Holdings: Glycogen synthase kinase 3 (GSK-3) and its inhibitors

Glycogen synthase kinase 3 (GSK-3) and its inhibitors: drug discovery and development

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Bibliographic Details
Format:	Electronic eBook
Language:	English
Published:	Hoboken, NJ Wiley-Interscience 2006
Series:	Wiley series in drug discovery and development
Subjects:	Glycogen synthase kinase-3 Glycogen synthase kinase-3 > Inhibitors Glycogen Synthase Kinase 3 > antagonists & inhibitors Protein Kinase Inhibitors > therapeutic use Glycogen Synthase Kinase 3 > physiology
Online Access:	FRO01 UBR01 Volltext Inhaltsverzeichnis
Item Description:	Includes bibliographical references and index
Physical Description:	1 Online-Ressource
ISBN:	9780470052174 9780471770015

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adam_text	CONTENTS FOREWORD—THE ORIGINS OF GSK 3 ix PREFACE xvii ACKNOWLEDGMENTS xix CONTRIBUTORS xxi ABBREVIATIONS xxv PART I CELLULAR FUNCTIONS OF GSK 3 1 1 Glycogen Synthase Kinase 3: An Introductory Synopsis 3 2 Glycogen Synthase Kinase 3(J (GSK 3P) a Key Signaling Enzyme: A Developmental Neurobiological Perspective 25 3 Role of GSK 3/Shaggy in Neuronal Cell Biology 45 4 The Crystal Structures of Glycogen Synthase Kinase 3 61 5 Kinase Kinase and Site Site Interactions in the Phosphorylation of Tau by GSK 3 83 vii viii CONTENTS PART II GSK 3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY 105 6 GSK 3, a Key Player in Alzheimer s Disease 107 7 Glycogen Synthase Kinase 3: A Target for Novel Mood Disorder Treatments 125 8 GSK 3 and Stem Cells 155 9 Glycogen Synthase Kinase 3: Role in Neurodegeneration and Neuroprotection 173 10 Protein Kinase Assays for Drug Discovery 189 11 Animal Models with Modified Expression of GSK 3 for the Study of Its Physiology and of Its Implications in Human Pathologies 203 PART III GSK 3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL 221 12 Lithium, the Seminal GSK 3 Inhibitor 223 13 Inhibition of GSK 3 as Therapeutic Strategy in Disease: Efficacy of AR A014418 243 14 TDZD s: Selective and ATP Noncompetitive Glycogen Synthase Kinase 3 Inhibitors 257 15 3 Amino Pyrazoles as Potent and Selective Glycogen Kinase Synthase 3 (GSK 3) Inhibitors 281 16 Marine Compounds as a New Source for Glycogen Synthase Kinase 3 Inhibitors 307 INDEX 333
adam_txt	CONTENTS FOREWORD—THE ORIGINS OF GSK 3 ix PREFACE xvii ACKNOWLEDGMENTS xix CONTRIBUTORS xxi ABBREVIATIONS xxv PART I CELLULAR FUNCTIONS OF GSK 3 1 1 Glycogen Synthase Kinase 3: An Introductory Synopsis 3 2 Glycogen Synthase Kinase 3(J (GSK 3P) a Key Signaling Enzyme: A Developmental Neurobiological Perspective 25 3 Role of GSK 3/Shaggy in Neuronal Cell Biology 45 4 The Crystal Structures of Glycogen Synthase Kinase 3 61 5 Kinase Kinase and Site Site Interactions in the Phosphorylation of Tau by GSK 3 83 vii viii CONTENTS PART II GSK 3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY 105 6 GSK 3, a Key Player in Alzheimer's Disease 107 7 Glycogen Synthase Kinase 3: A Target for Novel Mood Disorder Treatments 125 8 GSK 3 and Stem Cells 155 9 Glycogen Synthase Kinase 3: Role in Neurodegeneration and Neuroprotection 173 10 Protein Kinase Assays for Drug Discovery 189 11 Animal Models with Modified Expression of GSK 3 for the Study of Its Physiology and of Its Implications in Human Pathologies 203 PART III GSK 3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL 221 12 Lithium, the Seminal GSK 3 Inhibitor 223 13 Inhibition of GSK 3 as Therapeutic Strategy in Disease: Efficacy of AR A014418 243 14 TDZD's: Selective and ATP Noncompetitive Glycogen Synthase Kinase 3 Inhibitors 257 15 3 Amino Pyrazoles as Potent and Selective Glycogen Kinase Synthase 3 (GSK 3) Inhibitors 281 16 Marine Compounds as a New Source for Glycogen Synthase Kinase 3 Inhibitors 307 INDEX 333
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spelling	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development ed. by Ana Martinez ... Hoboken, NJ Wiley-Interscience 2006 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Wiley series in drug discovery and development Includes bibliographical references and index Glycogen synthase kinase-3 Glycogen synthase kinase-3 Inhibitors Glycogen Synthase Kinase 3 antagonists & inhibitors Protein Kinase Inhibitors therapeutic use Glycogen Synthase Kinase 3 physiology Martínez, Ana Sonstige oth Erscheint auch als Druck-Ausgabe, Hardcover 0-471-77001-9 https://onlinelibrary.wiley.com/doi/book/10.1002/0470052171 Verlag Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015638418&sequence=000010&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development Glycogen synthase kinase-3 Glycogen synthase kinase-3 Inhibitors Glycogen Synthase Kinase 3 antagonists & inhibitors Protein Kinase Inhibitors therapeutic use Glycogen Synthase Kinase 3 physiology
title	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development
title_auth	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development
title_exact_search	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development
title_exact_search_txtP	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development
title_full	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development ed. by Ana Martinez ...
title_fullStr	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development ed. by Ana Martinez ...
title_full_unstemmed	Glycogen synthase kinase 3 (GSK-3) and its inhibitors drug discovery and development ed. by Ana Martinez ...
title_short	Glycogen synthase kinase 3 (GSK-3) and its inhibitors
title_sort	glycogen synthase kinase 3 gsk 3 and its inhibitors drug discovery and development
title_sub	drug discovery and development
topic	Glycogen synthase kinase-3 Glycogen synthase kinase-3 Inhibitors Glycogen Synthase Kinase 3 antagonists & inhibitors Protein Kinase Inhibitors therapeutic use Glycogen Synthase Kinase 3 physiology
topic_facet	Glycogen synthase kinase-3 Glycogen synthase kinase-3 Inhibitors Glycogen Synthase Kinase 3 antagonists & inhibitors Protein Kinase Inhibitors therapeutic use Glycogen Synthase Kinase 3 physiology
url	https://onlinelibrary.wiley.com/doi/book/10.1002/0470052171 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=015638418&sequence=000010&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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