Fas signaling:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
New York, NY
Springer
2006
|
| Series: | Medical Intelligence Unit
|
| Subjects: | |
| Online Access: | UBR01 Volltext Inhaltsverzeichnis |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 9780387321721 9780387345734 |
| DOI: | 10.1007/0-387-34573-6 |
Staff View
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Record in the Search Index
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| adam_text | ¦ CONTENTS .I
Preface ix
1. FasL and Fas: Typical Members of the TNF Ligand
and Receptor Family 1
Anja Krippner Heidenreich and Peter Scheurich
The TNF Receptor and TNF Ligand Superfamilies 1
Identification of Fas and Its Ligand 2
The Membrane Receptor Fas 2
Fas Expression 5
The Fas Ligand 5
Membrane Bound and Soluble FasL 6
Receptor Ligand Complexes 7
Fas Signaling 8
2. FasL Independent Activation of Fas 13
Faustino Mollinedo and Consuelo Gajate
Fas Death Receptor Functions through Oligomerization
and a Cascade of Protein Protein Interactions 14
Fas Oligomerization without Interaction with Its Ligand FasL 15
Fas Mediated Apoptosis Does Not Require die Participation
of FasL 17
FasL Independent Translocation and Capping of Fas
into Membrane Rafts 18
FasL Independent Activation of Fas by Unrelated Agents 19
How Are Fas Clusters Formed from Internal Signals? 21
3. Role of Ceramide in CD95 Signaling 28
Volker Teichgraber, Gabriele Hessler and Erich Gulbins
Membrane Rafts 28
Ceramide Enriched Membrane Platforms 29
Function of Ceramide Enriched Membrane Platforms
for CD95 Signaling 30
Mechanisms of Receptor Clustering 33
Ceramide Enriched Membrane Platforms
as General Signaling Motif 34
4. Regulation of Fas Signaling by FLIP Proteins 38
Margot Thome
What Are the Structural Features of FLIP Family Proteins
That Contribute to Their Anti Apoptotic Function? 39
What Is the Molecular Function of Viral and Cellular FLIP? 39
What Is the Biological Function of the FLIP Proteins? 43
Is Altered FLIP Expression Linked to Pathologies? 45
5. Fas Induced Necrosis 51
Tom Vanden Berghe, Nele Festjens, Michael Kalai, Xavier Saelens
and Peter Vandenabeele
Three Types of Programmed Cell Death 52
Fas Is an Important Regulator of Cell Death 52
Enzymatic Systems Involved in the Execution of Necrotic Events 60
6. Fas—More Than an Apoptosis Inducer 69
Harald Wajant
Fas Induced NFkB Activation 70
Fas and JNK Activation 81
FasL and Fas Stimulate Proliferation and Differentiation 83
Fas and FasL in Inflammation 85
Fas Induced ERK Activation 86
7. Retrograde Fas Ligand Signaling 97
Andreas Linkermann, Jing Qian and Ottmar Janssen
Fas Ligand as a Costimulatory Molecule 97
Fas Ligand as an Accessory Molecule in T Cell Development 98
The Molecular Basis for Retrograde Fas Ligand Signaling 99
Retrograde Signaling in Other TNF Family Members 100
8. FasL and Fas in liver Homeostasis and Hepatic Injuries 103
Maria Eugenia Guicciardi and Gregory J. Gores
The Fas/FasL System in Liver Homeostasis and Regeneration 105
The Fas/FasL System in Liver Pathophysiology 106
Fas and the Development of Liver Fibrosis and Cirrhosis 112
9. Fas Activation, Development and Homeostasis of T Cells 118
Georg Hacker
Expression of Fas on T Cells and Susceptibility
to Fas Induced Apoptosis 118
Lpr and Gld Mice 118
Development and Selection of T Cells 120
Involvement of Fas Signalling in the Activation of T Cells 120
Role of Fas for T Cell Homeostasis 121
Activation Induced Cell Death 121
Role of Fas in the Accumulation of Unusual T Cells 123
Fas and Immune Privilege 12^
FasL as an Effector Molecule of Cytotoxic T Cells 124
10. The FasL Fas System in Disease and Therapy 128
Harald Wajant and Frank Henkler
Physiological Role of the FasL Fas System 128
Pathophysiology of FasL and Fas 133
Therapeutic Potential of FasL and Fas Neutralizing Reagents
and Fas Agonists 134
11. Tools for Activation and Neutralization of Fas Signaling 145
Pascal Schneider
Fas Agonists 146
Inhibitors of the Fas FasL System 150
Index 157
|
| adam_txt |
¦ CONTENTS .I
Preface ix
1. FasL and Fas: Typical Members of the TNF Ligand
and Receptor Family 1
Anja Krippner Heidenreich and Peter Scheurich
The TNF Receptor and TNF Ligand Superfamilies 1
Identification of Fas and Its Ligand 2
The Membrane Receptor Fas 2
Fas Expression 5
The Fas Ligand 5
Membrane Bound and Soluble FasL 6
Receptor Ligand Complexes 7
Fas Signaling 8
2. FasL Independent Activation of Fas 13
Faustino Mollinedo and Consuelo Gajate
Fas Death Receptor Functions through Oligomerization
and a Cascade of Protein Protein Interactions 14
Fas Oligomerization without Interaction with Its Ligand FasL 15
Fas Mediated Apoptosis Does Not Require die Participation
of FasL 17
FasL Independent Translocation and Capping of Fas
into Membrane Rafts 18
FasL Independent Activation of Fas by Unrelated Agents 19
How Are Fas Clusters Formed from Internal Signals? 21
3. Role of Ceramide in CD95 Signaling 28
Volker Teichgraber, Gabriele Hessler and Erich Gulbins
Membrane Rafts 28
Ceramide Enriched Membrane Platforms 29
Function of Ceramide Enriched Membrane Platforms
for CD95 Signaling 30
Mechanisms of Receptor Clustering 33
Ceramide Enriched Membrane Platforms
as General Signaling Motif 34
4. Regulation of Fas Signaling by FLIP Proteins 38
Margot Thome
What Are the Structural Features of FLIP Family Proteins
That Contribute to Their Anti Apoptotic Function? 39
What Is the Molecular Function of Viral and Cellular FLIP? 39
What Is the Biological Function of the FLIP Proteins? 43
Is Altered FLIP Expression Linked to Pathologies? 45
5. Fas Induced Necrosis 51
Tom Vanden Berghe, Nele Festjens, Michael Kalai, Xavier Saelens
and Peter Vandenabeele
Three Types of Programmed Cell Death 52
Fas Is an Important Regulator of Cell Death 52
Enzymatic Systems Involved in the Execution of Necrotic Events 60
6. Fas—More Than an Apoptosis Inducer 69
Harald Wajant
Fas Induced NFkB Activation 70
Fas and JNK Activation 81
FasL and Fas Stimulate Proliferation and Differentiation 83
Fas and FasL in Inflammation 85
Fas Induced ERK Activation 86
7. Retrograde Fas Ligand Signaling 97
Andreas Linkermann, Jing Qian and Ottmar Janssen
Fas Ligand as a Costimulatory Molecule 97
Fas Ligand as an Accessory Molecule in T Cell Development 98
The Molecular Basis for Retrograde Fas Ligand Signaling 99
Retrograde Signaling in Other TNF Family Members 100
8. FasL and Fas in liver Homeostasis and Hepatic Injuries 103
Maria Eugenia Guicciardi and Gregory J. Gores
The Fas/FasL System in Liver Homeostasis and Regeneration 105
The Fas/FasL System in Liver Pathophysiology 106
Fas and the Development of Liver Fibrosis and Cirrhosis 112
9. Fas Activation, Development and Homeostasis of T Cells 118
Georg Hacker
Expression of Fas on T Cells and Susceptibility
to Fas Induced Apoptosis 118
Lpr and Gld Mice 118
Development and Selection of T Cells 120
Involvement of Fas Signalling in the Activation of T Cells 120
Role of Fas for T Cell Homeostasis 121
Activation Induced Cell Death 121
Role of Fas in the Accumulation of Unusual T Cells 123
Fas and 'Immune Privilege' 12^
FasL as an Effector Molecule of Cytotoxic T Cells 124
10. The FasL Fas System in Disease and Therapy 128
Harald Wajant and Frank Henkler
Physiological Role of the FasL Fas System 128
Pathophysiology of FasL and Fas 133
Therapeutic Potential of FasL and Fas Neutralizing Reagents
and Fas Agonists 134
11. Tools for Activation and Neutralization of Fas Signaling 145
Pascal Schneider
Fas Agonists 146
Inhibitors of the Fas FasL System 150
Index 157 |
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| spelling | Fas signaling Harald Wajant New York, NY Springer 2006 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Medical Intelligence Unit Apoptosis (DE-588)4291096-1 gnd rswk-swf Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Apoptosis (DE-588)4291096-1 s Tumor-Nekrose-Faktor (DE-588)4202932-6 s Signaltransduktion (DE-588)4318717-1 s b DE-604 Wajant, Harald 1965- Sonstige (DE-588)12879979X oth Erscheint auch als Druck-Ausgabe, Hardcover 0-387-32172-1 https://doi.org/10.1007/0-387-34573-6 Verlag Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015694300&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fas signaling Apoptosis (DE-588)4291096-1 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| subject_GND | (DE-588)4291096-1 (DE-588)4202932-6 (DE-588)4318717-1 |
| title | Fas signaling |
| title_auth | Fas signaling |
| title_exact_search | Fas signaling |
| title_exact_search_txtP | Fas signaling |
| title_full | Fas signaling Harald Wajant |
| title_fullStr | Fas signaling Harald Wajant |
| title_full_unstemmed | Fas signaling Harald Wajant |
| title_short | Fas signaling |
| title_sort | fas signaling |
| topic | Apoptosis (DE-588)4291096-1 gnd Tumor-Nekrose-Faktor (DE-588)4202932-6 gnd Signaltransduktion (DE-588)4318717-1 gnd |
| topic_facet | Apoptosis Tumor-Nekrose-Faktor Signaltransduktion |
| url | https://doi.org/10.1007/0-387-34573-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015694300&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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