Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease: a randomised controlled trial
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
Tönning [u.a.]
Der Andere Verl.
2007
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Zugl.: Berlin, Univ., Diss., 2007. - Zsfassung in dt. und engl. Sprache |
| Physical Description: | 98 S. graph. Darst. 210 mm x 150 mm |
| ISBN: | 9783899595970 3899595971 |
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| 245 | 1 | 0 | |a Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease |b a randomised controlled trial |c von Kristina Norman |
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| adam_text | TABLE OF CONTENTS
1 INTRODUCTION 7
1.1 Background 8
1.2 Causes of malnutrition 10
1.3 Impact of malnutrition on organ function 11
1.4 Impact of malnutrition on outcome 13
1.5 Nutritional intervention 15
1.6 Aim of the study 16
2 PATIENTS AND METHODS 18
2.1 Study design 18
2.2 Inclusion criteria 18
2.3 Exclusion criteria 19
2.4 Protocol 19
2.4.1 Randomisation 19
2.4.2 Screening 19
2.5 Nutritional status 21
2.5.1 Subjective global assessment 21
2.6 Body composition 23
2.6.1 Anthropometry 23
2.6.2 Bioelectrical impedance analysis 24
2.7 Muscle function 27
2.7.1 Hand grip strength 27
2.7.2 Peak Flow 27
2.8 Quality of life 27
2.8.1 Obtaining absolute values 28
2.8.2 Normbased scoring 28
2.9 Laboratory parameters 30
2.10 Supplementation and dietary counselling 30
2.11 Statistics 31
3 RESULTS 32
3.1 Baseline 32
3.1.1 Clinical characteristics and nutritional parameters of the study population 32
3.1.2 Muscle function and quality of life 34
3.1.3 Laboratory parameters and disease severity 36
3.1.4 Correlations between nutritional and functional parameters at baseline 37
3.2 Intervention 38
3.2.1 Food and supplementation intake 39
3.2.2 Changes of nutritional status and body composition 40
3.2.3 Changes in muscle function 44
3.2.4 Improvement of quality of life 48
3.2.5 Changes in laboratory parameters 51
3.2.6 Mortality and readmissions during study period 51
3.2.7 Subgroup analysis: Evaluation according to patients younger or older than 60 years 52
4 DISCUSSION 57
4.1 Conclusion 69
5 SUMMARY 71
6 ZUSAMMENFASSUNG 73
7 ACKNOWLEDGEMENT 75
CURRICULUM VITAE 75
LIST OF PUBLICATIONS 76
EIDESSTATTLICHE ERKLARUNG 77
REFERENCES 78
Introduction
TABLES
Table 1: prevalence of malnutrition in hospital reported since 1990 9
Table 2: method protocol 21
Table 3: precision of the anthropometrical measurements a) intraindividual variability and b)
FROM DAY TO DAY VARIABILITY 23
Table 4: precision of bia measurements a) intraindividual variability and b) from day to day
VARIABILITY 26
Table 5: diagnoses of baseline study patients 32
Table 6: demographic data and nutritional parameters in all recruited study patients at
BASELINE 33
Table 7: muscle function at baseline 34
Table 8: quality of life in the baseline population 35
Table 9: length of stay, number of drugs per day and laboratory data 36
Table 10: baseline diagnoses of the intention to treat study population 38
Table 11: data on oral intake and supplementation 39
Table 12: changes in weight, bmi and anthropometric measures 41
Table 13: changes in body composition and impedance parameters 42
Table 14: correlations between changes m in anthropometric and bia derived parameters 43
Table 15: changes in muscle function parameters 44
Table 16: correlations between changes m of nutritional parameters and muscle
FUNCTION PARAMETERS 47
Table 17: absolute values of the quality of life scales during study period 48
Table 18: changes in laboratory parameters during the study period 51
Table 19: age distribution 52
Table 20: anthropometric and body composition changes in the subgroup z 60 years 53
Table 21: muscle function and quality of life changes in the subgroup no years 54
Table 22: anthropometric and body composition changes in the subgroup 60 years 55
Table 23: muscle function and quality of life changes in the subgroup 60 years 56
Introduction
FIGURES
Figure 1: screening 20
Figure 2: formation of the phase angle at the cell membrane in (aj and the determination of
RESISTANCE AND CAPACITANCE FROM THE IMPEDANCE AND THE PHASE ANGLE IN (B) 25
Figure 3: normbased scored values of quality of life in the patients recruited at
BASELINE, INDICATES SIGNIFICANT DIFFERENCES TO THE NORM VALUES, P 0.0001 36
Figure 4: correlation between total protein intake and change in hand grip strength 40
Figure 5: mean increase of body cell mass in intervention vs. control group during study
PERIOD (A) AND MEAN INCREASE OF PHASE ANGLE IN INTERVENTION VS. CONTROL GROUP
DURING STUDY PERIOD (B) 43
Figure 6: (A) change of hand grip strength and (b peak flow in the intervention and control
PATIENTS DURING THE STUDY PERIOD 44
Figure 7: correlation between changes in bcm and changes in hand grip strength 45
Figure 8: correlation between changes in bcm and changes in peak flow 45
Figure 9: hand grip strength change per mm* ama change, expressed as mean ±std 46
Figure 10: summarised and normbased data on quality of life: pcs physical component
SUMMARY AND MCS MENTAL COMPONENT SUMMARY AT BASELINE AND AFTER THREE MONTHS
IN (A) INTERVENTION GROUP AND (B) CONTROL GROUP; • =. P 0.05; = P 0.001 COMPARED TO NORM
VALUES (ONE SAMPLE T TEST) 49
Figure 11: correlation between change in hand grip strength and the scale physical
FUNCTIONING 50
|
| adam_txt |
TABLE OF CONTENTS
1 INTRODUCTION 7
1.1 Background 8
1.2 Causes of malnutrition 10
1.3 Impact of malnutrition on organ function 11
1.4 Impact of malnutrition on outcome 13
1.5 Nutritional intervention 15
1.6 Aim of the study 16
2 PATIENTS AND METHODS 18
2.1 Study design 18
2.2 Inclusion criteria 18
2.3 Exclusion criteria 19
2.4 Protocol 19
2.4.1 Randomisation 19
2.4.2 Screening 19
2.5 Nutritional status 21
2.5.1 Subjective global assessment 21
2.6 Body composition 23
2.6.1 Anthropometry 23
2.6.2 Bioelectrical impedance analysis 24
2.7 Muscle function 27
2.7.1 Hand grip strength 27
2.7.2 Peak Flow 27
2.8 Quality of life 27
2.8.1 Obtaining absolute values 28
2.8.2 Normbased scoring 28
2.9 Laboratory parameters 30
2.10 Supplementation and dietary counselling 30
2.11 Statistics 31
3 RESULTS 32
3.1 Baseline 32
3.1.1 Clinical characteristics and nutritional parameters of the study population 32
3.1.2 Muscle function and quality of life 34
3.1.3 Laboratory parameters and disease severity 36
3.1.4 Correlations between nutritional and functional parameters at baseline 37
3.2 Intervention 38
3.2.1 Food and supplementation intake 39
3.2.2 Changes of nutritional status and body composition 40
3.2.3 Changes in muscle function 44
3.2.4 Improvement of quality of life 48
3.2.5 Changes in laboratory parameters 51
3.2.6 Mortality and readmissions during study period 51
3.2.7 Subgroup analysis: Evaluation according to patients younger or older than 60 years 52
4 DISCUSSION 57
4.1 Conclusion 69
5 SUMMARY 71
6 ZUSAMMENFASSUNG 73
7 ACKNOWLEDGEMENT 75
CURRICULUM VITAE 75
LIST OF PUBLICATIONS 76
EIDESSTATTLICHE ERKLARUNG 77
REFERENCES 78
Introduction
TABLES
Table 1: prevalence of malnutrition in hospital reported since 1990 9
Table 2: method protocol 21
Table 3: precision of the anthropometrical measurements a) intraindividual variability and b)
FROM DAY TO DAY VARIABILITY 23
Table 4: precision of bia measurements a) intraindividual variability and b) from day to day
VARIABILITY 26
Table 5: diagnoses of baseline study patients 32
Table 6: demographic data and nutritional parameters in all recruited study patients at
BASELINE 33
Table 7: muscle function at baseline 34
Table 8: quality of life in the baseline population 35
Table 9: length of stay, number of drugs per day and laboratory data 36
Table 10: baseline diagnoses of the intention to treat study population 38
Table 11: data on oral intake and supplementation 39
Table 12: changes in weight, bmi and anthropometric measures 41
Table 13: changes in body composition and impedance parameters 42
Table 14: correlations between changes m in anthropometric and bia derived parameters 43
Table 15: changes in muscle function parameters 44
Table 16: correlations between changes m of nutritional parameters and muscle
FUNCTION PARAMETERS 47
Table 17: absolute values of the quality of life scales during study period 48
Table 18: changes in laboratory parameters during the study period 51
Table 19: age distribution 52
Table 20: anthropometric and body composition changes in the subgroup z 60 years 53
Table 21: muscle function and quality of life changes in the subgroup no years 54
Table 22: anthropometric and body composition changes in the subgroup 60 years 55
Table 23: muscle function and quality of life changes in the subgroup 60 years 56
Introduction
FIGURES
Figure 1: screening 20
Figure 2: formation of the phase angle at the cell membrane in (aj and the determination of
RESISTANCE AND CAPACITANCE FROM THE IMPEDANCE AND THE PHASE ANGLE IN (B) 25
Figure 3: normbased scored values of quality of life in the patients recruited at
BASELINE,' INDICATES SIGNIFICANT DIFFERENCES TO THE NORM VALUES, P 0.0001 36
Figure 4: correlation between total protein intake and change in hand grip strength 40
Figure 5: mean increase of body cell mass in intervention vs. control group during study
PERIOD (A) AND MEAN INCREASE OF PHASE ANGLE IN INTERVENTION VS. CONTROL GROUP
DURING STUDY PERIOD (B) 43
Figure 6: (A) change of hand grip strength and (b peak flow in the intervention and control
PATIENTS DURING THE STUDY PERIOD 44
Figure 7: correlation between changes in bcm and changes in hand grip strength 45
Figure 8: correlation between changes in bcm and changes in peak flow 45
Figure 9: hand grip strength change per mm* ama change, expressed as mean ±std 46
Figure 10: summarised and normbased data on quality of life: pcs physical component
SUMMARY AND MCS MENTAL COMPONENT SUMMARY AT BASELINE AND AFTER THREE MONTHS
IN (A) INTERVENTION GROUP AND (B) CONTROL GROUP; • =. P 0.05; " = P 0.001 COMPARED TO NORM
VALUES (ONE SAMPLE T TEST) 49
Figure 11: correlation between change in hand grip strength and the scale physical
FUNCTIONING 50 |
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| author | Norman, Kristina |
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| dewey-ones | 616 - Diseases |
| dewey-raw | 616.39 |
| dewey-search | 616.39 |
| dewey-sort | 3616.39 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
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| spelling | Norman, Kristina Verfasser aut Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial von Kristina Norman Tönning [u.a.] Der Andere Verl. 2007 98 S. graph. Darst. 210 mm x 150 mm txt rdacontent n rdamedia nc rdacarrier Zugl.: Berlin, Univ., Diss., 2007. - Zsfassung in dt. und engl. Sprache Zugl.: Berlin, Charité, Univ.-Med., Diss., 2007 Mangelernährung (DE-588)4138143-9 gnd rswk-swf Gastrointestinale Krankheit (DE-588)4114483-1 gnd rswk-swf Sekundärkrankheit (DE-588)4131705-1 gnd rswk-swf Proteinreiche Diät (DE-588)4246278-2 gnd rswk-swf Nährstoffmangel (DE-588)4345147-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Gastrointestinale Krankheit (DE-588)4114483-1 s Sekundärkrankheit (DE-588)4131705-1 s Mangelernährung (DE-588)4138143-9 s Nährstoffmangel (DE-588)4345147-0 s Proteinreiche Diät (DE-588)4246278-2 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015675745&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Norman, Kristina Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial Mangelernährung (DE-588)4138143-9 gnd Gastrointestinale Krankheit (DE-588)4114483-1 gnd Sekundärkrankheit (DE-588)4131705-1 gnd Proteinreiche Diät (DE-588)4246278-2 gnd Nährstoffmangel (DE-588)4345147-0 gnd |
| subject_GND | (DE-588)4138143-9 (DE-588)4114483-1 (DE-588)4131705-1 (DE-588)4246278-2 (DE-588)4345147-0 (DE-588)4113937-9 |
| title | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial |
| title_auth | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial |
| title_exact_search | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial |
| title_exact_search_txtP | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial |
| title_full | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial von Kristina Norman |
| title_fullStr | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial von Kristina Norman |
| title_full_unstemmed | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial von Kristina Norman |
| title_short | Effects of a three-month intervention with protein and energy rich supplements on body composition, muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease |
| title_sort | effects of a three month intervention with protein and energy rich supplements on body composition muscle function and quality of life in malnourished patients with nonneoplastic gastrointestinal disease a randomised controlled trial |
| title_sub | a randomised controlled trial |
| topic | Mangelernährung (DE-588)4138143-9 gnd Gastrointestinale Krankheit (DE-588)4114483-1 gnd Sekundärkrankheit (DE-588)4131705-1 gnd Proteinreiche Diät (DE-588)4246278-2 gnd Nährstoffmangel (DE-588)4345147-0 gnd |
| topic_facet | Mangelernährung Gastrointestinale Krankheit Sekundärkrankheit Proteinreiche Diät Nährstoffmangel Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015675745&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT normankristina effectsofathreemonthinterventionwithproteinandenergyrichsupplementsonbodycompositionmusclefunctionandqualityoflifeinmalnourishedpatientswithnonneoplasticgastrointestinaldiseasearandomisedcontrolledtrial |