Liposome technology: 1 Liposome preparation and related techniques
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Informa Healthcare
2007
|
| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 324 S. Ill., graph. Darst. |
| ISBN: | 084938821x 9780849388217 |
Internformat
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| 245 | 1 | 0 | |a Liposome technology |n 1 |p Liposome preparation and related techniques |c ed. by Gregory Gregoriadis |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a New York [u.a.] |b Informa Healthcare |c 2007 | |
| 300 | |a XX, 324 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a Liposomes |2 ram | |
| 650 | 7 | |a Vecteurs de médicaments |2 ram | |
| 650 | 4 | |a Drug carriers (Pharmacy) | |
| 650 | 4 | |a Drug targeting | |
| 650 | 4 | |a Liposomes | |
| 700 | 1 | |a Gregoriadis, Gregory |d 1937- |e Sonstige |0 (DE-588)107725797X |4 oth | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-015663293 | |
Datensatz im Suchindex
| _version_ | 1807591576273158144 |
|---|---|
| adam_text |
Contents
Preface . v
Acknowledgments . ix
Contributors . xvii
1. Formation and Properties of Fatty Acid
Vesicles (Liposomes) 1
Peter Walde, Trishool Namani, Kenichi Morigaki,
and Helmut Hauser
Introduction . 1
Ternary Phase Diagrams of Soap, the
Corresponding Fatty Acid, and Water . 3
Titration Curves . 7
Preparation of Fatty Acid Vesicles . 10
Properties of Fatty Acid Vesicles . 12
Applications of Fatty Acid Vesicles and
Conclusions . 15
References . 17
2. The Preparation of Lipid Vesicles (Liposomes) Using the
Coacervation Technique 21
Fumiyoshi Ishii
Introduction . 21
Methods . 22
Results and Discussion . 24
XI
xii Contents
Conclusions . 31
References . 32
3. Preparation of Liposomes and Oily Formulations by
Freeze Drying of Monophase Solutions 35
ChunLei Li, YingJie Deng, and JingXia Cui
Introduction . 35
Preparation of Liposomes . 36
Solubilization of Hydrophilic Drugs in Oil . 43
Concluding Remarks . 51
References . 52
4. Formation of Large Unilamellar Vesicles by Extrusion . 55
Barbara Mui and Michael J. Hope
Introduction . 55
Large Unilamellar Vesicles and Extrusion . 56
Mechanism of Extrusion . 58
Extrusion and Lipid Composition . 61
Applications . 64
References . 64
5. Preparation of Liposomes for Pulmonary Delivery Using
Medical Nebulizers 67
Kevin M. G. Taylor and Abdelbary M. A. Elhissi
Introduction . 67
Methodology . 70
Results and Discussion . 72
Conclusion . 82
References . 82
6. Immunopotentiating Reconstituted Influenza Virosomes . 85
Rinaldo Zurbriggen, Mario Amacker, and
Andreas R. Krammer
Introduction . 85
Mode of Action . 87
Virosome Based Vaccines on the Market . 91
Virosomes for Drug Delivery . 94
References . 94
Contents xiii
7. Lipoplexes in Gene Therapy Under the Considerations of
Scaling Up, Stability Issues, and Pharmaceutical
Requirements 97
Patrick Gdridel and Regime Peschka Suss
Introduction . 97
Liposome Formation . 100
Plasmid Production . 101
The Formation of Lipid DNA Complexes . 105
Biophysical Characterization of Lipoplexes . 108
Lipoplex Analysis . 113
Lyophilization of Lipoplexes . 114
Long Term Stability . 117
In Vitro Tests . 118
Pharmaceutical Considerations and Guidelines for
Pharmaceutical Development . 121
Conclusions . 124
References . 125
8. Synthesis and Advantages of Acid Labile Formulations
for Lipoplexes 139
Marie Garinot, Christophe Masson, Nathalie Mignet,
Michel Bessodes, and Daniel Scherman
Introduction . 139
Methodology . 142
Discussion and Comparison of Different
Systems . 155
Conclusions . 159
References . 160
9. Bioresponsive Liposomes and Their Use for
Macromolecular Delivery 165
Zhaohua Huang and Francis C. Szoka, Jr.
Introduction . 165
pH Responsive Liposomes . 166
Reduction Responsive Liposomes . 177
Enzyme Responsive Liposomes . 186
Multifunctional Bioresponsive Liposomes
(Artificial Viruses) . 189
Conclusion . 191
References . 192
xiv Contents
10. Polymeric Vesicles Based on Hydrophilic Polymers Bearing
Hydrophobic Pendant Groups 797
Ijeoma Florence Uchegbu, Shona Anderson,
Anthony Brownlie, and Xiaozhong Qu
Introduction . 197
Factors Governing Self Assembly . 199
Vesicle Preparation . 202
Drug Delivery Applications . 203
Conclusions . 206
References . 207
11. Mixed Vesicles and Mixed Micelles: Formation,
Thermodynamic Stability, and Pharmaceutical
Aspects 209
Patrick Garidel and Jtirgen Lasch
Introduction . 209
Detergents, Lipids, and Water . 210
The Formation of Mixed Lipid Detergent
Systems . 217
Pharmaceutical Aspects of Mixed Vesicles
and Mixed Micelles . 233
Conclusions . 235
References . 235
12. Vesicular Phospholipid Gels 241
Martin Brandl and Ulrich Massing
Introduction . 241
Hydration and Swelling of Phospholipids . 242
Preparation of VPGs . 243
Characteristics of VPGs . 245
SUV Dispersions Prepared from VPGs . 248
Examples of Pharmaceutical Applications . 254
Summary of the VPG Concept . 257
References . 257
13. Stabilization of Liposomes by Freeze Drying: Lessons
from Nature 261
John H. Crowe, Nelly M. Tsvetkova, Ann E. Oliver,
Chad Leidy, Josette Richer, and Lois M. Crowe
Introduction . 261
Trehalose and Biostability . 262
Contents Xv
Origins of the Trehalose Myth . 262
Effect of Lipid Type and Thermal History on Tm
in the Dry State . 264
There is More than One Way to Achieve the
Same End . 265
Trehalose has Useful Properties,
Nevertheless . 267
Glass Transitions and Stability . 267
Nonenzymatic Browning and Stability of the
Glycosidic Bond . 269
Enzymatic Destabilization of Liposomes in the
Dry State . 270
Phase Separation as a Source of Damage . 272
Maintenance of Domains in the Dry State . 274
References . 279
14. Hydrolysis of Phospholipids in Liposomes and Stability
Indicating Analytical Techniques 285
Daan J. A. Crommelin and Nicolaas J. Zuidam
Introduction . 285
Analytical Approaches: Progress Over the Last
10 Years . 286
Polyethyleneglycol Determination . 287
Chemical Degradation . 287
Sterilization . 291
Concluding Remarks . 293
References . 294
15. Process Development and Quality Control of Injectable
Liposomal Therapeutics 297
Gerard M. Jensen, Tarquinus H. Bunch, Ning Hu,
and Crispin G. S. Eley
Introduction and Perspective . 297
Process vs. Formulation . 299
Conclusions . 308
References . 309
Index . 311 |
| adam_txt |
Contents
Preface . v
Acknowledgments . ix
Contributors . xvii
1. Formation and Properties of Fatty Acid
Vesicles (Liposomes) 1
Peter Walde, Trishool Namani, Kenichi Morigaki,
and Helmut Hauser
Introduction . 1
Ternary Phase Diagrams of Soap, the
Corresponding Fatty Acid, and Water . 3
Titration Curves . 7
Preparation of Fatty Acid Vesicles . 10
Properties of Fatty Acid Vesicles . 12
Applications of Fatty Acid Vesicles and
Conclusions . 15
References . 17
2. The Preparation of Lipid Vesicles (Liposomes) Using the
Coacervation Technique 21
Fumiyoshi Ishii
Introduction . 21
Methods . 22
Results and Discussion . 24
XI
xii Contents
Conclusions . 31
References . 32
3. Preparation of Liposomes and Oily Formulations by
Freeze Drying of Monophase Solutions 35
ChunLei Li, YingJie Deng, and JingXia Cui
Introduction . 35
Preparation of Liposomes . 36
Solubilization of Hydrophilic Drugs in Oil . 43
Concluding Remarks . 51
References . 52
4. Formation of Large Unilamellar Vesicles by Extrusion . 55
Barbara Mui and Michael J. Hope
Introduction . 55
Large Unilamellar Vesicles and Extrusion . 56
Mechanism of Extrusion . 58
Extrusion and Lipid Composition . 61
Applications . 64
References . 64
5. Preparation of Liposomes for Pulmonary Delivery Using
Medical Nebulizers 67
Kevin M. G. Taylor and Abdelbary M. A. Elhissi
Introduction . 67
Methodology . 70
Results and Discussion . 72
Conclusion . 82
References . 82
6. Immunopotentiating Reconstituted Influenza Virosomes . 85
Rinaldo Zurbriggen, Mario Amacker, and
Andreas R. Krammer
Introduction . 85
Mode of Action . 87
Virosome Based Vaccines on the Market . 91
Virosomes for Drug Delivery . 94
References . 94
Contents xiii
7. Lipoplexes in Gene Therapy Under the Considerations of
Scaling Up, Stability Issues, and Pharmaceutical
Requirements 97
Patrick Gdridel and Regime Peschka Suss
Introduction . 97
Liposome Formation . 100
Plasmid Production . 101
The Formation of Lipid DNA Complexes . 105
Biophysical Characterization of Lipoplexes . 108
Lipoplex Analysis . 113
Lyophilization of Lipoplexes . 114
Long Term Stability . 117
In Vitro Tests . 118
Pharmaceutical Considerations and Guidelines for
Pharmaceutical Development . 121
Conclusions . 124
References . 125
8. Synthesis and Advantages of Acid Labile Formulations
for Lipoplexes 139
Marie Garinot, Christophe Masson, Nathalie Mignet,
Michel Bessodes, and Daniel Scherman
Introduction . 139
Methodology . 142
Discussion and Comparison of Different
Systems . 155
Conclusions . 159
References . 160
9. Bioresponsive Liposomes and Their Use for
Macromolecular Delivery 165
Zhaohua Huang and Francis C. Szoka, Jr.
Introduction . 165
pH Responsive Liposomes . 166
Reduction Responsive Liposomes . 177
Enzyme Responsive Liposomes . 186
Multifunctional Bioresponsive Liposomes
(Artificial Viruses) . 189
Conclusion . 191
References . 192
xiv Contents
10. Polymeric Vesicles Based on Hydrophilic Polymers Bearing
Hydrophobic Pendant Groups 797
Ijeoma Florence Uchegbu, Shona Anderson,
Anthony Brownlie, and Xiaozhong Qu
Introduction . 197
Factors Governing Self Assembly . 199
Vesicle Preparation . 202
Drug Delivery Applications . 203
Conclusions . 206
References . 207
11. Mixed Vesicles and Mixed Micelles: Formation,
Thermodynamic Stability, and Pharmaceutical
Aspects 209
Patrick Garidel and Jtirgen Lasch
Introduction . 209
Detergents, Lipids, and Water . 210
The Formation of Mixed Lipid Detergent
Systems . 217
Pharmaceutical Aspects of Mixed Vesicles
and Mixed Micelles . 233
Conclusions . 235
References . 235
12. Vesicular Phospholipid Gels 241
Martin Brandl and Ulrich Massing
Introduction . 241
Hydration and Swelling of Phospholipids . 242
Preparation of VPGs . 243
Characteristics of VPGs . 245
SUV Dispersions Prepared from VPGs . 248
Examples of Pharmaceutical Applications . 254
Summary of the VPG Concept . 257
References . 257
13. Stabilization of Liposomes by Freeze Drying: Lessons
from Nature 261
John H. Crowe, Nelly M. Tsvetkova, Ann E. Oliver,
Chad Leidy, Josette Richer, and Lois M. Crowe
Introduction . 261
Trehalose and Biostability . 262
Contents Xv
Origins of the Trehalose Myth . 262
Effect of Lipid Type and Thermal History on Tm
in the Dry State . 264
There is More than One Way to Achieve the
Same End . 265
Trehalose has Useful Properties,
Nevertheless . 267
Glass Transitions and Stability . 267
Nonenzymatic Browning and Stability of the
Glycosidic Bond . 269
Enzymatic Destabilization of Liposomes in the
Dry State . 270
Phase Separation as a Source of Damage . 272
Maintenance of Domains in the Dry State . 274
References . 279
14. Hydrolysis of Phospholipids in Liposomes and Stability
Indicating Analytical Techniques 285
Daan J. A. Crommelin and Nicolaas J. Zuidam
Introduction . 285
Analytical Approaches: Progress Over the Last
10 Years . 286
Polyethyleneglycol Determination . 287
Chemical Degradation . 287
Sterilization . 291
Concluding Remarks . 293
References . 294
15. Process Development and Quality Control of Injectable
Liposomal Therapeutics 297
Gerard M. Jensen, Tarquinus H. Bunch, Ning Hu,
and Crispin G. S. Eley
Introduction and Perspective . 297
Process vs. Formulation . 299
Conclusions . 308
References . 309
Index . 311 |
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| spelling | Liposome technology 1 Liposome preparation and related techniques ed. by Gregory Gregoriadis 3. ed. New York [u.a.] Informa Healthcare 2007 XX, 324 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Liposomes ram Vecteurs de médicaments ram Drug carriers (Pharmacy) Drug targeting Liposomes Gregoriadis, Gregory 1937- Sonstige (DE-588)107725797X oth (DE-604)BV022453352 1 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015663293&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Liposome technology Liposomes ram Vecteurs de médicaments ram Drug carriers (Pharmacy) Drug targeting Liposomes |
| title | Liposome technology |
| title_auth | Liposome technology |
| title_exact_search | Liposome technology |
| title_exact_search_txtP | Liposome technology |
| title_full | Liposome technology 1 Liposome preparation and related techniques ed. by Gregory Gregoriadis |
| title_fullStr | Liposome technology 1 Liposome preparation and related techniques ed. by Gregory Gregoriadis |
| title_full_unstemmed | Liposome technology 1 Liposome preparation and related techniques ed. by Gregory Gregoriadis |
| title_short | Liposome technology |
| title_sort | liposome technology liposome preparation and related techniques |
| topic | Liposomes ram Vecteurs de médicaments ram Drug carriers (Pharmacy) Drug targeting Liposomes |
| topic_facet | Liposomes Vecteurs de médicaments Drug carriers (Pharmacy) Drug targeting |
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