Advances in multiple sclerosis and experimental demyelinating diseases:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2008
|
| Series: | Current topics in microbiology and immunology
318 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | XIV, 360 S. Ill., graph. Darst. |
| ISBN: | 9783540736769 354073676X |
Staff View
MARC
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| 245 | 1 | 0 | |a Advances in multiple sclerosis and experimental demyelinating diseases |c Moses Rodriguez, ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
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| 650 | 4 | |a Multiple sclerosis |x Etiology | |
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Record in the Search Index
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| adam_text | Contents
Benign
Multiple
Sclerosis: A Distinct Clinical Entity
with Therapeutic Implications
.................................... 1
SJ.
Pittock and M. Rodriguez
Pathological Heterogeneity of Idiopathic Central Nervous System
Inflammatory Demyelinating Disorders
............................ 19
С
Lucchinetti
Multiple Sclerosis Genetics
....................................... 45
J.P. McElroy and J.R. Oksenberg
Imaging of Remyelination and
Neuronal
Health
..................... 73
B J.
Erickson
Immunological Aspects of Axon Injury in Multiple Sclerosis
........... 93
C.L. Howe
The Multiple Sclerosis
Degradóme:
Enzymatic Cascades
in Development and Progression of Central
Nervous System Inflammatory Disease
............................. 133
I.A.
Scarisbrick
Genetic Analysis of CNS Remyelination
............................ 177
A.J. Bieber
Remyelination in Experimental Models
of Toxin-Induced Demyelination
.................................. 193
W.F. Blakemore and RJ.M. Franklin
Remyelination-Promoting Human IgMs:
Developing a Therapeutic Reagent
for Demyelinating Disease
........................................213
A.E. Warrington and M. Rodriguez
xii Contents
Neuroimaging
of
Demyelination and Remyelination Models........... 241
I. Pirko and A J.
Johnson
Hormonal
Influences in
Multiple
Sclerosis
..........................267
E.A. Shuster
Statins and
Demyelination.......................................313
M.S.
Weber and S.S. Zamvil
Role of Uric Acid in Multiple Sclerosis
.............................325
S. Spitsin and H. Koprowski
Neuromyelitis
Optica:
Clinical Syndrome
and the NMO-IgG Autoantibody Marker
........................... 343
B.G.
Weinshenker
and
D.M.
Wingerchuk
Index
......................................................... 357
There is a need for a paradigm shift in our thinking about the pathogenesis of
multiple sclerosis.
Challenging
Charcoťs
hypothesis that inflammatory response is the primary
contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold
look at the causes and possible treatments of MS.
Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore
viruses, toxins and genetic defects as possible culprits. They present novel
methods to interrupt and reverse demyelination. This book examines the cor¬
relation between axonal loss and clinical deficits, including the implied role
of the CD8+
Τ
cell and perform. It assesses proteases, specifically, kallikrein
6,
which are strongly associated with active demyelination. By directing natural
autoantibodies against oligodendrocytes that demonstrate remyelination in ani¬
mal models, the authors envision clinical trials for remyelination enhancement.
As internationally recognized specialists in a wide range of MS disciplines, the
authors explore genetic tools for identifying patients who are most likely to
experience spontaneous remyelination. Epidemiology studies offer additional
avenues of treatment. Examples include uric acid, statin drugs, estrogen and
progesterone.
MS affects nearly
400,000
people in the United States, many of whom are bet¬
ween
18
and
40
years of age. With their novel, multifaceted approach to basic
science
-
and their applications in understanding cause and treatment
-
the
authors offer help to clinicians and hope to patients.
|
| adam_txt |
Contents
Benign
Multiple
Sclerosis: A Distinct Clinical Entity
with Therapeutic Implications
. 1
SJ.
Pittock and M. Rodriguez
Pathological Heterogeneity of Idiopathic Central Nervous System
Inflammatory Demyelinating Disorders
. 19
С
Lucchinetti
Multiple Sclerosis Genetics
. 45
J.P. McElroy and J.R. Oksenberg
Imaging of Remyelination and
Neuronal
Health
. 73
B J.
Erickson
Immunological Aspects of Axon Injury in Multiple Sclerosis
. 93
C.L. Howe
The Multiple Sclerosis
Degradóme:
Enzymatic Cascades
in Development and Progression of Central
Nervous System Inflammatory Disease
. 133
I.A.
Scarisbrick
Genetic Analysis of CNS Remyelination
. 177
A.J. Bieber
Remyelination in Experimental Models
of Toxin-Induced Demyelination
. 193
W.F. Blakemore and RJ.M. Franklin
Remyelination-Promoting Human IgMs:
Developing a Therapeutic Reagent
for Demyelinating Disease
.213
A.E. Warrington and M. Rodriguez
xii Contents
Neuroimaging
of
Demyelination and Remyelination Models. 241
I. Pirko and A J.
Johnson
Hormonal
Influences in
Multiple
Sclerosis
.267
E.A. Shuster
Statins and
Demyelination.313
M.S.
Weber and S.S. Zamvil
Role of Uric Acid in Multiple Sclerosis
.325
S. Spitsin and H. Koprowski
Neuromyelitis
Optica:
Clinical Syndrome
and the NMO-IgG Autoantibody Marker
. 343
B.G.
Weinshenker
and
D.M.
Wingerchuk
Index
. 357
"There is a need for a paradigm shift in our thinking about the pathogenesis of
multiple sclerosis."
Challenging
Charcoťs
hypothesis that inflammatory response is the primary
contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold
look at the causes and possible treatments of MS.
Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore
viruses, toxins and genetic defects as possible culprits. They present novel
methods to interrupt and reverse demyelination. This book examines the cor¬
relation between axonal loss and clinical deficits, including the implied role
of the CD8+
Τ
cell and perform. It assesses proteases, specifically, kallikrein
6,
which are strongly associated with active demyelination. By directing natural
autoantibodies against oligodendrocytes that demonstrate remyelination in ani¬
mal models, the authors envision clinical trials for remyelination enhancement.
As internationally recognized specialists in a wide range of MS disciplines, the
authors explore genetic tools for identifying patients who are most likely to
experience spontaneous remyelination. Epidemiology studies offer additional
avenues of treatment. Examples include uric acid, statin drugs, estrogen and
progesterone.
MS affects nearly
400,000
people in the United States, many of whom are bet¬
ween
18
and
40
years of age. With their novel, multifaceted approach to basic
science
-
and their applications in understanding cause and treatment
-
the
authors offer help to clinicians and hope to patients. |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
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| index_date | 2024-07-02T17:54:34Z |
| indexdate | 2024-07-09T20:58:55Z |
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| isbn | 9783540736769 354073676X |
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| spelling | Advances in multiple sclerosis and experimental demyelinating diseases Moses Rodriguez, ed. Berlin [u.a.] Springer 2008 XIV, 360 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in microbiology and immunology 318 Demyelinating Diseases physiopathology Demyelination Multiple Sclerosis physiopathology Multiple sclerosis Etiology Myelination Tiermodell (DE-588)4140660-6 gnd rswk-swf Multiple Sklerose (DE-588)4040693-3 gnd rswk-swf Entmarkungskrankheit (DE-588)4214431-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Multiple Sklerose (DE-588)4040693-3 s DE-604 Entmarkungskrankheit (DE-588)4214431-0 s Tiermodell (DE-588)4140660-6 s Rodriguez, Moses Sonstige oth Current topics in microbiology and immunology 318 (DE-604)BV002527248 318 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015705618&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015705618&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Advances in multiple sclerosis and experimental demyelinating diseases Current topics in microbiology and immunology Demyelinating Diseases physiopathology Demyelination Multiple Sclerosis physiopathology Multiple sclerosis Etiology Myelination Tiermodell (DE-588)4140660-6 gnd Multiple Sklerose (DE-588)4040693-3 gnd Entmarkungskrankheit (DE-588)4214431-0 gnd |
| subject_GND | (DE-588)4140660-6 (DE-588)4040693-3 (DE-588)4214431-0 (DE-588)4143413-4 |
| title | Advances in multiple sclerosis and experimental demyelinating diseases |
| title_auth | Advances in multiple sclerosis and experimental demyelinating diseases |
| title_exact_search | Advances in multiple sclerosis and experimental demyelinating diseases |
| title_exact_search_txtP | Advances in multiple sclerosis and experimental demyelinating diseases |
| title_full | Advances in multiple sclerosis and experimental demyelinating diseases Moses Rodriguez, ed. |
| title_fullStr | Advances in multiple sclerosis and experimental demyelinating diseases Moses Rodriguez, ed. |
| title_full_unstemmed | Advances in multiple sclerosis and experimental demyelinating diseases Moses Rodriguez, ed. |
| title_short | Advances in multiple sclerosis and experimental demyelinating diseases |
| title_sort | advances in multiple sclerosis and experimental demyelinating diseases |
| topic | Demyelinating Diseases physiopathology Demyelination Multiple Sclerosis physiopathology Multiple sclerosis Etiology Myelination Tiermodell (DE-588)4140660-6 gnd Multiple Sklerose (DE-588)4040693-3 gnd Entmarkungskrankheit (DE-588)4214431-0 gnd |
| topic_facet | Demyelinating Diseases physiopathology Demyelination Multiple Sclerosis physiopathology Multiple sclerosis Etiology Myelination Tiermodell Multiple Sklerose Entmarkungskrankheit Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015705618&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015705618&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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| work_keys_str_mv | AT rodriguezmoses advancesinmultiplesclerosisandexperimentaldemyelinatingdiseases |