Chemistry and medicines: an introductory text
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge
RSC Pub.
2006
|
| Subjects: | |
| Online Access: | Table of contents only Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references (p. 142-143) and index |
| Physical Description: | x, 156 p. ill. 24 cm |
| ISBN: | 0854046453 9780854046454 |
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Record in the Search Index
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| adam_text | CHEMISTRY AND MEDICINES AN INTRODUCTORY TEXT JAMES R HANSON DEPARTMENT
OF CHEMISTRY, UNIVERSITY OF SUSSEX, BRIGHTON, UK RSC PUBLISHING CONTENTS
CHAPTER 1 INTRODUCTION 1 1.1 AIMS 1 1.2 THE CLASSIFICATION OF DRUGS 1
1.3 TARGETS FOR THE MEDICINAL CHEMIST 2 1.3.1 HORMONES AS TARGETS 2
1.3.2 CELLULAR STRUCTURES AS TARGETS 4 1.4 THE STAGES IN THE DEVELOPMENT
OF A DRUG 5 1.5 THE SYNTHESIS OF A DRUG 6 1.6 THE HISTORY OF MEDICINAL
CHEMISTRY 8 CHAPTER 2 GENERAL PRINCIPLES OF MEDICINAL CHEMISTRY 20 2.1
AIMS 20 2.2 ADMINISTRATION AND ABSORPTION 20 2.3 THE GASTROINTESTINAL
TRACT 21 2.4 OTHER ROUTES OF ADMINISTRATION 23 2.5 PHYSICO-CHEMICAL
MEASUREMENTS 23 2.6 FORMULATION 24 2.7 DRUG METABOLISM 25 2.8 OXIDATION
BY CYTOCHROME P450S 26 2.9 THE HYDROXYLATION OF AROMATIC RINGS 27 2.10
THE HYDROXYLATION OF ALIPHATIC SYSTEMS 29 2.11 THE MONOAMINE OXIDASES 30
2.12 OTHER PHASE ONE CHANGES 31 2.13 PHASE TWO CHANGES 32 2.14 EXCRETION
33 2.15 PRO-DRUGS 33 2.16 QUANTITATIVE STRUCTURE: ACTIVITY RELATIONSHIPS
35 2.17 HANSCH QSAR ANALYSES 36 2.18 CRAIG PLOTS AND THE TOPLISS
DECISION TREE 38 2.19 DRUG: RECEPTOR INTERACTIONS 39 CHAPTER 3
NEUROTRANSMITTERS AS TARGETS 41 3.1 AIMS 41 3.2 INTRODUCTION 41 3.3 THE
NERVOUS SVSTCM 42 VU VIII CONTENTS 3.4 THE NEUROTRANSMITTERS 44 3.5
CELL-SURFACE RECEPTORS 45 3.6 ION-CHANNEL-LINKED RECEPTORS 45 3.7
KINASE-LINKED RECEPTORS 45 3.8 G-PROTEIN-LINKED RECEPTORS 46 3.9
AGONISTS AND ANTAGONISTS 48 3.10 ACETYLCHOLINE 48 3.11 NEUROMUSCULAR
BLOCKING AGENTS IN SURGERY 49 3.12 MUSCARINIC AGONISTS 51 3.13 LOCAL
ANAESTHETICS 52 3.14 CATECHOLAMINES AS NEUROTRANSMITTERS 53 3.15 THE
ADRENERGIC RECEPTORS 55 3.16 A-ADRENERGIC RECEPTOR AGONISTS 55 3.17
P-ADRENERGIC RECEPTOR AGONISTS - THE DEVELOPMENT OF ANTI-ASTHMA DRUGS 56
3.18 P R ADRENERGIC ANTAGONISTS P-BLOCKERS 59 3.19 THE TREATMENT OF
HYPERTENSION 61 CHAPTER 4 MEDICINAL CHEMISTRY AND THE CENTRAL NERVOUS
SYSTEM 64 4.1 AIMS 64 4.2 INTRODUCTION 64 4.3 THE TREATMENT OF
NEURODEGENERATIVE DISEASES 66 4.3.1 ALZHEIMER S DISEASE 66 4.3.2
PARKINSON S DISEASE 67 4.4 DOPAMINE ANTAGONISTS AS NEUROLEPTIC AGENTS 70
4.5 SEROTONIN AS A NEUROTRANSMITTER 72 4.6 THE TREATMENT OF DEPRESSION
73 4.7 GABA AS A NEUROTRANSMITTER 76 4.8 THE TREATMENT OF EPILEPSY 77
4.9 BENZODIAZEPINES AS ANXIOLYTIC AGENTS 78 4.10 BARBITURATE SLEEPING
TABLETS 80 4.11 OPIOIDS AS ANALGESICS 81 CHAPTER 5 LOCAL AND CIRCULATORY
HORMONE TARGETS 85 5.1 AIMS 85 5.2 INTRODUCTION 85 5.3 HISTAMINE AS A
TARGET 86 5.4 HISTAMINE ANTAGONISTS IN THE TREATMENT OF PEPTIC ULCERS 87
5.5 THE PROSTAGLANDINS AND NON-STEROIDAL ANTI- INFLAMMATORY AGENTS 90
5.6 THE DEVELOPMENT OF IBUPROFEN 92 CONTENTS J X 5.7 THE MECHANISM OF
ACTION OF ASPIRIN 94 5.8 MEDICINAL USES OF PROSTAGLANDINS 95 5.9 THE
STEROLS AND STEROID HORMONES 96 5.10 THE BIOSYNTHESIS OF THE STEROIDS 98
5.11 THE CONTROL OF CHOLESTEROL BIOSYNTHESIS 100 5.12 THE STEROIDAL
ANTI-INFLAMMATORY AGENTS 101 5.13 THE STEROIDAL ORAL CONTRACEPTIVES 103
5.14 THE ROLE OF NITRIC OXIDE 104 CHAPTER 6 ANTI-INFECTIVE AGENTS 105
6.1 AIMS 105 6.2 INTRODUCTION 105 6.3 BACTERIAL DISEASES 106 6.4
ANTISEPTICS 107 6.5 THE SULFONAMIDE ANTI-BACTERIAL AGENTS 108 6.6 THE
PENICILLINS 111 6.6.1 SEMI-SYNTHETIC PENICILLINS 114 6.7 CLAVULANIC ACID
AND THE INHIBITION OF P-LACTAMASES 114 6.8 THE CEPHALOSPORINS 115 6.9
THE MODE OF ACTION OF THE P-LACTAM ANTIBIOTICS 115 6.10 OTHER
ANTIBIOTICS 117 6.11 SYNTHETIC ANTI-BACTERIAL AGENTS 118 6.12 ANTI-VIRAL
AGENTS 118 6.12.1 VIRAL DISEASES 118 6.12.2 VIRAL STRUCTURE AND
REPLICATION 119 6.12.3 TARGETS FOR ANTI-VIRAL AGENTS 120 6.13 THE
INHIBITION OF NUCLEIC ACID BIOSYNTHESIS 120 6.14 INHIBITORS OF REVERSE
TRANSCRIPTASE 121 6.15 NEURAMINIDASE INHIBITORS 122 6.16 THE SYNTHESIS
OF NUDEOSIDE ANALOGUES 122 6.17 ANTI-FUNGAL AGENTS 124 6.18 ERGOSTEROL
BIOSYNTHESIS INHIBITORS 124 6.19 OTHER ANTI-FUNGAL AGENTS 126 6.20
PARASITIC INFECTIONS 126 6.20.1 THE TREATMENT OF MALARIA 126 CHAPTER 7
CANCER CHEMOTHERAPY 129 7.1 AIMS 129 7.2 INTRODUCTION 129 7.3 THE CELL
CYCLE 129 7.4 CANCER CHEMOTHERAPY 131 7.5 ANTI-METABOLITES 131 X
CONTENTS 7.6 ALKYLATING AGENTS 134 7.7 INTERCALATING AGENTS 137 7.8
ANTI-MITOTIC AGENTS 138 7.9 INTERFERENCE WITH SELECTED DEVELOPMENTAL
PROCESSES 138 7.9.1 THE TREATMENT OF BREAST CANCER 138 7.10 MONOCLONAL
ANTIBODIES 140 7.11 PROSTATE CANCER 141 FURTHER READING 142 GLOSSARY 144
SUBJECT INDEX 151
|
| adam_txt |
CHEMISTRY AND MEDICINES AN INTRODUCTORY TEXT JAMES R HANSON DEPARTMENT
OF CHEMISTRY, UNIVERSITY OF SUSSEX, BRIGHTON, UK RSC PUBLISHING CONTENTS
CHAPTER 1 INTRODUCTION 1 1.1 AIMS 1 1.2 THE CLASSIFICATION OF DRUGS 1
1.3 TARGETS FOR THE MEDICINAL CHEMIST 2 1.3.1 HORMONES AS TARGETS 2
1.3.2 CELLULAR STRUCTURES AS TARGETS 4 1.4 THE STAGES IN THE DEVELOPMENT
OF A DRUG 5 1.5 THE SYNTHESIS OF A DRUG 6 1.6 THE HISTORY OF MEDICINAL
CHEMISTRY 8 CHAPTER 2 GENERAL PRINCIPLES OF MEDICINAL CHEMISTRY 20 2.1
AIMS 20 2.2 ADMINISTRATION AND ABSORPTION 20 2.3 THE GASTROINTESTINAL
TRACT 21 2.4 OTHER ROUTES OF ADMINISTRATION 23 2.5 PHYSICO-CHEMICAL
MEASUREMENTS 23 2.6 FORMULATION 24 2.7 DRUG METABOLISM 25 2.8 OXIDATION
BY CYTOCHROME P450S 26 2.9 THE HYDROXYLATION OF AROMATIC RINGS 27 2.10
THE HYDROXYLATION OF ALIPHATIC SYSTEMS 29 2.11 THE MONOAMINE OXIDASES 30
2.12 OTHER PHASE ONE CHANGES 31 2.13 PHASE TWO CHANGES 32 2.14 EXCRETION
33 2.15 PRO-DRUGS 33 2.16 QUANTITATIVE STRUCTURE: ACTIVITY RELATIONSHIPS
35 2.17 HANSCH QSAR ANALYSES 36 2.18 CRAIG PLOTS AND THE TOPLISS
DECISION TREE 38 2.19 DRUG: RECEPTOR INTERACTIONS 39 CHAPTER 3
NEUROTRANSMITTERS AS TARGETS 41 3.1 AIMS 41 3.2 INTRODUCTION 41 3.3 THE
NERVOUS SVSTCM 42 VU VIII CONTENTS 3.4 THE NEUROTRANSMITTERS 44 3.5
CELL-SURFACE RECEPTORS 45 3.6 ION-CHANNEL-LINKED RECEPTORS 45 3.7
KINASE-LINKED RECEPTORS 45 3.8 G-PROTEIN-LINKED RECEPTORS 46 3.9
AGONISTS AND ANTAGONISTS 48 3.10 ACETYLCHOLINE 48 3.11 NEUROMUSCULAR
BLOCKING AGENTS IN SURGERY 49 3.12 MUSCARINIC AGONISTS 51 3.13 LOCAL
ANAESTHETICS 52 3.14 CATECHOLAMINES AS NEUROTRANSMITTERS 53 3.15 THE
ADRENERGIC RECEPTORS 55 3.16 A-ADRENERGIC RECEPTOR AGONISTS 55 3.17
P-ADRENERGIC RECEPTOR AGONISTS - THE DEVELOPMENT OF ANTI-ASTHMA DRUGS 56
3.18 P R ADRENERGIC ANTAGONISTS 'P-BLOCKERS' 59 3.19 THE TREATMENT OF
HYPERTENSION 61 CHAPTER 4 MEDICINAL CHEMISTRY AND THE CENTRAL NERVOUS
SYSTEM 64 4.1 AIMS 64 4.2 INTRODUCTION 64 4.3 THE TREATMENT OF
NEURODEGENERATIVE DISEASES 66 4.3.1 ALZHEIMER'S DISEASE 66 4.3.2
PARKINSON'S DISEASE 67 4.4 DOPAMINE ANTAGONISTS AS NEUROLEPTIC AGENTS 70
4.5 SEROTONIN AS A NEUROTRANSMITTER 72 4.6 THE TREATMENT OF DEPRESSION
73 4.7 GABA AS A NEUROTRANSMITTER 76 4.8 THE TREATMENT OF EPILEPSY 77
4.9 BENZODIAZEPINES AS ANXIOLYTIC AGENTS 78 4.10 BARBITURATE SLEEPING
TABLETS 80 4.11 OPIOIDS AS ANALGESICS 81 CHAPTER 5 LOCAL AND CIRCULATORY
HORMONE TARGETS 85 5.1 AIMS 85 5.2 INTRODUCTION 85 5.3 HISTAMINE AS A
TARGET 86 5.4 HISTAMINE ANTAGONISTS IN THE TREATMENT OF PEPTIC ULCERS 87
5.5 THE PROSTAGLANDINS AND NON-STEROIDAL ANTI- INFLAMMATORY AGENTS 90
5.6 THE DEVELOPMENT OF IBUPROFEN 92 CONTENTS J X 5.7 THE MECHANISM OF
ACTION OF ASPIRIN 94 5.8 MEDICINAL USES OF PROSTAGLANDINS 95 5.9 THE
STEROLS AND STEROID HORMONES 96 5.10 THE BIOSYNTHESIS OF THE STEROIDS 98
5.11 THE CONTROL OF CHOLESTEROL BIOSYNTHESIS 100 5.12 THE STEROIDAL
ANTI-INFLAMMATORY AGENTS 101 5.13 THE STEROIDAL ORAL CONTRACEPTIVES 103
5.14 THE ROLE OF NITRIC OXIDE 104 CHAPTER 6 ANTI-INFECTIVE AGENTS 105
6.1 AIMS 105 6.2 INTRODUCTION 105 6.3 BACTERIAL DISEASES 106 6.4
ANTISEPTICS 107 6.5 THE SULFONAMIDE ANTI-BACTERIAL AGENTS 108 6.6 THE
PENICILLINS 111 6.6.1 SEMI-SYNTHETIC PENICILLINS 114 6.7 CLAVULANIC ACID
AND THE INHIBITION OF P-LACTAMASES 114 6.8 THE CEPHALOSPORINS 115 6.9
THE MODE OF ACTION OF THE P-LACTAM ANTIBIOTICS 115 6.10 OTHER
ANTIBIOTICS 117 6.11 SYNTHETIC ANTI-BACTERIAL AGENTS 118 6.12 ANTI-VIRAL
AGENTS 118 6.12.1 VIRAL DISEASES 118 6.12.2 VIRAL STRUCTURE AND
REPLICATION 119 6.12.3 TARGETS FOR ANTI-VIRAL AGENTS 120 6.13 THE
INHIBITION OF NUCLEIC ACID BIOSYNTHESIS 120 6.14 INHIBITORS OF REVERSE
TRANSCRIPTASE 121 6.15 NEURAMINIDASE INHIBITORS 122 6.16 THE SYNTHESIS
OF NUDEOSIDE ANALOGUES 122 6.17 ANTI-FUNGAL AGENTS 124 6.18 ERGOSTEROL
BIOSYNTHESIS INHIBITORS 124 6.19 OTHER ANTI-FUNGAL AGENTS 126 6.20
PARASITIC INFECTIONS 126 6.20.1 THE TREATMENT OF MALARIA 126 CHAPTER 7
CANCER CHEMOTHERAPY 129 7.1 AIMS 129 7.2 INTRODUCTION 129 7.3 THE CELL
CYCLE 129 7.4 CANCER CHEMOTHERAPY 131 7.5 ANTI-METABOLITES 131 X
CONTENTS 7.6 ALKYLATING AGENTS 134 7.7 INTERCALATING AGENTS 137 7.8
ANTI-MITOTIC AGENTS 138 7.9 INTERFERENCE WITH SELECTED DEVELOPMENTAL
PROCESSES 138 7.9.1 THE TREATMENT OF BREAST CANCER 138 7.10 MONOCLONAL
ANTIBODIES 140 7.11 PROSTATE CANCER 141 FURTHER READING 142 GLOSSARY 144
SUBJECT INDEX 151 |
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| language | English |
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| spelling | Hanson, James Ralph Verfasser aut Chemistry and medicines an introductory text James R. Hanson Cambridge RSC Pub. 2006 x, 156 p. ill. 24 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references (p. 142-143) and index Farmacochemie gtt Pharmaceutical chemistry Chemistry, Pharmaceutical Pharmaceutical Preparations chemistry http://www.loc.gov/catdir/toc/fy0708/2006491858.html Table of contents only GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015689691&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hanson, James Ralph Chemistry and medicines an introductory text Farmacochemie gtt Pharmaceutical chemistry Chemistry, Pharmaceutical Pharmaceutical Preparations chemistry |
| title | Chemistry and medicines an introductory text |
| title_auth | Chemistry and medicines an introductory text |
| title_exact_search | Chemistry and medicines an introductory text |
| title_exact_search_txtP | Chemistry and medicines an introductory text |
| title_full | Chemistry and medicines an introductory text James R. Hanson |
| title_fullStr | Chemistry and medicines an introductory text James R. Hanson |
| title_full_unstemmed | Chemistry and medicines an introductory text James R. Hanson |
| title_short | Chemistry and medicines |
| title_sort | chemistry and medicines an introductory text |
| title_sub | an introductory text |
| topic | Farmacochemie gtt Pharmaceutical chemistry Chemistry, Pharmaceutical Pharmaceutical Preparations chemistry |
| topic_facet | Farmacochemie Pharmaceutical chemistry Chemistry, Pharmaceutical Pharmaceutical Preparations chemistry |
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