Human antibody therapeutics for viral disease:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2008
|
| Schriftenreihe: | Current topics in microbiology and immunology
317 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | XI, 188 S. Ill., graph. Darst. |
| ISBN: | 9783540721444 9783540721468 |
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| 245 | 1 | 0 | |a Human antibody therapeutics for viral disease |c Scott K. Dessain, ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
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| 650 | 4 | |a Immunoglobulins |x Therapeutic use | |
| 650 | 4 | |a Virus Diseases |x therapy | |
| 650 | 4 | |a Virus diseases |x Chemotherapy | |
| 650 | 4 | |a Virus diseases |x Treatment | |
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Datensatz im Suchindex
| _version_ | 1804136596564344832 |
|---|---|
| adam_text | The articles in this volume have been selected to demonstrate the progress in
the development of human antibody therapeutics for viral disease. Keck
et al.
review the nature of the immune response to the Hepatitis
С
virus and the
details of viral neutralization by antibodies, providing a conceptual model for
the clinical use of HCV-specific antibodies. Huber
et al.
summarize the initial
clinical experiences with antibody therapeutics for Human Immunodeficiency
Virus, which can be targeted to either the
HIV
virion or to host cell proteins. A
discussion of the breadth immune strategies that is required to control human
rabies is provided by Nagarajan
et al,
with a particular focus on India and other
countries in which rabies is endemic. The development of pavilizumab for
RSV
prophylaxis is reviewed in Wu
et al., in
addition to results of antibody optimi¬
zation studies that provide surprising insights and have broad general implica¬
tions for anti-viral antibody engineering. Mehlhop and Diamond explicate the
biology of West Nile Virus as a general model for flaviviruses, while using their
cloned antibodies as a springboard to consider the mechanisms of WNV neu¬
tralization. The volume concludes with a description of methods to clone
human antibodies in their native configurations, which access a class of anti¬
bodies that differ from those obtained by
recombinant
DNA
or transgenic
mouse methods.
The articles in this volume are definitive and comprehensive reviews written by
experts who have sought to define the principles of viral neutralization by
human antibodies. They explore and anticipate the obstacles and opportunities
that will be encountered as the power of human antibodies is harnessed to
address the vast, un-met need for effective anti-viral therapeutics.
Contents
Preface
........................................................
v
Contributors
................................................... ix
Therapeutic Control of Hepatitis
С
Virus:
The Role of Neutralizing Monoclonal Antibodies
..................... 1
Z.Y. Keck, K. Machida,
M.M.C.
Lai, J.K. Ball, A.H.
Patel,
and S.K.H. Foung
Antibodies for
HIV
Treatment and Prevention:
Window of Opportunity?
........................................ 39
M. Huber, W.C. Olson, and A. Trkola
Human Monoclonal Antibody and Vaccine Approaches
to Prevent Human Rabies
........................................ 67
T. Nagarajan, Charles E. Rupprecht, Scott K. Dessain,
P.N. Rangarajan, D. Thiagarajan, and V.A. Srinivasan
Immunoprophylaxis of
RSV
Infection: Advancing
from RSV-IGIV to Palivizumab and Motavizumab
................... 103
H. Wu,
D.S.
Pfarr, G.A. Losonsky, and
P.A.
Kiener
The Molecular Basis of Antibody Protection Against
West Nile Virus
................................................ 125
E. Mehlhop and M.S. Diamond
Exploring the Native Human Antibody Repertoire
to Create Antiviral Therapeutics
.................................. 155
S.K. Dessain, S.P. Adekar, and J.D. Berry
Index
......................................................... 185
|
| adam_txt |
The articles in this volume have been selected to demonstrate the progress in
the development of human antibody therapeutics for viral disease. Keck
et al.
review the nature of the immune response to the Hepatitis
С
virus and the
details of viral neutralization by antibodies, providing a conceptual model for
the clinical use of HCV-specific antibodies. Huber
et al.
summarize the initial
clinical experiences with antibody therapeutics for Human Immunodeficiency
Virus, which can be targeted to either the
HIV
virion or to host cell proteins. A
discussion of the breadth immune strategies that is required to control human
rabies is provided by Nagarajan
et al,
with a particular focus on India and other
countries in which rabies is endemic. The development of pavilizumab for
RSV
prophylaxis is reviewed in Wu
et al., in
addition to results of antibody optimi¬
zation studies that provide surprising insights and have broad general implica¬
tions for anti-viral antibody engineering. Mehlhop and Diamond explicate the
biology of West Nile Virus as a general model for flaviviruses, while using their
cloned antibodies as a springboard to consider the mechanisms of WNV neu¬
tralization. The volume concludes with a description of methods to clone
human antibodies in their native configurations, which access a class of anti¬
bodies that differ from those obtained by
recombinant
DNA
or transgenic
mouse methods.
The articles in this volume are definitive and comprehensive reviews written by
experts who have sought to define the principles of viral neutralization by
human antibodies. They explore and anticipate the obstacles and opportunities
that will be encountered as the power of human antibodies is harnessed to
address the vast, un-met need for effective anti-viral therapeutics.
Contents
Preface
.
v
Contributors
. ix
Therapeutic Control of Hepatitis
С
Virus:
The Role of Neutralizing Monoclonal Antibodies
. 1
Z.Y. Keck, K. Machida,
M.M.C.
Lai, J.K. Ball, A.H.
Patel,
and S.K.H. Foung
Antibodies for
HIV
Treatment and Prevention:
Window of Opportunity?
. 39
M. Huber, W.C. Olson, and A. Trkola
Human Monoclonal Antibody and Vaccine Approaches
to Prevent Human Rabies
. 67
T. Nagarajan, Charles E. Rupprecht, Scott K. Dessain,
P.N. Rangarajan, D. Thiagarajan, and V.A. Srinivasan
Immunoprophylaxis of
RSV
Infection: Advancing
from RSV-IGIV to Palivizumab and Motavizumab
. 103
H. Wu,
D.S.
Pfarr, G.A. Losonsky, and
P.A.
Kiener
The Molecular Basis of Antibody Protection Against
West Nile Virus
. 125
E. Mehlhop and M.S. Diamond
Exploring the Native Human Antibody Repertoire
to Create Antiviral Therapeutics
. 155
S.K. Dessain, S.P. Adekar, and J.D. Berry
Index
. 185 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
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| spelling | Human antibody therapeutics for viral disease Scott K. Dessain, ed. Berlin [u.a.] Springer 2008 XI, 188 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in microbiology and immunology 317 Antibodies therapeutic use Immunoglobulins Immunoglobulins Therapeutic use Virus Diseases therapy Virus diseases Chemotherapy Virus diseases Treatment Immuntherapie (DE-588)4026640-0 gnd rswk-swf Antikörper (DE-588)4002290-0 gnd rswk-swf Viruskrankheit (DE-588)4063605-7 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Viruskrankheit (DE-588)4063605-7 s Antikörper (DE-588)4002290-0 s Immuntherapie (DE-588)4026640-0 s DE-604 Dessain, Scott K. Sonstige oth Current topics in microbiology and immunology 317 (DE-604)BV002527248 317 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015705585&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015705585&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Human antibody therapeutics for viral disease Current topics in microbiology and immunology Antibodies therapeutic use Immunoglobulins Immunoglobulins Therapeutic use Virus Diseases therapy Virus diseases Chemotherapy Virus diseases Treatment Immuntherapie (DE-588)4026640-0 gnd Antikörper (DE-588)4002290-0 gnd Viruskrankheit (DE-588)4063605-7 gnd |
| subject_GND | (DE-588)4026640-0 (DE-588)4002290-0 (DE-588)4063605-7 (DE-588)4143413-4 |
| title | Human antibody therapeutics for viral disease |
| title_auth | Human antibody therapeutics for viral disease |
| title_exact_search | Human antibody therapeutics for viral disease |
| title_exact_search_txtP | Human antibody therapeutics for viral disease |
| title_full | Human antibody therapeutics for viral disease Scott K. Dessain, ed. |
| title_fullStr | Human antibody therapeutics for viral disease Scott K. Dessain, ed. |
| title_full_unstemmed | Human antibody therapeutics for viral disease Scott K. Dessain, ed. |
| title_short | Human antibody therapeutics for viral disease |
| title_sort | human antibody therapeutics for viral disease |
| topic | Antibodies therapeutic use Immunoglobulins Immunoglobulins Therapeutic use Virus Diseases therapy Virus diseases Chemotherapy Virus diseases Treatment Immuntherapie (DE-588)4026640-0 gnd Antikörper (DE-588)4002290-0 gnd Viruskrankheit (DE-588)4063605-7 gnd |
| topic_facet | Antibodies therapeutic use Immunoglobulins Immunoglobulins Therapeutic use Virus Diseases therapy Virus diseases Chemotherapy Virus diseases Treatment Immuntherapie Antikörper Viruskrankheit Aufsatzsammlung |
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