.7
7.8
7.9
References 2S0
II Drug Dissolution and Solubility
8
Gladys E.
Abbreviations
Symbols
8.1
8.2
8.3
8.3.1
8.3.2
8.3.2.1
8.3.2.2
8.3.2.3
8.3.3
8.3.4
8.4
8.4.1
8.4.2
8.4.3
8.4.4
8.4.5
8.4.6
Boundary
References
9
Chris Lipinski
Abbreviations
Symbols
Introduction
9.2
χ Ι
9.3
9.4
9.5
9.6
9.6.1
9.6.2
9.7
9.8
9.8.1
9.8.2
9.9
9.9.1
9.9.2
9.9.3
9.9.4
9.10
9.11
References
10
James W. McFarland, Chau
Abbreviations
Symbols
10.1
10.2
10.3
10.4
10.5
10.6
10.7
Acknowledgments
References
III Role of Transporters and Metabolism in Oral Absorption
Π
Ho-Chul Shin, Christopher P. Landowski, Duxin Sun, and Cordon
Abbreviations
11.1
11.2
11.2.1
11.2.2
11.2.3
11.2.4
11.2.5
Contents
11.2.6
11.2.7 Vitamin Transporters 263
11.2.8
11.2.9
11.2.10
11.2.11
11.2.12
11.2.13
11.3
References
12
Hiroshi Suzuki and Yuichi Sugiyama
Abbreviations
12.1
12.2
12.2.1
12.2.1.1
12.2.1.2
Anions
12.2.2
12.2.3
12.3
12.3.1
12.3.2
(MRP2)
12.3.3
(BCRP)
12.3.4
12.4
12.5
12.5.1
Membrane
12.5.2
Canalicular Membrane
12.6
References
13
Bioavailability
Kevin Beaumont
Abbreviations
13.1
13.2
13.3
x¡¡ I
13.3.1
13.3.2
13.3.3
13.3.4
13.4
13.4.1
13.4.2
13.4.3
13.4.4
13.5
References
321
14
Charles
Abbreviations
14.1
14.2
14.3
14.4
14.4.1
14.4.2
References
333
IV Computational Approaches to Drug Absorption and Bioavailabilit/
15
Per
Abbreviations
Symbols
15.1
15.2
15.3
15.4
15.5
15.6
the Drug Discovery Process
15.7
Acknowledgement
References
16
Absorption Prediction
Ulf
Abbreviations
Contents
Symbols 358
16.1
16.2
16.2.1
16.2.2
16.3
16.3.1
16.3.2
16.3.3
16.3.4
16.4
16.4.1
16.4.2
16.4.3
16.4.4
16.4.5
16.4.6
16.4.7
16.4.8
16.4.9
16.4.10
16.4.11
16.5
16.5.1
16.5.2
16.5.3
16.5.4
References
17
Gabriele
Raimund Mannhold
Abbreviations
Symbols 406
17.1
17.2
17.3
17.3.1
17.3.2
17.3.3
17.4
Software
Acknowledgements
References
xiv
18
Michael B.
Abbreviations
Symbols
18.1
18.2
18.3
18.4
18.4.1
18.4.2
18.5
18.6
References
19
Artrn K. Mandagere and Barry Jones
Abbreviations
Symbols
19.1
19.2
19.2.1
19.2.2
19.3
19.3.1
19.3.2
19.3.3
19.3.3.1
19.3.3.2 ß-Blockers 454
19.3.3.3
19.4
Species
19.5
Pharmacokinetic Studies
19.6
References
20
Anna
Abbreviations
Symbols
20.1
20.1.1
20.1.2
20.1.3
P-gp
Contents
20.2
20.2.1
Maximum P-gp-ATPase Activation,
20.2.2
Activation
20.2.3
20.3
20.3.1
Interactions
20.3.2
20.3.3
20.3.4
Affinity
20.3.5
20.3.6
20.4 SAR
20.4.1
Rate
20.4.2
Н
20.4.3
20.5
20.5.1
References
V Drug Development Issues
21
Future
Bertil Abrahamsson
Abbreviations
Symbols
21.1
21.2
Administration
21.3
21.4
21.5
21.6
21.6.1
21.6.1.1
21.6.1.2
21.6.2
21.6.2.1
21.6.2.2
xvi
21.6.2.3
21.6.2.4
21.7
Disclaimer
References
22
Bente Steffansen,
Abbreviations
22.1
22.2
22.3
22.4
22.4.1
22.4.2
22.5
22.6
References
23
Administered Medications
Clive G.
Abbreviations and Symbols
23.1
23.2
23.3
23.3.1
23.4
23.4.1
23.4.2
23.4.3
23.4.4
23.4.5
23.4.6
23.5
23.5.1
23.5.2
23.5.3
23.6
23.7
23.8 pH 564
23.9
References
Index
|
| adam_txt |
Contents
Preface
Foreword
List of Authors
1 Studies of Membrane Permeability and Oral Absorption
Ί
Han van
Abbreviations
Symbols
1.1
1.2
1.3
1.3.1
1.4
1.5
1.5.1
1.6
1.6.1
1.7
1.7.1
1.8
1.9
1.9.1
1.9.2
1.9.3
1.9.4
1.9.5
References
2
John
Abbreviations
Symbols
vi
2.1
2.2
2.3
2.3.1
2.3.2
2.3.3
2.3.3.1 Chromatographie Hydrophobicity
2.3.3.2 Microemulsion Electrokinetic
2.3.3.3
2.3.3.4
2.3.3.5
2.4
2.4.1
2.4.2
2.4.3
2.4.4
2.4.5
2.4.6 pH
2.5
Acknowledgments
References
3
Alex Avdeef
Abbreviations
Symbols
3.1
3.2
Measurement
3.3
3.3.1
3.3.2
3.3.3
3.3.4
3.3.5
3.4
3.4.1
3.4.2
3.4.3
Solutions
3.4.4
free Solutions
3.4.5
3.4.6
Conditions
Contents
3.4.7
Retention
3.4.8
3.4.9
3.4.10
3.4.11
20%
Acknowledgments
References
4
A General Overview
Per
Abbreviations
Symbols
4.1
4.2
4.2.1
4.2.2
4.3
4.3.1
43.2
4.3.2.1
4.3.2.2
4.4
Acknowledgements
References
5
Anna-Lena Ungell and
Abbreviations
Symbols
5.1
5.2
5.3
5.3.1
5.3.2
5.3.3 2/4/
5.3.4
5.3.5
5.4
5.4.1
5.4.2
5.4.3
5.4.4
viii
5.4.5
5.4.6
5.5
5.5.1
5.5.2
5.5.3
5.5.4
5.5.5
5.5.6
5.6
References
6
Chris Logan
Abbreviations
Symbols
6.1
6.1.1
6.1.2
6.2
6.3
6.4
6.4.1 Radiolabels 139
6.4.2
6.4.2.1
6.4.2.2
6.4.3
6.5
6.5.1
6.5.2
6.5.3
6.6
6.7
6.7.1
6.7.2
6.8
6.8.1
6.8.2
6.8.3
6.9
References
7
Nielas
Abbreviations
Symbols
Contents
7.1
7.2
Metabolism (Eg and Eh) and Absolute unavailability (F) of Drugs
Administered Orally to Humans
7.3
Techniques
7.4
7.5
7.6
7.7
7.8
7.9
References 2S0
II Drug Dissolution and Solubility
8
Gladys E.
Abbreviations
Symbols
8.1
8.2
8.3
8.3.1
8.3.2
8.3.2.1
8.3.2.2
8.3.2.3
8.3.3
8.3.4
8.4
8.4.1
8.4.2
8.4.3
8.4.4
8.4.5
8.4.6
Boundary
References
9
Chris Lipinski
Abbreviations
Symbols
Introduction
9.2
χ Ι
9.3
9.4
9.5
9.6
9.6.1
9.6.2
9.7
9.8
9.8.1
9.8.2
9.9
9.9.1
9.9.2
9.9.3
9.9.4
9.10
9.11
References
10
James W. McFarland, Chau
Abbreviations
Symbols
10.1
10.2
10.3
10.4
10.5
10.6
10.7
Acknowledgments
References
III Role of Transporters and Metabolism in Oral Absorption
Π
Ho-Chul Shin, Christopher P. Landowski, Duxin Sun, and Cordon
Abbreviations
11.1
11.2
11.2.1
11.2.2
11.2.3
11.2.4
11.2.5
Contents
11.2.6
11.2.7 Vitamin Transporters 263
11.2.8
11.2.9
11.2.10
11.2.11
11.2.12
11.2.13
11.3
References
12
Hiroshi Suzuki and Yuichi Sugiyama
Abbreviations
12.1
12.2
12.2.1
12.2.1.1
12.2.1.2
Anions
12.2.2
12.2.3
12.3
12.3.1
12.3.2
(MRP2)
12.3.3
(BCRP)
12.3.4
12.4
12.5
12.5.1
Membrane
12.5.2
Canalicular Membrane
12.6
References
13
Bioavailability
Kevin Beaumont
Abbreviations
13.1
13.2
13.3
x¡¡ I
13.3.1
13.3.2
13.3.3
13.3.4
13.4
13.4.1
13.4.2
13.4.3
13.4.4
13.5
References
321
14
Charles
Abbreviations
14.1
14.2
14.3
14.4
14.4.1
14.4.2
References
333
IV Computational Approaches to Drug Absorption and Bioavailabilit/
15
Per
Abbreviations
Symbols
15.1
15.2
15.3
15.4
15.5
15.6
the Drug Discovery Process
15.7
Acknowledgement
References
16
Absorption Prediction
Ulf
Abbreviations
Contents
Symbols 358
16.1
16.2
16.2.1
16.2.2
16.3
16.3.1
16.3.2
16.3.3
16.3.4
16.4
16.4.1
16.4.2
16.4.3
16.4.4
16.4.5
16.4.6
16.4.7
16.4.8
16.4.9
16.4.10
16.4.11
16.5
16.5.1
16.5.2
16.5.3
16.5.4
References
17
Gabriele
Raimund Mannhold
Abbreviations
Symbols 406
17.1
17.2
17.3
17.3.1
17.3.2
17.3.3
17.4
Software
Acknowledgements
References
xiv
18
Michael B.
Abbreviations
Symbols
18.1
18.2
18.3
18.4
18.4.1
18.4.2
18.5
18.6
References
19
Artrn K. Mandagere and Barry Jones
Abbreviations
Symbols
19.1
19.2
19.2.1
19.2.2
19.3
19.3.1
19.3.2
19.3.3
19.3.3.1
19.3.3.2 ß-Blockers 454
19.3.3.3
19.4
Species
19.5
Pharmacokinetic Studies
19.6
References
20
Anna
Abbreviations
Symbols
20.1
20.1.1
20.1.2
20.1.3
P-gp
Contents
20.2
20.2.1
Maximum P-gp-ATPase Activation,
20.2.2
Activation
20.2.3
20.3
20.3.1
Interactions
20.3.2
20.3.3
20.3.4
Affinity
20.3.5
20.3.6
20.4 SAR
20.4.1
Rate
20.4.2
Н
20.4.3
20.5
20.5.1
References
V Drug Development Issues
21
Future
Bertil Abrahamsson
Abbreviations
Symbols
21.1
21.2
Administration
21.3
21.4
21.5
21.6
21.6.1
21.6.1.1
21.6.1.2
21.6.2
21.6.2.1
21.6.2.2
xvi
21.6.2.3
21.6.2.4
21.7
Disclaimer
References
22
Bente Steffansen,
Abbreviations
22.1
22.2
22.3
22.4
22.4.1
22.4.2
22.5
22.6
References
23
Administered Medications
Clive G.
Abbreviations and Symbols
23.1
23.2
23.3
23.3.1
23.4
23.4.1
23.4.2
23.4.3
23.4.4
23.4.5
23.4.6
23.5
23.5.1
23.5.2
23.5.3
23.6
23.7
23.8 pH 564
23.9
References
Index |
| any_adam_object | 1 |
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| author_GND | (DE-588)11443963X |
| building | Verbundindex |
| bvnumber | BV022500236 |
| classification_rvk | VX 8550 |
| ctrlnum | (OCoLC)634564479 (DE-599)BVBBV022500236 |
| discipline | Chemie / Pharmazie |
| discipline_str_mv | Chemie / Pharmazie |
| edition | 4th repr. |
| format | Book |
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| genre | 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV022500236 |
| illustrated | Illustrated |
| index_date | 2024-07-02T17:55:11Z |
| indexdate | 2024-07-09T20:58:57Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-015707303 |
| oclc_num | 634564479 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXIV, 579 S. Ill., graph. Darst. |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Wiley-VCH |
| record_format | marc |
| series | Methods and principles in medicinal chemistry |
| series2 | Methods and principles in medicinal chemistry |
| spelling | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability ed. by Han van de Waterbeemd ... 4th repr. Weinheim Wiley-VCH 2007 XXIV, 579 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods and principles in medicinal chemistry 18 Literaturangaben Bioverfügbarkeit (DE-588)4145660-9 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf Arzneimittel (DE-588)4003115-9 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Pharmazeutische Chemie (DE-588)4132158-3 s Arzneimittel (DE-588)4003115-9 s Bioverfügbarkeit (DE-588)4145660-9 s DE-604 Waterbeemd, Han van de 1954- Sonstige (DE-588)11443963X oth Methods and principles in medicinal chemistry 18 (DE-604)BV035418617 18 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015707303&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability Methods and principles in medicinal chemistry Bioverfügbarkeit (DE-588)4145660-9 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Arzneimittel (DE-588)4003115-9 gnd |
| subject_GND | (DE-588)4145660-9 (DE-588)4132158-3 (DE-588)4003115-9 (DE-588)4143413-4 |
| title | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability |
| title_auth | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability |
| title_exact_search | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability |
| title_exact_search_txtP | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability |
| title_full | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability ed. by Han van de Waterbeemd ... |
| title_fullStr | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability ed. by Han van de Waterbeemd ... |
| title_full_unstemmed | Drug bioavailability estimation of solubility, permeability, absorption and bioavailability ed. by Han van de Waterbeemd ... |
| title_short | Drug bioavailability |
| title_sort | drug bioavailability estimation of solubility permeability absorption and bioavailability |
| title_sub | estimation of solubility, permeability, absorption and bioavailability |
| topic | Bioverfügbarkeit (DE-588)4145660-9 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd Arzneimittel (DE-588)4003115-9 gnd |
| topic_facet | Bioverfügbarkeit Pharmazeutische Chemie Arzneimittel Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015707303&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV035418617 |
| work_keys_str_mv | AT waterbeemdhanvande drugbioavailabilityestimationofsolubilitypermeabilityabsorptionandbioavailability |